Publication Information

{'id': 'https://openalex.org/W2078400045', 'doi': 'https://doi.org/10.1091/mbc.3.11.1269', 'title': 'Biochemical and physiological changes induced by anthrax lethal toxin in J774 macrophage-like cells.', 'display_name': 'Biochemical and physiological changes induced by anthrax lethal toxin in J774 macrophage-like cells.', 'publication_year': 1992, 'publication_date': '1992-11-01', 'ids': {'openalex': 'https://openalex.org/W2078400045', 'doi': 'https://doi.org/10.1091/mbc.3.11.1269', 'mag': '2078400045', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1457831', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/275693'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1091/mbc.3.11.1269', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188085164', 'display_name': 'Molecular Biology of the Cell', 'issn_l': '1059-1524', 'issn': ['1059-1524', '1939-4586'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319721', 'host_organization_name': 'American Society for Cell Biology', 'host_organization_lineage': ['https://openalex.org/P4310319721'], 'host_organization_lineage_names': ['American Society for Cell Biology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc275693?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5088935592', 'display_name': 'Philip Hanna', 'orcid': 'https://orcid.org/0000-0002-9418-6840'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P C Hanna', 'raw_affiliation_strings': ['Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115.', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055679208', 'display_name': 'Sims K. Kochi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S Kochi', 'raw_affiliation_strings': ['Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115.', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5078561820', 'display_name': 'R. John Collier', 'orcid': 'https://orcid.org/0000-0002-2427-4239'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R J Collier', 'raw_affiliation_strings': ['Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115.', 'institution_ids': ['https://openalex.org/I136199984']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.966, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 102, 'citation_normalized_percentile': {'value': 0.900499, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '3', 'issue': '11', 'first_page': '1269', 'last_page': '1277'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11515', 'display_name': 'Bacillus and Francisella bacterial research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11515', 'display_name': 'Bacillus and Francisella bacterial research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10120', 'display_name': 'Bacterial Genetics and Biotechnology', 'score': 0.9729, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11455', 'display_name': 'Microbial Inactivation Methods', 'score': 0.9632, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/osmotic-concentration', 'display_name': 'Osmotic concentration', 'score': 0.71170473}, {'id': 'https://openalex.org/keywords/efflux', 'display_name': 'Efflux', 'score': 0.5294164}, {'id': 'https://openalex.org/keywords/osmotic-shock', 'display_name': 'Osmotic shock', 'score': 0.42491364}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7185923}, {'id': 'https://openalex.org/C129900496', 'wikidata': 'https://www.wikidata.org/wiki/Q643555', 'display_name': 'Osmotic concentration', 'level': 2, 'score': 0.71170473}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.6862725}, {'id': 'https://openalex.org/C57409179', 'wikidata': 'https://www.wikidata.org/wiki/Q1218293', 'display_name': 'Lysis', 'level': 2, 'score': 0.67509955}, {'id': 'https://openalex.org/C2777367657', 'wikidata': 'https://www.wikidata.org/wiki/Q184651', 'display_name': 'Toxin', 'level': 2, 'score': 0.5690027}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5520384}, {'id': 'https://openalex.org/C200082930', 'wikidata': 'https://www.wikidata.org/wiki/Q22327148', 'display_name': 'Efflux', 'level': 2, 'score': 0.5294164}, {'id': 'https://openalex.org/C2777318727', 'wikidata': 'https://www.wikidata.org/wiki/Q409464', 'display_name': 'Lactate dehydrogenase', 'level': 3, 'score': 0.51585907}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.48613068}, {'id': 'https://openalex.org/C73588182', 'wikidata': 'https://www.wikidata.org/wiki/Q2663023', 'display_name': 'Cytolysis', 'level': 4, 'score': 0.46183252}, {'id': 'https://openalex.org/C168529131', 'wikidata': 'https://www.wikidata.org/wiki/Q13656562', 'display_name': 'Osmotic shock', 'level': 3, 'score': 0.42491364}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.27665544}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.18849227}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.09547275}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000942', 'descriptor_name': 'Antigens, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001408', 'descriptor_name': 'Bacillus anthracis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001427', 'descriptor_name': 'Bacterial Toxins', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002463', 'descriptor_name': 'Cell Membrane Permeability', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000244', 'descriptor_name': 'Adenosine Diphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000244', 'descriptor_name': 'Adenosine Diphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000249', 'descriptor_name': 'Adenosine Monophosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000249', 'descriptor_name': 'Adenosine Monophosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001427', 'descriptor_name': 'Bacterial Toxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002463', 'descriptor_name': 'Cell Membrane Permeability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009994', 'descriptor_name': 'Osmolar Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1091/mbc.3.11.1269', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188085164', 'display_name': 'Molecular Biology of the Cell', 'issn_l': '1059-1524', 'issn': ['1059-1524', '1939-4586'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319721', 'host_organization_name': 'American Society for Cell Biology', 'host_organization_lineage': ['https://openalex.org/P4310319721'], 'host_organization_lineage_names': ['American Society for Cell Biology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc275693', 'pdf_url': 'https://europepmc.org/articles/pmc275693?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC275693', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1457831', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc275693', 'pdf_url': 'https://europepmc.org/articles/pmc275693?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'score': 0.83, 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1536607091', 'https://openalex.org/W1555708849', 'https://openalex.org/W1570872125', 'https://openalex.org/W1587381346', 'https://openalex.org/W1589415602', 'https://openalex.org/W1870608827', 'https://openalex.org/W1906629914', 'https://openalex.org/W1926803865', 'https://openalex.org/W1963191890', 'https://openalex.org/W1974917488', 'https://openalex.org/W1980108836', 'https://openalex.org/W1993005324', 'https://openalex.org/W1994173318', 'https://openalex.org/W1998228104', 'https://openalex.org/W1999414534', 'https://openalex.org/W2029821093', 'https://openalex.org/W2054027422', 'https://openalex.org/W2055422081', 'https://openalex.org/W2060898607', 'https://openalex.org/W2073345785', 'https://openalex.org/W2076436500', 'https://openalex.org/W2083435317', 'https://openalex.org/W2105086378', 'https://openalex.org/W2138949997', 'https://openalex.org/W2153648499', 'https://openalex.org/W2176061808', 'https://openalex.org/W2292968055', 'https://openalex.org/W4241588117'], 'related_works': ['https://openalex.org/W4313341530', 'https://openalex.org/W2620370100', 'https://openalex.org/W2107684873', 'https://openalex.org/W2030400914', 'https://openalex.org/W2012343470', 'https://openalex.org/W1998825320', 'https://openalex.org/W1981714108', 'https://openalex.org/W1573436053', 'https://openalex.org/W1551032917', 'https://openalex.org/W1520397689'], 'abstract_inverted_index': {'Experiments': [0], 'were': [1, 34, 37, 58, 136, 151, 173], 'performed': [2], 'to': [3, 47, 63, 73, 86, 144, 195, 222, 255, 262, 268], 'probe': [4], 'the': [5, 28, 40, 145, 162, 169, 192, 202, 205, 231, 235], 'mechanism': [6], 'by': [7, 138, 156, 240], 'which': [8, 36], 'Bacillus': [9], 'anthracis': [10], 'Lethal': [11], 'Toxin': [12], '(LeTx)': [13], 'causes': [14], 'lysis': [15], 'of': [16, 22, 27, 32, 42, 71, 100, 104, 110, 140, 158, 191, 204, 213, 217, 225, 230, 237, 242, 257], 'J774': [17], 'macrophage-like': [18], 'cells.': [19], 'After': [20], 'incubation': [21], 'cells': [23], 'with': [24], 'saturating': [25], 'concentrations': [26], 'toxin,': [29], 'two': [30], 'categories': [31], 'effects': [33], 'found,': [35], 'distinguishable': [38], 'on': [39], 'basis': [41], 'chronology,': [43], 'Ca(2+)-dependence,': [44], 'and': [45, 65, 67, 75, 93, 108, 118, 135, 168, 185, 198, 215], 'sensitivity': [46], 'osmolarity.': [48], 'The': [49, 210], 'earliest': [50, 203], 'events': [51, 78, 127, 150, 172], '(category': [52, 79], 'I),': [53], 'beginning': [54, 95, 121], '45': [55], 'min': [56], 'postchallenge,': [57], 'an': [59, 129], 'increase': [60], 'in': [61, 83, 175, 245, 252], 'permeability': [62, 85, 253], '22Na': [64], '86Rb': [66], 'a': [68], 'rapid': [69], 'conversion': [70], 'ATP': [72, 166], 'ADP': [74], 'AMP.': [76], 'Later': [77], 'II)': [80], 'included': [81], 'alterations': [82], 'membrane': [84, 194], '45Ca,': [87], '51Cr,': [88], '36Cl,': [89], '35SO4,': [90], '3H-amino': [91], 'acids,': [92], '3H-uridine,': [94], 'at': [96, 114, 122], '60': [97], 'min;': [98, 117], 'inhibition': [99], 'macromolecular': [101], 'synthesis,': [102], 'leakage': [103], 'cellular': [105], 'lactate': [106], 'dehydrogenase': [107], 'onset': [109], 'gross': [111], 'morphological': [112], 'changes,': [113], 'approximately': [115], '75': [116], 'cell': [119], 'lysis,': [120], '90': [123], 'min.': [124], 'Category': [125], 'II': [126, 171], 'exhibited': [128], 'absolute': [130], 'requirement': [131], 'for': [132, 183], 'extracellular': [133], 'Ca2+': [134], 'blocked': [137, 174], 'addition': [139], '0.3': [141], 'M': [142], 'sucrose': [143], 'medium,': [146], 'whereas': [147], 'category': [148, 170], 'I': [149], 'attenuated,': [152], 'but': [153], 'not': [154], 'blocked,': [155], 'either': [157], 'these': [159], 'conditions.': [160], 'On': [161], 'other': [163], 'hand,': [164], 'both': [165], 'depletion': [167, 224, 241], 'osmotically': [176], 'stabilized': [177], 'medium': [178], 'that': [179, 189], 'was': [180], 'also': [181], 'isoionic': [182], 'Na+': [184, 214], 'K+.': [186], 'This': [187], 'suggests': [188], 'permeabilization': [190], 'plasma': [193], 'monovalent': [196, 246], 'cations': [197], 'water': [199], 'may': [200], 'be': [201, 220, 260], 'physiological': [206], 'changes': [207, 251, 265], 'described': [208], 'here.': [209], 'resulting': [211], 'influx': [212, 236, 256], 'efflux': [216], 'K+': [218], 'would': [219, 259], 'expected': [221, 261], 'cause': [223], 'ATP,': [226, 243], 'via': [227], 'increased': [228], 'activity': [229], 'Na+/K+': [232], 'pump.': [233], 'Subsequently': [234], 'Ca2+,': [238], 'induced': [239], 'imbalances': [244], 'cautions,': [247], 'and/or': [248], 'more': [249], 'dramatic': [250], 'due': [254], 'water,': [258], 'trigger': [263], 'widespread': [264], 'leading': [266], 'ultimately': [267], 'cytolysis.': [269]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2078400045', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-08T19:17:31.229854', 'created_date': '2016-06-24'}