Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2077399237', 'doi': 'https://doi.org/10.1016/0090-6980(82)90074-0', 'title': 'Prostacyclin and prostagladin synthesis in isolated brain capillaries', 'display_name': 'Prostacyclin and prostagladin synthesis in isolated brain capillaries', 'publication_year': 1982, 'publication_date': '1982-03-01', 'ids': {'openalex': 'https://openalex.org/W2077399237', 'doi': 'https://doi.org/10.1016/0090-6980(82)90074-0', 'mag': '2077399237', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6808590'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0090-6980(82)90074-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S161580142', 'display_name': 'Prostaglandins', 'issn_l': '0090-6980', 'issn': ['0090-6980', '1878-416X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068215960', 'display_name': 'Á Gecse', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I227486990', 'display_name': 'University of Szeged', 'ror': 'https://ror.org/01pnej532', 'country_code': 'HU', 'type': 'education', 'lineage': ['https://openalex.org/I227486990']}], 'countries': ['HU'], 'is_corresponding': False, 'raw_author_name': 'Á. Gecse', 'raw_affiliation_strings': ['Institute of Phathophysiology, University Medical School of Szeged, P.O. Box 531, Hungary'], 'affiliations': [{'raw_affiliation_string': 'Institute of Phathophysiology, University Medical School of Szeged, P.O. Box 531, Hungary', 'institution_ids': ['https://openalex.org/I227486990']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018694685', 'display_name': 'Anna Ottlecz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I227486990', 'display_name': 'University of Szeged', 'ror': 'https://ror.org/01pnej532', 'country_code': 'HU', 'type': 'education', 'lineage': ['https://openalex.org/I227486990']}], 'countries': ['HU'], 'is_corresponding': False, 'raw_author_name': 'Anna Ottlecz', 'raw_affiliation_strings': ['Institute of Phathophysiology, University Medical School of Szeged, P.O. Box 531, Hungary'], 'affiliations': [{'raw_affiliation_string': 'Institute of Phathophysiology, University Medical School of Szeged, P.O. Box 531, Hungary', 'institution_ids': ['https://openalex.org/I227486990']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087159638', 'display_name': 'Zsófia Mezei', 'orcid': 'https://orcid.org/0000-0002-7557-862X'}, 'institutions': [{'id': 'https://openalex.org/I227486990', 'display_name': 'University of Szeged', 'ror': 'https://ror.org/01pnej532', 'country_code': 'HU', 'type': 'education', 'lineage': ['https://openalex.org/I227486990']}], 'countries': ['HU'], 'is_corresponding': False, 'raw_author_name': 'Zsófia Mezei', 'raw_affiliation_strings': ['Institute of Phathophysiology, University Medical School of Szeged, P.O. Box 531, Hungary'], 'affiliations': [{'raw_affiliation_string': 'Institute of Phathophysiology, University Medical School of Szeged, P.O. Box 531, Hungary', 'institution_ids': ['https://openalex.org/I227486990']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040249483', 'display_name': 'Gyula Telegdy', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'G. Telegdy', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073563003', 'display_name': 'Ferenc Joó', 'orcid': 'https://orcid.org/0000-0001-9457-8038'}, 'institutions': [{'id': 'https://openalex.org/I2800351701', 'display_name': 'HUN-REN Szegedi Biológiai Kutatóközpont', 'ror': 'https://ror.org/016gb1631', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I2800351701', 'https://openalex.org/I7597260']}, {'id': 'https://openalex.org/I4210122500', 'display_name': 'Institute of Biophysics', 'ror': 'https://ror.org/038synb39', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I2800351701', 'https://openalex.org/I4210122500', 'https://openalex.org/I7597260']}], 'countries': ['HU'], 'is_corresponding': False, 'raw_author_name': 'F. Joó', 'raw_affiliation_strings': ['Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, Szeged, P.O. Box 521, Hungary, H-6701'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, Szeged, P.O. Box 521, Hungary, H-6701', 'institution_ids': ['https://openalex.org/I2800351701', 'https://openalex.org/I4210122500']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087937776', 'display_name': 'E. Dux', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800351701', 'display_name': 'HUN-REN Szegedi Biológiai Kutatóközpont', 'ror': 'https://ror.org/016gb1631', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I2800351701', 'https://openalex.org/I7597260']}, {'id': 'https://openalex.org/I4210122500', 'display_name': 'Institute of Biophysics', 'ror': 'https://ror.org/038synb39', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I2800351701', 'https://openalex.org/I4210122500', 'https://openalex.org/I7597260']}], 'countries': ['HU'], 'is_corresponding': False, 'raw_author_name': 'E. Dux', 'raw_affiliation_strings': ['Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, Szeged, P.O. Box 521, Hungary, H-6701'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, Szeged, P.O. Box 521, Hungary, H-6701', 'institution_ids': ['https://openalex.org/I2800351701', 'https://openalex.org/I4210122500']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000388702', 'display_name': 'Irina Karnushina', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800351701', 'display_name': 'HUN-REN Szegedi Biológiai Kutatóközpont', 'ror': 'https://ror.org/016gb1631', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I2800351701', 'https://openalex.org/I7597260']}, {'id': 'https://openalex.org/I4210122500', 'display_name': 'Institute of Biophysics', 'ror': 'https://ror.org/038synb39', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I2800351701', 'https://openalex.org/I4210122500', 'https://openalex.org/I7597260']}], 'countries': ['HU'], 'is_corresponding': False, 'raw_author_name': 'Irina Karnushina', 'raw_affiliation_strings': ['Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, Szeged, P.O. Box 521, Hungary, H-6701'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, Szeged, P.O. Box 521, Hungary, H-6701', 'institution_ids': ['https://openalex.org/I2800351701', 'https://openalex.org/I4210122500']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.377, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 70, 'citation_normalized_percentile': {'value': 0.839138, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '23', 'issue': '3', 'first_page': '287', 'last_page': '297'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolic Disorders and Biochemical Genetics', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vascular-permeability', 'display_name': 'Vascular permeability', 'score': 0.5582656}, {'id': 'https://openalex.org/keywords/prostaglandin-d2', 'display_name': 'Prostaglandin D2', 'score': 0.46010578}, {'id': 'https://openalex.org/keywords/p-glycoprotein', 'display_name': 'P-glycoprotein', 'score': 0.457614}], 'concepts': [{'id': 'https://openalex.org/C2781128415', 'wikidata': 'https://www.wikidata.org/wiki/Q412050', 'display_name': 'Prostacyclin', 'level': 2, 'score': 0.94048077}, {'id': 'https://openalex.org/C2778815084', 'wikidata': 'https://www.wikidata.org/wiki/Q79803', 'display_name': 'Guinea pig', 'level': 2, 'score': 0.7715589}, {'id': 'https://openalex.org/C2780664492', 'wikidata': 'https://www.wikidata.org/wiki/Q209717', 'display_name': 'Prostaglandin', 'level': 2, 'score': 0.7577634}, {'id': 'https://openalex.org/C2778078955', 'wikidata': 'https://www.wikidata.org/wiki/Q407699', 'display_name': 'Arachidonic acid', 'level': 3, 'score': 0.63937265}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5933385}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5676637}, {'id': 'https://openalex.org/C113045295', 'wikidata': 'https://www.wikidata.org/wiki/Q7916465', 'display_name': 'Vascular permeability', 'level': 2, 'score': 0.5582656}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49168378}, {'id': 'https://openalex.org/C2777361909', 'wikidata': 'https://www.wikidata.org/wiki/Q419750', 'display_name': 'Prostaglandin D2', 'level': 3, 'score': 0.46010578}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.45877585}, {'id': 'https://openalex.org/C2777198256', 'wikidata': 'https://www.wikidata.org/wiki/Q4860325', 'display_name': 'Prostaglandin E', 'level': 2, 'score': 0.45644456}, {'id': 'https://openalex.org/C2777956040', 'wikidata': 'https://www.wikidata.org/wiki/Q416554', 'display_name': 'Prostaglandin E2', 'level': 2, 'score': 0.41308868}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33922347}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.20884672}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19060394}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002196', 'descriptor_name': 'Capillaries', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': True}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D011453', 'descriptor_name': 'Prostaglandins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001095', 'descriptor_name': 'Arachidonic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001095', 'descriptor_name': 'Arachidonic Acids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002196', 'descriptor_name': 'Capillaries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002196', 'descriptor_name': 'Capillaries', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006168', 'descriptor_name': 'Guinea Pigs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009638', 'descriptor_name': 'Norepinephrine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009638', 'descriptor_name': 'Norepinephrine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011453', 'descriptor_name': 'Prostaglandins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013045', 'descriptor_name': 'Species Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0090-6980(82)90074-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S161580142', 'display_name': 'Prostaglandins', 'issn_l': '0090-6980', 'issn': ['0090-6980', '1878-416X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6808590', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1965214002', 'https://openalex.org/W1967312698', 'https://openalex.org/W1974012442', 'https://openalex.org/W1974883852', 'https://openalex.org/W1994624311', 'https://openalex.org/W1996354056', 'https://openalex.org/W1998079370', 'https://openalex.org/W1999026417', 'https://openalex.org/W2021403302', 'https://openalex.org/W2024385007', 'https://openalex.org/W2030768867', 'https://openalex.org/W2045461798', 'https://openalex.org/W2051999871', 'https://openalex.org/W2056355779', 'https://openalex.org/W2065732704', 'https://openalex.org/W2067032172', 'https://openalex.org/W2075826032', 'https://openalex.org/W2079938883', 'https://openalex.org/W2400385996', 'https://openalex.org/W4235028970'], 'related_works': ['https://openalex.org/W3197333736', 'https://openalex.org/W2439651673', 'https://openalex.org/W2332695010', 'https://openalex.org/W2077179568', 'https://openalex.org/W2009676263', 'https://openalex.org/W1996660231', 'https://openalex.org/W1995293799', 'https://openalex.org/W1967876710', 'https://openalex.org/W1810219105', 'https://openalex.org/W1226498253'], 'abstract_inverted_index': {'The': [0, 23], 'synthesis': [1], 'of': [2, 13, 59, 87, 92, 105], 'prostacyclin': [3, 43], 'and': [4, 15, 33, 95, 110], 'prostaglandins': [5, 25, 96], 'was': [6, 49, 66, 72], 'examined': [7], 'in': [8, 74, 78, 100], 'isolated': [9], 'blood-free': [10], 'brain': [11], 'capillaries': [12, 76], 'guinea-pigs': [14, 61], 'rats': [16], 'using': [17], '1-14C-arachidonic': [18], 'acid': [19], 'as': [20], 'a': [21], 'precursor.': [22], 'main': [24], 'synthesized': [26], 'by': [27], 'guinea-pig': [28, 75], 'microvessels': [29], 'were': [30], 'prostaglandin': [31, 34, 38, 53, 65, 70, 84], 'D2': [32], 'E2.': [35], 'Substantially': [36], 'less': [37], 'F2': [39], 'alpha': [40, 48], 'or': [41], 'the': [42, 60, 63, 79, 83, 101], 'stable': [44], 'metabolite,': [45], '6-oxo-prostaglandin': [46], 'F1': [47], 'synthesized.': [50], 'Rat': [51], 'capillary': [52], 'distribution': [54], 'differed': [55], 'substantially': [56], 'from': [57], 'that': [58], 'although': [62], 'principle': [64], 'also': [67], 'PGD2.': [68], 'Total': [69], 'conversion': [71], 'greater': [73], 'than': [77], 'rat.': [80], 'Norepinephrine': [81], 'stimulated': [82], 'forming': [85], 'capacity': [86], 'blood': [88, 108], 'free': [89], 'cerebral': [90, 107], 'microvasculature': [91], 'guinea-pigs.': [93], 'Prostacyclin': [94], 'could': [97], 'be': [98], 'involved': [99], 'activity': [102], 'dependent': [103], 'regulation': [104], 'regional': [106], 'flow': [109], 'permeability.': [111]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2077399237', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-08-20T03:30:38.051328', 'created_date': '2016-06-24'}