Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2078009213', 'doi': 'https://doi.org/10.1016/j.juro.2012.02.552', 'title': '483 RHOGDIÁ SUPPRESSES GROWTH AND SURVIVAL OF PROSTATE CANCER CELLS BY REGULATING ANDROGEN RECEPTOR (AR) SIGNALING PATHWAY', 'display_name': '483 RHOGDIÁ SUPPRESSES GROWTH AND SURVIVAL OF PROSTATE CANCER CELLS BY REGULATING ANDROGEN RECEPTOR (AR) SIGNALING PATHWAY', 'publication_year': 2012, 'publication_date': '2012-04-01', 'ids': {'openalex': 'https://openalex.org/W2078009213', 'doi': 'https://doi.org/10.1016/j.juro.2012.02.552', 'mag': '2078009213'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.juro.2012.02.552', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109567068', 'display_name': 'Yezi Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yezi Zhu', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070783001', 'display_name': 'Ramakumar Tummala', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ramakumar Tummala', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101592945', 'display_name': 'Chengfei Liu', 'orcid': 'https://orcid.org/0000-0002-2452-8788'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chengfei Liu', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012734277', 'display_name': 'Wei Lou', 'orcid': 'https://orcid.org/0000-0002-4688-1216'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Lou', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070199787', 'display_name': 'Nagalakshmi Nadiminty', 'orcid': 'https://orcid.org/0000-0003-3408-3206'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nagalakshmi Nadiminty', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088621070', 'display_name': 'Christopher P. Evans', 'orcid': 'https://orcid.org/0000-0001-5626-8901'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher Evans', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048369552', 'display_name': 'Allen C. Gao', 'orcid': 'https://orcid.org/0000-0002-5966-9038'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Allen Gao', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.252, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.536833, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 64, 'max': 72}, 'biblio': {'volume': '187', 'issue': '4S', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9883, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9883, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2779723316', 'wikidata': 'https://www.wikidata.org/wiki/Q6459234', 'display_name': 'LNCaP', 'level': 4, 'score': 0.9464599}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8465704}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.7007432}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5851359}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.54544175}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.43902993}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.42920834}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.4144979}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3041513}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2155079}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.19822583}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.08319461}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.juro.2012.02.552', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.65, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4362487847', 'https://openalex.org/W2356769105', 'https://openalex.org/W2347235584', 'https://openalex.org/W2343596771', 'https://openalex.org/W2152536832', 'https://openalex.org/W2110155536', 'https://openalex.org/W2095873383', 'https://openalex.org/W2093382902', 'https://openalex.org/W2076586151', 'https://openalex.org/W2005564231'], 'abstract_inverted_index': {'You': [0], 'have': [1, 170, 264], 'accessJournal': [2], 'of': [3, 134, 142, 209, 246, 270, 274, 294, 299, 307, 312, 316, 336, 351, 367, 375], 'UrologyProstate': [4], 'Cancer:': [5], 'Basic': [6], 'Research': [7], 'III1': [8], 'Apr': [9], '2012483': [10], 'RHOGDIÁ': [11], 'SUPPRESSES': [12], 'GROWTH': [13], 'AND': [14, 131], 'SURVIVAL': [15], 'OF': [16], 'PROSTATE': [17], 'CANCER': [18], 'CELLS': [19], 'BY': [20], 'REGULATING': [21], 'ANDROGEN': [22], 'RECEPTOR': [23], '(AR)': [24, 347], 'SIGNALING': [25], 'PATHWAY': [26], 'Yezi': [27, 42, 413], 'Zhu,': [28], 'Ramakumar': [29, 53, 422], 'Tummala,': [30], 'Chengfei': [31, 64, 431], 'Liu,': [32], 'Wei': [33, 75, 440], 'Lou,': [34], 'Nagalakshmi': [35, 86, 449], 'Nadiminty,': [36], 'Christopher': [37, 97, 458], 'Evans,': [38], 'and': [39, 108, 211, 229, 236, 281, 302, 348, 357, 373, 391, 409], 'Allen': [40, 109, 467], 'Gao': [41, 111, 468], 'ZhuYezi': [43], 'Zhu': [44, 414], 'Sacramento,': [45, 56, 67, 78, 89, 100, 112, 415, 424, 433, 442, 451, 460, 469], 'CA': [46, 57, 68, 79, 90, 101, 113, 416, 425, 434, 443, 452, 461, 470], 'More': [47, 58, 69, 80, 91, 102, 114, 417, 426, 435, 444, 453, 462, 471], 'articles': [48, 59, 70, 81, 92, 103, 115, 418, 427, 436, 445, 454, 463, 472], 'by': [49, 60, 71, 82, 93, 104, 116, 180, 238, 379, 386, 404, 419, 428, 437, 446, 455, 464, 473], 'this': [50, 61, 72, 83, 94, 105, 117, 261, 420, 429, 438, 447, 456, 465, 474], 'author': [51, 62, 73, 84, 95, 106, 118, 421, 430, 439, 448, 457, 466, 475], ',': [52, 63, 74, 85, 96, 107], 'TummalaRamakumar': [54], 'Tummala': [55, 423], 'LiuChengfei': [65], 'Liu': [66, 432], 'LouWei': [76], 'Lou': [77, 441], 'NadimintyNagalakshmi': [87], 'Nadiminty': [88, 450], 'EvansChristopher': [98], 'Evans': [99, 459], 'GaoAllen': [110], 'View': [119], 'All': [120, 477], 'Author': [121], 'Informationhttps://doi.org/10.1016/j.juro.2012.02.552AboutPDF': [122], 'ToolsAdd': [123], 'to': [124, 148, 158, 165, 196, 226, 290], 'favoritesDownload': [125], 'CitationsTrack': [126], 'CitationsPermissionsReprints': [127], 'ShareFacebookTwitterLinked': [128], 'InEmail': [129], 'INTRODUCTION': [130], 'OBJECTIVES': [132], 'Treatment': [133], 'primary': [135], 'prostate': [136, 160, 175, 337, 376], 'cancer': [137, 161, 176, 377], '(CaP)': [138], 'is': [139, 162], 'the': [140, 155, 194, 205, 230, 247, 297, 304, 333, 349, 371], 'withdrawal': [141], 'androgens.': [143], 'However,': [144], 'CaP': [145, 271, 287, 300], 'eventually': [146], 'progresses': [147], 'grow': [149, 197], 'in': [150, 198, 224, 252, 278, 284, 320, 324], 'a': [151, 173, 199, 268], 'castration-resistant': [152, 159, 200], 'state.': [153, 201], 'Understanding': [154], 'mechanisms': [156], 'leading': [157], 'very': [163], 'critical': [164], 'develop': [166], 'effective': [167], 'therapy.': [168], 'We': [169, 203], 'previously': [171], 'generated': [172], 'new': [174, 189], 'cell': [177, 190], 'line': [178, 191], 'LNCaP-IL6+': [179, 212, 253, 279, 308], 'treating': [181], 'LNCaP': [182, 210, 291, 318], 'cells': [183, 213, 254, 280, 288, 301, 319, 378], 'chronically': [184], 'with': [185, 344], 'interleukin-6': [186], '(IL6).': [187], 'The': [188, 218], 'has': [192, 328], 'acquires': [193], 'ability': [195, 335], 'METHODS': [202], 'compared': [204, 289], 'protein': [206], 'expression': [207, 356, 369], 'profiles': [208], 'using': [214, 241], 'two-dimensional': [215], 'gel': [216], 'electrophoresis.': [217], 'gels': [219], 'were': [220, 234], 'then': [221], 'silver': [222], 'stained': [223], 'order': [225], 'visualize': [227], 'proteins': [228], 'differentially': [231], 'expressed': [232], 'spots': [233, 248], 'identified': [235, 256, 265], 'characterized': [237], 'micro': [239], 'sequencing': [240], 'MALDI-PMF': [242], 'mass': [243], 'spectrometry.': [244], 'One': [245], 'that': [249, 330, 365], 'was': [250, 255, 276, 282], 'lost': [251], 'as': [257, 267], 'RhoGDIá.': [258], 'RESULTS': [259], 'In': [260, 340], 'study,': [262], 'we': [263], 'RhoGDIá': [266, 275, 295, 313, 331, 342, 352, 368], 'suppressor': [269], 'growth.': [272, 339], 'Expression': [273], 'reduced': [277], 'down-regulated': [283], 'more': [285], 'aggressive': [286], 'cells.': [292], 'Overexpression': [293], 'inhibited': [296], 'growth': [298, 306, 315], 'reversed': [303], 'androgen-independent': [305], 'cells,': [309], 'while': [310], 'down-regulation': [311], 'enhanced': [314], 'androgen-sensitive': [317], 'androgen-deprived': [321], 'conditions.': [322], 'Our': [323], 'vivo': [325], 'xenografts': [326], 'study': [327], 'shown': [329], 'suppressed': [332], 'tumorigenic': [334], 'tumor': [338], 'addition,': [341], 'interacts': [343], 'androgen': [345], 'receptor': [346], 'overexpression': [350], 'down': [353], 'regulates': [354], 'AR': [355, 358, 381], 'transcriptional': [359], 'activity.': [360], 'CONCLUSIONS': [361], 'These': [362], 'results': [363], 'demonstrate': [364], 'loss': [366], 'promotes': [370], 'development': [372], 'progression': [374], 'activating': [380], 'signaling': [382], 'pathway.': [383], '©': [384], '2012': [385, 403], 'American': [387, 405], 'Urological': [388, 406], 'Association': [389, 407], 'Education': [390, 408], 'Research,': [392, 410], 'Inc.FiguresReferencesRelatedDetails': [393], 'Volume': [394], '187Issue': [395], '4SApril': [396], '2012Page:': [397], 'e198': [398], 'Advertisement': [399, 478, 479], 'Copyright': [400], '&': [401], 'Permissions©': [402], 'Inc.MetricsAuthor': [411], 'Information': [412], 'Expand': [476], 'PDF': [480], 'downloadLoading': [481], '...': [482]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2078009213', 'counts_by_year': [{'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-13T11:25:48.062532', 'created_date': '2016-06-24'}