Title: Efficacy and tolerability of paroxetine in patients with fibromyalgia syndrome: a single-blind study
Abstract: The efficacy and tolerability of paroxetine, a selective serotonin reuptake inhibitor, were evaluated in a 12-week, single-blind, randomized study. Forty outpatients with fibromyalgia syndrome (FMS) were allocated to receive paroxetine 20 mg once daily for 3 months (group A; n = 20) or placebo once daily for 3 months (group B; n = 20). The investigator's overall assessment of paroxetine's efficacy was much improved or improved in 68% of group A patients, slightly improved in 24%, and no change in 8%. Group A patients' overall assessment of paroxetine's efficacy was much improved or improved in 40%, slightly improved in 48%, and no change in 12%. The investigator's and group B patients' overall assessments of the placebo's efficacy were no change in 96% and 82% and slightly improved in 4% and 18%, respectively. The investigator's overall assessment of tolerability was very good or good in 82% of group A patients and very good or good in 98% of group B patients. The patients' overall assessment of tolerability was very good or good in 70% in group A and in 18% in group B. Based on the findings, paroxetine appeared to be effective and well tolerated in our group of patients with FMS. Key words: fibromyalgia, selective serotonin re-uptake inhibitors, paroxetine, efficacy, tolerability.
Publication Year: 1999
Publication Date: 1999-12-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 19
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