Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2078050161', 'doi': 'https://doi.org/10.1371/journal.pone.0090358', 'title': 'Vasohibin 2 Decreases the Cisplatin Sensitivity of Hepatocarcinoma Cell Line by Downregulating p53', 'display_name': 'Vasohibin 2 Decreases the Cisplatin Sensitivity of Hepatocarcinoma Cell Line by Downregulating p53', 'publication_year': 2014, 'publication_date': '2014-03-04', 'ids': {'openalex': 'https://openalex.org/W2078050161', 'doi': 'https://doi.org/10.1371/journal.pone.0090358', 'mag': '2078050161', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24595063', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3942424'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0090358', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090358&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090358&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008990095', 'display_name': 'Zhanjun Li', 'orcid': 'https://orcid.org/0000-0001-6914-8589'}, 'institutions': [{'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}, {'id': 'https://openalex.org/I4210152119', 'display_name': 'Jiangsu Province Hospital', 'ror': 'https://ror.org/04py1g812', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210152119']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhanjun Li', 'raw_affiliation_strings': ['Laboratory of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China', 'institution_ids': ['https://openalex.org/I83519826', 'https://openalex.org/I4210152119']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101602612', 'display_name': 'Min Tu', 'orcid': 'https://orcid.org/0000-0003-1017-8825'}, 'institutions': [{'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}, {'id': 'https://openalex.org/I4210152119', 'display_name': 'Jiangsu Province Hospital', 'ror': 'https://ror.org/04py1g812', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210152119']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Min Tu', 'raw_affiliation_strings': ['Laboratory of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China', 'institution_ids': ['https://openalex.org/I83519826', 'https://openalex.org/I4210152119']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113573342', 'display_name': 'Bei Han', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210090625', 'display_name': "Nanjing Children's Hospital", 'ror': 'https://ror.org/000xvke80', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210090625']}, {'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bei Han', 'raw_affiliation_strings': ["Department of Endocrinology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing, China"], 'affiliations': [{'raw_affiliation_string': "Department of Endocrinology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing, China", 'institution_ids': ['https://openalex.org/I4210090625', 'https://openalex.org/I83519826']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101518257', 'display_name': 'Yuqing Gu', 'orcid': 'https://orcid.org/0000-0002-9873-9449'}, 'institutions': [{'id': 'https://openalex.org/I4210143819', 'display_name': "Taizhou First People's Hospital", 'ror': 'https://ror.org/04jyt7608', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210143819']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuqing Gu', 'raw_affiliation_strings': ["Department of General Surgery, Taicang City First People's Hospital, Suzhou, China"], 'affiliations': [{'raw_affiliation_string': "Department of General Surgery, Taicang City First People's Hospital, Suzhou, China", 'institution_ids': ['https://openalex.org/I4210143819']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050762332', 'display_name': 'Xiaofeng Xue', 'orcid': 'https://orcid.org/0000-0002-0963-7994'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}, {'id': 'https://openalex.org/I4210153519', 'display_name': 'First Affiliated Hospital of Soochow University', 'ror': 'https://ror.org/051jg5p78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153519']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaofeng Xue', 'raw_affiliation_strings': ['Department of General Surgery, the First Affiliated Hospital of Suzhou University, Suzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, the First Affiliated Hospital of Suzhou University, Suzhou, China', 'institution_ids': ['https://openalex.org/I3923682', 'https://openalex.org/I4210153519']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100751359', 'display_name': 'Jie Sun', 'orcid': 'https://orcid.org/0000-0001-7823-2897'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jie Sun', 'raw_affiliation_strings': ["Department of General Surgery, Fuyang People's Hospital, Fuyang, China"], 'affiliations': [{'raw_affiliation_string': "Department of General Surgery, Fuyang People's Hospital, Fuyang, China", 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054926223', 'display_name': 'Qianqian Ge', 'orcid': 'https://orcid.org/0000-0003-4862-0615'}, 'institutions': [{'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}, {'id': 'https://openalex.org/I4210152119', 'display_name': 'Jiangsu Province Hospital', 'ror': 'https://ror.org/04py1g812', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210152119']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qianqian Ge', 'raw_affiliation_strings': ['Laboratory of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China', 'institution_ids': ['https://openalex.org/I83519826', 'https://openalex.org/I4210152119']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100671685', 'display_name': 'Yi Miao', 'orcid': 'https://orcid.org/0000-0003-2542-8663'}, 'institutions': [{'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}, {'id': 'https://openalex.org/I4210152119', 'display_name': 'Jiangsu Province Hospital', 'ror': 'https://ror.org/04py1g812', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210152119']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yi Miao', 'raw_affiliation_strings': ['Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China', 'Laboratory of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China', 'institution_ids': ['https://openalex.org/I83519826', 'https://openalex.org/I4210152119']}, {'raw_affiliation_string': 'Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China', 'institution_ids': ['https://openalex.org/I83519826', 'https://openalex.org/I4210152119']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041557013', 'display_name': 'Zhuyin Qian', 'orcid': 'https://orcid.org/0000-0002-9709-4829'}, 'institutions': [{'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}, {'id': 'https://openalex.org/I4210152119', 'display_name': 'Jiangsu Province Hospital', 'ror': 'https://ror.org/04py1g812', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210152119']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Zhuyin Qian', 'raw_affiliation_strings': ['Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China', 'institution_ids': ['https://openalex.org/I83519826', 'https://openalex.org/I4210152119']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5063784705', 'display_name': 'Wentao Gao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}, {'id': 'https://openalex.org/I4210152119', 'display_name': 'Jiangsu Province Hospital', 'ror': 'https://ror.org/04py1g812', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210152119']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Wentao Gao', 'raw_affiliation_strings': ['Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China', 'institution_ids': ['https://openalex.org/I83519826', 'https://openalex.org/I4210152119']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5041557013', 'https://openalex.org/A5063784705'], 'corresponding_institution_ids': ['https://openalex.org/I83519826', 'https://openalex.org/I4210152119', 'https://openalex.org/I83519826', 'https://openalex.org/I4210152119'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 1.369, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.684356, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '9', 'issue': '3', 'first_page': 'e90358', 'last_page': 'e90358'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.8009599}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.70949996}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.68497586}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.6684365}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.5537598}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.47474557}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.46433365}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.44909889}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.44147053}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.43270776}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.38918012}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.33201468}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32039317}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.15438232}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.078573436}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D042501', 'descriptor_name': 'Angiogenic Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042501', 'descriptor_name': 'Angiogenic Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003710', 'descriptor_name': 'Demography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055785', 'descriptor_name': 'Gene Knockdown Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056945', 'descriptor_name': 'Hep G2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051028', 'descriptor_name': 'bcl-2-Associated X Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051028', 'descriptor_name': 'bcl-2-Associated X Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0090358', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090358&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/76091c3c9c704f7fbbd2ed77ddc03797', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3942424', 'pdf_url': 'https://europepmc.org/articles/pmc3942424?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942424', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24595063', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0090358', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090358&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.82, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1650797637', 'https://openalex.org/W1964829819', 'https://openalex.org/W1972383646', 'https://openalex.org/W1980079044', 'https://openalex.org/W1981608445', 'https://openalex.org/W1981989535', 'https://openalex.org/W1987413505', 'https://openalex.org/W1995227659', 'https://openalex.org/W2000230388', 'https://openalex.org/W2004962201', 'https://openalex.org/W2007935491', 'https://openalex.org/W2010706742', 'https://openalex.org/W2015311204', 'https://openalex.org/W2022810274', 'https://openalex.org/W2028593825', 'https://openalex.org/W2033295965', 'https://openalex.org/W2035794058', 'https://openalex.org/W2038464222', 'https://openalex.org/W2046100584', 'https://openalex.org/W2054260164', 'https://openalex.org/W2070648660', 'https://openalex.org/W2073641425', 'https://openalex.org/W2074779122', 'https://openalex.org/W2084464937', 'https://openalex.org/W2090099441', 'https://openalex.org/W2091049960', 'https://openalex.org/W2096826728', 'https://openalex.org/W2103404052', 'https://openalex.org/W2104694670', 'https://openalex.org/W2106787323', 'https://openalex.org/W2108177844', 'https://openalex.org/W2110400490', 'https://openalex.org/W2112070936', 'https://openalex.org/W2135635475', 'https://openalex.org/W2136455486', 'https://openalex.org/W2146133266', 'https://openalex.org/W2149129433', 'https://openalex.org/W2153184644', 'https://openalex.org/W2156299289', 'https://openalex.org/W2159515687', 'https://openalex.org/W2159959302', 'https://openalex.org/W2163823502', 'https://openalex.org/W2164277862', 'https://openalex.org/W2169178790', 'https://openalex.org/W4249769808'], 'related_works': ['https://openalex.org/W4386799875', 'https://openalex.org/W4361818978', 'https://openalex.org/W4361818627', 'https://openalex.org/W4361818220', 'https://openalex.org/W4213065871', 'https://openalex.org/W3157667906', 'https://openalex.org/W3103789129', 'https://openalex.org/W2800322456', 'https://openalex.org/W2406608798', 'https://openalex.org/W2091461259'], 'abstract_inverted_index': {'Hepatocellular': [0], 'carcinoma': [1], '(HCC)': [2], 'is': [3, 14, 25], 'a': [4, 61, 138, 244, 279], 'prevalent': [5], 'problem': [6], 'worldwide.': [7], 'Chemotherapy,': [8], 'especially': [9], 'cisplatin': [10], '(CDDP)-based': [11], 'systemic': [12], 'chemotherapy,': [13], 'the': [15, 30, 42, 51, 96, 101, 127, 132, 162, 165, 181, 220, 225, 260, 266], 'best': [16], 'option': [17], 'for': [18], 'advanced': [19], 'liver': [20, 109], 'cancer.': [21], 'However,': [22], 'CDDP': [23, 128, 147, 205, 226, 272], 'resistance': [24], 'becoming': [26], 'common': [27], 'and': [28, 53, 69, 86, 98, 117, 130, 142, 172, 203, 223, 228, 251, 273], 'hindering': [29], 'clinical': [31], 'application': [32], 'of': [33, 45, 55, 100, 103, 135, 164, 183, 230, 247, 263, 268], 'CDDP.': [34, 179], 'Meanwhile,': [35], 'no': [36], 'consensus': [37], 'has': [38], 'been': [39], 'reached': [40], 'regarding': [41], 'chemotherapeutic': [43], 'use': [44], 'vasohibin': [46], '2': [47], '(VASH2),': [48], 'which': [49], 'promotes': [50], 'angiogenesis': [52], 'proliferation': [54], 'cancer': [56, 74, 91, 110], 'cells.': [57, 232, 255], 'In': [58, 189], 'this': [59], 'work,': [60], 'tissue': [62], 'microarray': [63], 'was': [64, 80, 87], 'used': [65], 'to': [66, 271], 'observe': [67], 'VASH2': [68, 79, 104, 115, 124, 136, 153, 184, 216, 242, 264, 276], 'its': [70], 'possible': [71], 'role': [72], 'in': [73, 83, 108, 191, 265], 'treatment.': [75], 'Results': [76], 'showed': [77], 'that': [78, 123, 131, 152, 215, 237, 275], 'highly': [81], 'expressed': [82], 'HCC': [84], 'tissues': [85], 'significantly': [88, 185], 'correlated': [89], 'with': [90, 105, 200, 240], 'differentiation.': [92], 'To': [93], 'further': [94], 'investigate': [95], 'efficacy': [97], 'mechanism': [99], 'combination': [102], 'anti-cancer': [106], 'drugs': [107], 'cells,': [111], 'we': [112], 'stably': [113], 'built': [114], 'overexpression': [116, 134, 154], 'knockdown': [118, 182, 217], 'cell': [119, 133, 140], 'lines.': [120], 'We': [121, 149, 213], 'found': [122, 214], 'can': [125], 'influence': [126], 'sensitivity': [129], 'had': [137, 243], 'higher': [139, 245], 'viability': [141], 'lower': [143], 'apoptosis': [144, 229], 'rate': [145], 'after': [146, 176], 'exposure.': [148], 'also': [150], 'observed': [151], 'downregulated': [155, 241], 'wild-type': [156, 248], 'p53,': [157, 249], 'as': [158, 160], 'well': [159], 'suppressed': [161], 'expression': [163, 246], 'pro-apoptotic': [166], 'protein': [167, 170], 'BCL2-associated': [168], 'X': [169], '(Bax)': [171], 'cleaved': [173], 'caspase-3': [174], '(CC-3)': [175], 'treatment': [177, 206], 'by': [178], 'Conversely,': [180], 'inhibited': [186], 'these': [187], 'effects.': [188], 'an': [190], 'vivo': [192], 'chemosensitivity': [193], 'study,': [194], 'nude': [195], 'mice': [196], 'were': [197], 'subcutaneously': [198], 'injected': [199], 'tumor': [201, 221, 231, 238], 'cells': [202, 239, 270], 'received': [204], 'through': [207], 'intraperitoneal': [208], 'administration': [209], 'every': [210], '3': [211], 'days.': [212], 'markedly': [218], 'limited': [219], 'growth': [222], 'enhanced': [224], 'toxicity': [227], 'Western': [233], 'blot': [234], 'analysis': [235], 'revealed': [236], 'Bax,': [250], 'CC-3': [252], 'than': [253], 'control': [254], 'Overall,': [256], 'our': [257], 'results': [258], 'indicated': [259], 'novel': [261], 'roles': [262], 'chemoresistance': [267], 'hepatocarcinoma': [269], 'suggested': [274], 'may': [277], 'be': [278], 'promising': [280], 'anticancer': [281], 'target.': [282]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2078050161', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}], 'updated_date': '2024-12-24T14:40:45.247759', 'created_date': '2016-06-24'}