Publication Information

{'id': 'https://openalex.org/W2077492083', 'doi': 'https://doi.org/10.1002/jnr.490210212', 'title': 'Insulin‐like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro', 'display_name': 'Insulin‐like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro', 'publication_year': 1988, 'publication_date': '1988-10-01', 'ids': {'openalex': 'https://openalex.org/W2077492083', 'doi': 'https://doi.org/10.1002/jnr.490210212', 'mag': '2077492083', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3216421'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jnr.490210212', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76417895', 'display_name': 'Journal of Neuroscience Research', 'issn_l': '0360-4012', 'issn': ['0360-4012', '1097-4547'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012816784', 'display_name': 'F. Arthur McMorris', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I102322052', 'display_name': 'The Wistar Institute', 'ror': 'https://ror.org/04wncat98', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I102322052']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'F. A. McMorris', 'raw_affiliation_strings': ['† Wistar Institute, Philadelphia, PA 19104'], 'affiliations': [{'raw_affiliation_string': '† Wistar Institute, Philadelphia, PA 19104', 'institution_ids': ['https://openalex.org/I102322052']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108427814', 'display_name': 'Monique Dubois‐Dalcq', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210110767', 'display_name': 'National Institute of Neurological Disorders and Stroke', 'ror': 'https://ror.org/01s5ya894', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210110767']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M. Dubois‐Dalcq', 'raw_affiliation_strings': ['Laboratory of Molecular Genetics, National Institute of Neurological and Communicative Disorders and Strokes, National Institutes of Health, Bethesda, Maryland'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Genetics, National Institute of Neurological and Communicative Disorders and Strokes, National Institutes of Health, Bethesda, Maryland', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210110767']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4640, 'currency': 'USD', 'value_usd': 4640, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 13.807, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 361, 'citation_normalized_percentile': {'value': 0.999765, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '21', 'issue': '2-4', 'first_page': '199', 'last_page': '209'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Neurogenesis and neuroplasticity mechanisms', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/galactocerebroside', 'display_name': 'Galactocerebroside', 'score': 0.93601936}, {'id': 'https://openalex.org/keywords/microculture', 'display_name': 'Microculture', 'score': 0.5577893}, {'id': 'https://openalex.org/keywords/cell-sorting', 'display_name': 'Cell Sorting', 'score': 0.48629913}, {'id': 'https://openalex.org/keywords/precursor-cell', 'display_name': 'Precursor cell', 'score': 0.46279028}], 'concepts': [{'id': 'https://openalex.org/C2781017270', 'wikidata': 'https://www.wikidata.org/wiki/Q2756638', 'display_name': 'Galactocerebroside', 'level': 5, 'score': 0.93601936}, {'id': 'https://openalex.org/C2777542381', 'wikidata': 'https://www.wikidata.org/wiki/Q502961', 'display_name': 'Astrocyte', 'level': 3, 'score': 0.61970705}, {'id': 'https://openalex.org/C201750760', 'wikidata': 'https://www.wikidata.org/wiki/Q1896218', 'display_name': 'Progenitor cell', 'level': 3, 'score': 0.61247605}, {'id': 'https://openalex.org/C2776985911', 'wikidata': 'https://www.wikidata.org/wiki/Q916698', 'display_name': 'Oligodendrocyte', 'level': 4, 'score': 0.59571075}, {'id': 'https://openalex.org/C49377226', 'wikidata': 'https://www.wikidata.org/wiki/Q6839421', 'display_name': 'Microculture', 'level': 3, 'score': 0.5577893}, {'id': 'https://openalex.org/C2780689927', 'wikidata': 'https://www.wikidata.org/wiki/Q24766801', 'display_name': 'Insulin-like growth factor', 'level': 4, 'score': 0.5449719}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.53553253}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.5161115}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.5020778}, {'id': 'https://openalex.org/C2778630268', 'wikidata': 'https://www.wikidata.org/wiki/Q17113277', 'display_name': 'Cell sorting', 'level': 3, 'score': 0.48629913}, {'id': 'https://openalex.org/C124964019', 'wikidata': 'https://www.wikidata.org/wiki/Q11616062', 'display_name': 'Precursor cell', 'level': 3, 'score': 0.46279028}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.46084476}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.44930744}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.43781224}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.43535286}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.22869638}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.22723916}, {'id': 'https://openalex.org/C2778609137', 'wikidata': 'https://www.wikidata.org/wiki/Q105790271', 'display_name': 'Myelin', 'level': 3, 'score': 0.20824575}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14379084}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.096141875}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.09126067}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.0786781}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D002554', 'descriptor_name': 'Cerebrosides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005699', 'descriptor_name': 'Galactosylceramides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007334', 'descriptor_name': 'Insulin-Like Growth Factor I', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009457', 'descriptor_name': 'Neuroglia', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D009836', 'descriptor_name': 'Oligodendroglia', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D013002', 'descriptor_name': 'Somatomedins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002554', 'descriptor_name': 'Cerebrosides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005699', 'descriptor_name': 'Galactosylceramides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007334', 'descriptor_name': 'Insulin-Like Growth Factor I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009457', 'descriptor_name': 'Neuroglia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009836', 'descriptor_name': 'Oligodendroglia', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009836', 'descriptor_name': 'Oligodendroglia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009836', 'descriptor_name': 'Oligodendroglia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011919', 'descriptor_name': 'Rats, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013002', 'descriptor_name': 'Somatomedins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jnr.490210212', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S76417895', 'display_name': 'Journal of Neuroscience Research', 'issn_l': '0360-4012', 'issn': ['0360-4012', '1097-4547'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3216421', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1501040940', 'https://openalex.org/W1811206105', 'https://openalex.org/W1829859617', 'https://openalex.org/W1939198520', 'https://openalex.org/W1972524334', 'https://openalex.org/W1974967725', 'https://openalex.org/W1977994351', 'https://openalex.org/W1979286083', 'https://openalex.org/W1987885030', 'https://openalex.org/W2004660705', 'https://openalex.org/W2005272267', 'https://openalex.org/W2007434276', 'https://openalex.org/W2012639883', 'https://openalex.org/W2027983444', 'https://openalex.org/W2036567890', 'https://openalex.org/W2050601632', 'https://openalex.org/W2055451031', 'https://openalex.org/W2074558188', 'https://openalex.org/W2078326745', 'https://openalex.org/W2096428903', 'https://openalex.org/W2126907710', 'https://openalex.org/W2145481755', 'https://openalex.org/W2221064544'], 'related_works': ['https://openalex.org/W98120376', 'https://openalex.org/W3143837429', 'https://openalex.org/W2080613430', 'https://openalex.org/W2076642460', 'https://openalex.org/W2075066674', 'https://openalex.org/W2073266150', 'https://openalex.org/W2035143691', 'https://openalex.org/W1982001626', 'https://openalex.org/W1979953624', 'https://openalex.org/W141487097'], 'abstract_inverted_index': {'Abstract': [0], 'We': [1], 'investigated': [2], 'the': [3, 15, 69, 73, 77, 82, 86, 93, 96, 110, 118, 127, 133, 144, 147, 150, 161, 174, 191, 209, 241], 'mechanisms': [4], 'by': [5, 81, 160], 'which': [6, 45], 'insulin‐like': [7], 'growth': [8, 74, 137], 'factor': [9], 'I': [10], '(IGF‐I)': [11], 'acts': [12, 225], 'to': [13, 35, 68, 131, 187, 230, 248, 251], 'increase': [14, 117, 189], 'number': [16, 119, 192, 210], 'of': [17, 23, 58, 64, 92, 112, 120, 146, 157, 163, 173, 176, 193, 211, 237], 'oligodendrocytes': [18, 108, 219], 'that': [19, 124, 195, 216], 'develop': [20, 252], 'in': [21, 95, 109, 126, 149, 190, 226, 240], 'cultures': [22], 'cells': [24, 51, 94, 148, 183, 194, 215, 239], 'explanted': [25], 'from': [26], 'perinatal': [27], 'rat': [28], 'cerebrum.': [29], 'Fluorescence‐activated': [30], 'cell': [31, 212], 'sorting': [32], 'was': [33], 'used': [34], 'isolate': [36], 'bipotential': [37], 'A2B5‐positive': [38], 'oligodendrocyte‐type': [39], '2': [40, 122], 'astrocyte': [41], '(O‐2A)': [42], 'progenitor': [43], 'cells,': [44], 'were': [46, 152], 'then': [47], 'inoculated': [48], 'as': [49], 'single': [50], 'into': [52, 100, 199, 218, 253], 'microculture': [53], 'wells': [54], 'containing': [55], 'feeder': [56], 'layers': [57], 'X‐irradiated': [59], 'type': [60, 121], '1': [61], 'astrocytes.': [62], 'Addition': [63], '100': [65], 'ng/ml': [66], 'IGF‐I': [67, 114, 129, 177, 207, 224], 'culture': [70], 'medium': [71], 'increased': [72, 208], 'rate': [75], 'and': [76, 138, 165, 244], 'ultimate': [78], 'size': [79], 'reached': [80], 'resulting': [83], 'clones': [84, 98, 151], 'during': [85, 202], '18‐day': [87], 'experimental': [88], 'period.': [89], 'Moreover,': [90, 206], '75–80%': [91], 'IGF‐I‐treated': [97], 'differentiated': [99], 'galactocerebroside': [101], '(GC)‐positive': [102], 'oligodendrocytes,': [103], 'whereas': [104], 'only': [105], '25–30%': [106], 'became': [107], 'absence': [111], 'IGF‐I.': [113], 'did': [115], 'not': [116, 170], 'astrocytes': [123], 'developed': [125, 217], 'clones.': [128], 'appeared': [130], 'have': [132], 'greatest': [134], 'effect': [135], 'on': [136, 178], 'differentiation': [139], 'at': [140, 153], 'a': [141, 185, 203], 'stage': [142, 156], 'when': [143], 'majority': [145], 'an': [154], 'intermediate': [155, 181], 'development,': [158], 'characterized': [159], 'expression': [162], 'A2B5': [164], 'O4': [166], 'glycolipid': [167], 'antigens': [168], 'but': [169], 'GC.': [171], 'Analysis': [172], 'effects': [175], 'O4‐positive,': [179], 'GC‐negative': [180], 'precursor': [182, 238], 'revealed': [184], 'two': [186, 227], 'fivefold': [188], 'incorporated': [196], '3': [197], 'H‐thymidine': [198], 'their': [200], 'DNA': [201], '5‐h': [204], 'pulse.': [205], 'sorter‐purified': [213], 'O4‐positive': [214], '4–8': [220], 'days': [221], 'later.': [222], 'Therefore,': [223], 'different': [228], 'ways': [229], 'promote': [231], 'oligodendrocyte': [232], 'development:': [233], 'It': [234], 'promotes': [235], 'proliferation': [236], 'O‐2A': [242], 'lineage,': [243], 'it': [245], 'induces': [246], 'precursors': [247], 'become': [249], 'committed': [250], 'oligodendrocytes.': [254]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2077492083', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-15T17:23:33.952712', 'created_date': '2016-06-24'}