Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2077223577', 'doi': 'https://doi.org/10.1016/j.expneurol.2008.05.015', 'title': 'Adenosine A2A receptor antagonism increases nNOS-immunoreactive neurons in the striatum of Huntington transgenic mice', 'display_name': 'Adenosine A2A receptor antagonism increases nNOS-immunoreactive neurons in the striatum of Huntington transgenic mice', 'publication_year': 2008, 'publication_date': '2008-05-31', 'ids': {'openalex': 'https://openalex.org/W2077223577', 'doi': 'https://doi.org/10.1016/j.expneurol.2008.05.015', 'mag': '2077223577', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18586241'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.expneurol.2008.05.015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S165592611', 'display_name': 'Experimental Neurology', 'issn_l': '0014-4886', 'issn': ['0014-4886', '1090-2430'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001399282', 'display_name': 'Sara Cipriani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'S. Cipriani', 'raw_affiliation_strings': ['Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy', 'institution_ids': ['https://openalex.org/I45084792']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023036818', 'display_name': 'Elisa Bizzoco', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'E. Bizzoco', 'raw_affiliation_strings': ['Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy', 'institution_ids': ['https://openalex.org/I45084792']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091031182', 'display_name': 'Marco Gianfriddo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117667', 'display_name': 'Siena Biotech (Italy)', 'ror': 'https://ror.org/02ka1d450', 'country_code': 'IT', 'type': 'company', 'lineage': ['https://openalex.org/I4210117667']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'M. Gianfriddo', 'raw_affiliation_strings': ['Siena Biotech S.p.A., 53100 Siena, Italy'], 'affiliations': [{'raw_affiliation_string': 'Siena Biotech S.p.A., 53100 Siena, Italy', 'institution_ids': ['https://openalex.org/I4210117667']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012025043', 'display_name': 'Alessia Melani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}, {'id': 'https://openalex.org/I4210162269', 'display_name': 'Centro Neurolesi Bonino Pulejo', 'ror': 'https://ror.org/05tzq2c96', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I4210162269']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'A. Melani', 'raw_affiliation_strings': ['Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy', "IRCCS Centro Neurolesi 'Bonino-Pulejo' Messina, Italy"], 'affiliations': [{'raw_affiliation_string': 'Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy', 'institution_ids': ['https://openalex.org/I45084792']}, {'raw_affiliation_string': "IRCCS Centro Neurolesi 'Bonino-Pulejo' Messina, Italy", 'institution_ids': ['https://openalex.org/I4210162269']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067663192', 'display_name': 'Maria Giuliana Vannucchi', 'orcid': 'https://orcid.org/0000-0002-1060-5025'}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'M.G. Vannucchi', 'raw_affiliation_strings': ['Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy', 'institution_ids': ['https://openalex.org/I45084792']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013199489', 'display_name': 'Felicita Pedata', 'orcid': 'https://orcid.org/0000-0002-6841-3712'}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'F. Pedata', 'raw_affiliation_strings': ['Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy', 'institution_ids': ['https://openalex.org/I45084792']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5013199489'], 'corresponding_institution_ids': ['https://openalex.org/I45084792'], 'apc_list': {'value': 3810, 'currency': 'USD', 'value_usd': 3810, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.2, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 22, 'citation_normalized_percentile': {'value': 0.620181, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '213', 'issue': '1', 'first_page': '163', 'last_page': '170'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10949', 'display_name': 'Molecular Mechanisms of Neurodegenerative Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10949', 'display_name': 'Molecular Mechanisms of Neurodegenerative Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10919', 'display_name': 'Deep Brain Stimulation for Neurological Disorders', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Molecular Mechanisms of Ion Channels Regulation', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/adenosine-a2a-receptor', 'display_name': 'Adenosine A2A receptor', 'score': 0.8121575}, {'id': 'https://openalex.org/keywords/medium-spiny-neuron', 'display_name': 'Medium spiny neuron', 'score': 0.77346647}, {'id': 'https://openalex.org/keywords/neuromodulation', 'display_name': 'Neuromodulation', 'score': 0.512829}], 'concepts': [{'id': 'https://openalex.org/C2780062018', 'wikidata': 'https://www.wikidata.org/wiki/Q1319792', 'display_name': 'Striatum', 'level': 3, 'score': 0.8575133}, {'id': 'https://openalex.org/C2778491162', 'wikidata': 'https://www.wikidata.org/wiki/Q3063865', 'display_name': 'Adenosine A2A receptor', 'level': 5, 'score': 0.8121575}, {'id': 'https://openalex.org/C85714458', 'wikidata': 'https://www.wikidata.org/wiki/Q17152690', 'display_name': 'Medium spiny neuron', 'level': 4, 'score': 0.77346647}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5826464}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.53389823}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.51392365}, {'id': 'https://openalex.org/C141035611', 'wikidata': 'https://www.wikidata.org/wiki/Q5532934', 'display_name': 'Genetically modified mouse', 'level': 4, 'score': 0.47107545}, {'id': 'https://openalex.org/C61174792', 'wikidata': 'https://www.wikidata.org/wiki/Q420510', 'display_name': 'Glutamate receptor', 'level': 3, 'score': 0.44120696}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.4308715}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.43052632}, {'id': 'https://openalex.org/C2779177108', 'wikidata': 'https://www.wikidata.org/wiki/Q18356742', 'display_name': 'GABAergic', 'level': 3, 'score': 0.4233754}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.37667665}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37234518}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.32597506}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.24739212}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.23682207}, {'id': 'https://openalex.org/C67907053', 'wikidata': 'https://www.wikidata.org/wiki/Q356147', 'display_name': 'Adenosine receptor', 'level': 4, 'score': 0.2163234}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.20002565}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.061662674}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003342', 'descriptor_name': 'Corpus Striatum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006816', 'descriptor_name': 'Huntington Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006816', 'descriptor_name': 'Huntington Disease', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D026602', 'descriptor_name': 'Nitrergic Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D052248', 'descriptor_name': 'Nitric Oxide Synthase Type I', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D043705', 'descriptor_name': 'Receptor, Adenosine A2A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000241', 'descriptor_name': 'Adenosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000241', 'descriptor_name': 'Adenosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D058917', 'descriptor_name': 'Adenosine A2 Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003342', 'descriptor_name': 'Corpus Striatum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D003342', 'descriptor_name': 'Corpus Striatum', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D003342', 'descriptor_name': 'Corpus Striatum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019610', 'descriptor_name': 'Cytoprotection', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019610', 'descriptor_name': 'Cytoprotection', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D019610', 'descriptor_name': 'Cytoprotection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006816', 'descriptor_name': 'Huntington Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006816', 'descriptor_name': 'Huntington Disease', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D007395', 'descriptor_name': 'Interneurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007395', 'descriptor_name': 'Interneurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007395', 'descriptor_name': 'Interneurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D026602', 'descriptor_name': 'Nitrergic Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D026602', 'descriptor_name': 'Nitrergic Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052248', 'descriptor_name': 'Nitric Oxide Synthase Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043705', 'descriptor_name': 'Receptor, Adenosine A2A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.expneurol.2008.05.015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S165592611', 'display_name': 'Experimental Neurology', 'issn_l': '0014-4886', 'issn': ['0014-4886', '1090-2430'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18586241', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.77, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 76, 'referenced_works': ['https://openalex.org/W1551550807', 'https://openalex.org/W1570714205', 'https://openalex.org/W1579287598', 'https://openalex.org/W1667686291', 'https://openalex.org/W1670130194', 'https://openalex.org/W1976087201', 'https://openalex.org/W1977197484', 'https://openalex.org/W1977437565', 'https://openalex.org/W1977860760', 'https://openalex.org/W1979523972', 'https://openalex.org/W1982111522', 'https://openalex.org/W1984139957', 'https://openalex.org/W1989387017', 'https://openalex.org/W1989927249', 'https://openalex.org/W1991736396', 'https://openalex.org/W1993068285', 'https://openalex.org/W1993724278', 'https://openalex.org/W1994243055', 'https://openalex.org/W1994426409', 'https://openalex.org/W1995287360', 'https://openalex.org/W1996592124', 'https://openalex.org/W1998974178', 'https://openalex.org/W1999942346', 'https://openalex.org/W2000400298', 'https://openalex.org/W2002526073', 'https://openalex.org/W2004098916', 'https://openalex.org/W2004601258', 'https://openalex.org/W2007620493', 'https://openalex.org/W2008380097', 'https://openalex.org/W2010723168', 'https://openalex.org/W2013063789', 'https://openalex.org/W2014804210', 'https://openalex.org/W2020913507', 'https://openalex.org/W2024430647', 'https://openalex.org/W2026792513', 'https://openalex.org/W2026793631', 'https://openalex.org/W2029068965', 'https://openalex.org/W2034818574', 'https://openalex.org/W2038031154', 'https://openalex.org/W2043885800', 'https://openalex.org/W2054939193', 'https://openalex.org/W2059640915', 'https://openalex.org/W2060545591', 'https://openalex.org/W2062213087', 'https://openalex.org/W2062214351', 'https://openalex.org/W2062232335', 'https://openalex.org/W2062682951', 'https://openalex.org/W2063185527', 'https://openalex.org/W2067153644', 'https://openalex.org/W2068084690', 'https://openalex.org/W2070782694', 'https://openalex.org/W2076420735', 'https://openalex.org/W2079279463', 'https://openalex.org/W2079791220', 'https://openalex.org/W2081763017', 'https://openalex.org/W2082961737', 'https://openalex.org/W2083617962', 'https://openalex.org/W2083868750', 'https://openalex.org/W2085506644', 'https://openalex.org/W2116051210', 'https://openalex.org/W2119833067', 'https://openalex.org/W2121642311', 'https://openalex.org/W2122131368', 'https://openalex.org/W2124661414', 'https://openalex.org/W2130826999', 'https://openalex.org/W2133638214', 'https://openalex.org/W2135061224', 'https://openalex.org/W2136306454', 'https://openalex.org/W2146267270', 'https://openalex.org/W2147428924', 'https://openalex.org/W2149920094', 'https://openalex.org/W2171637070', 'https://openalex.org/W2240679513', 'https://openalex.org/W3152061996', 'https://openalex.org/W4323283997', 'https://openalex.org/W57997574'], 'related_works': ['https://openalex.org/W4388597939', 'https://openalex.org/W4247786827', 'https://openalex.org/W3138727255', 'https://openalex.org/W3116707624', 'https://openalex.org/W3093917743', 'https://openalex.org/W2976995946', 'https://openalex.org/W2883665250', 'https://openalex.org/W2331817391', 'https://openalex.org/W2038754384', 'https://openalex.org/W2023637370'], 'abstract_inverted_index': {'Medium': [0], 'spiny': [1], 'GABAergic': [2], 'projection': [3], 'neurons': [4, 73], 'are': [5], 'progressively': [6], 'lost': [7], 'in': [8, 55, 59, 75, 86, 95, 122, 126, 138, 145], "Huntington's": [9], 'disease': [10], '(HD),': [11], 'whereas': [12], 'there': [13], 'is': [14, 140], 'preferential': [15], 'sparing': [16], 'of': [17, 33, 71, 78, 118, 135], 'the': [18, 31, 34, 69, 76, 87, 96, 106, 113, 127, 132, 143], 'few': [19], 'interneurons': [20], 'co-expressing': [21], 'NPY,': [22], 'somatostatin': [23], 'and': [24, 44, 52], 'neuronal': [25], 'nitric': [26], 'oxide': [27], 'synthase.': [28], 'We': [29, 129], 'investigated': [30], 'effect': [32, 134], 'selective': [35], 'adenosine': [36, 119], 'A2A': [37, 120, 136], 'receptor': [38], 'antagonist': [39], 'SCH58261': [40, 65, 91], '(0.01': [41], 'mg/kg,': [42], 'acutely': [43], 'chronically': [45, 66], 'administered': [46, 67], 'i.p.)': [47], 'on': [48], 'nNOS': [49, 124], 'striatal': [50, 146], 'expression': [51, 125], 'motor': [53, 102], 'impairment': [54], 'R6/2': [56, 79], 'transgenic': [57], 'mice': [58], 'clearly': [60], 'symptomatic': [61], 'phase': [62], '(10–11-week': [63], 'old).': [64], 'increased': [68], 'number': [70], 'nNOS-immunoreactive': [72], '(nNOS-IR)': [74], 'striatum': [77, 88], 'mice.': [80], 'No': [81], 'glial': [82], 'activation': [83], 'was': [84], 'detected': [85], 'or': [89], 'cortex.': [90], 'also': [92], 'improved': [93], 'walking': [94], 'inclined': [97], 'plane': [98], 'test': [99], 'but': [100], 'not': [101], 'capability': [103], 'evaluated': [104], 'by': [105], 'rotarod': [107], 'test.': [108], 'These': [109], 'findings': [110], 'demonstrate': [111], 'for': [112], 'first': [114], 'time': [115], 'a': [116], 'role': [117], 'receptors': [121], 'regulating': [123], 'striatum.': [128], 'suggest': [130], 'that': [131], 'protective': [133], 'antagonism': [137], 'HD': [139], 'related': [141], 'to': [142], 'increase': [144], 'nNOS-IR': [147], 'neurons.': [148]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2077223577', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-17T16:00:29.416971', 'created_date': '2016-06-24'}