Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

Name: Work Video:
Duration: 3 min 30 s
Vincent J. Wacher; Chi‐Yuan Wu; Leslie Z. Benet
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'article.I': [208], 'have': [209], 'read': [210], 'accept': [212], 'the': [213, 223, 276, 302, 919, 982, 1068, 1074, 1221, 1272, 1335, 1393, 1422, 1536, 1563, 1566, 1644, 1676, 1681, 1685, 1744, 1960, 1986, 2020, 2023, 2124, 2280, 2435, 2438, 2491, 2501, 2540, 2549, 2601, 2611, 2653, 2662, 2681, 2719, 2944, 2948, 2982, 2986, 3018, 3048, 3155], 'Wiley': [214], 'Online': [215], 'Library': [216], 'UseShareable': [221], 'LinkUse': [222], 'link': [224], 'a': [228, 405, 608, 1217, 1416, 2131, 2404, 2506, 3004, 3123], 'article': [233], 'with': [234, 404, 756, 772, 1430, 1879, 1935, 2221, 2289, 2314, 2500], 'your': [235], 'friends': [236], 'colleagues.': [238], 'Learn': [239], 'more.Copy': [240], 'URL': [241], 'References': [242], '1': [243], 'Harris': [244, 1016, 1708], 'AL,': [245, 1709], 'Hochhauser': [246], 'D.': [247, 2928], 'Mechanisms': [248, 999], 'multidrug': [250, 823, 963, 1222, 1336, 1394, 1589, 1621, 1718, 1812, 1842, 2225, 2281, 2932, 3049, 3077], 'resistance': [251, 755, 794, 824, 964, 1001, 1223, 1337, 1395, 1590, 1639, 1716, 1813, 1843, 1934, 1964, 2226, 2282, 2544, 2933, 2973, 3050, 3078, 3213], 'treatment.': [254], 'Acta': [255], 'Oncol': [256, 564, 1796, 1826, 1942], '31:': [257], '205–': [258, 2059], '213,': [259], '1992.': [260, 285, 783, 908, 1088, 1174, 1254, 1294, 1320, 1401, 1500, 1577, 1910, 2012, 2142, 2184, 2239, 2450, 2668, 2850, 3031, 3179, 3255], '2': [261, 2613], 'Vendrik': [262], 'CPJ,': [263], 'Bergers': [264], 'JJ,': [265, 1770], 'De': [266], 'Jong': [267], 'WH,': [268], 'Steerenberg': [269], 'PA.': [270, 3211], 'Resistance': [271], 'cytostatic': [273], 'drugs': [274, 1003, 2714], 'at': [275, 1997, 2938], 'cellular': [277, 719], 'level.': [278], 'Cancer': [279, 370, 498, 729, 760, 988, 1009, 1046, 1083, 1193, 1225, 1343, 1593, 1656, 1730, 1885, 2057, 2102, 2136, 2162, 2202, 2234, 2320, 2339, 2363, 2386, 2900], 'Chemother': [280], 'Pharmacol': [281, 344, 415, 641, 663, 904, 927, 1113, 1134, 1168, 1249, 1290, 1434, 1519, 1546, 1626, 1694, 2758, 3058, 3219], '29:': [282, 567, 2916], '413–': [283], '429,': [284], 'Thiebaut': [287], 'F,': [288, 1663, 2040, 2213, 2885, 2963], 'Tsuruo': [289, 698, 958, 1858], 'T,': [290, 326, 626, 699, 934, 1205, 1354, 1404, 1442, 1837, 1859, 2395, 2533, 2733, 3233], 'Hamada': [291], 'H,': [292, 701, 1265, 1861, 1981, 2113, 2348, 2453], 'Gottesman': [293, 818, 2429], 'MM,': [294], 'Pastan': [295, 816, 2427], 'I,': [296, 813, 817, 1259, 1665, 2428], 'Willingham': [297], 'MC.': [298, 2824, 2999], 'Cellular': [299], 'localization': [300], 'multidrug-resistance': [303], 'gene': [304, 1071, 1338, 1419, 1559, 1844, 1992, 2408, 2441, 2545, 2871, 2930, 2974, 3020, 3214], 'product': [305, 1339], 'P-glycoprotein': [306, 972, 1305, 1452, 2255, 2283, 2568, 2890, 3191], 'normal': [308, 398, 3249], 'human': [309, 360, 399, 409, 634, 658, 680, 858, 1030, 1069, 1080, 1108, 1158, 1287, 1412, 1690, 1749, 1961, 1987, 2159, 2229, 2439, 2471, 2577, 2743, 2781, 2894, 3080], 'tissues.': [310], 'Proc': [311, 2950, 3088, 3171], 'Natl': [312, 2951, 3089, 3172], 'Acad': [313, 2952, 3173], 'Sci': [314, 692, 2953, 3090, 3174], 'USA': [315, 2954, 3175], '84:': [316], '7735–': [317], '7738,': [318], '1987.': [319, 1974], '4': [320], 'Zhou': [321, 354], 'X-J,': [322, 355], 'Zhou-Pan': [323, 350], 'X-R,': [324, 351], 'Gauthier': [325], 'Placidi': [327], 'M,': [328, 511, 842, 874, 876, 1201, 1261, 1301, 1467, 1774, 1805, 1835, 2378], 'Maurel': [329, 1266], 'P,': [330, 505, 509, 1237, 1669, 1772, 1803, 2109, 2269, 2374, 2590], 'Rahmani': [331], 'R.': [332], 'Human': [333, 1304, 1451], 'liver': [334, 361, 524, 635, 659, 681, 859, 1034, 1081, 1159, 1691, 1750, 2498, 2744, 2782, 3148], 'microsomal': [335, 915, 2507, 2807], 'isozymes': [339], 'mediated': [340, 2747], 'vindesine': [341], 'biotransformation.': [342], 'Biochem': [343, 903, 926, 1371, 1518, 1570, 1625, 1693, 2479, 2509, 2812, 2845, 2873, 3026], '45:': [345, 1114, 1627], '853–': [346], '861,': [347], '1993.': [348, 375, 446, 471, 502, 539, 621, 696, 954, 1198, 1230, 1347, 1464, 1523, 1630, 1734, 1767, 1856, 2061, 2208, 2296, 2483, 2528, 2585, 2704, 2730, 2793, 2817, 2878, 3062, 3202], '5': [349], 'Sérée': [352], 'E,': [353, 507, 1633, 1951, 2089], 'et': [356, 547, 578, 745, 1238, 1302, 1329, 1775, 1982, 2275, 2305, 2458, 2886], 'al.': [357, 548, 579, 746, 1239, 1303, 1330, 1776, 1983, 2276, 2306, 2459, 2887], 'Involvement': [358, 683], 'vinblastine': [366, 1715], 'metabolism:': [367], 'Drug': [368, 1492, 1761], 'interactions.': [369], 'Res': [371, 730, 989, 1047, 1084, 1194, 1226, 1572, 1594, 1886, 2163, 2235, 2511, 2581], '53:': [372, 1195, 1227], '5121–': [373], '5126,': [374], '6': [376], 'Murray': [377, 421, 450, 473, 572, 592, 2797], 'GI,': [378, 422, 451, 474, 573, 593], 'Barnes': [379], 'TS,': [380, 2399], 'Sewell': [381], 'HF,': [382], 'Ewen': [383, 427, 454, 479, 598], 'SWB,': [384, 428, 455, 480, 599], 'Melvin': [385, 429, 456, 481, 600], 'WT,': [386, 430, 457, 482, 601, 739, 996], 'Burke': [387, 431, 458, 483, 602], 'MD.': [388, 432, 459, 484, 603], 'The': [389, 485, 1123, 1557, 2595, 2929, 3074], 'immunocytochemical': [390], 'localisation': [391], 'P-450': [396, 861, 1066, 1755, 1989, 2787, 3107, 3121, 3150], 'hepatic': [400, 557, 914, 1031, 2806], 'extrahepatic': [402], 'tissues': [403], 'monoclonal': [406], 'antibody': [407], 'P-450.': [411, 661], 'Br': [412, 775, 1341, 2755], 'J': [413, 441, 562, 616, 759, 776, 800, 830, 863, 1167, 1314, 1342, 1458, 1655, 1729, 1794, 1824, 1940, 2006, 2478, 2615, 2639, 2698, 2756, 2874, 2899, 3127], 'Clin': [414, 640, 801, 1248, 1433, 1795, 1825, 1941, 2757], '25:': [416, 2991], '465–': [417], '475,': [418], '1988.': [419, 1439, 2392, 2958], '7': [420, 1996], 'Weaver': [423, 452, 477, 576, 596], 'RJ,': [424, 453, 478, 577, 597, 1379, 1921, 2376, 2922, 2961], 'Paterson': [425, 475], 'PJ,': [426, 476], 'Expression': [433, 549, 3238], 'xenobiotic': [435], 'metabolizing': [436, 518, 1244], 'enzymes': [437, 519, 552, 688, 1479, 1682, 2803, 3241], 'breast': [439, 1190, 2689], 'cancer.': [440, 585, 2161, 2178, 2362], 'Pathol': [442, 617, 2180], '169:': [443], '347–': [444], '353,': [445], '8': [447], 'McKay': [448, 594], 'JA,': [449, 595, 3207], 'Xenobiotic': [460], 'metabolising': [461], 'enzyme': [462, 1425], 'expression': [463, 486, 515, 582, 606, 1273, 1778, 1845, 1925, 2278, 2570, 2655, 2891, 2975, 3015, 3192], 'colonic': [465], 'neoplasia.': [466], 'Gut': [467, 586], '34:': [468, 866, 928], '1234–': [469], '1239,': [470], '9': [472], 'P-450,': [489], 'epoxide': [490], 'hydrolase,': [491], 'glutathione': [493, 533, 2866], '5-transferase': [494], 'hepatocellular': [496], 'carcinoma.': [497, 2385], '71:': [499, 2205], '36–': [500], '43,': [501], '10': [503], 'Fritz': [504], 'Behrle': [506], 'Beaune': [508, 1668], 'Eichelbaum': [510], 'Kroemer': [512], 'HK.': [513], 'Differential': [514], 'primary': [521, 554, 1284, 2133, 3164], 'secondary': [523, 556], 'neoplasm:': [525], 'Immunohistochemical': [526], 'characterization': [527, 3002], 'S-transferase.': [534], 'Histochemistry': [535], '99:': [536], '443–': [537], '451,': [538], '11': [540], 'Philip': [541], 'PA,': [542], 'Kaklamanis': [543], 'L,': [544, 1257, 2648, 2769], 'Ryley': [545], 'N,': [546, 1299, 2246, 2248], 'xenobioticmetabolizing': [551], 'tumors': [558], 'man.': [560], 'Int': [561, 758, 1654, 2898], 'Radiat': [563], 'Biol': [565, 1010, 1315, 1459, 2699, 3128], 'Phys': [566], '277–': [568], '283,': [569], '1994.': [570, 590, 835, 1051, 1117, 1598, 1800, 1830, 2421, 2516, 2643, 2762, 2904, 2919, 3098], '12': [571], 'Shaw': [574], 'D,': [575, 651, 2352, 2673, 2969], 'Cytochrome': [580, 604, 1476], 'oesophageal': [584], '35:': [587], '599–': [588], '603,': [589], '13': [591], 'is': [607, 1105, 1332, 2287, 2552, 2746, 2934, 2976, 3021], 'common': [609], 'molecular': [610], 'event': [611], 'soft': [613], 'sarcomas.': [615], '171:': [618], '49–': [619], '52,': [620], '14': [622], 'Bargetzi': [623], 'MJ,': [624, 809], 'Aoyama': [625, 1353], 'Gonzalez': [627, 1098, 1357], 'FJ,': [628, 1099, 1358], 'Meyer': [629, 1407], 'UA.': [630, 1408], 'Lidocaine': [631], 'metabolism': [632, 917, 1154, 1410, 1542, 2741], 'microsomes': [636, 1032, 1160, 2745], 'P450IIIA4.': [639], 'Ther': [642, 1135, 1170, 1250, 1435, 3220], '46:': [643, 1520, 2790], '521–': [644, 1854], '527,': [645], '1989.': [646, 993, 1660, 2326], '15': [647], 'Guengerich': [648, 837, 1022, 1468, 1740], 'FP,': [649, 838, 1023, 1469], 'Muller-Enoch': [650], 'Blair': [652], 'IA.': [653], 'Oxidation': [654, 849, 1742], 'quinidine': [656, 712], 'Mol': [662, 1112, 1289, 1545, 2988, 3057], '30:': [664], '287–': [665], '295,': [666], '1986.': [667, 2345], '16': [668], 'Trivier': [669], 'JM,': [670, 1177, 2924], 'Libersa': [671], 'C,': [672, 674, 811, 846, 1203, 1471, 1671, 2301, 2881], 'Belloc': [673], 'Lhermitte': [675], 'M.': [676, 1209, 1556, 1611, 2017, 2519, 2567, 2798], 'Amiodarone': [677], 'N-deethylation': [678], 'microsomes:': [682, 2783], '(first': [689], 'report).': [690], 'Life': [691], '52:': [693, 1085, 1136, 2236], 'PL91–': [694], '96,': [695], '17': [697], 'Lida': [700, 1860], 'Kitatani': [702], 'Y,': [703, 815, 938, 1446, 1667, 2535, 2709], 'Yokota': [704], 'K,': [705, 936, 957, 1297, 1381, 1444, 1897, 1977, 2244, 2426, 2455, 2592], 'Tsukagoshi': [706, 1862], 'S,': [707, 786, 1207, 1503, 1703, 1863, 2855], 'Sakurai': [708, 1864], 'Y.': [709, 1865], 'Effects': [710, 1268], 'related': [714, 2174], 'compounds': [715], 'on': [716, 973, 1271, 1278, 1820, 2022, 2600, 2610, 2830], 'cytotoxicity': [717], 'accumulation': [720, 1645, 1867], 'vincristine': [722, 1869], 'adriamycin': [724, 1871], 'drug-resistant': [726, 1873], 'tumor': [727, 1822, 1875, 2052, 2231, 3055], 'cells.': [728, 829, 987, 1192, 1624, 1653, 1823, 1851, 3056], '44:': [731, 1657], '4303–': [732], '4307,': [733], '1984.': [734, 3133], '18': [735], 'van': [736, 1322, 2270], 'der': [737], 'Graaf': [738], 'de': [740, 1552, 1806], 'Vries': [741], 'EG,': [742, 1095, 3101, 3140], 'Uges': [743], 'DR,': [744], 'In': [747], 'vitro': [748], 'vivo': [751], 'modulation': [752, 1810], 'multi-drug': [754], 'amiodarone.': [757], '48:': [761], '616–': [762], '622,': [763], '1991.': [764, 806, 869, 1014, 1139, 1376, 1550, 1698, 1946, 2035, 2564, 3224], '19': [765], 'Breckenridge': [766], 'A.': [767, 1507, 1532, 2115, 3186], 'Clinical': [768, 1809, 2335], 'significance': [769], 'interactions': [771, 1427], 'antifungal': [773], 'agents.': [774, 948, 1793], 'Dermatol': [777], '126': [778], '(suppl': [779], '39):': [780], '19–': [781], '22,': [782], '20': [784], 'Gupta': [785], 'Kim': [787, 1020], 'J,': [788, 1093, 1144, 1181, 1263, 1584, 1701, 1979, 2215, 2250, 2350, 2372], 'Gollapudi': [789], 'S.': [790, 1586], 'Reversal': [791, 960, 1587, 1636], 'daunorubicin': [793], 'P388/ADR': [796], 'cells': [797, 1876, 2691], 'itraconazole.': [799], 'Invest': [802], '87:': [803], '1467–': [804], '1469,': [805], '21': [807], 'Siegsmund': [808], 'Cardarelli': [810], 'Aksentijevich': [812], 'Sugimoto': [814], 'MM.': [819, 2430], 'Ketoconazole': [820], 'effectively': [821], 'reverses': [822], 'highly': [826], 'resistant': [827, 1622, 1719, 1821], 'KB': [828], 'Urol': [831], '151:': [832], '485–': [833], '491,': [834], '22': [836], 'Brian': [839], 'WR,': [840], 'Iwasaki': [841], 'Sari': [843], 'M-A,': [844], 'Bäärnhielm': [845], 'Berntsson': [847], 'P.': [848, 1267], 'dihydropyridine': [851, 1153], 'calcium': [852, 881, 891, 920, 1880], 'channel': [853, 882, 892, 921], 'blockers': [854, 893, 922], 'analogues': [856], 'IIIA4.': [862], 'Med': [864, 2617], 'Chem': [865, 1316, 1460, 1496, 2700, 3129], '1838–': [867], '1844,': [868], '23': [870], 'Hollt': [871], 'V,': [872, 1406, 2997, 3184], 'Kouba': [873], 'Dietel': [875], 'Vogt': [877], 'G.': [878], 'Stereoisomers': [879], 'antagonists': [883, 1881], 'which': [884], 'differ': [885], 'markedly': [886], 'their': [888, 1726], 'potencies': [889], 'as': [890, 1389, 1421, 1680], 'are': [894, 1480], 'equally': [895], 'effective': [896], 'modulating': [898], 'transport': [900, 945, 977, 1564], 'P-glycoprotein.': [902, 1340], '43:': [905, 1436, 2323, 3059], '2601–': [906], '2608,': [907], '24': [909], 'Renton': [910], 'KW.': [911], 'Inhibition': [912, 1151], 'diltiazem': [923], 'verapamil.': [925, 1939], '2549–': [929], '2553,': [930], '1985.': [931, 2266], '25': [932], 'Saeki': [933, 1441], 'Ueda': [935, 1296, 1443, 2425], 'Tanigawara': [937, 1445], 'Hori': [939, 1447], 'R,': [940, 1448, 1893, 1955, 2457, 2796, 2853, 2965, 3036], 'Komano': [941, 1449], 'T.': [942, 959, 1450], 'P-glycoprotein-mediated': [943], 'transcellular': [944], 'MDR-reversing': [947], 'FEBS': [949, 3197], 'Lett': [950, 3198], '324:': [951], '99–': [952], '102,': [953], '26': [955], 'Yusa': [956], 'mechanism': [961], 'verapamil:': [966], 'Direct': [967], 'binding': [968, 2502, 2636, 2862], 'verapamil': [970, 979], 'specific': [974, 2356], 'sites': [975, 2609], 'outward': [980], 'across': [981], 'plasma': [983], 'membrane': [984], 'K562/ADM': [986], '49:': [990, 3221], '5002–': [991], '5006,': [992], '27': [994], 'Beck': [995, 1504], 'Danks': [997], 'MK.': [998, 2628], 'that': [1004, 2548, 2606, 3017, 3115], 'inhibit': [1005], 'DNA': [1006, 2635], 'topoisomerases.': [1007], 'Semin': [1008], '2:': [1011, 2103, 2561], '235–': [1012], '244,': [1013], '28': [1015], 'JW,': [1017], 'Rahman': [1018], 'A,': [1019, 1142, 2111, 2274, 2299, 2304, 2588, 2671], 'BR,': [1021], 'Collins': [1024], 'JM.': [1025, 2971], 'Metabolism': [1026], 'taxol': [1028], 'slices:': [1035], 'Participation': [1036, 2799], '3A4': [1040], 'an': [1042, 2464], 'unknown': [1043], 'enzyme.': [1045], '54:': [1048, 1595], '4026–': [1049], '4035,': [1050], '29': [1052], 'Lewis': [1053], 'AD,': [1054], 'Lau': [1055], 'DH,': [1056], 'Duran': [1057], 'GE,': [1058], 'Wolf': [1059], 'CR,': [1060], 'Sikic': [1061], '81.': [1062], 'Role': [1063, 1752, 2784], 'from': [1067], 'CYP3A': [1070, 1242, 2753, 2835], 'family': [1072, 1420, 1679, 3215], 'potentiation': [1075], 'morpholino': [1077], 'doxorubicin': [1078, 1650], 'microsomes.': [1082, 1692, 1751], '4379–': [1086], '4384,': [1087], '30': [1089], 'Relling': [1090], 'MV,': [1091], 'Nemec': [1092], 'Schuetz': [1094, 1096, 3100, 3137, 3139], 'JD,': [1097, 3138], 'Korzekwa': [1100, 1359], 'KR.': [1101], 'O-Demethylation': [1102], 'epipodophyllotoxins': [1104], 'catalyzed': [1106], '3A4.': [1111, 2788], '352–': [1115], '358,': [1116], '31': [1118], 'Rowinsky': [1119], 'EK,': [1120], 'Donehower': [1121], 'RC.': [1122], 'clinical': [1124, 1932, 2309], 'pharmacology': [1125], 'use': [1127], 'antimicrotubule': [1129], 'agents': [1130, 1391, 2599], 'chemotherapeutics.': [1133], '35–': [1137], '84,': [1138], '32': [1140], 'Miniscalco': [1141], 'Lundahl': [1143], 'Regardh': [1145], 'CG,': [1146], 'Edgar': [1147], 'B,': [1148, 1528, 2038], 'Eriksson': [1149], 'UG.': [1150], 'rat': [1156, 1515, 2497, 2805, 2839, 3053, 3111, 3147, 3169, 3195], 'flavonoids': [1162], 'found': [1163], 'grapefruit': [1165], 'juice.': [1166], 'Exp': [1169, 2616, 2914], '261:': [1171], '1195–': [1172], '1199,': [1173], '33': [1175], 'Phang': [1176], 'Poore': [1178], 'CM,': [1179, 1233, 1919], 'Lopaczynska': [1180], 'Yen': [1182], 'GC.': [1183], 'Flavonol-stimulated': [1184], 'efflux': [1185, 3046], '7,12-dimethylbenz(a)anthracene': [1187], 'multidrug-resistant': [1189, 1652, 2258, 2893], '5977–': [1196], '5981,': [1197], '34': [1199], 'Gosland': [1200], 'Tsuboi': [1202], 'Hoffman': [1204], 'Goodin': [1206], 'Vore': [1208], '17-β-Estradiol': [1210], 'glucuronide:': [1211], 'An': [1212], 'inducer': [1213], 'cholestasis': [1215], 'physiological': [1218], 'transporter.': [1224], '5382–': [1228], '5385,': [1229], '35': [1231], 'Hunt': [1232], 'Watkins': [1234], 'PB,': [1235], 'Saenger': [1236], 'Heterogeneity': [1240], 'isoforms': [1243], 'erythromycin': [1245], 'cortisol.': [1247], '51:': [1251], '18–': [1252], '23,': [1253], '36': [1255], 'Pichard': [1256], 'Fabre': [1258], 'Daujat': [1260], 'Domergue': [1262], 'Joyeux': [1264], 'corticosteroids': [1270], 'cytochromes': [1275], 'cyclosporin': [1279, 1454], 'A': [1280, 1455, 1614, 2199], 'oxidase': [1281, 1991], 'cultures': [1285, 3166], 'hepatocytes.': [1288, 3170, 3196], '41:': [1291, 1695], '1047–': [1292], '1055,': [1293], '37': [1295], 'Okamura': [1298], 'Hirai': [1300], 'transports': [1306, 1453], 'cortisol,': [1307], 'aldosterone': [1308], 'dexamethasone,': [1310], 'but': [1311], 'not': [1312], 'progesterone.': [1313], '267:': [1317], '24248–': [1318], '24252,': [1319], '38': [1321], 'Kalken': [1323], 'CK,': [1324], 'Broxterman': [1325], 'HJ,': [1326], 'Pinedo': [1327], 'HM,': [1328], 'Cortisol': [1331], 'transported': [1333], '67:': [1344], '284–': [1345], '289,': [1346], '39': [1348], 'Waxman': [1349], 'DJ,': [1350, 1580], 'Lapenson': [1351], 'DP,': [1352], 'Gelboin': [1355], 'HV,': [1356], 'K.': [1360, 1475, 1808], 'Steroid': [1361], 'hormone': [1362], 'hydroxylase': [1363, 2751], 'eleven': [1366], 'cDNA-expressed': [1367], 'P450s.': [1369], 'Arch': [1370, 2811, 2844, 3025], 'Bio-phys': [1372], '290:': [1373, 2875], '160–': [1374], '166,': [1375], '40': [1377], 'Arceci': [1378, 2921, 2960], 'Stieglitz': [1380], 'Bierer': [1382], 'BE.': [1383], 'Immunosuppressants': [1384], 'FK506': [1385, 1485], 'rapamycin': [1387, 1487], 'function': [1388], 'reversal': [1390, 1713, 1930], 'phenotype.': [1396, 2291], 'Blood': [1397, 1906], '80:': [1398, 1907], '1528–': [1399], '1536,': [1400], '41': [1402], 'Kronbach': [1403], 'Fischer': [1405], 'Cyclosporine': [1409], 'liver:': [1413, 2840], 'Identification': [1414, 1674], 'P-450III': [1418], 'major': [1423], 'cyclosporine-metabolizing': [1424], 'explains': [1426], 'cyclosporine': [1429, 1819], 'other': [1431, 2337], 'drugs.': [1432], '630–': [1437], '635,': [1438], '42': [1440], 'FK506.': [1457], '268:': [1461, 2701], '6077–': [1462], '6080,': [1463], '43': [1465], 'Sattler': [1466], 'Yun': [1470, 1736], 'Christians': [1472], 'U,': [1473, 1707, 2191], 'Sewing': [1474], 'responsible': [1481], 'biotransformation': [1483], 'man': [1489], 'rat.': [1491], 'Metab': [1493, 1762], 'Dispos': [1494, 1763], 'Fate': [1495], '20:': [1497, 2418], '753–': [1498], '761,': [1499], '44': [1501], 'Chasserot-Golaz': [1502], 'G,': [1505], 'Venetianer': [1506], 'Biotransformation': [1508], '17-β-hydroxy-11': [1510], '-β-(4-dimethylaminophenol)-17-ã-1': [1511], '-propynylestra-4,9-dien-3-one': [1512], '(RU486)': [1513], 'hepatoma': [1516, 1850], 'variants.': [1517], '2100–': [1521], '2103,': [1522], '45': [1524], 'Eberhart': [1525], 'DC,': [1526], 'Gemzik': [1527], 'Halvorson': [1529], 'MR,': [1530], 'Parkinson': [1531], 'Species': [1533], 'differences': [1534], 'toxicity': [1537], 'IIIA-dependent': [1541], 'digitoxiri.': [1544], '40:': [1547], '859–': [1548], '867,': [1549], '46': [1551], 'Lannoy': [1553], 'IA,': [1554], 'Silverman': [1555, 3206], 'MDR1': [1558, 2440], 'product,': [1560], 'P-glycoprotein,': [1561], 'mediates': [1562, 2863], 'cardiac': [1567], 'glycoside,': [1568], 'digoxin.': [1569], 'Biophys': [1571, 2510, 2813, 2846, 3027], 'Comm': [1573], '189:': [1574], '551–': [1575], '557,': [1576], '47': [1578], 'Gruol': [1579], 'Zee': [1581], 'MC,': [1582, 2486], 'Trotter': [1583], 'Bourgeois': [1585], 'RU-486.': [1592], '3088–': [1596], '3091,': [1597], '48': [1599], 'Hait': [1600], 'WN,': [1601], 'Gesmonde': [1602], 'JF,': [1603, 2771], 'Murren': [1604], 'JR,': [1605, 2242, 2397], 'Yang': [1606, 3066], 'J-M,': [1607], 'Chen': [1608], 'H-X,': [1609], 'Reiss': [1610], 'Terfenadine': [1612], '(Seldane):': [1613], 'new': [1615], 'restoring': [1618], 'sensitivity': [1619], '401–': [1628], '406,': [1629], '49': [1631], 'Hofsli': [1632], 'Nissen-Meyer': [1634], 'erythromycin:': [1641], 'Erythromycin': [1642], 'increases': [1643, 2677], 'actinomycin': [1647], 'D': [1648], '149–': [1658], '154,': [1659], '50': [1661], 'Jacolot': [1662], 'Simon': [1664], 'Dreano': [1666], 'Riche': [1670], 'Berthou': [1672], 'F.': [1673, 2042, 2064], 'P450IIIA': [1678], 'involved': [1683], 'N-demethylation': [1686], 'tamoxifen': [1688], '1911–': [1696], '1919,': [1697], '51': [1699], 'Kirk': [1700], 'Houlbrook': [1702], 'Stuart': [1704], 'NS,': [1705], 'Stratford': [1706], 'Carmichael': [1710], 'Selective': [1712], 'cell': [1720, 2098, 2121, 2232, 2260, 2896, 3083], 'lines': [1721, 3084], 'tamoxifen,': [1723], 'toremifene': [1724], 'metabolites.': [1727], 'Eur': [1728, 2477], '29A:': [1731], '1152–': [1732], '1157,': [1733], '52': [1735], 'CH,': [1737], 'Okerholm': [1738], 'RA,': [1739], 'FP.': [1741], 'antihistaminic': [1745], 'terfenadine': [1747], '3A(4)': [1756], 'N-dealkylation': [1758], 'C-hydroxylation.': [1760], '21:': [1764], '403–': [1765], '409,': [1766], '53': [1768], 'Cornelissen': [1769], 'Sonneveld': [1771, 1802, 2268], 'Schoester': [1773, 1804], 'MDR-1': [1777], 'response': [1780], 'vincristine,': [1782], 'doxorubicin,': [1783], 'dexamethasone': [1785, 1847, 1901, 2827, 3153, 3189], 'multiple': [1788, 1815, 1904, 1962], 'myeloma': [1789], 'refractory': [1790], 'alkylating': [1792], '12:': [1797, 1827], '115–': [1798], '119,': [1799], '54': [1801], 'Leeuw': [1807], 'myeloma:': [1816], 'Effect': [1817, 2825], '1584–': [1828], '1591,': [1829], '55': [1831], 'Zhao': [1832], 'J-Y,': [1833], 'Ikeguchi': [1834], 'Eckersberg': [1836, 2532], 'Kuo': [1838, 2536], 'MT.': [1839, 2537], 'Modulation': [1840, 2431], 'cultured': [1849, 3194], 'Endocrinology': [1852, 2664], '133:': [1853], '528,': [1855], '56': [1857], 'Increased': [1866], 'P388': [1874], 'following': [1877], 'incubation': [1878], 'calmodulin': [1883], 'inhibitors.': [1884], '42:': [1887], '4730–': [1888], '4733,': [1889], '1982.': [1890], '57': [1891], 'Alexanian': [1892], 'Dimopoulos': [1894], 'MA,': [1895], 'Delasalle': [1896], 'Barlogie': [1898], 'B.': [1899, 2380], 'Primary': [1900], 'treatment': [1902], 'myeloma.': [1905], '887–': [1908], '890,': [1909], '58': [1911], 'Miller': [1912], 'TP,': [1913], 'Grogan': [1914], 'TM,': [1915, 2822], 'Dalton': [1916], 'WS,': [1917], 'Spier': [1918], 'Scheper': [1920], 'Salmon': [1922, 2375], 'SE.': [1923], 'P-Glycoprotein': [1924], 'malignant': [1927], 'lymphoma': [1928], 'plus': [1937], 'high-dose': [1938], '9:': [1943], '17–': [1944], '24,': [1945], '59': [1947], 'Callen': [1948], 'DF,': [1949], 'Baker': [1950], 'Simmers': [1952], 'RN,': [1953], 'Seshadri': [1954], 'Roninson': [1956], 'IB.': [1957], 'Localization': [1958, 2402], 'gene,': [1965], 'MDR1,': [1966], '7q21.1.': [1968], 'Hum': [1969, 2007, 2179], 'Genet': [1970, 2008, 2031, 2137, 2203, 2321, 2340, 2364, 2387], '77:': [1971], '142–': [1972], '144,': [1973], '60': [1975], 'Inoue': [1976], 'Inazawa': [1978], 'Nakagawa': [1980], 'Assignment': [1984], 'nifedipine': [1990], '(CYP3A4)': [1993], 'chromosome': [1995, 2027, 2357], 'band': [1998], 'q22.1': [1999], 'fluorescence': [2001, 2413], 'situ': [2003, 2415], 'hybridization.': [2004, 2416], 'Jpn': [2005], '37:': [2009], '133–': [2010], '138,': [2011], '61': [2013], 'Tsui': [2014], 'L-C,': [2015], 'Farrall': [2016], 'Report': [2018], 'committee': [2021], 'genetic': [2024], 'constitution': [2025], '7.': [2028], 'Cytogenet': [2029, 2138, 2204, 2322, 2341, 2365, 2388], 'Cell': [2030, 2558, 2724], '58:': [2032], '337–': [2033], '381,': [2034], '62': [2036], 'Johansson': [2037], 'Mertens': [2039], 'Mitelman': [2041, 2063], 'Cytogenetic': [2043, 2116, 2200, 2218, 2307], 'deletion': [2044], 'maps': [2045], 'hematologic': [2047], 'neoplasms:': [2048], 'Circumstantial': [2049], 'evidence': [2050], 'suppressor': [2053], 'loci.': [2054], 'Genes': [2055, 2100], 'Chrom': [2056, 2101], '8:': [2058, 2640], '218,': [2060], '63': [2062], 'Catalog': [2065], 'Chromosome': [2067, 2171, 2330, 2381], 'Aberrations': [2068], 'Cancer,': [2070], '4th': [2071], 'Ed.': [2072], 'Wiley-Liss': [2073], 'Inc.,': [2074], 'New': [2075], 'York,': [2076], '1991,': [2077], 'pp.': [2078], '475–': [2079, 2641], '573.': [2080], '64': [2081], 'Storto': [2082], 'PD,': [2083], 'Saidman': [2084], 'SL,': [2085], 'Demetris': [2086], 'AJ,': [2087], 'Letessier': [2088], 'Whiteside': [2090], 'TL,': [2091], 'Gollin': [2092], 'SM.': [2093], 'Chromosomal': [2094], 'breakpoints': [2095], 'cholangiocarcinoma': [2097], 'lines.': [2099, 2233, 2261, 2897], '300–': [2104], '310,': [2105], '1990.': [2106, 2167, 2621, 2994], '65': [2107], 'Osella': [2108], 'Carlson': [2110], 'Wyandt': [2112], 'Milunsky': [2114], 'studies': [2117], 'eight': [2119], 'squamous': [2120], 'carcinomas': [2122], 'head': [2125], 'neck.': [2127], 'Deletion': [2128, 2194], '7q,': [2130], 'possible': [2132], 'chromosomal': [2134], 'event.': [2135], '59:': [2139], '73–': [2140], '78,': [2141], '66': [2143], 'Brothman': [2144], 'AR,': [2145], 'Peehl': [2146], 'DM,': [2147], 'Patel': [2148], 'AM,': [2149, 2189], 'McNeal': [2150], 'JE.': [2151], 'Frequency': [2152], 'pattern': [2154], 'karyotypic': [2156], 'abnormalities': [2157, 2172], 'prostate': [2160, 2177], '50:': [2164], '3795–': [2165], '3803,': [2166], '67': [2168], 'Sandberg': [2169, 2192, 2328, 2353], 'AA.': [2170, 2193, 2329, 2354], 'events': [2175], '23:': [2181], '368–': [2182], '380,': [2183], '68': [2185], 'Ozisik': [2186], 'YY,': [2187], 'Meloni': [2188], 'Surti': [2190], '7q22': [2195], 'uterine': [2197], 'leiomyoma.': [2198], 'review.': [2201], '1–': [2206], '6,': [2207], '69': [2209], 'Nieuwint': [2210], 'AWM,': [2211], 'Baas': [2212, 2962], 'Wiegant': [2214], 'Joenje': [2216], 'H.': [2217, 2675], 'alterations': [2219], 'associated': [2220, 2288, 2569], 'P-glycoprotein-': [2222], 'non-P-glycoprotein-mediated': [2224], 'SW-1573': [2228], 'lung': [2230, 2578], '4361–': [2237], '4371,': [2238], '70': [2240], 'Riordan': [2241], 'Deuchars': [2243], 'Kaertner': [2245], 'Alon': [2247], 'Trent': [2249], 'Ling': [2251], 'V.': [2252, 2857], 'Amplification': [2253], 'genes': [2256], 'mammalian': [2259], 'Nature': [2262], '316:': [2263], '817–': [2264], '819,': [2265], '71': [2267], 'Dongen': [2271], 'JJM,': [2272], 'Hagemeijer': [2273], 'High': [2277], 'high-risk': [2285], 'myelodysplasia': [2286], 'immature': [2290], 'Leukemia': [2292], '7:': [2293], '963–': [2294], '969,': [2295], '72': [2297], 'Iurlo': [2298], 'Mecucci': [2300], 'Van': [2302], 'Orshoven': [2303], 'investigations': [2310], '76': [2312, 2393], 'cases': [2313], 'therapy-related': [2315], 'leukemia': [2316], 'myelodysplastic': [2318], 'syndrome.': [2319], '227–': [2324], '241,': [2325], '73': [2327], 'changes': [2331, 2358], 'bladder': [2333], 'cancer:': [2334], 'correlations.': [2338], '19:': [2342], '163–': [2343], '175,': [2344], '74': [2346], 'Ochi': [2347], 'Takeuchi': [2349], 'Holyoke': [2351], 'Possible': [2355], 'large': [2360], 'bowel': [2361], '10:': [2366], '121–': [2367], '122,': [2368], '1983.': [2369], '75': [2370], 'Couturier': [2371], 'Vielh': [2373], 'Lombard': [2377], 'Dutrillaux': [2379], 'imbalance': [2382], 'endometrial': [2384], '33:': [2389], '67–': [2390], '76,': [2391], 'Taguchi': [2394], 'Testa': [2396], 'Papis': [2398], 'Schweinfest': [2400], 'C.': [2401], 'candidate': [2405], 'colon': [2406], 'tumor-suppressor': [2407], '(DRA)': [2409], '7q22-q31.1': [2411], 'Genomics': [2417], '146–': [2419], '147,': [2420], '77': [2422], 'Chin': [2423], 'K-V,': [2424], 'promoter': [2436, 2556], 'ras': [2443], 'p53.': [2445], 'Science': [2446], '255:': [2447], '459–': [2448], '462,': [2449], '78': [2451], 'Hashimoto': [2452], 'Toide': [2454], 'Kitamura': [2456], 'Gene': [2460], 'structure': [2461], 'CYP3A4,': [2463], 'adult-specific': [2465], 'form': [2466], 'livers,': [2472], 'its': [2474], 'transcriptional': [2475], 'control.': [2476], '218:': [2480], '585–': [2481], '595,': [2482], '79': [2484], 'Wright': [2485], 'Paine': [2487], 'AJ.': [2488], 'Induction': [2489, 3104], 'subfamily': [2495], 'correlates': [2499], 'inducers': [2504], 'protein.': [2508], 'Commun': [2512], '201:': [2513], '973–': [2514], '979,': [2515], '80': [2517], 'Pfahl': [2518], 'Nuclear': [2520], 'receptor/AP-1': [2521], 'interaction.': [2522], 'Endocr': [2523], 'Rev': [2524], '14:': [2525], '651–': [2526], '658,': [2527], '81': [2529], 'Teeter': [2530], 'LD,': [2531], 'Tsai': [2534], 'Analysis': [2538, 3009, 3159], 'Chinese': [2541], 'hamster': [2542], 'P-glycoprotein/multidrug': [2543], 'pgp1': [2546], 'reveals': [2547, 3016], 'AP-1': [2550, 2632, 2861], 'site': [2551], 'essential': [2553], 'activity.': [2557, 2637], 'Growth': [2559], 'Diff': [2560], '429–': [2562], '437,': [2563], '82': [2565], 'Volm': [2566], 'c-fos': [2572, 2657, 2694], 'c-jun': [2574, 2696], 'products': [2575], 'carcinomas.': [2579], 'Anticancer': [2580], '13:': [2582], '375–': [2583], '378,': [2584], '83': [2586], 'Granelli-Piperno': [2587], 'Nolan': [2589], 'Inaba': [2591], 'Steinman': [2593], 'RM.': [2594], 'effect': [2596], 'immunosuppressive': [2598], 'induction': [2602, 2859, 3042, 3075, 3118], 'nuclear': [2604], 'factors': [2605], 'bind': [2607], 'interleukin': [2612], 'promoter.': [2614], '172:': [2618], '1869–': [2619], '1872,': [2620], '84': [2622], 'Pennypacker': [2623], 'KR,': [2624], 'Hong': [2625], 'J-S,': [2626], 'McMillian': [2627], 'Pharmacological': [2629], 'regulation': [2630], 'transcription': [2633, 2832], 'factor': [2634], 'FASEB': [2638], '478,': [2642], '85': [2644], 'Kirkland': [2645], 'JL,': [2646], 'Murthy': [2647], 'Stancel': [2649], 'GM.': [2650], 'Progesterone': [2651], 'inhibits': [2652], 'estrogen-induced': [2654], 'messenger': [2658], 'ribonucleic': [2659], 'acid': [2660, 2809], 'uterus.': [2663, 2949, 2987], '130:': [2665], '3223–': [2666], '3230,': [2667], '86': [2669], 'Philips': [2670], 'Chalbos': [2672], 'Rochefort': [2674], 'Estradiol': [2676, 3041], 'antiestrogens': [2679], 'antagonize': [2680], 'growth': [2682], 'factor-induced': [2683], 'activator': [2684], 'protein-1': [2685], 'MCF7': [2688], 'without': [2692], 'affecting': [2693], 'synthesis.': [2697], '14103–': [2702], '14108,': [2703], '87': [2705], 'Pavlath': [2706], 'GK,': [2707], 'Shimizu': [2708, 2710], 'N.': [2711], 'Cytoskeletal': [2712], 'active': [2713], 'modulate': [2715], 'signal': [2716], 'transduction': [2717], 'protein': [2720], 'kinase': [2721], 'C': [2722], 'pathway.': [2723], 'Struc': [2725], 'Funct': [2726], '18:': [2727, 3095], '151–': [2728], '160,': [2729], '88': [2731], 'Andersson': [2732], 'Miners': [2734], 'JO,': [2735], 'Veronese': [2736], 'ME,': [2737], 'Birkett': [2738], 'DJ.': [2739, 2775], 'Diazepam': [2740], 'both': [2749], '5-mephenytoin': [2750], 'isoforms.': [2754], '38:': [2759], '131–': [2760], '137,': [2761], '89': [2763], 'LeDuc': [2764], 'BW,': [2765], 'Sinclair': [2766, 2770], 'PR,': [2767], 'Shuster': [2768], 'Evans': [2772], 'JE,': [2773], 'Greenblatt': [2774], 'Norcocaine': [2776], 'N-hydroxynorcocaine': [2778], 'formation': [2779], 'Pharmacology': [2789], '294–': [2791], '300,': [2792], '90': [2794], 'Martini': [2795], 'retinoic': [2808], '4-hydroxylation.': [2810], '303:': [2814], '57–': [2815], '66,': [2816], '91': [2818], 'Telhada': [2819], 'MB,': [2820], 'Pereira': [2821], 'Lechner': [2823, 2998], 'phenobarbital': [2829], 'run-on': [2831], 'rate': [2833], 'mRNA': [2836], 'concentration': [2837], 'Changes': [2841], 'during': [2842, 2941], 'development.': [2843], '298:': [2847], '715–': [2848], '725,': [2849], '92': [2851], 'Pinkus': [2852], 'Bergelson': [2854], 'Daniel': [2856], 'Phenobarbital': [2858], 'activation': [2864, 3145], 'S-transferase': [2867], 'quinone': [2869], 'reductase': [2870], 'expression.': [2872], '637–': [2876], '640,': [2877], '93': [2879], 'Muller': [2880], 'Bailly': [2882], 'J-D,': [2883], 'Goubin': [2884], 'Verapamil': [2888], 'decreases': [2889], 'leukemic': [2895], '56:': [2901], '749–': [2902], '754,': [2903], '94': [2905], 'Gustavson': [2906], 'LE,': [2907], 'LZ.': [2909], 'Menopause:': [2910], 'Pharmacodynamics': [2911], 'pharmacokinetics.': [2913], 'Gerontol': [2915], '437–': [2917], '444,': [2918], '95': [2920], 'Croop': [2923, 2970], 'Horowitz': [2925, 2966], 'SB,': [2926, 2967], 'Housman': [2927, 2968], 'encoding': [2931], 'induced': [2935], 'expressed': [2937], 'high': [2939], 'levels': [2940], 'pregnancy': [2942], 'secretory': [2945, 2983], 'epithelium': [2946, 2984], '85:': [2955], '4350–': [2956], '4354,': [2957], '96': [2959], 'Raponi': [2964], 'Multidrug': [2972, 3212], 'controlled': [2977], 'steroid': [2979], 'hormones': [2980], 'Reprod': [2989], 'Dev': [2990], '101–': [2992], '109,': [2993], '97': [2995], 'Ribeiro': [2996], 'Cloning': [3000], 'novel': [3005], 'CYP3A1': [3006, 3011], 'allelic': [3007], 'variant:': [3008], 'CYP3A2': [3013, 3019], 'sexhormone-dependent': [3014], 'regulated': [3022], 'testosterone.': [3024], '293:': [3028], '147–': [3029], '152,': [3030], '98': [3032], 'Jancis': [3033], 'EM,': [3034], 'Carbone': [3035], 'Loechner': [3037], 'KJ,': [3038], 'Dannies': [3039], 'PS.': [3040, 3103, 3142], 'rhodamine': [3044], '123': [3045], 'pump': [3051], 'pituitary': [3054], '51–': [3060], '56,': [3061], '99': [3063], 'Biing': [3064], 'JT,': [3065], 'YF,': [3067], 'Liu': [3068], 'HS,': [3069], 'Ye': [3070], 'CT,': [3071], 'Chao': [3072], 'CF.': [3073], 'cervical': [3081], 'carcinoma': [3082, 3247], 'estrogenic': [3086], 'hormones.': [3087], 'Counc': [3091], 'Rep': [3092], 'China': [3093], 'B': [3094], '64–': [3096], '70,': [3097], '100': [3099], 'Guzelian': [3102, 3141], 'glucocorticoids': [3109, 3116], 'liver.': [3112], 'II.': [3113], 'Evidence': [3114], 'regulate': [3117], 'non-classical': [3124], 'receptor': [3125], 'mechanism.': [3126], '259:': [3130], '2007–': [3131], '2012,': [3132], '101': [3134], 'Burger': [3135], 'H-J,': [3136], 'Paradoxical': [3143], 'transchptional': [3144], '3A1': [3151], 'antiglucocorticoid': [3156], 'pregnenolone': [3157], '16α-carbonitrile:': [3158], 'transient': [3161], 'transfection': [3162], 'into': [3163], 'monolayer': [3165], 'adult': [3168], '89:': [3176], '2145–': [3177], '2149,': [3178], '102': [3180], 'Fardel': [3181], 'O,': [3182], 'Lecureur': [3183], 'Guillouzo': [3185], 'Regulation': [3187], '327:': [3199], '189–': [3200], '193,': [3201], '103': [3203], 'Thorgeirsson': [3204], 'SS,': [3205], 'Gant': [3208], 'TW,': [3209], 'Marino': [3210], 'chemical': [3217], 'carcinogens.': [3218], '283–': [3222], '292,': [3223], '104': [3225], 'Peters': [3226], 'WHM,': [3227], 'Boon': [3228], 'CEW,': [3229], 'Roelofs': [3230], 'HMJ,': [3231], 'Wobbes': [3232], 'Nagengast': [3234], 'FM,': [3235], 'Kremers': [3236], 'PG.': [3237], 'drug-metabolizing': [3240], 'P-170': [3243], 'glycoprotein': [3244], 'colorectal': [3246], 'mucosa.': [3250], 'Gastroenterology': [3251], '103:': [3252], '448–': [3253], '455,': [3254], 'Citing': [3256], 'Literature': [3257], 'Volume13,': [3258], 'Issue3July': [3259], '1995Pages': [3260], 'ReferencesRelatedInformation': [3262]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2077510533', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 21}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 24}, {'year': 2013, 'cited_by_count': 37}, {'year': 2012, 'cited_by_count': 24}], 'updated_date': '2024-12-17T10:49:16.276707', 'created_date': '2016-06-24'}
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