Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2077394888', 'doi': 'https://doi.org/10.1038/nm1196-1263', 'title': 'Corrective gene transfer in the human skin disorder lamellar ichthyosis', 'display_name': 'Corrective gene transfer in the human skin disorder lamellar ichthyosis', 'publication_year': 1996, 'publication_date': '1996-11-01', 'ids': {'openalex': 'https://openalex.org/W2077394888', 'doi': 'https://doi.org/10.1038/nm1196-1263', 'mag': '2077394888', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8898758'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nm1196-1263', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203256638', 'display_name': 'Nature Medicine', 'issn_l': '1078-8956', 'issn': ['1078-8956', '1546-170X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101934003', 'display_name': 'Keith Choate', 'orcid': 'https://orcid.org/0000-0002-2176-4822'}, 'institutions': [{'id': 'https://openalex.org/I204866599', 'display_name': 'VA Palo Alto Health Care System', 'ror': 'https://ror.org/00nr17z89', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I204866599', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210125474']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K A Choate', 'raw_affiliation_strings': ['Veterans Affairs Palo Alto Health Care System, Palo Alto VA Medical Center, California 94304, USA.'], 'affiliations': [{'raw_affiliation_string': 'Veterans Affairs Palo Alto Health Care System, Palo Alto VA Medical Center, California 94304, USA.', 'institution_ids': ['https://openalex.org/I204866599']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074358664', 'display_name': 'D A Medalie', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'D A Medalie', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054959711', 'display_name': 'Jeffrey R. Morgan', 'orcid': 'https://orcid.org/0000-0002-7546-3443'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J R Morgan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083628557', 'display_name': 'Mary L. Williams', 'orcid': 'https://orcid.org/0000-0001-5660-4311'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'P A Khavari', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.499, 'has_fulltext': False, 'cited_by_count': 165, 'citation_normalized_percentile': {'value': 0.895012, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '2', 'issue': '11', 'first_page': '1263', 'last_page': '1267'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11650', 'display_name': 'Biology and Pathology of Keratins and Related Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11650', 'display_name': 'Biology and Pathology of Keratins and Related Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12610', 'display_name': 'Functions and Regulation of RNA Editing by ADARs', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12924', 'display_name': 'Genetic Disorders Causing Tissue Mineralization Abnormalities', 'score': 0.9697, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lamellar-ichthyosis', 'display_name': 'Lamellar ichthyosis', 'score': 0.9014728}, {'id': 'https://openalex.org/keywords/gene-transfer', 'display_name': 'Gene transfer', 'score': 0.552102}, {'id': 'https://openalex.org/keywords/connective-tissue-mineralization', 'display_name': 'Connective Tissue Mineralization', 'score': 0.472523}, {'id': 'https://openalex.org/keywords/human-skin', 'display_name': 'Human skin', 'score': 0.4304202}], 'concepts': [{'id': 'https://openalex.org/C2779483664', 'wikidata': 'https://www.wikidata.org/wiki/Q3804556', 'display_name': 'Lamellar ichthyosis', 'level': 3, 'score': 0.9014728}, {'id': 'https://openalex.org/C2776292323', 'wikidata': 'https://www.wikidata.org/wiki/Q523893', 'display_name': 'Ichthyosis', 'level': 2, 'score': 0.78548265}, {'id': 'https://openalex.org/C3018928802', 'wikidata': 'https://www.wikidata.org/wiki/Q83185', 'display_name': 'Gene transfer', 'level': 3, 'score': 0.552102}, {'id': 'https://openalex.org/C16005928', 'wikidata': 'https://www.wikidata.org/wiki/Q171171', 'display_name': 'Dermatology', 'level': 1, 'score': 0.539645}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.48889366}, {'id': 'https://openalex.org/C2777459323', 'wikidata': 'https://www.wikidata.org/wiki/Q5259911', 'display_name': 'Human skin', 'level': 2, 'score': 0.4304202}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.31458658}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.30647963}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2664311}], 'mesh': [{'descriptor_ui': 'D018014', 'descriptor_name': 'Gene Transfer Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017490', 'descriptor_name': 'Ichthyosis, Lamellar', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D015603', 'descriptor_name': 'Keratinocytes', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D011503', 'descriptor_name': 'Transglutaminases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016475', 'descriptor_name': '3T3 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000091344', 'descriptor_name': 'Filaggrin Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017490', 'descriptor_name': 'Ichthyosis, Lamellar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017490', 'descriptor_name': 'Ichthyosis, Lamellar', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015603', 'descriptor_name': 'Keratinocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D011503', 'descriptor_name': 'Transglutaminases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011503', 'descriptor_name': 'Transglutaminases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nm1196-1263', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203256638', 'display_name': 'Nature Medicine', 'issn_l': '1078-8956', 'issn': ['1078-8956', '1546-170X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8898758', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1559678336', 'https://openalex.org/W1836923250', 'https://openalex.org/W1966549550', 'https://openalex.org/W1974469880', 'https://openalex.org/W1975988029', 'https://openalex.org/W1977225005', 'https://openalex.org/W1997994503', 'https://openalex.org/W1998465575', 'https://openalex.org/W2009726317', 'https://openalex.org/W2023251802', 'https://openalex.org/W2023884778', 'https://openalex.org/W2031508786', 'https://openalex.org/W2032740831', 'https://openalex.org/W2036189250', 'https://openalex.org/W2045375365', 'https://openalex.org/W2045934824', 'https://openalex.org/W2046145594', 'https://openalex.org/W2049043712', 'https://openalex.org/W2052522043', 'https://openalex.org/W2052775108', 'https://openalex.org/W2055562285', 'https://openalex.org/W2058426053', 'https://openalex.org/W2067204579', 'https://openalex.org/W2067480460', 'https://openalex.org/W2072024103', 'https://openalex.org/W2072466722', 'https://openalex.org/W2072770481', 'https://openalex.org/W2073370269', 'https://openalex.org/W2080673718', 'https://openalex.org/W2086263346', 'https://openalex.org/W2234723792', 'https://openalex.org/W32039910'], 'related_works': ['https://openalex.org/W4297254902', 'https://openalex.org/W3143466087', 'https://openalex.org/W2770124872', 'https://openalex.org/W2560958410', 'https://openalex.org/W2399025449', 'https://openalex.org/W2124642801', 'https://openalex.org/W2107724362', 'https://openalex.org/W2026533139', 'https://openalex.org/W2014143915', 'https://openalex.org/W2010569859'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2077394888', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-09-01T03:33:32.943976', 'created_date': '2016-06-24'}