Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2077662314', 'doi': 'https://doi.org/10.1111/j.1460-9568.2008.06152.x', 'title': 'Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system', 'display_name': 'Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system', 'publication_year': 2008, 'publication_date': '2008-04-01', 'ids': {'openalex': 'https://openalex.org/W2077662314', 'doi': 'https://doi.org/10.1111/j.1460-9568.2008.06152.x', 'mag': '2077662314', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18412630'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1460-9568.2008.06152.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S171130801', 'display_name': 'European Journal of Neuroscience', 'issn_l': '0953-816X', 'issn': ['0953-816X', '1460-9568'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071565068', 'display_name': 'Raya Al‐Shawi', 'orcid': 'https://orcid.org/0000-0002-9174-8924'}, 'institutions': [{'id': 'https://openalex.org/I4210157979', 'display_name': 'Roland Hill (United Kingdom)', 'ror': 'https://ror.org/05d4tza70', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210157979']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Raya Al‐Shawi', 'raw_affiliation_strings': ['Centre for Biomedical Sciences, University College London, Hampstead Campus, Rowland Hill Campus, Rowland Hill Street, London NW3 2PF, UK', 'Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK', 'institution_ids': ['https://openalex.org/I4210157979', 'https://openalex.org/I45129253']}, {'raw_affiliation_string': 'Centre for Biomedical Sciences, University College London, Hampstead Campus, Rowland Hill Campus, Rowland Hill Street, London NW3 2PF, UK', 'institution_ids': ['https://openalex.org/I4210157979', 'https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106512597', 'display_name': 'Angela Hafner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210157979', 'display_name': 'Roland Hill (United Kingdom)', 'ror': 'https://ror.org/05d4tza70', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210157979']}, {'id': 'https://openalex.org/I75951250', 'display_name': 'Freie Universität Berlin', 'ror': 'https://ror.org/046ak2485', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I75951250']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['DE', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Angela Hafner', 'raw_affiliation_strings': ['Centre for Biomedical Sciences, University College London, Hampstead Campus, Rowland Hill Campus, Rowland Hill Street, London NW3 2PF, UK', 'Department of Biochemistry, Institute of Chemistry and Biochemistry, Freie Universitat Berlin, 14195 Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Centre for Biomedical Sciences, University College London, Hampstead Campus, Rowland Hill Campus, Rowland Hill Street, London NW3 2PF, UK', 'institution_ids': ['https://openalex.org/I4210157979', 'https://openalex.org/I45129253']}, {'raw_affiliation_string': 'Department of Biochemistry, Institute of Chemistry and Biochemistry, Freie Universitat Berlin, 14195 Berlin, Germany', 'institution_ids': ['https://openalex.org/I75951250']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035637744', 'display_name': 'Jessica Olson', 'orcid': 'https://orcid.org/0000-0002-8941-794X'}, 'institutions': [{'id': 'https://openalex.org/I4210157979', 'display_name': 'Roland Hill (United Kingdom)', 'ror': 'https://ror.org/05d4tza70', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210157979']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jessica Olson', 'raw_affiliation_strings': ['Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK', 'institution_ids': ['https://openalex.org/I4210157979', 'https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051046176', 'display_name': 'Soyon Chun', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210157979', 'display_name': 'Roland Hill (United Kingdom)', 'ror': 'https://ror.org/05d4tza70', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210157979']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Soyon Chun', 'raw_affiliation_strings': ['Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK', 'institution_ids': ['https://openalex.org/I4210157979', 'https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068652587', 'display_name': 'Saba Raza', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I4210157979', 'display_name': 'Roland Hill (United Kingdom)', 'ror': 'https://ror.org/05d4tza70', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210157979']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Saba Raza', 'raw_affiliation_strings': ['Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I4210157979']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027951737', 'display_name': 'Christopher Thrasivoulou', 'orcid': 'https://orcid.org/0000-0001-9425-8624'}, 'institutions': [{'id': 'https://openalex.org/I4210157979', 'display_name': 'Roland Hill (United Kingdom)', 'ror': 'https://ror.org/05d4tza70', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210157979']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Christopher Thrasivoulou', 'raw_affiliation_strings': ['Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK', 'institution_ids': ['https://openalex.org/I4210157979', 'https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002493210', 'display_name': 'Simon Lovestone', 'orcid': 'https://orcid.org/0000-0003-0473-4565'}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Simon Lovestone', 'raw_affiliation_strings': ['MRC Centre for Neurodegeneration Research, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Centre for Neurodegeneration Research, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091904097', 'display_name': 'Richard Killick', 'orcid': 'https://orcid.org/0000-0002-8815-3436'}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Richard Killick', 'raw_affiliation_strings': ['MRC Centre for Neurodegeneration Research, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Centre for Neurodegeneration Research, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070611649', 'display_name': 'J. Paul Simons', 'orcid': 'https://orcid.org/0000-0002-5007-6674'}, 'institutions': [{'id': 'https://openalex.org/I4210157979', 'display_name': 'Roland Hill (United Kingdom)', 'ror': 'https://ror.org/05d4tza70', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210157979']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Paul Simons', 'raw_affiliation_strings': ['Centre for Biomedical Sciences, University College London, Hampstead Campus, Rowland Hill Campus, Rowland Hill Street, London NW3 2PF, UK', 'Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK', 'institution_ids': ['https://openalex.org/I4210157979', 'https://openalex.org/I45129253']}, {'raw_affiliation_string': 'Centre for Biomedical Sciences, University College London, Hampstead Campus, Rowland Hill Campus, Rowland Hill Street, London NW3 2PF, UK', 'institution_ids': ['https://openalex.org/I4210157979', 'https://openalex.org/I45129253']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5091148139', 'display_name': 'T. Cowen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I4210157979', 'display_name': 'Roland Hill (United Kingdom)', 'ror': 'https://ror.org/05d4tza70', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210157979']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Timothy Cowen', 'raw_affiliation_strings': ['Centre for Biomedical Sciences, University College London, Hampstead Campus, Rowland Hill Campus, Rowland Hill Street, London NW3 2PF, UK', 'Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK'], 'affiliations': [{'raw_affiliation_string': 'Centre for Biomedical Sciences, University College London, Hampstead Campus, Rowland Hill Campus, Rowland Hill Street, London NW3 2PF, UK', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I4210157979']}, {'raw_affiliation_string': 'Department of Anatomy and Developmental Biology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK', 'institution_ids': ['https://openalex.org/I4210157979', 'https://openalex.org/I45129253']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3090, 'currency': 'USD', 'value_usd': 3090, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.015, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 94, 'citation_normalized_percentile': {'value': 0.999853, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '27', 'issue': '8', 'first_page': '2103', 'last_page': '2114'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Neurogenesis and neuroplasticity mechanisms', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12061', 'display_name': 'Axon Guidance and Neuronal Signaling', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neurite', 'display_name': 'Neurite', 'score': 0.4928434}], 'concepts': [{'id': 'https://openalex.org/C2776925932', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neurodegeneration', 'level': 3, 'score': 0.6420994}, {'id': 'https://openalex.org/C2776287375', 'wikidata': 'https://www.wikidata.org/wiki/Q3407681', 'display_name': 'Basal forebrain', 'level': 3, 'score': 0.62689877}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.59275824}, {'id': 'https://openalex.org/C92020748', 'wikidata': 'https://www.wikidata.org/wiki/Q420457', 'display_name': 'Neurotrophin', 'level': 3, 'score': 0.5831044}, {'id': 'https://openalex.org/C2778423431', 'wikidata': 'https://www.wikidata.org/wiki/Q417782', 'display_name': 'Nerve growth factor', 'level': 3, 'score': 0.5494567}, {'id': 'https://openalex.org/C113246987', 'wikidata': 'https://www.wikidata.org/wiki/Q1534415', 'display_name': 'Neurite', 'level': 3, 'score': 0.4928434}, {'id': 'https://openalex.org/C160539049', 'wikidata': 'https://www.wikidata.org/wiki/Q3064187', 'display_name': 'Neurotrophic factors', 'level': 3, 'score': 0.47709614}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.4582881}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.44650674}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4022724}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.35646528}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.34460348}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.21757525}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.10455963}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07802409}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009410', 'descriptor_name': 'Nerve Degeneration', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D020932', 'descriptor_name': 'Nerve Growth Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D033942', 'descriptor_name': 'Adaptor Proteins, Vesicular Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D031204', 'descriptor_name': 'Caloric Restriction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018613', 'descriptor_name': 'Microscopy, Confocal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009410', 'descriptor_name': 'Nerve Degeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020932', 'descriptor_name': 'Nerve Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009924', 'descriptor_name': 'Organ Culture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016548', 'descriptor_name': 'Prosencephalon', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016548', 'descriptor_name': 'Prosencephalon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017978', 'descriptor_name': 'Receptors, Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017475', 'descriptor_name': 'Receptors, Nerve Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017475', 'descriptor_name': 'Receptors, Nerve Growth Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1460-9568.2008.06152.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S171130801', 'display_name': 'European Journal of Neuroscience', 'issn_l': '0953-816X', 'issn': ['0953-816X', '1460-9568'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18412630', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1522048223', 'https://openalex.org/W1561325891', 'https://openalex.org/W1782952521', 'https://openalex.org/W1804610736', 'https://openalex.org/W1880716631', 'https://openalex.org/W1898066581', 'https://openalex.org/W1965679064', 'https://openalex.org/W1969479602', 'https://openalex.org/W1972712630', 'https://openalex.org/W1990073151', 'https://openalex.org/W1991886821', 'https://openalex.org/W2000797303', 'https://openalex.org/W2009690405', 'https://openalex.org/W2010686124', 'https://openalex.org/W2014256027', 'https://openalex.org/W2014273803', 'https://openalex.org/W2014526193', 'https://openalex.org/W2033744604', 'https://openalex.org/W2045832057', 'https://openalex.org/W2046344792', 'https://openalex.org/W2048483121', 'https://openalex.org/W2052970827', 'https://openalex.org/W2056033744', 'https://openalex.org/W2056678948', 'https://openalex.org/W2059254989', 'https://openalex.org/W2060117309', 'https://openalex.org/W2064332425', 'https://openalex.org/W2068501914', 'https://openalex.org/W2072405601', 'https://openalex.org/W2074514790', 'https://openalex.org/W2075181528', 'https://openalex.org/W2082739481', 'https://openalex.org/W2085488971', 'https://openalex.org/W2087090756', 'https://openalex.org/W2089124684', 'https://openalex.org/W2090236147', 'https://openalex.org/W2091613063', 'https://openalex.org/W2099981436', 'https://openalex.org/W2114313593', 'https://openalex.org/W2132590272', 'https://openalex.org/W2136714025', 'https://openalex.org/W2151190673', 'https://openalex.org/W2151320555', 'https://openalex.org/W2158884063', 'https://openalex.org/W2163462038', 'https://openalex.org/W2167392643', 'https://openalex.org/W2330956224', 'https://openalex.org/W2777548161', 'https://openalex.org/W955336216'], 'related_works': ['https://openalex.org/W4390441111', 'https://openalex.org/W2163625071', 'https://openalex.org/W2159633303', 'https://openalex.org/W2085762033', 'https://openalex.org/W2072195292', 'https://openalex.org/W2006739656', 'https://openalex.org/W2003195160', 'https://openalex.org/W1971786551', 'https://openalex.org/W156730779', 'https://openalex.org/W1484397242'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'precursor': [2], 'form': [3], 'of': [4, 58, 65, 69, 85, 96, 114, 117, 146, 153, 169, 218], 'the': [5, 15, 37, 93, 111, 143, 166], 'nerve': [6], 'growth': [7], 'factor': [8], '(proNGF),': [9], 'forms': [10], 'a': [11, 139], 'heterotrimeric': [12], 'complex': [13, 21], 'with': [14, 215], 'receptors': [16, 38], 'p75': [17, 39, 186], 'and': [18, 36, 40, 45, 61, 101, 120, 181, 203], 'sortilin;': [19], 'this': [20], 'has': [22, 126], 'been': [23], 'implicated': [24], 'in': [25, 56, 98, 110, 142, 176, 184, 212, 221], 'neuron': [26], 'cell': [27, 54, 83], 'death.': [28], 'However,': [29], 'it': [30], 'is': [31, 106], 'not': [32, 68], 'known': [33, 127], 'whether': [34], 'proNGF': [35, 52, 75, 97, 104, 219], 'sortilin': [41, 162, 172, 210], 'contribute': [42], 'to': [43, 77, 137], 'age‐': [44], 'disease‐related': [46], 'neurodegeneration.': [47], 'Here': [48], 'we': [49, 196], 'show': [50], 'that': [51, 103, 164, 198], 'induces': [53], 'death': [55, 84], 'subpopulations': [57], 'basal': [59, 179], 'forebrain': [60, 180], 'peripheral': [62, 121], 'sympathetic': [63, 88, 182], 'neurons': [64, 155], 'old,': [66], 'but': [67], 'young,': [70], 'adult': [71, 87], 'rodents.': [72], 'In': [73, 150], 'contrast,': [74, 185], 'appears': [76], 'induce': [78], 'neurite': [79], 'outgrowth': [80], 'rather': [81], 'than': [82], 'young': [86], 'neurons.': [89], 'We': [90], 'have': [91], 'examined': [92], 'neurotoxic': [94], 'role': [95], 'old': [99], 'age,': [100], 'find': [102], 'protein': [105], 'elevated': [107, 216], 'during': [108], 'ageing': [109, 177], 'projection': [112], 'areas': [113], 'some': [115, 222], 'populations': [116], 'vulnerable': [118], 'central': [119], 'neurons;': [122, 183], 'caloric': [123], 'restriction,': [124], 'which': [125], 'neuroprotective': [128], 'effects,': [129], 'partially': [130], 'prevents': [131], 'these': [132, 194], 'increases.': [133], 'Sortilin': [134], 'was': [135, 156], 'found': [136], 'play': [138], 'significant': [140], 'part': [141], 'observed': [144], 'patterns': [145], 'age‐related': [147, 200], 'proNGF‐mediated': [148], 'neurotoxicity.': [149], 'particular,': [151], 'survival': [152], 'aged': [154], 'rescued': [157], 'by': [158, 208], 'neurotensin,': [159], 'an': [160], 'alternative': [161], 'ligand': [163], 'blocks': [165], 'sortilin‐mediated': [167], 'effects': [168], 'proNGF.': [170], 'Furthermore,': [171], 'immunoreactivity': [173], 'increases': [174], 'markedly': [175], 'rodent': [178], 'levels': [187, 217], 'are': [188], 'either': [189], 'unchanged': [190], 'or': [191], 'reduced.': [192], 'From': [193], 'data': [195], 'propose': [197], 'selective': [199], 'neuronal': [201], 'atrophy': [202], 'neurodegeneration': [204], 'may': [205], 'be': [206], 'mediated': [207], 'increased': [209], 'expression': [211, 220], 'neurons,': [213], 'together': [214], 'targets.': [223]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2077662314', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-10T02:49:26.467364', 'created_date': '2016-06-24'}