Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2077874095', 'doi': 'https://doi.org/10.1128/mcb.00380-10', 'title': 'Single-Molecule Analysis Reveals Changes in the DNA Replication Program for the <i>POU5F1</i> Locus upon Human Embryonic Stem Cell Differentiation', 'display_name': 'Single-Molecule Analysis Reveals Changes in the DNA Replication Program for the <i>POU5F1</i> Locus upon Human Embryonic Stem Cell Differentiation', 'publication_year': 2010, 'publication_date': '2010-09-01', 'ids': {'openalex': 'https://openalex.org/W2077874095', 'doi': 'https://doi.org/10.1128/mcb.00380-10', 'mag': '2077874095', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20647538', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2937526'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.00380-10', 'pdf_url': 'https://mcb.asm.org/content/mcb/30/18/4521.full.pdf', 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://mcb.asm.org/content/mcb/30/18/4521.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5057681007', 'display_name': 'Sherri S. Schultz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sherri S. Schultz', 'raw_affiliation_strings': ['Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461', 'institution_ids': ['https://openalex.org/I129975664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043249237', 'display_name': 'Sabrina C. Desbordes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39965400', 'display_name': 'Kettering University', 'ror': 'https://ror.org/03rcspa57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39965400']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sabrina C. Desbordes', 'raw_affiliation_strings': ['Developmental Biology Program and Department of Neurosurgery, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065'], 'affiliations': [{'raw_affiliation_string': 'Developmental Biology Program and Department of Neurosurgery, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065', 'institution_ids': ['https://openalex.org/I39965400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041723537', 'display_name': 'Zhuo Du', 'orcid': 'https://orcid.org/0000-0002-6322-4656'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhuo Du', 'raw_affiliation_strings': ['Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461.', 'institution_ids': ['https://openalex.org/I129975664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026635017', 'display_name': 'Settapong T Kosiyatrakul', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Settapong Kosiyatrakul', 'raw_affiliation_strings': ['Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461.', 'institution_ids': ['https://openalex.org/I129975664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015585820', 'display_name': 'Inna Lipchina', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39965400', 'display_name': 'Kettering University', 'ror': 'https://ror.org/03rcspa57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39965400']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Inna Lipchina', 'raw_affiliation_strings': ['Developmental Biology Program and Department of Neurosurgery, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065'], 'affiliations': [{'raw_affiliation_string': 'Developmental Biology Program and Department of Neurosurgery, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065', 'institution_ids': ['https://openalex.org/I39965400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065135570', 'display_name': 'Lorenz Studer', 'orcid': 'https://orcid.org/0000-0003-0741-7987'}, 'institutions': [{'id': 'https://openalex.org/I39965400', 'display_name': 'Kettering University', 'ror': 'https://ror.org/03rcspa57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39965400']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lorenz Studer', 'raw_affiliation_strings': ['Developmental Biology Program and Department of Neurosurgery, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065'], 'affiliations': [{'raw_affiliation_string': 'Developmental Biology Program and Department of Neurosurgery, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065', 'institution_ids': ['https://openalex.org/I39965400']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5003677739', 'display_name': 'Carl L. Schildkraut', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carl L. Schildkraut', 'raw_affiliation_strings': ['Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461.', 'institution_ids': ['https://openalex.org/I129975664']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.548, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 25, 'citation_normalized_percentile': {'value': 0.705674, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '30', 'issue': '18', 'first_page': '4521', 'last_page': '4534'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10505', 'display_name': 'Induction and Differentiation of Pluripotent Stem Cells', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10505', 'display_name': 'Induction and Differentiation of Pluripotent Stem Cells', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10621', 'display_name': 'Stochasticity in Gene Regulatory Networks', 'score': 0.9914, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/homeobox-protein-nanog', 'display_name': 'Homeobox protein NANOG', 'score': 0.6158047}, {'id': 'https://openalex.org/keywords/single-cell-analysis', 'display_name': 'Single-Cell Analysis', 'score': 0.556543}, {'id': 'https://openalex.org/keywords/embryonic-stem-cells', 'display_name': 'Embryonic Stem Cells', 'score': 0.521129}, {'id': 'https://openalex.org/keywords/pluripotent-stem-cells', 'display_name': 'Pluripotent Stem Cells', 'score': 0.515334}, {'id': 'https://openalex.org/keywords/cellular-reprogramming', 'display_name': 'Cellular Reprogramming', 'score': 0.511654}, {'id': 'https://openalex.org/keywords/licensing-factor', 'display_name': 'Licensing factor', 'score': 0.41916865}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.85524917}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.6278148}, {'id': 'https://openalex.org/C207701140', 'wikidata': 'https://www.wikidata.org/wiki/Q420522', 'display_name': 'Homeobox protein NANOG', 'level': 5, 'score': 0.6158047}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.53587246}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.47744113}, {'id': 'https://openalex.org/C175193931', 'wikidata': 'https://www.wikidata.org/wiki/Q18047065', 'display_name': 'DNA replication factor CDT1', 'level': 5, 'score': 0.47267422}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46044904}, {'id': 'https://openalex.org/C107459253', 'wikidata': 'https://www.wikidata.org/wiki/Q674925', 'display_name': 'Induced pluripotent stem cell', 'level': 4, 'score': 0.44528595}, {'id': 'https://openalex.org/C54266558', 'wikidata': 'https://www.wikidata.org/wiki/Q6543075', 'display_name': 'Licensing factor', 'level': 5, 'score': 0.41916865}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.36398685}, {'id': 'https://openalex.org/C104690221', 'wikidata': 'https://www.wikidata.org/wiki/Q5165872', 'display_name': 'Control of chromosome duplication', 'level': 4, 'score': 0.36307883}], 'mesh': [{'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D053595', 'descriptor_name': 'Embryonic Stem Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D050814', 'descriptor_name': 'Octamer Transcription Factor-3', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053595', 'descriptor_name': 'Embryonic Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D053595', 'descriptor_name': 'Embryonic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042783', 'descriptor_name': 'Endothelial Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D042783', 'descriptor_name': 'Endothelial Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D042783', 'descriptor_name': 'Endothelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071317', 'descriptor_name': 'Nanog Homeobox Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050814', 'descriptor_name': 'Octamer Transcription Factor-3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050814', 'descriptor_name': 'Octamer Transcription Factor-3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019076', 'descriptor_name': 'Transgenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.00380-10', 'pdf_url': 'https://mcb.asm.org/content/mcb/30/18/4521.full.pdf', 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2937526', 'pdf_url': 'https://europepmc.org/articles/pmc2937526?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937526', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20647538', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.00380-10', 'pdf_url': 'https://mcb.asm.org/content/mcb/30/18/4521.full.pdf', 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.45}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1217246038', 'https://openalex.org/W1528443459', 'https://openalex.org/W1669659061', 'https://openalex.org/W1965428318', 'https://openalex.org/W1968931043', 'https://openalex.org/W1971118226', 'https://openalex.org/W1972766500', 'https://openalex.org/W1981088384', 'https://openalex.org/W1983543025', 'https://openalex.org/W1983921161', 'https://openalex.org/W1986345698', 'https://openalex.org/W1987465149', 'https://openalex.org/W1993557546', 'https://openalex.org/W2003890579', 'https://openalex.org/W2008628928', 'https://openalex.org/W2021924340', 'https://openalex.org/W2022214898', 'https://openalex.org/W2022539055', 'https://openalex.org/W2025899010', 'https://openalex.org/W2030665161', 'https://openalex.org/W2032737065', 'https://openalex.org/W2033421234', 'https://openalex.org/W2033568291', 'https://openalex.org/W2037632104', 'https://openalex.org/W2042633640', 'https://openalex.org/W2049955797', 'https://openalex.org/W2053374394', 'https://openalex.org/W2054765269', 'https://openalex.org/W2057321580', 'https://openalex.org/W2060355887', 'https://openalex.org/W2066608321', 'https://openalex.org/W2071919914', 'https://openalex.org/W2083172100', 'https://openalex.org/W2083886963', 'https://openalex.org/W2091540767', 'https://openalex.org/W2092235484', 'https://openalex.org/W2100805144', 'https://openalex.org/W2102599158', 'https://openalex.org/W2107575419', 'https://openalex.org/W2134466644', 'https://openalex.org/W2144141448', 'https://openalex.org/W2150163104', 'https://openalex.org/W2152069828', 'https://openalex.org/W2152466351', 'https://openalex.org/W2153087859', 'https://openalex.org/W2157251845', 'https://openalex.org/W2160506011', 'https://openalex.org/W2164031201', 'https://openalex.org/W2170949514', 'https://openalex.org/W233481338', 'https://openalex.org/W4236316592'], 'related_works': ['https://openalex.org/W4379533959', 'https://openalex.org/W3199954500', 'https://openalex.org/W2897002055', 'https://openalex.org/W2728950137', 'https://openalex.org/W2434643092', 'https://openalex.org/W2083389050', 'https://openalex.org/W2045603269', 'https://openalex.org/W2031154391', 'https://openalex.org/W1984054726', 'https://openalex.org/W1586781566'], 'abstract_inverted_index': {'Human': [0], 'embryonic': [1], 'stem': [2], 'cells': [3, 48, 55, 58, 130, 196], '(hESCs),': [4], 'due': [5], 'to': [6, 16, 42, 92], 'their': [7], 'pluripotent': [8], 'nature,': [9], 'represent': [10], 'a': [11, 77, 89], 'particularly': [12], 'relevant': [13], 'model': [14], 'system': [15], 'study': [17], 'the': [18, 21, 30, 34, 43, 74, 104, 113, 120, 129, 136, 139, 157, 161, 165, 173, 180, 205], 'relationship': [19], 'between': [20], 'replication': [22, 35, 117, 155, 176, 206, 216], 'program': [23, 36, 207], 'and': [24, 39, 52, 71, 73, 119, 172, 197, 211], 'differentiation': [25], 'state.': [26], 'Here,': [27], 'we': [28], 'define': [29, 212], 'basic': [31, 108], 'properties': [32, 109], 'of': [33, 45, 95, 110, 116, 123, 141, 154, 167, 169, 175, 204, 209], 'in': [37, 84, 144, 151, 185, 193, 215], 'hESCs': [38, 210], 'compare': [40], 'them': [41], 'programs': [44], 'hESC-derived': [46, 194], 'multipotent': [47, 195], '(neural': [49], 'rosette': [50], 'cells)': [51], 'primary': [53], 'differentiated': [54], '(microvascular': [56], 'endothelial': [57], '[MECs]).': [59], 'We': [60, 87, 100, 132], 'characterized': [61], 'three': [62], 'genomic': [63], 'loci:': [64], 'two': [65, 186], 'pluripotency': [66], 'regulatory': [67], 'genes,': [68], 'POU5F1': [69, 162, 181], '(OCT4)': [70], 'NANOG,': [72], 'IGH': [75], 'locus,': [76], 'locus': [78], 'that': [79, 102], 'is': [80], 'transcriptionally': [81], 'active': [82], 'specifically': [83], 'B-lineage': [85], 'cells.': [86], 'applied': [88], 'high-resolution': [90], 'approach': [91], 'capture': [93], 'images': [94], 'individual': [96], 'replicated': [97], 'DNA': [98, 158], 'molecules.': [99], 'demonstrate': [101], 'for': [103, 135, 156], 'loci': [105], 'studied,': [106], 'several': [107], 'replication,': [111], 'including': [112], 'average': [114, 121], 'speed': [115], 'forks': [118], 'density': [122], 'initiation': [124, 142, 170], 'sites,': [125], 'were': [126, 149, 183, 191], 'conserved': [127, 184], 'among': [128], 'analyzed.': [131], 'also': [133], 'demonstrate,': [134], 'first': [137], 'time,': [138], 'presence': [140], 'zones': [143, 171], 'hESCs.': [145], 'However,': [146], 'significant': [147], 'differences': [148], 'evident': [150], 'other': [152], 'aspects': [153], 'segment': [159], 'containing': [160], 'gene.': [163], 'Specifically,': [164], 'locations': [166], 'centers': [168], 'direction': [174], 'fork': [177], 'progression': [178], 'through': [179], 'gene': [182], 'independent': [187], 'hESC': [188, 218], 'lines': [189], 'but': [190], 'different': [192], 'MECs.': [198], 'Thus,': [199], 'our': [200], 'data': [201], 'identify': [202], 'features': [203], 'characteristic': [208], 'specific': [213], 'changes': [214], 'during': [217], 'differentiation.': [219]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2077874095', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-08-31T21:35:15.481100', 'created_date': '2016-06-24'}