Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2078518439', 'doi': 'https://doi.org/10.1172/jci38151', 'title': 'Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells', 'display_name': 'Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells', 'publication_year': 2009, 'publication_date': '2009-05-08', 'ids': {'openalex': 'https://openalex.org/W2078518439', 'doi': 'https://doi.org/10.1172/jci38151', 'mag': '2078518439', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19411760', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2689111'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci38151', 'pdf_url': 'http://www.jci.org/articles/view/38151/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/38151/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101791180', 'display_name': 'Gang Lü', 'orcid': 'https://orcid.org/0000-0002-7319-4315'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gang Lu', 'raw_affiliation_strings': ['Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA.', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000748289', 'display_name': 'Haipeng Sun', 'orcid': 'https://orcid.org/0000-0003-2128-3209'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Haipeng Sun', 'raw_affiliation_strings': ['Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112819932', 'display_name': 'Pengxiang She', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I82783531', 'display_name': 'Penn State Milton S. Hershey Medical Center', 'ror': 'https://ror.org/01h22ap11', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I82783531']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pengxiang She', 'raw_affiliation_strings': ['Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, USA.', 'institution_ids': ['https://openalex.org/I82783531']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109913094', 'display_name': 'Ji-Youn Youn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ji-Youn Youn', 'raw_affiliation_strings': ['Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044149969', 'display_name': 'Sarah Warburton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sarah Warburton', 'raw_affiliation_strings': ['Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006098122', 'display_name': 'Peipei Ping', 'orcid': 'https://orcid.org/0000-0003-3583-3881'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Peipei Ping', 'raw_affiliation_strings': ['Departments of Physiology and Medicine, David Geffen School of Medicine, and'], 'affiliations': [{'raw_affiliation_string': 'Departments of Physiology and Medicine, David Geffen School of Medicine, and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088650648', 'display_name': 'Thomas M. Vondriska', 'orcid': 'https://orcid.org/0009-0000-5238-1245'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas M. Vondriska', 'raw_affiliation_strings': ['Departments of Physiology and Medicine, David Geffen School of Medicine, and', 'Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.', 'institution_ids': ['https://openalex.org/I161318765']}, {'raw_affiliation_string': 'Departments of Physiology and Medicine, David Geffen School of Medicine, and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018191047', 'display_name': 'Hua Cai', 'orcid': 'https://orcid.org/0000-0001-8747-6156'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hua Cai', 'raw_affiliation_strings': ['Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042437739', 'display_name': 'Christopher J. Lynch', 'orcid': 'https://orcid.org/0000-0003-2453-5838'}, 'institutions': [{'id': 'https://openalex.org/I82783531', 'display_name': 'Penn State Milton S. Hershey Medical Center', 'ror': 'https://ror.org/01h22ap11', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I82783531']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher J. Lynch', 'raw_affiliation_strings': ['Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, USA.', 'institution_ids': ['https://openalex.org/I82783531']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100710570', 'display_name': 'Yibin Wang', 'orcid': 'https://orcid.org/0000-0003-0852-0767'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yibin Wang', 'raw_affiliation_strings': ['Departments of Physiology and Medicine, David Geffen School of Medicine, and', 'Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.', 'Molecular Biology Institute, UCLA, Los Angeles, California, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.', 'institution_ids': ['https://openalex.org/I161318765']}, {'raw_affiliation_string': 'Departments of Physiology and Medicine, David Geffen School of Medicine, and', 'institution_ids': []}, {'raw_affiliation_string': 'Molecular Biology Institute, UCLA, Los Angeles, California, USA.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5100710570'], 'corresponding_institution_ids': ['https://openalex.org/I161318765'], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.225, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 208, 'citation_normalized_percentile': {'value': 0.999467, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '119', 'issue': '6', 'first_page': '1678', 'last_page': '1687'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolism and Genetic Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11027', 'display_name': 'Metabolism and Genetic Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dephosphorylation', 'display_name': 'Dephosphorylation', 'score': 0.7469434}, {'id': 'https://openalex.org/keywords/catabolism', 'display_name': 'Catabolism', 'score': 0.6523489}, {'id': 'https://openalex.org/keywords/branched-chain-amino-acid', 'display_name': 'Branched-chain amino acid', 'score': 0.46451464}], 'concepts': [{'id': 'https://openalex.org/C181912034', 'wikidata': 'https://www.wikidata.org/wiki/Q1101143', 'display_name': 'Dephosphorylation', 'level': 4, 'score': 0.7469434}, {'id': 'https://openalex.org/C178666793', 'wikidata': 'https://www.wikidata.org/wiki/Q422476', 'display_name': 'Phosphatase', 'level': 3, 'score': 0.67902756}, {'id': 'https://openalex.org/C96942376', 'wikidata': 'https://www.wikidata.org/wiki/Q21130714', 'display_name': 'Catabolism', 'level': 3, 'score': 0.6523489}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.6264891}, {'id': 'https://openalex.org/C2779214519', 'wikidata': 'https://www.wikidata.org/wiki/Q402575', 'display_name': 'Maple syrup urine disease', 'level': 4, 'score': 0.5307619}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.520209}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.49287796}, {'id': 'https://openalex.org/C389152', 'wikidata': 'https://www.wikidata.org/wiki/Q6593007', 'display_name': 'Protein phosphatase 2', 'level': 4, 'score': 0.4719716}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.47056767}, {'id': 'https://openalex.org/C2780677274', 'wikidata': 'https://www.wikidata.org/wiki/Q420726', 'display_name': 'Branched-chain amino acid', 'level': 4, 'score': 0.46451464}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.3692518}, {'id': 'https://openalex.org/C2776580952', 'wikidata': 'https://www.wikidata.org/wiki/Q483745', 'display_name': 'Leucine', 'level': 3, 'score': 0.1801934}], 'mesh': [{'descriptor_ui': 'D000597', 'descriptor_name': 'Amino Acids, Branched-Chain', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000597', 'descriptor_name': 'Amino Acids, Branched-Chain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D042942', 'descriptor_name': '3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042942', 'descriptor_name': '3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000597', 'descriptor_name': 'Amino Acids, Branched-Chain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002522', 'descriptor_name': 'Chlorocebus aethiops', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023421', 'descriptor_name': 'Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci38151', 'pdf_url': 'http://www.jci.org/articles/view/38151/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2689111', 'pdf_url': 'https://europepmc.org/articles/pmc2689111?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689111', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19411760', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci38151', 'pdf_url': 'http://www.jci.org/articles/view/38151/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Affordable and clean energy', 'id': 'https://metadata.un.org/sdg/7', 'score': 0.5}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1491920498', 'https://openalex.org/W1568216032', 'https://openalex.org/W1569754812', 'https://openalex.org/W1908039135', 'https://openalex.org/W1921797022', 'https://openalex.org/W193034086', 'https://openalex.org/W1975989105', 'https://openalex.org/W1976723592', 'https://openalex.org/W1988525424', 'https://openalex.org/W1988601440', 'https://openalex.org/W1997457202', 'https://openalex.org/W2013004671', 'https://openalex.org/W2016701287', 'https://openalex.org/W2018487770', 'https://openalex.org/W2018632850', 'https://openalex.org/W2037178468', 'https://openalex.org/W2045830082', 'https://openalex.org/W2048991275', 'https://openalex.org/W2052413134', 'https://openalex.org/W2058663061', 'https://openalex.org/W2070114695', 'https://openalex.org/W2078594804', 'https://openalex.org/W2079326459', 'https://openalex.org/W2079486812', 'https://openalex.org/W2113912243', 'https://openalex.org/W2116487065', 'https://openalex.org/W2120748454', 'https://openalex.org/W2123817202', 'https://openalex.org/W2129782385', 'https://openalex.org/W2130143715', 'https://openalex.org/W2131392379', 'https://openalex.org/W2133036882', 'https://openalex.org/W2134894096', 'https://openalex.org/W2144019683', 'https://openalex.org/W2165218727', 'https://openalex.org/W2170562590', 'https://openalex.org/W2205527471', 'https://openalex.org/W2264407089', 'https://openalex.org/W4206321286', 'https://openalex.org/W59903519'], 'related_works': ['https://openalex.org/W4239029233', 'https://openalex.org/W3165929206', 'https://openalex.org/W3142834158', 'https://openalex.org/W3025957543', 'https://openalex.org/W2399418957', 'https://openalex.org/W2168642368', 'https://openalex.org/W2147519392', 'https://openalex.org/W2056779425', 'https://openalex.org/W1991320072', 'https://openalex.org/W1971335607'], 'abstract_inverted_index': {'The': [0], 'branched-chain': [1], 'amino': [2, 7, 25], 'acids': [3, 8, 26], '(BCAA)': [4], 'are': [5], 'essential': [6], 'required': [9, 169], 'for': [10, 170, 185], 'protein': [11], 'homeostasis,': [12], 'energy': [13], 'balance,': [14], 'and': [15, 76, 101, 123, 132, 176], 'nutrient': [16], 'signaling.': [17], 'In': [18], 'individuals': [19], 'with': [20], 'deficiencies': [21], 'in': [22, 41, 106, 121, 124, 156, 180], 'BCAA,': [23], 'these': [24], 'can': [27], 'be': [28, 183], 'preserved': [29], 'through': [30, 69], 'inhibition': [31, 72], 'of': [32, 49, 73, 79, 104, 109, 113, 143, 173, 188], 'the': [33, 38, 70, 77, 98, 107, 138, 165], 'branched-chain-alpha-ketoacid': [34], 'dehydrogenase': [35], '(BCKD)': [36], 'complex,': [37], 'rate-limiting': [39], 'step': [40], 'their': [42], 'metabolism.': [43], 'BCKD': [44, 59, 74, 99, 110, 157, 167, 174], 'is': [45, 56, 164], 'inhibited': [46], 'by': [47, 58, 154], 'phosphorylation': [48], 'its': [50], 'E1alpha': [51, 118], 'subunit': [52], 'at': [53], 'Ser293,': [54], 'which': [55], 'catalyzed': [57], 'kinase.': [60], 'During': [61], 'BCAA': [62, 129], 'excess,': [63], 'phosphorylated': [64], 'Ser293': [65, 105], '(pSer293)': [66], 'becomes': [67], 'dephosphorylated': [68], 'concerted': [71], 'kinase': [75], 'activity': [78, 175], 'an': [80], 'unknown': [81], 'intramitochondrial': [82], 'phosphatase.': [83], 'Using': [84], 'unbiased,': [85], 'proteomic': [86], 'approaches,': [87], 'we': [88], 'have': [89], 'found': [90], 'that': [91, 162, 178], 'a': [92, 133, 150, 186], 'mitochondrial-targeted': [93], 'phosphatase,': [94], 'PP2Cm,': [95], 'specifically': [96], 'binds': [97], 'complex': [100], 'induces': [102], 'dephosphorylation': [103, 119], 'presence': [108], 'substrates.': [111], 'Loss': [112], 'PP2Cm': [114, 163, 181], 'completely': [115], 'abolished': [116], 'substrate-induced': [117], 'both': [120], 'vitro': [122], 'vivo.': [125], 'PP2Cm-deficient': [126], 'mice': [127], 'exhibited': [128], 'catabolic': [130], 'defects': [131, 155, 179], 'metabolic': [134], 'phenotype': [135], 'similar': [136], 'to': [137], 'intermittent': [139], 'or': [140], 'intermediate': [141], 'types': [142], 'human': [144, 189], 'maple': [145], 'syrup': [146], 'urine': [147], 'disease': [148], '(MSUD),': [149], 'hereditary': [151], 'disorder': [152], 'caused': [153], 'activity.': [158], 'These': [159], 'results': [160], 'indicate': [161], 'endogenous': [166], 'phosphatase': [168], 'nutrient-mediated': [171], 'regulation': [172], 'suggest': [177], 'may': [182], 'responsible': [184], 'subset': [187], 'MSUD.': [190]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2078518439', 'counts_by_year': [{'year': 2024, 'cited_by_count': 20}, {'year': 2023, 'cited_by_count': 26}, {'year': 2022, 'cited_by_count': 20}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 18}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2025-01-09T03:16:39.572132', 'created_date': '2016-06-24'}