Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2078234659', 'doi': 'https://doi.org/10.1016/0262-1746(83)90045-8', 'title': 'Prostacyclin and thromboxane in diabetic children', 'display_name': 'Prostacyclin and thromboxane in diabetic children', 'publication_year': 1983, 'publication_date': '1983-07-01', 'ids': {'openalex': 'https://openalex.org/W2078234659', 'doi': 'https://doi.org/10.1016/0262-1746(83)90045-8', 'mag': '2078234659', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6351104'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0262-1746(83)90045-8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S60290705', 'display_name': 'Prostaglandins Leukotrienes and Medicine', 'issn_l': '0262-1746', 'issn': ['0262-1746', '1879-2847'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310321208', 'host_organization_name': 'Churchill Livingstone', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310321208'], 'host_organization_lineage_names': ['Elsevier BV', 'Churchill Livingstone'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059829176', 'display_name': 'Marja‐Liisa Käär', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': True, 'raw_author_name': 'Marja-Liisa Kaar', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, University of Helsinki, SF-00290 Helsinki 29', 'Departments of Pediatrics and Clinical Chemistry, University of Oulu, SF-90220 Oulu 22 USA', 'Finland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pediatrics and Clinical Chemistry, University of Oulu, SF-90220 Oulu 22 USA', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Obstetrics and Gynecology, University of Helsinki, SF-00290 Helsinki 29', 'institution_ids': ['https://openalex.org/I133731052']}, {'raw_affiliation_string': 'Finland', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005613415', 'display_name': 'Pietari Kääpä', 'orcid': 'https://orcid.org/0000-0003-1616-2058'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'P. Kääpä', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, University of Helsinki, SF-00290 Helsinki 29', 'Departments of Pediatrics and Clinical Chemistry, University of Oulu, SF-90220 Oulu 22 USA', 'Finland'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, University of Helsinki, SF-00290 Helsinki 29', 'institution_ids': ['https://openalex.org/I133731052']}, {'raw_affiliation_string': 'Finland', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of Pediatrics and Clinical Chemistry, University of Oulu, SF-90220 Oulu 22 USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001051995', 'display_name': 'Lasse Viinikka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'L. Viinikka', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, University of Helsinki, SF-00290 Helsinki 29', 'Departments of Pediatrics and Clinical Chemistry, University of Oulu, SF-90220 Oulu 22 USA', 'Finland'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, University of Helsinki, SF-00290 Helsinki 29', 'institution_ids': ['https://openalex.org/I133731052']}, {'raw_affiliation_string': 'Finland', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of Pediatrics and Clinical Chemistry, University of Oulu, SF-90220 Oulu 22 USA', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009892971', 'display_name': 'Olavi Ylikorkala', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'O. Ylikorkala', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, University of Helsinki, SF-00290 Helsinki 29', 'Departments of Pediatrics and Clinical Chemistry, University of Oulu, SF-90220 Oulu 22 USA', 'Finland'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, University of Helsinki, SF-00290 Helsinki 29', 'institution_ids': ['https://openalex.org/I133731052']}, {'raw_affiliation_string': 'Finland', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of Pediatrics and Clinical Chemistry, University of Oulu, SF-90220 Oulu 22 USA', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5059829176'], 'corresponding_institution_ids': ['https://openalex.org/I133731052'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.369, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.61423, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 77}, 'biblio': {'volume': '11', 'issue': '3', 'first_page': '339', 'last_page': '344'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10678', 'display_name': 'Cyclooxygenase-2 Inhibitors in Inflammation and Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10678', 'display_name': 'Cyclooxygenase-2 Inhibitors in Inflammation and Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy in Cardiovascular Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10285', 'display_name': 'Prevention and Treatment of Venous Thromboembolism', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2724', 'display_name': 'Internal Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thromboxane-b2', 'display_name': 'Thromboxane B2', 'score': 0.66346073}, {'id': 'https://openalex.org/keywords/prostaglandins', 'display_name': 'Prostaglandins', 'score': 0.504815}], 'concepts': [{'id': 'https://openalex.org/C2781128415', 'wikidata': 'https://www.wikidata.org/wiki/Q412050', 'display_name': 'Prostacyclin', 'level': 2, 'score': 0.96192443}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.74492514}, {'id': 'https://openalex.org/C2776785769', 'wikidata': 'https://www.wikidata.org/wiki/Q412212', 'display_name': 'Thromboxane', 'level': 3, 'score': 0.7054272}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6994531}, {'id': 'https://openalex.org/C2781080829', 'wikidata': 'https://www.wikidata.org/wiki/Q3009646', 'display_name': 'Thromboxane B2', 'level': 3, 'score': 0.66346073}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6255755}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.60883117}, {'id': 'https://openalex.org/C2781024287', 'wikidata': 'https://www.wikidata.org/wiki/Q774909', 'display_name': 'Thromboxane A2', 'level': 3, 'score': 0.5552916}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.52678025}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.48225242}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.44968787}], 'mesh': [{'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D011453', 'descriptor_name': 'Prostaglandins', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D013928', 'descriptor_name': 'Thromboxane A2', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D013931', 'descriptor_name': 'Thromboxanes', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D015121', 'descriptor_name': '6-Ketoprostaglandin F1 alpha', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D015121', 'descriptor_name': '6-Ketoprostaglandin F1 alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002675', 'descriptor_name': 'Child, Preschool', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003922', 'descriptor_name': 'Diabetes Mellitus, Type 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011453', 'descriptor_name': 'Prostaglandins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013928', 'descriptor_name': 'Thromboxane A2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013929', 'descriptor_name': 'Thromboxane B2', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D013929', 'descriptor_name': 'Thromboxane B2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013931', 'descriptor_name': 'Thromboxanes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0262-1746(83)90045-8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S60290705', 'display_name': 'Prostaglandins Leukotrienes and Medicine', 'issn_l': '0262-1746', 'issn': ['0262-1746', '1879-2847'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310321208', 'host_organization_name': 'Churchill Livingstone', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310321208'], 'host_organization_lineage_names': ['Elsevier BV', 'Churchill Livingstone'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6351104', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W149224131', 'https://openalex.org/W1971445480', 'https://openalex.org/W1978285417', 'https://openalex.org/W1979352847', 'https://openalex.org/W1980581864', 'https://openalex.org/W1984823527', 'https://openalex.org/W2003916939', 'https://openalex.org/W2009554982', 'https://openalex.org/W2019900301', 'https://openalex.org/W2020334235', 'https://openalex.org/W2021403302', 'https://openalex.org/W2022736564', 'https://openalex.org/W2023072129', 'https://openalex.org/W2024559337', 'https://openalex.org/W2025577952', 'https://openalex.org/W2030087792', 'https://openalex.org/W2047059660', 'https://openalex.org/W2048047313', 'https://openalex.org/W2050449640', 'https://openalex.org/W2053541480', 'https://openalex.org/W2061815762', 'https://openalex.org/W2065710903', 'https://openalex.org/W2072708063', 'https://openalex.org/W2082483337', 'https://openalex.org/W2088580000', 'https://openalex.org/W2132328847', 'https://openalex.org/W2321057355', 'https://openalex.org/W2410338066', 'https://openalex.org/W2413640721', 'https://openalex.org/W2417311977', 'https://openalex.org/W262676802'], 'related_works': ['https://openalex.org/W98406121', 'https://openalex.org/W2410214984', 'https://openalex.org/W2274179425', 'https://openalex.org/W2078234659', 'https://openalex.org/W2077181129', 'https://openalex.org/W2065601289', 'https://openalex.org/W2063842831', 'https://openalex.org/W2053182919', 'https://openalex.org/W2044880765', 'https://openalex.org/W2023365057'], 'abstract_inverted_index': {'Plasma': [0], 'concentrations': [1], 'of': [2, 6, 14, 23, 29, 53, 68, 95], 'a': [3, 21, 48], 'stable': [4], 'metabolite': [5, 22], 'prostacyclin,': [7], '6-keto-prostaglandin': [8], 'Fla': [9], '(6-keto-PGF1a),': [10], 'and': [11, 38, 66], 'the': [12, 30, 82, 93], 'ability': [13], 'platelets': [15, 44], 'to': [16, 47, 73], 'generate': [17], 'thromboxane': [18, 24], 'B2': [19], '(TxB2),': [20], 'A2,': [25], 'during': [26], 'spontaneous': [27], 'clotting': [28], 'blood': [31], 'were': [32, 70], 'measured': [33], 'in': [34, 60], '40': [35], 'diabetic': [36, 96], 'children': [37], '16': [39], 'healthy': [40], 'controls.': [41], 'The': [42, 64, 77], "diabetics'": [43], 'generated': [45], 'TxB2': [46, 74], 'lesser': [49], 'extent': [50], 'than': [51], 'those': [52], 'controls,': [54], 'whereas': [55], 'no': [56], 'difference': [57], 'was': [58], 'seen': [59], 'plasma': [61], '6-keto-PGF1a': [62], 'concentration.': [63], 'balance': [65], 'duration': [67], 'diabetes': [69], 'not': [71, 80], 'related': [72], 'or': [75, 87], '6-Keto-PGF1a.': [76], 'results': [78], 'do': [79], 'support': [81], 'theory': [83], 'that': [84], 'an': [85], 'absolute': [86], 'relative': [88], 'prostacyclin': [89], 'deficiency': [90], 'could': [91], 'trigger': [92], 'onset': [94], 'vascular': [97], 'complications.': [98]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2078234659', 'counts_by_year': [], 'updated_date': '2024-09-13T23:06:05.594554', 'created_date': '2016-06-24'}