Title: 1255 CEA, CA 15-3 and MCA: Comparative clinical relevance in breast cancer
Abstract: To comparatively investigate the clinical relevance of the serum tumor markers CEA, CA 15-3 and MCA simultaneous determinations of the serum concentrations of the three tumor markers CEA, CA 15-3 and MCA were performed in 419 sequential breast cancer patients. CEA and MCA were determined by means of enzyme-immuno-assays and CA 153 by a radio-immuno-assay. Results The serum concentration of all three tumor markers correlates with tumor activity and tumor mass. The receiver operating characteristics (ROC) curves show that CA 15-3 has the highest sensitivity and specificity. All three tumor markers do not show any dependence on age, but on the location of metastases; the median serum values decrease in the sequence osseous, visceral or soft tissue metastases. With a combination of tumor markers, the gain in sensitivity is associated with a loss of specificity; the combination of CA I5 + CEA appears to be the most favourable. The combination of all three tumor markers does not have any advantage over the double combination CA 15-3 + CEA. Conclusion CA 15-3 has the highest sensitivity and specificity. As combinations of tumor markers CA 15-3 + CEA as well as MCA + CEA are recommended. To comparatively investigate the clinical relevance of the serum tumor markers CEA, CA 15-3 and MCA simultaneous determinations of the serum concentrations of the three tumor markers CEA, CA 15-3 and MCA were performed in 419 sequential breast cancer patients. CEA and MCA were determined by means of enzyme-immuno-assays and CA 153 by a radio-immuno-assay. The serum concentration of all three tumor markers correlates with tumor activity and tumor mass. The receiver operating characteristics (ROC) curves show that CA 15-3 has the highest sensitivity and specificity. All three tumor markers do not show any dependence on age, but on the location of metastases; the median serum values decrease in the sequence osseous, visceral or soft tissue metastases. With a combination of tumor markers, the gain in sensitivity is associated with a loss of specificity; the combination of CA I5 + CEA appears to be the most favourable. The combination of all three tumor markers does not have any advantage over the double combination CA 15-3 + CEA. CA 15-3 has the highest sensitivity and specificity. As combinations of tumor markers CA 15-3 + CEA as well as MCA + CEA are recommended.
Publication Year: 1995
Publication Date: 1995-11-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 23
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