Publication Information

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[68, 168, 317, 371, 467, 992, 1062, 1624, 1928, 2599, 3950], 'viewing': [69], 'most': [71, 2353], 'recent': [72, 213], 'version': [73], 'article.': [76], 'Previous': [77, 82], 'versions:': [78], 'October': [79], '2,': [80], '2006:': [81], 'Version': [83], '1': [84, 533, 2695, 3894, 4099, 4179], 'The': [85, 913, 1410, 1637, 2134, 2203, 3064, 3454, 4046], 'idea': [86, 1302], 'that': [87, 165, 185, 207, 220, 282, 293, 367, 414, 435, 458, 479, 492, 525, 554, 685, 736, 747, 887, 935, 957, 991, 1019, 1303, 1359, 1378, 1413, 1616, 1701, 1708, 1919, 2012, 2062, 2174, 2317, 2377, 2508, 2551, 2582], 'activation': [88, 159, 195, 268, 2227, 2263, 2405, 2427, 2449, 2988, 3223, 3371], 'sympathetic': [91, 158, 194, 267, 284, 388, 501, 505, 587, 622, 648, 666, 738, 783, 834, 1054, 1147, 1368, 1382, 1472, 1516, 1687, 1719, 1836, 1980, 2066, 2082, 2206, 2253, 2262, 2277, 2329, 2429, 2511, 2535, 2771, 2795, 2863, 3092, 3141, 3191, 3230, 3522, 3547, 3587, 3612, 3638, 3665, 3789, 3866, 4049, 4087], 'nervous': [92, 438, 734, 806, 883, 1438, 1465, 1751, 1852, 1970, 2278, 2707, 3613, 4130], 'system': [93, 439, 453, 735, 807, 1439, 1466, 1752, 2279, 2283, 2307, 2708, 3456, 3480], 'is': [94, 115, 190, 226, 303, 363, 390, 431, 440, 482, 576, 682, 751, 836, 841, 874, 901, 919, 954, 1703, 1709, 1804, 1808, 1916, 1958, 2039, 2052, 2060, 2139, 2201, 2211, 2315, 2383, 2608, 2616, 2851, 2859, 3043, 3194], 'part': [95], 'parcel': [97], 'apparent': [100], 'positive': [101, 290, 2193, 2548], 'feedback': [102, 291, 2194, 2549], 'cycle': [103], 'cardiac': [105, 355, 635, 2127, 2564, 2881, 2972, 3091, 3586, 3788, 3841], 'deterioration': [106, 2562], 'setting': [109, 375, 471, 986, 1863], 'chronic': [111, 1312, 1535, 2238, 3052, 3070, 3297, 3323, 3593], 'heart': [112, 281, 360, 1529, 2122, 2710, 2727, 2749, 2775, 2804, 2824, 2867, 2887, 2904, 2923, 2942, 2991, 3016, 3053, 3072, 3098, 3127, 3145, 3171, 3197, 3234, 3256, 3298, 3325, 3486, 3500, 3529, 3551, 3594, 4019, 4052, 4092], 'failure': [113, 3017, 3552], '(CHF)': [114], 'not': [116, 920, 1224, 3225], 'a': [117, 151, 289, 483, 517, 592, 641, 651, 659, 1130, 1306, 1418, 1451, 1480, 1534, 1734, 1740, 1782, 1809, 1813, 1868, 1946, 2143, 2152, 2155, 2178, 2192, 2237, 2313, 2325, 2412, 2423, 2438, 2483, 2498, 2545, 2554, 2572, 2579, 2609, 2751, 3272, 3531, 3554], 'new': [118, 412], 'one.': [119], 'Several': [120, 1373, 1446], 'reviews': [121], 'have': [122, 347, 416, 1009, 1375, 1448, 1613, 1738, 1901, 1987, 2269], 'clearly': [123, 149, 477, 523, 745, 1988, 2090], 'summarized': [124], 'evidence': [126, 200, 1866, 1918, 2289, 2806], 'for': [127, 154, 193, 288, 354, 420, 915, 1482, 1762, 1771, 1867, 1978, 2045, 2136, 2636, 3533, 3556, 3698], 'concept': [129, 244], 'using': [130, 1553, 1889], 'both': [131, 141, 459, 571, 1085, 1178, 1237, 1272, 1441, 1554, 1617, 1775, 1882, 1911, 2158, 2460, 2477], 'clinical': [132, 3482], 'data': [133, 214, 1014, 1169, 2171, 2645], 'information': [135, 1961], 'from': [136, 140, 215, 273, 277, 742, 862, 1002, 1015, 1170, 1268, 1610, 1887, 2380, 2807, 3045], 'experimental': [137, 179, 199, 720, 1337, 4091], 'models.1–4': [138], 'Evidence': [139], 'neural': [142, 2030, 3919, 4088], 'recordings': [143], 'measurement': [145], 'circulating': [147], 'catecholamines': [148], 'document': [150, 1533], 'central': [152, 387, 437, 461, 594, 733, 805, 833, 882, 1038, 1381, 1393, 1437, 1464, 1486, 1576, 1690, 1750, 1851, 1871, 1969, 2305, 2417, 2504, 2594, 3046, 3694, 3782, 3863, 4129], 'origin': [153, 4047], 'much': [155, 1959], 'CHF.5–7': [161], 'Furthermore,': [162, 565, 771, 1552, 2118], 'fact': [164], 'sympathoinhibitory': [166, 1706, 1811, 2471], 'reflexes': [167, 262, 316, 370, 3143, 3617], 'depressed': [169, 252], 'CHF': [171, 394, 722, 789, 868, 998, 1022, 1206, 1221, 1281, 1290, 1585, 1883, 2132, 2187, 2267, 2365, 2490, 2516, 2540, 2603], 'has': [172, 182, 205, 218, 245, 475, 688, 1330, 1342, 1399, 1428, 1695, 1768, 1840, 2284, 2378], 'been': [173, 183, 349, 476, 1343, 1400, 1696, 1769, 1842, 1902, 2270, 2285], 'well': [174, 365, 921, 1076], 'established': [175, 1450], 'humans8,9': [177], 'animals.10–12': [180], 'It': [181, 474, 575, 953, 1694], 'suggested': [184], 'abnormal': [186, 372], 'arterial': [187, 223, 632, 1521, 3660], 'baroreflex': [188, 224, 569, 583, 598, 1522, 2095, 2936, 3041, 3661], 'function': [189, 225, 570, 584, 1122, 1257, 1350, 1523, 1848, 2083, 2096, 2302, 2330, 2901, 3042, 3121], 'largely': [191, 2271], 'responsible': [192], 'CHF.13': [197], 'However,': [198, 1956], 'sino-aortic': [202, 3020], 'denervated': [203, 3021], 'dogs': [204, 3096], 'challenged': [206], 'concept.14': [208], 'On': [209], 'other': [211, 610, 692, 928], 'hand,': [212], 'laboratory': [217, 744, 1004, 1017, 1612], 'shown': [219, 1344, 1377, 1615, 1739, 1843, 1903, 1989, 2655], 'depression': [221], 'an': [227, 254, 706, 815, 895, 1114, 1175, 1684, 1704, 1834, 1990, 2230, 3460], 'early': [228], 'phenomenon': [229, 1192], 'conscious': [231, 550, 717, 1525, 1642, 3019, 3123, 3737, 3821, 3847], 'rabbits': [232, 869, 1202, 1526, 1569, 1630, 1643, 1756, 2085, 3124, 3169, 3526], 'during': [233, 562, 2746, 3253], 'development': [235], 'pacing-induced': [237, 1528, 1632, 3015, 3126, 3528], 'CHF.15In': [238], 'past': [240], 'several': [241, 260, 489, 1712], 'years,': [242], 'emerged': [246], 'that,': [247, 877], 'addition': [249, 601, 1780], 'baroreflex,': [253, 604], 'increase': [255, 1685, 2231, 2415], 'sensitivity': [258, 312, 664, 3193, 3991], 'sympathoexcitatory': [261, 296, 484, 543, 560, 1217, 1879, 2183], 'also': [263, 946, 1194, 1614, 1841, 2244], 'contribute': [264, 1857, 2446, 2492, 3226], 'CHF.16–19': [270], 'Enhanced': [271, 3118, 3162, 3247], 'input': [272], 'peripheral': [274, 463, 509, 1766, 2596, 3067, 3119], 'chemoreceptors16,20': [275], 'receptors': [278, 1045, 1061, 1095, 1128, 1138, 1153, 1241, 1539, 1876, 2323, 2570, 3436, 3860, 3987, 4100, 4152], 'traverse': [283], 'pathways21': [285], 'may': [286, 399, 415, 657, 945, 980, 1046, 1159, 1792, 1856, 2064, 2445, 2509, 2583], 'provide': [287], 'mechanism': [292, 827, 914, 979, 1855, 2135, 2195], 'exacerbates': [294], 'process,': [297], 'although': [298], 'humans': [300, 1341, 2800], 'issue': [302, 1434], 'less': [304, 1960], 'clear.22': [305], 'Activation': [306, 930], 'enhancement': [309], 'these': [314, 2137], 'latter': [315], 'attributable,': [318], 'part,': [320, 846], 'changes': [322, 1638, 2724], 'interstitial': [325], 'milieu': [326], 'which': [328, 386, 829, 908, 1581, 1717, 2197, 2261, 2615], 'afferents': [330], 'reside.': [331], 'Alterations': [332], 'local': [335, 1820], 'production': [336, 1564, 2216, 2435, 4126], 'substances': [338, 353], 'such': [339, 630, 669, 996, 2071], 'as': [340, 351, 631, 670, 997, 1075, 1077, 2072, 2151, 2324], 'bradykinin,': [341], 'NO,': [342, 1872, 2614], 'prostaglandins,': [343], 'so': [345], 'forth,': [346], 'all': [348, 443], 'implicated': [350], 'excitatory': [352, 689], 'chemoreceptor': [357], 'afferents23–29': [358], 'failure.Because': [361], 'it': [362, 656, 840, 885, 2059], 'generally': [364, 2617], 'accepted': [366], 'above': [369], 'CHF,': [377, 2098], 'review': [379], 'will': [380, 408], 'concentrate': [381], 'on': [382, 401, 410, 1057, 1226, 1233, 1251, 1514, 1962, 2081, 2115, 2252, 3347, 3729, 3840], 'mechanisms': [384, 2259, 2822, 3496], 'by': [385, 585, 590, 828, 847, 967, 994, 1402, 1593, 1652, 1689, 1698, 1930, 1983, 2196, 2208, 2214, 2236, 2260, 2331, 2404, 2587, 2661, 3342, 3372, 3693, 3952, 4119, 4174], 'outflow': [389, 588, 623, 835, 1326, 1688, 2067, 2207, 2430, 4050], 'regulated': [391], 'state': [395, 1222, 2268, 2491, 2517, 2556, 3483], 'how': [397], 'impact': [400, 2510], 'cardiovascular': [402, 611, 627, 1317, 1347, 2028, 3640, 3757, 3990], 'reflex': [403, 2900, 3094, 3249, 3275, 3589, 3791], 'function.': [404, 1899, 1981, 2349, 2565, 2592, 3868], 'In': [405, 511, 600, 719, 1167, 1779, 1942, 2466], 'addition,': [406, 1943, 2467], 'we': [407, 1173, 1499, 1560], 'comment': [409], 'some': [411, 1772, 2642], 'strategies': [413], 'important': [417, 693, 983, 1104, 1705, 2354], 'therapeutic': [418], 'implications': [419], 'patients': [421, 2802, 2885], 'with': [422, 442, 486, 769, 788, 1021, 1203, 1527, 1541, 1570, 1631, 1644, 1757, 1973, 2054, 2086, 2437, 2803, 2886, 3097, 3125, 3170, 3527, 3592], 'CHF.Central': [423], 'Angiotensin': [424, 3435, 3654, 3754, 4146], 'II': [425, 450, 465, 481, 531, 556, 567, 581, 606, 620, 639, 715, 801, 831, 892, 963, 1214, 1397, 1415, 1490, 1954, 2176, 2210, 2251, 2320, 2363, 2567, 2598, 3048, 3403, 3655, 3728, 3755, 3786, 3819, 3839, 3892, 3942, 4024, 4058, 4097, 4121, 4147, 4151], 'Outflow': [428, 1294], 'CHFThere': [430], 'certainly': [432], 'no': [433, 683, 792, 2101], 'doubt': [434], 'endowed': [441], 'components': [446, 3731], 'renin–angiotensin': [449, 2282, 2306], '(Ang': [451], 'II)': [452], '(including': [454], 'angiotensin': [455, 3047, 3402, 3534, 3560, 3727, 3818, 3838, 3891, 3941, 3985, 4023, 4057, 4096, 4120, 4150, 4177], 'receptors)': [456], 'renin–Ang': [464], 'systems': [466, 2745], 'activated': [468, 672], 'CHF.30–36': [473], 'demonstrated': [478, 746, 926, 1358, 1479, 1561, 1697], 'Ang': [480, 530, 555, 566, 580, 605, 619, 638, 714, 800, 830, 891, 962, 1189, 1213, 1396, 1414, 1454, 1489, 1504, 1579, 1672, 1953, 2175, 2209, 2250, 2319, 2362, 2397, 2566, 2597], 'peptide': [485, 687, 893, 1230, 2190], 'effects': [487, 690, 1314, 1925, 2031, 2077, 2107, 2138, 2248, 2520, 3815], 'at': [488, 504, 843, 878, 1096, 1242, 1711], 'different': [490, 654], 'loci': [491], 'include': [493], 'hypothalamus': [495, 1249, 1732, 1824], 'medulla,': [497], 'spinal': [499, 3273], 'cord,': [500], 'ganglia,': [502], 'nerve': [506, 784, 1369, 1473, 1517, 2512, 2536, 2772, 2796, 2969, 3231, 3523, 3548, 3666], 'endings': [507], 'tissues.37': [510], 'experiments': [512, 1888], 'carried': [513], 'out': [514], 'more': [515, 593, 823, 1385, 1829, 2286], 'than': [516, 1033, 2288], 'decade': [518], 'ago,': [519], 'Kumagai': [520, 3632], 'Reid38': [522], 'showed': [524, 1113, 2011], 'systemic': [526], 'administration': [527, 776, 1577], 'type': [532, 3893, 4098], '(AT1)': [534, 3986], 'receptor': [535, 703, 726, 749, 773, 856, 917, 941, 1276, 1284, 2160, 2200, 2389, 3049, 3370, 3581, 3700, 3896, 4180], 'antagonist': [536], 'losartan': [537], 'inhibited': [538], 'pressor': [540, 708], 'renal': [542, 1515, 2968, 3368, 3664, 3814, 4154], 'responses': [544, 649, 3013, 3340, 3641, 3759], 'carotid': [546, 563, 3165, 3643], 'occlusion': [547], 'normal': [549, 795, 809, 1406, 1442, 1592, 2104, 2309, 2799], 'rabbits.': [551, 1282, 3738], 'They': [552], 'concluded': [553], 'contributed': [557], 'response': [561, 709, 1487, 1574], 'occlusion.': [564, 3644], 'inhibits': [568, 582, 3637], 'acutely': [572, 3656], 'chronically.39,40': [574], 'still': [577], 'unclear': [578], 'whether': [579], 'augmenting': [586], 'or': [589, 1599, 2450, 2547], 'playing': [591], 'role': [595, 643, 660, 1320, 1502, 1869, 1947, 1964, 2180, 2335, 2360, 2425, 2574, 3065, 3173, 3532, 3555], 'pathway.': [599], 'mediates': [607, 1305, 4016], 'alterations': [608, 1323, 2458, 3295], 'reflexes.41–43': [612], 'Both': [613, 1283, 2593], 'intracerebral': [614], 'intravertebral': [616, 3837], 'injection': [617, 712], 'increases': [621], 'activates': [625, 832], 'various': [626, 729, 988, 1352, 1542, 1993], 'end': [628], 'points,': [629], 'pressure': [633], 'output.44,45': [636], 'Because': [637, 1806, 2047], 'plays': [640, 2177], 'critical': [642], 'modulation': [646, 1052, 1118, 1253, 2369, 2588, 3270], 'variety': [652, 1308], 'reflexes,': [655], 'play': [658, 1945, 2422, 2571], 'altering': [662, 968, 1979], 'motor': [667], 'neurons': [668, 1186, 1691, 1821, 2456], 'those': [671], 'rostral': [675, 3899], 'ventrolateral': [676, 3900], 'medulla': [677, 1247, 1826, 3901], '(RVLM).': [678], 'Of': [679], 'course': [680], 'there': [681, 1957], 'question': [684], 'integrative': [694], 'afferent': [696, 3093, 3142, 3192, 3338, 3588, 3790], 'pathways.46–49Brain': [697], 'selective': [698], 'overexpression': [699, 3983], 'AT1a': [702], 'results': [704, 811, 2552], 'enhanced': [707, 1562, 1835, 2094, 3195, 3585, 3989], 'intracerebroventricular': [711, 1654, 3817], 'mice.50': [718], 'animals,': [721], 'markedly': [723], 'elevates': [724], 'AT1': [725, 748, 772, 818, 855, 898, 940, 1042, 1092, 1127, 1179, 1238, 1273, 1457, 1507, 1538, 1875, 2159, 2372, 2388, 3580, 3699, 3859], 'expression': [727, 750, 970, 1183, 2161, 3050], 'areas': [730], 'regulate': [737, 964, 1718, 2584], 'outflow.15,51': [739], 'A': [740, 1759, 1892, 2374, 2528], 'study': [741], 'increased': [752, 1287, 2055, 2121, 2478, 2600, 2852, 4124], 'RVLM51': [755], 'nucleus': [759, 3945, 4182], 'tractus': [760, 3916, 4183], 'solitarius': [761], '(NTS)': [762], '(Figure': [763, 1207, 1606], '1A': [764], '1B)52': [766], 'animals': [768, 810, 1338, 1776], 'CHF.': [770, 1647, 2073, 2432], 'antisense': [774, 3583], 'oligonucleotide': [775], 'into': [777, 803, 1364], 'cerebral': [779], 'ventricles': [780], 'reduced': [781, 1625, 2091], 'baseline': [782], 'activity': [785, 1370, 1518, 1726, 2444, 2487, 2513, 2537, 2773, 2797, 2864, 2970, 3163, 3232, 3524, 3549], 'rats': [787, 1020, 1754, 2004, 3591], 'while': [790, 2099], 'having': [791, 2100], 'effect': [793, 2102, 2114], 'rats.36': [796], 'infusion': [798, 3783, 4122], 'directly': [802], 'sympathoexcitation': [813, 4017], 'upregulation': [816, 896, 918, 937, 1176, 1536, 1991, 2385, 3701, 4173], 'receptors.40': [819], 'As': [820], 'discussed': [821], 'detail': [824], 'below,': [825], 'complex,': [837], 'but': [838, 923, 1232], 'apparently': [839, 2140], 'mediated,': [842], 'least': [844, 879], 'reactive': [848], 'oxidant': [849, 1950], 'stress': [850, 1951, 2147, 2341, 2419], '(ROS).51,53,54Download': [851], 'figureDownload': [852, 1263, 1634, 2525], 'PowerPointFigure': [853, 1264, 1635, 2526], '1.': [854], 'protein': [857, 944, 1029, 1277, 2019, 2442], '(A)': [858], 'message': [860, 942], '(B)': [861], 'RVLM': [864, 1032, 1199, 1270, 1366, 1567, 1628, 2000, 2150], 'sham': [866, 1035, 1279], '(with': [870, 1677], 'permission,': [871, 1678], 'Circulation': [872, 1679, 3995, 4132], 'Research).It': [873], 'interest': [876], 'system,': [884, 1971, 3614], 'seems': [886, 2400, 2420], 'high': [888, 959], 'levels': [889, 960, 2056, 2395, 3320], 'evoke': [894], 'receptors.': [899], 'This': [900, 978, 1191, 1854, 2189, 2399, 2542], 'contrast': [903], 'many': [905, 1699, 1920, 2025], 'nonpeptide': [906], 'receptors,': [907], 'show': [909], 'opposite': [911], 'response.': [912], 'understood': [922], 'can': [924, 1193, 1723], 'be': [925, 947, 981, 1047, 1103, 1160, 1195, 1588, 1793, 1905, 2402, 2620], 'systems.55': [929], 'specific': [932, 1243, 2453], 'transcription': [933, 2408], 'factors': [934], 'mediate': [936, 1129, 1683], 'operative': [948], 'through': [949, 2220, 2411, 2457], 'c-Jun/JNK/c-fos': [951], 'pathway.56': [952], 'worth': [955], 'noting': [956], 'chronically': [958], 'membrane': [965, 1108, 2346], 'potential': [966, 1977], 'potassium': [972, 976, 1120, 2242, 2461], 'channel': [973, 1121, 1256, 1847, 2348, 2464, 2591], 'proteins': [974], 'currents.57–59': [977], 'very': [982, 1161], 'disease': [989, 1328, 1353, 1444, 2311], 'states': [990, 1329], 'characterized': [993], 'sympathoexcitation,': [995], 'hypertension.': [1000], 'Data': [1001], 'Sumners': [1006], 'coworkers60,61': [1008], 'confirmed': [1010], 'mechanism.': [1012], 'Preliminary': [1013, 1608], 'our': [1016, 1611], 'indicates': [1018, 1657, 2173, 2624], 'express': [1023], 'lower': [1024], 'amounts': [1025], 'KV4.3': [1028], 'do': [1034, 1139], 'rats.Finally,': [1036], 'interactions': [1039, 1090], 'between': [1040, 1091, 1389, 3609], 'AT2': [1044, 1060, 1094, 1137, 1152, 1181, 1240, 1275], 'importance': [1049], 'outflow.': [1055, 1837], 'Based': [1056], 'binding': [1058, 2018], 'experiments,': [1059], 'dense': [1063], 'organum': [1066], 'vasculosum': [1067], 'lamina': [1070], 'terminalis': [1071], 'subfornical': [1073], 'organ,': [1074], 'area': [1080], 'postrema': [1081], 'NTS': [1083, 1998], 'WKY': [1086], 'SHR.62,63': [1088], 'Functional': [1089], 'single': [1098], 'neuron': [1099], 'level': [1100, 1800], 'seem': [1101], 'regulating': [1106], 'neuronal': [1107, 1260, 1349, 1725, 1743, 1859, 2585], 'potential.': [1109], 'Gelband': [1110], 'et': [1111, 1476, 1985], 'al64': [1112], 'interaction': [1115], 'cultured': [1124, 1185], 'catecholaminergic': [1125], 'neurons.': [1126], 'decrease': [1131, 1741], 'outward': [1133, 2241], 'K+': [1134], 'current,': [1135], 'whereas': [1136], 'just': [1140], 'opposite.': [1142], 'standpoint': [1145], 'regulation,': [1148], 'ability': [1150, 1932], 'activate': [1155], 'NO': [1157, 1702, 1722, 1744, 1791, 1807, 1817, 1936, 1940, 2474, 2481], 'pathway': [1158, 2376, 2550, 2581], 'important,': [1162], 'especially': [1163, 1972], 'after': [1164, 2005], 'cellular': [1165], 'injury.65–67': [1166], 'preliminary': [1168], 'laboratory,': [1172, 1498], 'observed': [1174], 'gene': [1182], 'exposed': [1187], 'II.': [1190, 1673, 2398, 3535, 3561], 'seen': [1196], 'intact': [1201], 'without': [1205, 1646], '2).': [1208], 'Therefore,': [1209], 'participation': [1211], 'process': [1218, 1880, 2184], 'depends': [1223], 'only': [1225], 'amount': [1228], 'available': [1231], 'density': [1235], 'sites': [1244, 1713], 'their': [1252, 1319, 1931, 1976, 2637], 'ion': [1255, 2347, 2590], 'thereby': [1259, 1832], 'excitability.': [1261], 'Download': [1262, 2524], '2.': [1265], 'Western': [1266], 'blots': [1267], 'subtypes': [1285], 'were': [1286, 1650], 'state.ROS': [1291], 'FailureBecause': [1297], 'now': [1300, 1376, 1449], 'well-accepted': [1301], 'ROSs': [1304, 1379], 'wide': [1307], 'acute': [1310, 3761], 'biological': [1313], 'system,68': [1318], 'mediating': [1322], 'autonomic': [1325, 1898, 3730], 'become': [1331, 1828], 'interest.': [1333], 'Antioxidant': [1334], 'therapy': [1335, 2274, 4085], 'normalize': [1346], 'models.69–77': [1354], 'Zanzinger': [1355], 'Czachurski78': [1357], 'superoxide': [1360, 1423, 1460, 1483, 1512, 1563, 1682, 1802, 2218, 4125], 'dismutase': [1361], '(SOD)': [1362], 'injected': [1363], 'decreased': [1367], 'swine.': [1372], 'groups': [1374, 1447], 'stimulate': [1380, 1417], 'outflow.79,80': [1383], 'Perhaps': [1384], 'importantly,': [1386], 'link': [1388, 1452], 'generation': [1391, 1421, 1803, 2338, 2577], 'ROS': [1394, 2580], 'stimulation': [1398, 2204, 3734], 'supported': [1401, 2660], 'numerous': [1403], 'studies': [1404, 1431, 1494, 1532, 1609], 'pathological': [1408, 2555], 'states.': [1409, 1445], 'initial': [1411], 'demonstration': [1412], 'could': [1416, 1587], 'NAD(P)H': [1419, 1509, 1546, 1603, 2163, 2224, 3703, 4026, 4102], 'oxidase–dependent': [1420], 'vascular': [1425, 1923], 'smooth': [1426], 'muscle81': [1427], 'prompted': [1429], 'multiple': [1430], 'investigating': [1432], 'among': [1453], 'II,': [1455, 1505, 1580, 3611], 'receptor,': [1458, 1508], 'signaling': [1461], 'relating': [1467], 'regulation': [1470, 2344, 2533, 2769, 2966, 3619], 'activity.53,80,82–84': [1474], 'Zimmerman': [1475, 4109], 'al54,84': [1477], 'convincingly': [1478], 'requirement': [1481], 'mouse.In': [1493], 'conducted': [1495], 'determined': [1500], 'oxidase,': [1510, 1604], 'anion': [1513, 1839, 2219, 2434], '(RSNA)': [1519], 'failure.15,40,51,53': [1530], 'These': [1531, 2008, 2106], 'along': [1540, 2436], 'subunits': [1543], 'oxidase': [1547, 2164, 3704], 'complex': [1548], 'RVLM.': [1551, 3706], 'dihydroethidium': [1555], 'staining': [1556], 'lucigenin': [1558], 'chemiluminescence,': [1559], 'CHF.51': [1571], 'Importantly,': [1572], 'was': [1582, 2659], 'augmented': [1583], 'rabbits,': [1586], 'restored': [1589, 2126], 'near': [1591], 'either': [1594, 2448], 'SOD': [1596, 1619, 1622, 2441], 'mimetic': [1597], 'tempol': [1598], 'inhibitor': [1601], 'apocynin': [1605], '3).40,51': [1607], 'CuZn': [1618], 'Mn': [1621], 'synthesis': [1623, 1747, 1786], 'CHF.85Download': [1633], '3.': [1636], 'RSNA': [1640, 2092], 'All': [1648], 'agents': [1649], 'administered': [1651], 'route.': [1655], 'Tem': [1656], 'tempol;': [1658], 'Apo,': [1659], 'apocynin;': [1660], 'DETC,': [1661], 'diethylcarbamic': [1662], 'acid.': [1663], '*P<0.05;': [1664], '**P<0.01;': [1665], '***P<0.001': [1666], 'vs': [1667, 1671], 'control.': [1668, 3921], '#P<0.05;': [1669], '##P<0.01': [1670], 'N=6': [1674], 'per': [1675], 'group.': [1676], 'Research).How': [1680], 'might': [1681], 'CHF?': [1693], 'laboratories': [1700], 'substance': [1707, 3373, 3953], 'released': [1710], 'brain,': [1716], 'function.86–91': [1720], 'Certainly': [1721], 'modulate': [1724, 1845, 1897], 'RVLM,': [1729], 'NTS,': [1730], 'via': [1733], 'GABA': [1735], 'mechanism.92–95': [1736], 'We': [1737, 2074], 'synthase': [1745, 1937], '(nNOS)': [1746], 'CHF.96–98': [1758], 'similar': [1760], 'finding': [1761], 'eNOS': [1763], 'circulation': [1767, 2940], 'known': [1770], 'time': [1773], 'humans.99–104': [1778], 'reduction': [1783, 1814, 2144, 2156, 2439, 2484, 3408], 'NOS,': [1788], 'any': [1789, 2113], 'formed': [1790, 3401], 'immediately': [1794], 'converted': [1795], 'peroxynitrite': [1797], 'if': [1798], 'high.': [1805], 'well-known': [1810], 'substance,': [1812], 'bioavailable': [1816], 'would': [1818], 'predispose': [1819], 'excitable': [1830], 'generate': [1833], 'Superoxide': [1838, 2433, 4015], 'calcium': [1846, 2233, 2463], 'system.105': [1853], 'excitability': [1860, 2586], 'CHF.Additional': [1865], 'ROS,': [1873], 'hypertension': [1885, 1912], 'comes': [1886], '3-hydroxy-3-methylglutaryl': [1890], 'coenzyme': [1891], 'reductase': [1893], 'inhibitors': [1894], '(statins)': [1895], 'Statins': [1900], 'beneficial': [1906], 'treatment': [1909, 2080, 2089, 2120], 'CHF.106–110': [1914], 'There': [1915], 'clear': [1917], 'pleiotropic': [1924], 'statins': [1927, 1944, 1966, 2063], 'mediated': [1929, 2213, 2403, 3251, 3951], 'augment': [1934], 'endothelial': [1935], '(NOS)': [1938], 'production.111–113': [1941], 'reducing': [1949], 'signaling.114–117': [1955], 'regard': [1974], 'Studies': [1982], 'Kishi': [1984], 'al118–121': [1986], 'NOS': [1994], 'isoforms': [1995], 'stroke-prone': [2002], 'hypertensive': [2003], 'statin': [2006, 2033, 2119], 'treatment.': [2007], 'investigators': [2009], 'further': [2010, 2212, 2561], 'inhibition': [2013, 2048], 'small': [2016], 'GTP': [2017], 'Rho': [2020, 2022, 2037, 2050], 'kinase': [2023, 2038, 2051], 'mimicked': [2024], 'treatment.122–127': [2034], 'Inhibition': [2035], 'one': [2040], 'target': [2043], 'actions': [2044, 3939], 'statins.128–130': [2046], 'associated': [2053], 'NOS,128,131': [2058], 'plausible': [2061], 'inhibit': [2065], 'NO-depleted': [2069], 'states,': [2070, 2312], 'investigated': [2075], 'simvastatin': [2079], 'CHF.132,133': [2087], 'Statin': [2088], 'animals.': [2105], 'occurred': [2108], 'absence': [2111], 'plasma': [2116], 'lipids.': [2117], 'rate': [2123], 'variability': [2124], 'sympathovagal': [2128], 'balance': [2129], 'state.': [2133, 2188, 2541, 2604], 'because': [2141, 2228, 2475], 'oxidative': [2146, 2340, 2418], 'result': [2153], 'production.53To': [2165], 'summarize,': [2166], 'bulk': [2168], 'existing': [2170], 'strongly': [2172], 'pivotal': [2179, 2326, 2573], 'initiates': [2191], 'its': [2198, 2322, 2334, 2569, 3844], 'own': [2199], 'upregulated.': [2202], 'action': [2222], 'oxidase.': [2225, 4027, 4103], 'Neuronal': [2226], 'entry': [2234], 'downregulation': [2239], 'currents': [2243], 'contributes': [2245, 2558], 'function.Summary': [2254], 'ConclusionsUntil': [2256], 'recently,': [2257], 'occurs': [2264], 'unknown,': [2272], 'targeting': [2275], 'empirical': [2287], 'based.': [2290], 'With': [2291], 'advent': [2293], 'newer': [2295], 'techniques': [2296], 'localize': [2298], 'evaluate': [2300], 'picture': [2314], 'emerging': [2316], 'implicates': [2318], 'regulator': [2327], 'virtue': [2332], 'One': [2350], 'reproducible': [2356], 'aspects': [2357], 'relates': [2366], 'receptor.': [2373], 'novel': [2375], 'come': [2379], 'work': [2382, 2654], 'face': [2392], 'elevated': [2394, 3228], 'factor': [2409, 2607], 'AP1': [2410], 'cJun/Jnk': [2413], 'pathway.The': [2414], 'major': [2424], 'sensitization': [2451], 'populations': [2454], 'activity.': [2465, 3667], 'reductions': [2468], 'influence': [2472], 'scavenging': [2479], 'nNOS': [2486, 2612], 'sympathoexcitation.': [2494], 'Figure': [2495], '4': [2496], 'provides': [2497], 'schematic': [2499, 2529], 'overview': [2500, 2530], 'relevant': [2503], 'events': [2505], 'pathways': [2507], 'exercise': [2522, 3520], 'training.': [2523], '4.': [2527], 'scheme': [2543], 'describes': [2544], 'feed-forward': [2546], 'Another': [2605], 'contributing': [2606], 'loss': [2610], 'believed': [2618], 'sympathoinhibitory.': [2621], 'Dashed': [2622], 'line': [2623], 'mutual': [2625], 'inhibition.I': [2626], 'thank': [2627], 'Lie': [2628], 'Gao,': [2629], 'Harold': [2630], 'D.': [2631, 3453], 'Schultz,': [2632], 'Yu-Long': [2634], 'Li': [2635, 3572, 3682, 4005, 4038, 4074], 'valuable': [2638], 'assistance': [2639], 'providing': [2641], 'described': [2646], 'article.Source': [2649], 'FundingSome': [2651], 'article': [2658], 'National': [2662], 'Institutes': [2663], 'Health': [2665], 'grant': [2666], 'PO-1': [2667], 'HL62222.DisclosuresNone.FootnotesCorrespondence': [2668], 'Zucker,': [2672], '985850': [2684], 'Omaha,': [2688], 'NE': [2689], '68198-5850.': [2690], 'E-mail': [2691], '[email': [2692], 'protected]': [2693], 'References': [2694], 'Esler': [2696, 2702, 2839], 'M,': [2697, 2763, 2877, 3003, 3031, 3286, 3307, 3313, 3391, 3393, 3395], 'Kaye': [2698, 2847], 'D,': [2699, 2703, 4010, 4079], 'Lambert': [2700, 2841], 'G,': [2701], 'Jennings': [2704], 'G.': [2705, 2986], 'Adrenergic': [2706], 'failure.': [2711, 2728, 2776, 2868, 2905, 2924, 2943, 2973, 2992, 3054, 3073, 3099, 3128, 3146, 3198, 3235, 3257, 3299, 3326, 3487, 3501, 3595], 'Am': [2712, 2729, 2812, 2906, 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3417, 3465], '83:': [2755], '21–29.CrossrefMedlineGoogle': [2756], 'Scholar4': [2757], 'IH,': [2759, 2914, 3084, 3115, 3157, 3577, 4035], 'Wang': [2760, 2915, 3006, 3085, 3112, 3136, 3158, 3184, 3245, 3287, 3578, 3680, 3779, 3883, 4003, 4040, 4042, 4072, 4166], 'W,': [2761, 2916, 3007, 3113, 3137, 3159, 3185, 3288, 3681, 4004, 4043, 4073], 'Brändle': [2762, 2917, 3002, 3285], 'Schultz': [2764, 3116, 3160, 3186, 3684, 3777, 4007, 4036, 4076], 'HD,': [2765, 3187, 3685, 3778, 4008, 4037, 4077], 'Patel': [2766, 3004, 3515, 3574, 4044], 'KP.': [2767, 4045], 'Neural': [2768], 'Prog': [2777, 4062], 'Cardiovas': [2778, 3415], 'Dis.': [2779], '1995;': [2780, 4160], '37:': [2781], '397–414.CrossrefMedlineGoogle': [2782], 'Scholar5': [2783], 'Ferguson': [2784, 2819], 'DW,': [2785], 'Berg': [2786], 'WJ,': [2787], 'Sanders': [2788], 'JS.': [2789], 'Clinical': [2790, 3327], 'hemodynamic': [2792], 'correlates': [2793], 'direct': [2808], 'microneurographic': [2809], 'recordings.': [2810], 'Coll': 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