Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2079294971', 'doi': 'https://doi.org/10.1002/(sici)1097-4547(19981101)54:3<301::aid-jnr1>3.0.co;2-w', 'title': "Molecular aspects of Huntington's disease", 'display_name': "Molecular aspects of Huntington's disease", 'publication_year': 1998, 'publication_date': '1998-11-01', 'ids': {'openalex': 'https://openalex.org/W2079294971', 'doi': 'https://doi.org/10.1002/(sici)1097-4547(19981101)54:3<301::aid-jnr1>3.0.co;2-w', 'mag': '2079294971', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9819135'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-4547(19981101)54:3<301::aid-jnr1>3.0.co;2-w', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76417895', 'display_name': 'Journal of Neuroscience Research', 'issn_l': '0360-4012', 'issn': ['0360-4012', '1097-4547'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013133520', 'display_name': 'Hobart W. Walling', 'orcid': 'https://orcid.org/0000-0001-5428-1387'}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hobart W. Walling', 'raw_affiliation_strings': ['Department of Pharmacological and Physiological Science, Saint Louis University Health Sciences Center, Missouri 63104, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacological and Physiological Science, Saint Louis University Health Sciences Center, Missouri 63104, USA.', 'institution_ids': ['https://openalex.org/I47838141']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012462653', 'display_name': 'Joseph J. Baldassare', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph J. Baldassare', 'raw_affiliation_strings': ['Department of Pharmacological and Physiological Science, Saint Louis University Health Sciences Center, St. Louis, Missouri'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacological and Physiological Science, Saint Louis University Health Sciences Center, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I47838141']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5114061800', 'display_name': 'Thomas C. Westfall', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas C. Westfall', 'raw_affiliation_strings': ['Department of Pharmacological and Physiological Science, Saint Louis University Health Sciences Center, St. Louis, Missouri'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacological and Physiological Science, Saint Louis University Health Sciences Center, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I47838141']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4640, 'currency': 'USD', 'value_usd': 4640, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.617, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 50, 'citation_normalized_percentile': {'value': 0.560947, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '54', 'issue': '3', 'first_page': '301', 'last_page': '308'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10949', 'display_name': 'Genetic Neurodegenerative Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10949', 'display_name': 'Genetic Neurodegenerative Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10919', 'display_name': 'Neurological disorders and treatments', 'score': 0.9781, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/huntingtin-protein', 'display_name': 'Huntingtin Protein', 'score': 0.72139466}], 'concepts': [{'id': 'https://openalex.org/C2781427258', 'wikidata': 'https://www.wikidata.org/wiki/Q2620886', 'display_name': 'Huntingtin', 'level': 4, 'score': 0.95657206}, {'id': 'https://openalex.org/C2910011555', 'wikidata': 'https://www.wikidata.org/wiki/Q2620886', 'display_name': 'Huntingtin Protein', 'level': 5, 'score': 0.72139466}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.69003487}, {'id': 'https://openalex.org/C166252455', 'wikidata': 'https://www.wikidata.org/wiki/Q6736610', 'display_name': 'Trinucleotide repeat expansion', 'level': 4, 'score': 0.6581116}, {'id': 'https://openalex.org/C2780647506', 'wikidata': 'https://www.wikidata.org/wiki/Q190564', 'display_name': "Huntington's disease", 'level': 3, 'score': 0.58209413}, {'id': 'https://openalex.org/C36823959', 'wikidata': 'https://www.wikidata.org/wiki/Q373027', 'display_name': 'Exon', 'level': 3, 'score': 0.48780158}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.47115266}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.43686557}, {'id': 'https://openalex.org/C29512474', 'wikidata': 'https://www.wikidata.org/wiki/Q16860021', 'display_name': 'Nuclear protein', 'level': 4, 'score': 0.41973135}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2758559}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.20434675}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.18242183}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.17403692}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.100219846}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.073226064}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.06051016}], 'mesh': [{'descriptor_ui': 'D006816', 'descriptor_name': 'Huntington Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071058', 'descriptor_name': 'Huntingtin Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006816', 'descriptor_name': 'Huntington Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006816', 'descriptor_name': 'Huntington Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006816', 'descriptor_name': 'Huntington Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014452', 'descriptor_name': 'Ubiquitins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014452', 'descriptor_name': 'Ubiquitins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-4547(19981101)54:3<301::aid-jnr1>3.0.co;2-w', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76417895', 'display_name': 'Journal of Neuroscience Research', 'issn_l': '0360-4012', 'issn': ['0360-4012', '1097-4547'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9819135', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 86, 'referenced_works': ['https://openalex.org/W1526095797', 'https://openalex.org/W1579354139', 'https://openalex.org/W1613986623', 'https://openalex.org/W1760694280', 'https://openalex.org/W1786914655', 'https://openalex.org/W1963552002', 'https://openalex.org/W1965747240', 'https://openalex.org/W1970765799', 'https://openalex.org/W1970831375', 'https://openalex.org/W1973758214', 'https://openalex.org/W1976201058', 'https://openalex.org/W1977983193', 'https://openalex.org/W1978104052', 'https://openalex.org/W1978580506', 'https://openalex.org/W1985474993', 'https://openalex.org/W1988110501', 'https://openalex.org/W1989657037', 'https://openalex.org/W1993470377', 'https://openalex.org/W1994285647', 'https://openalex.org/W1999961963', 'https://openalex.org/W2002644780', 'https://openalex.org/W2002763309', 'https://openalex.org/W2008202443', 'https://openalex.org/W2008561777', 'https://openalex.org/W2011867765', 'https://openalex.org/W2012442320', 'https://openalex.org/W2013063789', 'https://openalex.org/W2020206460', 'https://openalex.org/W2020619883', 'https://openalex.org/W2025578163', 'https://openalex.org/W2028138492', 'https://openalex.org/W2028142104', 'https://openalex.org/W2028547922', 'https://openalex.org/W2029003444', 'https://openalex.org/W2029948374', 'https://openalex.org/W2030410903', 'https://openalex.org/W2032161390', 'https://openalex.org/W2032255653', 'https://openalex.org/W2035796612', 'https://openalex.org/W2038253384', 'https://openalex.org/W2038610378', 'https://openalex.org/W2041156762', 'https://openalex.org/W2042716629', 'https://openalex.org/W2043440035', 'https://openalex.org/W2043501837', 'https://openalex.org/W2044030703', 'https://openalex.org/W2044559546', 'https://openalex.org/W2048802800', 'https://openalex.org/W2052883021', 'https://openalex.org/W2055418221', 'https://openalex.org/W2056730920', 'https://openalex.org/W2058543711', 'https://openalex.org/W2062682951', 'https://openalex.org/W2066099397', 'https://openalex.org/W2067161006', 'https://openalex.org/W2069003894', 'https://openalex.org/W2069389331', 'https://openalex.org/W2073282970', 'https://openalex.org/W2078001244', 'https://openalex.org/W2079250951', 'https://openalex.org/W2079813087', 'https://openalex.org/W2081085542', 'https://openalex.org/W2081868255', 'https://openalex.org/W2082056883', 'https://openalex.org/W2082501455', 'https://openalex.org/W2085141229', 'https://openalex.org/W2094172710', 'https://openalex.org/W2095344231', 'https://openalex.org/W2104811082', 'https://openalex.org/W2112072636', 'https://openalex.org/W2112604508', 'https://openalex.org/W2121642311', 'https://openalex.org/W2131176843', 'https://openalex.org/W2132082584', 'https://openalex.org/W2132502212', 'https://openalex.org/W2139826556', 'https://openalex.org/W2153196213', 'https://openalex.org/W2159269805', 'https://openalex.org/W2170998869', 'https://openalex.org/W2171705617', 'https://openalex.org/W2188519171', 'https://openalex.org/W2266315341', 'https://openalex.org/W34572746', 'https://openalex.org/W4292587951', 'https://openalex.org/W85227649', 'https://openalex.org/W983894645'], 'related_works': ['https://openalex.org/W3196103581', 'https://openalex.org/W2414710448', 'https://openalex.org/W2378232066', 'https://openalex.org/W2315853123', 'https://openalex.org/W2159691947', 'https://openalex.org/W2146763467', 'https://openalex.org/W2072197614', 'https://openalex.org/W2033394951', 'https://openalex.org/W1896472383', 'https://openalex.org/W143538493'], 'abstract_inverted_index': {'Journal': [0, 523, 555, 570], 'of': [1, 12, 25, 39, 70, 96, 126, 140, 171, 197, 244, 254, 267, 278, 304, 308, 330, 335, 343, 365, 412, 423, 440, 446, 456, 513, 524, 539, 556, 571, 574], 'Neuroscience': [2, 525], 'ResearchVolume': [3], '54,': [4], 'Issue': [5], '3': [6], 'p.': [7], '301-308': [8, 474], 'Mini-Review': [9], 'Molecular': [10, 559], 'aspects': [11, 439], "Huntington's": [13, 290, 486, 540, 575], 'disease': [14, 291, 297, 332, 487], 'Hobart': [15, 20, 116, 121], 'W.': [16, 21, 117, 122], 'Walling,': [17, 118], 'Corresponding': [18, 119], 'Author': [19, 120], 'Walling': [22, 123], '[email protected]': [23, 124], 'Department': [24, 69, 95, 125, 170, 196], 'Pharmacological': [26, 40, 71, 97, 127, 141, 172, 198], 'and': [27, 41, 72, 98, 128, 142, 173, 199, 242, 246, 258, 265, 284, 319, 385, 404, 415, 420, 453, 558, 582], 'Physiological': [28, 42, 73, 99, 129, 143, 174, 200], 'Science,': [29, 43, 74, 100, 130, 144, 175, 201], 'Saint': [30, 44, 75, 101, 131, 145, 176, 202], 'Louis': [31, 45, 76, 102, 132, 146, 177, 203], 'University': [32, 46, 77, 103, 133, 147, 178, 204], 'Health': [33, 47, 78, 104, 134, 148, 179, 205], 'Sciences': [34, 48, 79, 105, 135, 149, 180, 206], 'Center,': [35, 49, 80, 106, 136, 150, 181, 207], 'St.': [36, 54, 81, 107, 137, 155, 182, 208], 'Louis,': [37, 55, 82, 108, 138, 156, 183, 209], 'MissouriDept.': [38, 139], '1402': [50, 151], 'S.': [51, 152, 542, 566], 'Grand': [52, 153], 'Blvd.,': [53, 154], 'MO': [56, 157], '63104.Search': [57, 158], 'for': [58, 84, 110, 159, 185, 211, 387], 'more': [59, 85, 111, 160, 186, 212], 'papers': [60, 86, 112, 161, 187, 213], 'by': [61, 87, 113, 162, 188, 214], 'this': [62, 88, 114, 163, 189, 215, 279, 433], 'authorJoseph': [63, 164], 'J.': [64, 67, 165, 168, 459, 567], 'Baldassare,': [65, 166], 'Joseph': [66, 167], 'Baldassare': [68, 169], 'MissouriSearch': [83, 109, 184, 210], 'authorThomas': [89, 190], 'C.': [90, 93, 191, 194], 'Westfall,': [91, 192], 'Thomas': [92, 193], 'Westfall': [94, 195], 'author': [115, 216], 'First': [217], 'published:': [218], '12': [219], 'December': [220], '1998': [221, 465], 'https://doi.org/10.1002/(SICI)1097-4547(19981101)54:3<301::AID-JNR1>3.0.CO;2-WCitations:': [222], '32AboutRelatedInformationPDFPDF': [223], 'ToolsRequest': [224], 'permissionExport': [225], 'citationAdd': [226], 'to': [227, 250, 273, 354, 379, 393, 417, 481], 'favoritesTrack': [228], 'citation': [229], 'ShareShare': [230], 'Give': [231], 'accessShare': [232], 'full': [233], 'text': [234], 'accessClose': [235], 'modalShare': [236], 'full-text': [237, 252, 276], 'accessPlease': [238], 'review': [239], 'our': [240], 'Terms': [241, 264], 'Conditions': [243, 266], 'Use': [245], 'check': [247], 'box': [248], 'below': [249, 272], 'share': [251, 274], 'version': [253, 277], 'article.I': [255], 'have': [256], 'read': [257], 'accept': [259], 'the': [260, 270, 305, 309, 331, 336, 340, 358, 383, 421, 437, 443, 482, 535], 'Wiley': [261], 'Online': [262], 'Library': [263], 'UseShareable': [268], 'LinkUse': [269], 'link': [271], 'a': [275, 294, 344, 509, 562], 'article': [280], 'with': [281, 382, 395, 450], 'your': [282], 'friends': [283], 'colleagues.': [285], 'Learn': [286], 'more.Copy': [287], 'URL': [288], 'Abstract': [289], '(HD)': [292], 'is': [293, 320, 333], 'progressive': [295], 'neurodegenerative': [296], 'striking': [298], 'principally': [299], 'medium': [300], 'spiny': [301], 'GABAergic': [302], 'neurons': [303], 'caudate': [306], 'nucleus': [307], 'basal': [310], 'ganglia.': [311], 'It': [312], 'affects': [313], 'about': [314], 'one': [315], 'in': [316, 322, 339, 357, 429, 485, 508, 534, 578], '10,000': [317], 'individuals': [318], 'transmitted': [321], 'an': [323, 405], 'autosomal': [324], 'dominant': [325], 'fashion.': [326], 'The': [327, 349, 362], 'molecular': [328, 438, 483], 'basis': [329], 'expansion': [334, 409], 'trinucleotide': [337], 'CAG': [338, 350], 'first': [341], 'exon': [342], 'gene': [345, 529], 'on': [346], 'chromosome': [347], 'four.': [348], 'repeats': [351, 356], 'are': [352], 'translated': [353], 'polyglutamine': [355], 'expressed': [359], 'protein,': [360], 'huntingtin.': [361], 'normal': [363], 'function': [364], 'huntingtin': [366, 418, 457], 'remains': [367], 'incompletely': [368], 'characterized,': [369], 'but': [370], 'based': [371], 'upon': [372], 'recently': [373], 'defined': [374], 'protein-protein': [375], 'interactions,': [376, 448], 'it': [377], 'appears': [378], 'be': [380], 'associated': [381], 'cytoskeleton': [384], 'required': [386], 'neurogenesis.': [388], 'Huntingtin': [389], 'has': [390], 'been': [391], 'demonstrated': [392], 'interact': [394], 'such': [396], 'proteins': [397], 'as': [398], 'HAP1,': [399], 'HIP1,': [400], 'microtubules,': [401], 'GADPH,': [402], 'calmodulin,': [403], 'ubiquitin-conjugating': [406], 'enzyme.': [407], 'Polyglutamine': [408], 'alters': [410], 'many': [411], 'these': [413], 'interactions': [414, 477], 'leads': [416], 'aggregation': [419], 'formation': [422], 'neuronal': [424], 'nuclear': [425], 'inclusions,': [426], 'ultimately': [427], 'culminating': [428], 'cell': [430, 511], 'death.': [431], 'In': [432], 'review,': [434], 'we': [435], 'discuss': [436], 'HD,': [441], 'including': [442], 'present': [444], 'understanding': [445], 'huntingtin-protein': [447], 'studies': [449], 'transgenic': [451, 488], 'mice,': [452], 'postulated': [454], 'mechanisms': [455, 581], 'aggregation.': [458], 'Neurosci.': [460], 'Res.': [461], '54:301–308,': [462], '1998.': [463], '©': [464], 'Wiley-Liss,': [466], 'Inc.': [467], 'Citing': [468], 'Literature': [469], 'Volume54,': [470], 'Issue31': [471], 'November': [472], '1998Pages': [473], 'RelatedInformation': [475], 'RecommendedHAP1-huntingtin': [476], 'do': [478], 'not': [479], 'contribute': [480], 'pathology': [484], 'miceFabien': [489], 'Bertaux,': [490], 'Alan': [491], 'H': [492], 'Sharp,': [493], 'Christopher': [494], 'A': [495], 'Ross,': [496], 'Hans': [497], 'Lehrach,': [498], 'Gillian': [499, 552], 'P': [500], 'Bates,': [501, 554], 'Erich': [502], 'Wanker,': [503], 'FEBS': [504], 'LettersUbiquitin-proteasome': [505], 'system': [506], 'alterations': [507], 'striatal': [510], 'model': [512, 538], "huntington's": [514], 'diseaseJesse': [515], 'M.': [516], 'Hunter,': [517], 'Mathieu': [518], 'Lesort,': [519], 'Gail': [520], 'V.W.': [521], 'Johnson,': [522], 'ResearchThe': [526], 'polyubiquitin': [527], 'Ubc': [528], 'modulates': [530], 'histone': [531], 'H2A': [532], 'monoubiquitylation': [533], 'R6/2': [536], 'mouse': [537], 'diseaseJohn': [541], 'Bett,': [543], 'Caroline': [544], 'L.': [545], 'Benn,': [546], 'Kwon-Yul': [547], 'Ryu,': [548], 'Ron': [549], 'R.': [550], 'Kopito,': [551], 'P.': [553], 'Cellular': [557], "MedicineHuntington's": [560], 'disease:': [561, 576], 'clinical': [563], 'reviewP.': [564], 'McColgan,': [565], 'Tabrizi,': [568], 'European': [569], 'NeurologyAnimal': [572], 'models': [573], 'implications': [577], 'uncovering': [579], 'pathogenic': [580], 'developing': [583], 'therapiesLin-hui': [584], 'WANG,': [585], 'Zheng-hong': [586], 'QIN,': [587], 'Acta': [588], 'Pharmacologica': [589], 'Sinica': [590]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2079294971', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-15T14:28:56.677090', 'created_date': '2016-06-24'}