Title: Irregular regeneration of hepatocytes is an important factor in the hepatocarcinogenesis of liver disease
Abstract: HepatologyVolume 33, Issue 2 p. 357-362 Original ArticleFree Access Irregular regeneration of hepatocytes is an important factor in the hepatocarcinogenesis of liver disease Yukiko Ueno, Yukiko Ueno Third Department of Internal Medicine, Nihon University School of Medicine, Itabashiku, Tokyo, JapanSearch for more papers by this authorMitsuhiko Moriyama M.D., Corresponding Author Mitsuhiko Moriyama M.D. [email protected] Third Department of Internal Medicine, Nihon University School of Medicine, Itabashiku, Tokyo, JapanThird Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi kamimachi, Itabashiku, Tokyo 173-8610, Japan.fax: (81) 3-3956-8496.===Search for more papers by this authorToshikazu Uchida, Toshikazu Uchida Second Department of Pathology, Showa University of School of Medicine, Shinagawaku, Tokyo, JapanSearch for more papers by this authorYasuyuki Arakawa, Yasuyuki Arakawa Third Department of Internal Medicine, Nihon University School of Medicine, Itabashiku, Tokyo, JapanSearch for more papers by this author Yukiko Ueno, Yukiko Ueno Third Department of Internal Medicine, Nihon University School of Medicine, Itabashiku, Tokyo, JapanSearch for more papers by this authorMitsuhiko Moriyama M.D., Corresponding Author Mitsuhiko Moriyama M.D. [email protected] Third Department of Internal Medicine, Nihon University School of Medicine, Itabashiku, Tokyo, JapanThird Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi kamimachi, Itabashiku, Tokyo 173-8610, Japan.fax: (81) 3-3956-8496.===Search for more papers by this authorToshikazu Uchida, Toshikazu Uchida Second Department of Pathology, Showa University of School of Medicine, Shinagawaku, Tokyo, JapanSearch for more papers by this authorYasuyuki Arakawa, Yasuyuki Arakawa Third Department of Internal Medicine, Nihon University School of Medicine, Itabashiku, Tokyo, JapanSearch for more papers by this author First published: 30 December 2003 https://doi.org/10.1053/jhep.2001.21902Citations: 46AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract The goal of this study was to assess the relationship between the degree of irregular regeneration of hepatocytes (IR) and the development of hepatocellular carcinoma (HCC). We examined the liver biopsy specimens from patients with chronic liver disease (CLD), and the noncancerous liver tissue in the surgically resected specimens from patients with HCC. Liver tissues were obtained from 18 patients with B-viral CLD, 38 with C-viral CLD, and 5 with nonB-nonC (NBNC)-CLD who underwent liver biopsy, and 24 patients with B-viral HCC, 67 with C-viral HCC, and 17 with NBNC-HCC who underwent surgical resection. The IR score of the noncancerous region of the liver of the HCC patients and that of the liver biopsy specimens of the CLD patients, were compared. Of the 108 samples of noncancerous liver tissue from the HCC patients, 70% showed an IR score of moderate or higher (IR = 3 or 4), and only 1.9% showed an IR score of none or minimal (IR = 0 or 1). 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