Title: A novel nucleoside phosphoramidite synthon derived from 1R, 2S-ephedrine
Abstract: The stereoselective synthesis of the nucleoside phosphoramidite 6 by reaction of the chiral oxazaphospholidine 4 with 5′-DMT-T is reported. The novel phosphoramidite synthon, 6, is stereoselectively converted to 8 by oxidative sulfurization with 1. The oxazaphospholidines, 6 and 8, are a new class of potential nucleoside synthons for the synthesis of oligonucleotides.
Publication Year: 1995
Publication Date: 1995-05-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 57
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