Publication Information

{'id': 'https://openalex.org/W2079213216', 'doi': 'https://doi.org/10.3892/ijo.2015.2963', 'title': 'The DNA damage/repair cascade in glioblastoma cell lines after chemotherapeutic agent treatment', 'display_name': 'The DNA damage/repair cascade in glioblastoma cell lines after chemotherapeutic agent treatment', 'publication_year': 2015, 'publication_date': '2015-04-16', 'ids': {'openalex': 'https://openalex.org/W2079213216', 'doi': 'https://doi.org/10.3892/ijo.2015.2963', 'mag': '2079213216', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25892134', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4441296'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/ijo.2015.2963', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/ijo.2015.2963/download', 'source': {'id': 'https://openalex.org/S169822654', 'display_name': 'International Journal of Oncology', 'issn_l': '1019-6439', 'issn': ['1019-6439'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.spandidos-publications.com/10.3892/ijo.2015.2963/download', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040353814', 'display_name': 'Laura Annovazzi', 'orcid': 'https://orcid.org/0000-0002-8043-9886'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'LAURA ANNOVAZZI', 'raw_affiliation_strings': ['Neuro-Bio-Oncology Center, Policlinico di Monza Foundation (Vercelli), I-13100 Vercelli, Italy'], 'affiliations': [{'raw_affiliation_string': 'Neuro-Bio-Oncology Center, Policlinico di Monza Foundation (Vercelli), I-13100 Vercelli, Italy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071251685', 'display_name': 'Valentina Caldera', 'orcid': 'https://orcid.org/0000-0003-2148-2160'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'VALENTINA CALDERA', 'raw_affiliation_strings': ['Neuro-Bio-Oncology Center, Policlinico di Monza Foundation (Vercelli), I-13100 Vercelli, Italy'], 'affiliations': [{'raw_affiliation_string': 'Neuro-Bio-Oncology Center, Policlinico di Monza Foundation (Vercelli), I-13100 Vercelli, Italy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038819550', 'display_name': 'Marta Mellai', 'orcid': 'https://orcid.org/0000-0002-9139-517X'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'MARTA MELLAI', 'raw_affiliation_strings': ['Neuro-Bio-Oncology Center, Policlinico di Monza Foundation (Vercelli), I-13100 Vercelli, Italy'], 'affiliations': [{'raw_affiliation_string': 'Neuro-Bio-Oncology Center, Policlinico di Monza Foundation (Vercelli), I-13100 Vercelli, Italy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006463761', 'display_name': 'Chiara Riganti', 'orcid': 'https://orcid.org/0000-0001-9787-4836'}, 'institutions': [{'id': 'https://openalex.org/I55143463', 'display_name': 'University of Turin', 'ror': 'https://ror.org/048tbm396', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I55143463']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'CHIARA RIGANTI', 'raw_affiliation_strings': ['Department of Oncology, University of Turin, I-10126 Turin, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, University of Turin, I-10126 Turin, Italy', 'institution_ids': ['https://openalex.org/I55143463']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035816396', 'display_name': 'Luigi Battaglia', 'orcid': 'https://orcid.org/0000-0002-5081-3638'}, 'institutions': [{'id': 'https://openalex.org/I55143463', 'display_name': 'University of Turin', 'ror': 'https://ror.org/048tbm396', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I55143463']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'LUIGI BATTAGLIA', 'raw_affiliation_strings': ['Department of Drug Science and Technology, University of Turin, I-10125 Turin, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Drug Science and Technology, University of Turin, I-10125 Turin, Italy', 'institution_ids': ['https://openalex.org/I55143463']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021255644', 'display_name': 'Daniela Chirio', 'orcid': 'https://orcid.org/0000-0002-4615-5812'}, 'institutions': [{'id': 'https://openalex.org/I55143463', 'display_name': 'University of Turin', 'ror': 'https://ror.org/048tbm396', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I55143463']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'DANIELA CHIRIO', 'raw_affiliation_strings': ['Department of Drug Science and Technology, University of Turin, I-10125 Turin, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Drug Science and Technology, University of Turin, I-10125 Turin, Italy', 'institution_ids': ['https://openalex.org/I55143463']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034345612', 'display_name': 'Antonio Melcarne', 'orcid': 'https://orcid.org/0000-0002-1925-2641'}, 'institutions': [{'id': 'https://openalex.org/I2802395249', 'display_name': 'CTO Hospital', 'ror': 'https://ror.org/05ph11m41', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802395249']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'ANTONIO MELCARNE', 'raw_affiliation_strings': ['Department of Neurosurgery, CTO Hospital, Città della Salute e della Scienza, I-10126 Turin, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosurgery, CTO Hospital, Città della Salute e della Scienza, I-10126 Turin, Italy', 'institution_ids': ['https://openalex.org/I2802395249']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5011983771', 'display_name': 'Davide Schiffer', 'orcid': None}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'DAVIDE SCHIFFER', 'raw_affiliation_strings': ['Neuro-Bio-Oncology Center, Policlinico di Monza Foundation (Vercelli), I-13100 Vercelli, Italy'], 'affiliations': [{'raw_affiliation_string': 'Neuro-Bio-Oncology Center, Policlinico di Monza Foundation (Vercelli), I-13100 Vercelli, Italy', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.897, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 49, 'citation_normalized_percentile': {'value': 0.76674, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '46', 'issue': '6', 'first_page': '2299', 'last_page': '2308'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10129', 'display_name': 'Glioma Diagnosis and Treatment', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/temozolomide', 'display_name': 'Temozolomide', 'score': 0.72806346}, {'id': 'https://openalex.org/keywords/comet-assay', 'display_name': 'Comet Assay', 'score': 0.48833057}], 'concepts': [{'id': 'https://openalex.org/C2777389519', 'wikidata': 'https://www.wikidata.org/wiki/Q425088', 'display_name': 'Temozolomide', 'level': 3, 'score': 0.72806346}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6471674}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.6259768}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.5855197}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.57254004}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.57014763}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.5040971}, {'id': 'https://openalex.org/C2780358455', 'wikidata': 'https://www.wikidata.org/wiki/Q903780', 'display_name': 'Comet assay', 'level': 4, 'score': 0.48833057}, {'id': 'https://openalex.org/C2778227246', 'wikidata': 'https://www.wikidata.org/wiki/Q1365309', 'display_name': 'Glioma', 'level': 2, 'score': 0.4776967}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.44220716}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.42916372}, {'id': 'https://openalex.org/C105696609', 'wikidata': 'https://www.wikidata.org/wiki/Q1068809', 'display_name': 'Cell cycle checkpoint', 'level': 4, 'score': 0.42181438}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3310963}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.13117853}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.06915259}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004273', 'descriptor_name': 'DNA, Neoplasm', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004273', 'descriptor_name': 'DNA, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003606', 'descriptor_name': 'Dacarbazine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003606', 'descriptor_name': 'Dacarbazine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003606', 'descriptor_name': 'Dacarbazine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000077204', 'descriptor_name': 'Temozolomide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/ijo.2015.2963', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/ijo.2015.2963/download', 'source': {'id': 'https://openalex.org/S169822654', 'display_name': 'International Journal of Oncology', 'issn_l': '1019-6439', 'issn': ['1019-6439'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4441296', 'pdf_url': 'https://europepmc.org/articles/pmc4441296?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441296', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/2318/1520405', 'pdf_url': 'https://iris.unito.it/bitstream/2318/1520405/1/Annovazzi%2c%20Int%20J%20Oncol%2c%202015.pdf', 'source': {'id': 'https://openalex.org/S4306400637', 'display_name': 'Institutional Research Information System University of Turin (University of Turin)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I55143463', 'host_organization_name': 'University of Turin', 'host_organization_lineage': ['https://openalex.org/I55143463'], 'host_organization_lineage_names': ['University of Turin'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25892134', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/ijo.2015.2963', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/ijo.2015.2963/download', 'source': {'id': 'https://openalex.org/S169822654', 'display_name': 'International Journal of Oncology', 'issn_l': '1019-6439', 'issn': ['1019-6439'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.85, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1592086275', 'https://openalex.org/W1864544636', 'https://openalex.org/W1965239527', 'https://openalex.org/W1967232610', 'https://openalex.org/W1968601707', 'https://openalex.org/W1970682316', 'https://openalex.org/W1980808550', 'https://openalex.org/W1982198436', 'https://openalex.org/W1982865433', 'https://openalex.org/W1998023952', 'https://openalex.org/W2014211655', 'https://openalex.org/W2024589556', 'https://openalex.org/W2034328391', 'https://openalex.org/W2036575025', 'https://openalex.org/W2045963360', 'https://openalex.org/W2050072146', 'https://openalex.org/W2058015674', 'https://openalex.org/W2060551076', 'https://openalex.org/W2063916050', 'https://openalex.org/W2065069443', 'https://openalex.org/W2067367060', 'https://openalex.org/W2086833517', 'https://openalex.org/W2089482729', 'https://openalex.org/W2089703995', 'https://openalex.org/W2092629964', 'https://openalex.org/W2095532398', 'https://openalex.org/W2097647068', 'https://openalex.org/W2104336168', 'https://openalex.org/W2105100844', 'https://openalex.org/W2119836028', 'https://openalex.org/W2123730023', 'https://openalex.org/W2130926378', 'https://openalex.org/W2135872518', 'https://openalex.org/W2136431054', 'https://openalex.org/W2147129352', 'https://openalex.org/W2150144069', 'https://openalex.org/W2167414381', 'https://openalex.org/W2168588359', 'https://openalex.org/W2471619462'], 'related_works': ['https://openalex.org/W2963466627', 'https://openalex.org/W2900295007', 'https://openalex.org/W2235074116', 'https://openalex.org/W2116193195', 'https://openalex.org/W2081927132', 'https://openalex.org/W2041906258', 'https://openalex.org/W2036747859', 'https://openalex.org/W2022503084', 'https://openalex.org/W2019927904', 'https://openalex.org/W2013860214'], 'abstract_inverted_index': {'Therapeutic': [0], 'resistance': [1], 'in': [2, 33, 123, 126, 156, 159, 187, 200, 218, 222], 'glioblastoma': [3], 'multiforme': [4], '(GBM)': [5], 'has': [6], 'been': [7], 'linked': [8], 'to': [9, 56, 63, 108, 114, 132], 'a': [10, 110, 182, 201], 'subpopulation': [11], 'of': [12, 36, 98, 138, 151, 185], 'cells': [13, 21, 81, 186, 198], 'with': [14], 'stem': [15, 20], 'cell-like': [16], 'properties,': [17], 'the': [18, 32, 52, 91, 136, 139, 149, 170], 'glioma': [19, 47], '(GSCs),': [22], 'responsible': [23], 'for': [24], 'cancer': [25], 'progression': [26], 'and': [27, 43, 59, 95, 101, 113, 117, 204], 'recurrence.': [28], 'This': [29], 'study': [30], 'investigated': [31], 'vitro': [34], 'cytotoxicity': [35], 'three': [37, 104], 'chemotherapeutics,': [38], 'temozolomide': [39], '(TMZ),': [40], 'doxorubicin': [41], '(Dox)': [42], 'paclitaxel': [44], '(PTX)': [45], 'on': [46, 70], 'cell': [48, 60, 64, 73, 119, 130], 'lines,': [49, 74], 'by': [50, 83, 88, 93, 146], 'analyzing': [51], 'molecular': [53], 'mechanisms': [54], 'leading': [55], 'DNA': [57, 85, 133], 'repair': [58, 147, 163], 'resistance,': [61], 'or': [62, 79], 'death.': [65], 'The': [66, 103, 128, 161], 'drugs': [67, 105], 'were': [68, 106, 215], 'tested': [69], '16': [71], 'GBM': [72], 'grown': [75], 'as': [76], 'neurospheres': [77], '(NS)': [78], 'adherent': [80], '(AC),': [82], 'studying': [84], 'damage': [86, 134, 140], 'occurrence': [87], 'Comet': [89], 'assay,': [90], 'expression': [92, 150], 'immunofluorescence': [94], 'western': [96], 'blotting': [97], 'checkpoint/repair': [99, 152, 213], 'molecules': [100, 153], 'apoptosis.': [102], 'able': [107], 'provoke': [109], 'genotoxic': [111], 'injury': [112], 'inhibit': [115], 'dose-': [116], 'time-dependently': [118], 'proliferation,': [120], 'more': [121, 167], 'evidently': [122], 'AC': [124], 'than': [125, 158, 169], 'NS.': [127], 'first': [129], 'response': [131], 'was': [135], 'activation': [137], 'sensors': [141], '(p-ATM,': [142], 'p-53BP1,': [143], 'γ-H2AX),': [144], 'followed': [145], 'effectors;': [148], 'appeared': [154], 'higher': [155], 'NS': [157, 188], 'AC.': [160], 'non-homologous': [162], 'pathway': [164], '(NHEJ)': [165], 'seemed': [166], 'involved': [168], 'homologous': [171], 'one': [172], '(HR).': [173], 'Apoptosis': [174], 'occurred': [175], 'after': [176, 207], 'long': [177], 'treatment': [178], 'times,': [179], 'but': [180, 220], 'only': [181], 'small': [183], 'percentage': [184], 'underwent': [189], 'death,': [190], 'even': [191], 'at': [192], 'high': [193], 'drug': [194, 208], 'concentration,': [195], 'whereas': [196], 'most': [197], 'survived': [199], 'quiescent': [202], 'state': [203], 'resumed': [205], 'proliferation': [206], 'removal.': [209], 'In': [210], 'tumor': [211], 'specimens,': [212], 'proteins': [214], 'constitutively': [216], 'expressed': [217], 'GBMs,': [219], 'not': [221], 'low-grade': [223], 'gliomas.': [224]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2079213216', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 4}], 'updated_date': '2025-01-17T22:54:33.449470', 'created_date': '2016-06-24'}