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866, 893], 'WJ,': [499, 867, 894], 'Varnum': [500], 'MD,': [501], 'Adelman': [502], 'JP,': [503], 'Maylie': [504, 870, 895], 'antiarrhythmics': [510], 'NE-10133': [513], 'inhibit': [514], 'oocytes': [520], 'myocytes.': [527, 1069, 2093], 'Biochem': [528], 'Biophys': [529, 578, 681, 1759], 'Res': [530, 860, 1030, 1460, 1791, 1976, 2095], 'Commun': [531], '202:': [533], '265–': [534], '270.': [535], '11': [536], 'Conder': [537, 561, 1738], 'ML,': [538, 562, 1739], 'Hess': [539], 'TA,': [540], 'Smith': [541, 563, 1736], "D'Alonzo": [543], 'AJ,': [544, 1921], 'McCullough': [545, 567, 1742], 'JR.': [546, 568, 1743], 'channels.': [554, 2008, 2027], 'A609.': [559], '12': [560], 'Atwal': [565, 1740], 'KS,': [566, 1741], 'currents': [574, 604, 1063, 1722, 1963, 2086], 'cells.': [577, 613, 1727], '66:': [581, 1097, 1762], 'A326.': [582], '13': [583], 'Davies': [584], 'MP,': [585], 'Freeman': [586], 'LC,': [587], 'Kass': [588], 'RS.': [589], 'Dual': [590], 'actions': [591], 'drug': [598, 1320, 1470], 'potassium': [602, 777, 1701], 'channel': [603, 733, 948, 1867, 1966], 'sinoatrial': [611], 'node': [612], 'Ther': [617, 1638], '276:': [619], '1149–': [620], '1154.': [621], '14': [622], 'Drexler': [623, 654, 687, 977], 'AP,': [624, 655, 688, 978], 'Al-Khalidi': [625], 'H,': [626, 718, 1553, 1924], 'et': [629, 758, 1490, 1525, 1925], 'al.': [630, 759, 1491, 1526, 1926], 'Comparison': [631, 1105, 1163], 'dihydrochloride': [634, 665, 1531], '(NE-10064)': [635, 666, 873, 1059, 1396, 1987, 2023], 'selected': [637], 'agents': [641, 800, 858, 1114, 1568], 'rabbit': [644], 'model': [645, 1200, 1504], 'proarrhythmia.': [647], 'A33.': [652], '15': [653], 'Kostreva': [662, 979, 1136], 'DR.': [663, 1057], 'prolongs': [667, 874], 'rabbits,': [672], 'species': [674], 'lacking': [675], 'slow': [677, 1752], '(IKs).': [680], '1995;': [683, 785, 889, 966, 1073, 1704, 1887, 2032], '68:': [684], 'A111.': [685], '16': [686], 'Micklas': [689], 'JM,': [690], 'RR.': [692, 1193, 1219, 1561], 'Suppression': [693], 'inducible': [695], 'arrhythmias': [697], 'dogs': [702, 992, 1116, 1876], 'previous': [704], 'myocardial': [705, 1942], 'infarction.': [706, 1943], '28:': [711], '848–': [712], '855.': [713], '17': [714], 'Eigenberger': [715], 'Suessbrich': [717], 'JJ,': [720, 1619, 1645], 'Jurkiewicz': [721, 754, 1001, 1711], 'NK,': [722, 755, 1002], 'F,': [724, 943, 1893], 'Characterization': [727, 2080], 'blockade': [730, 734, 1838, 1868, 2002], 'HERG': [732, 1697], 'azimilide:': [740, 2079], 'Mechanism': [741], 'specificity.': [743], 'Pflügers': [744], 'Arch-Eur': [745], '433:': [749], 'R88.': [750], '18': [751], 'Fermini': [752], 'Jow': [756], 'Use-dependent': [760], '(azimilide)': [769], 'repolarization:': [772], 'Block': [773], 'L-type': [779], 'calcium': [780], 'currents.': [781], '26:': [786, 1888], '259–': [787], '271.': [788], '19': [789], 'Gintant': [790, 813, 833], 'GA.': [791, 814, 834], 'Paradoxical': [792], 'effect': [793, 1087, 1419, 1443, 1563, 1846, 2072], 'combined': [795], 'canine': [803, 820, 842, 1305, 1540, 1631, 1997], 'potential.': [806, 1094], 'Circulation': [807, 827, 1070, 1095, 1513, 1580, 1850], '94:': [809, 1582, 1852], '1–': [810, 830, 1075, 1516, 1583, 1853], '160.': [811, 1854], '20': [812], 'Pharmacologie': [815], 'identification': [816], 'myocytes:': [822, 1999], '(azimilide).': [826], '90:': [829, 1515], '146.': [831], '21': [832], 'Two': [835], 'components': [836], 'atrium': [843], 'ventricle—does': [845], 'I-KS': [846], 'play': [847], 'role': [849], 'reverse': [852, 880, 1425, 1449], 'rate': [853], 'dependence': [854], 'Circ': [859, 1029, 1459, 1790, 1975, 2094], '78:': [862, 1793], '26–': [863], '22': [865], 'Gibson': [868], 'KJ,': [869], 'JG.': [871, 896], 'rate-dependent': [881], 'manner': [882], '18:': [890], '853.': [891], '23': [892], 'maintaining': [901], 'repolarizing': [902], 'block': [904, 1019, 1777, 1787], 'd,': [906], 'l-sotalol': [907], 'isoproterenol.': [909], '17:': [912, 1047, 1310, 1331], '755.': [913], '24': [914], 'Harrison': [915], 'DC.': [916], 'Current': [917], 'classification': [918, 1593], 'drues': [921], 'as': [922, 2051], 'guide': [924], 'their': [926, 1175], 'rational': [927], 'clinical': [928], 'use.': [929], 'Drugs': [930], '1986;': [931, 1479], '31:': [932], '93–': [933], '95.': [934], '25': [935], 'Wagner': [938], 'CA,': [939], 'modulation': [949], 'pH': [951], 'inhibition': [954], '(NE-10064).': [962, 1512], '291:': [967], '205–': [968], '208.': [969], '26': [970], 'Jackson': [971], 'KN,': [972], 'Lowe': [973, 1134], 'ER,': [974, 1135], 'Benn': [975, 1132], 'DR,': [976, 980, 1133, 1137], 'Mittelstadt': [981, 1138], 'SW.': [982, 1139], 'Effect': [983, 1927], 'left': [987, 1120, 1935], 'function': [989], 'during': [993, 1399], 'ischemia.': [994, 1179], 'A429.': [999], '27': [1000], 'Sanguinetti': [1003, 1678, 1709, 1771], 'MC.': [1004, 1772], 'potentials': [1010], 'methane-sulfonanilide': [1013], 'agent.': [1017, 1818], 'Specific': [1018], 'rapidly': [1021], 'activating': [1022], 'dofetilide.': [1028, 1270], '75–': [1033], '83.': [1034], '28': [1035], 'Kulbertus': [1036], 'HE.': [1037], 'treatment': [1039], 'atrial': [1041, 1066, 1257, 1260, 1306, 1498, 1536, 1542, 1726, 1970], 'arrhythmias.': [1042], '1991;': [1046, 1330, 1731], 'S32–': [1048], 'S35.': [1049], '29': [1050], 'Lamorgese': [1051], 'Kirian': [1053], 'van': [1055], 'Wagoner': [1056], 'blocks': [1060, 1297], 'outward': [1061, 1715], '8)': [1072], '92:': [1074], '575.': [1076], '30': [1077], 'Lascault': [1078], 'G,': [1079], 'Asta': [1080], 'J,': [1081, 1280, 1983, 2017], 'Cameron': [1082], 'Waxman': [1084], 'MB.': [1085], 'Electrophysiologic': [1086], '1982;': [1096, 1639], '11–': [1098], '294.': [1099], '31': [1100], 'Lavine': [1101], 'SJ,': [1102], 'Prcevski': [1103], 'P.': [1104, 1394, 1416, 1440], 'type': [1111, 1508], 'chronic': [1118], 'ischemic': [1119], 'dysfunction.': [1122], 'Invest': [1124], '44:': [1127], '211A.': [1128], '32': [1129], 'Beta-adrenergic': [1140, 1220], 'pentobarbital-anesthetized': [1147], 'rat.': [1148], 'A427.': [1153], '33': [1154], 'McIntosh': [1155], 'Tanira': [1157], 'Pacini': [1159], 'Kane': [1161], 'KA.': [1162], 'electrophysiological': [1166, 1628], 'sotalol': [1171], 'E-4031': [1173], 'modification': [1176], 'simulated': [1178], '23:': [1184], '653–': [1185], '657.': [1186], '34': [1187], 'An': [1194], 'vitro': [1196, 1806], 'heart': [1199], 'providing': [1201], 'contractility': [1202], 'electrophysiology': [1204, 1807], 'data': [1205], 'compounds.': [1208], '1988;': [1210], '30:': [1211], 'A178.': [1212], '35': [1213], 'perfused': [1232], 'heart.': [1235], '7:': [1239, 1386, 1822], 'A108.': [1240], '36': [1241], 'Nattel': [1242], 'Liu': [1244], 'L,': [1245], 'St-Georges': [1246], 'D.': [1247], 'experimental': [1256], 'fibrillation': [1258, 1401, 1874], 'electrophysiologic': [1261], 'properties.': [1262], 'Concentration-dependence': [1263], 'comparison': [1265], 'IKr': [1268, 1700, 1840], 'blocker': [1269], 'Am': [1272, 1728, 2029], 'Coll': [1273, 2030], 'Cardiol': [1274, 1660, 2031], '1997': [1275, 1461, 2012, 2096], '(in': [1276, 1462, 2013, 2097], 'press).': [1277, 1463, 2014, 2098], '37': [1278], 'Pinto': [1279], 'Boyden': [1281], 'Wit': [1283], 'which': [1296], 'slowly-activating': [1299], '(IKs)': [1303], 'flutter.': [1307], '777.': [1311], '38': [1312], 'Podrid': [1313], 'PJ.': [1314, 1836, 1865], 'toxicity': [1317], 'therapy:': [1321, 1471], 'Benefit': [1322], 'versus': [1323], 'risk.': [1324], '6)': [1329], 'S65–': [1332], 'S73.': [1333], '39': [1334], 'Poole': [1335], 'JE,': [1336], 'Bardy': [1337], 'GH.': [1338], 'Sudden': [1339], 'death.': [1341], 'In:': [1342, 1597], 'DP': [1343, 1598], 'Zipes,': [1344, 1599], 'Jalife,': [1346, 1601], 'eds.': [1347, 1602], 'Cardiac': [1348, 1603], 'Electrophysiology': [1349, 1604], 'from': [1350, 1605], 'Cell': [1351, 1606, 1659, 1703], 'Bedside.': [1353, 1608], 'Philadelphia': [1354, 1609], ':': [1355, 1610], 'W.B.': [1356, 1611], 'Saunders': [1357, 1612], 'Company,': [1358, 1613], '1995:': [1359, 1614], '812–': [1360], '832.': [1361], '40': [1362], 'Pong': [1363], 'SF,': [1364], 'Kinney': [1365], 'CM,': [1366], 'Moorehead': [1367, 1803], 'TJ.': [1368, 1804], 'Binding': [1369], 'profiles': [1370], 'agent,': [1378, 1510], 'rat': [1380, 2091], 'brain': [1381], 'receptors.': [1382], 'A474.': [1387], '41': [1388], 'Qi': [1389, 1411, 1435], 'X,': [1390, 1412, 1436], 'Newman': [1391, 1413, 1437], 'Dorian': [1393, 1415, 1439], 'coherence': [1398], 'dog.': [1405], '730.': [1409], '42': [1410], '(NE-10064):': [1422, 1446], 'Prevention': [1423, 1447], 'use-dependence': [1426, 1450], 'open-chest': [1428, 1457], '692.': [1433], '43': [1434], 'monophasic': [1452], '44': [1464], 'Reiser': [1465], 'HJ,': [1466], 'Sullivan': [1467], 'ME.': [1468], 'New': [1472], 'drugs': [1473, 1776], 'changing': [1475], 'concepts.': [1476], 'Fed': [1477], '45:': [1480], '2206–': [1481], '2212.': [1482], '45': [1483], 'Restivo': [1484, 1519, 1550], 'Hegazy': [1486, 1521], 'Caref': [1488, 1554], 'EB,': [1489, 1555], 'Termination': [1492], 'prevention': [1494, 1871], 'circus': [1496, 1534], 'movement': [1497, 1535], 'flutter': [1499, 1537], 'sterile': [1502], 'pericarditis': [1503], '413.': [1517], '46': [1518], 'El-Hamamy': [1523], 'efficacy': [1528, 1572], 'functional': [1533], 'right': [1541], 'enlargement': [1543], 'model.': [1544], '664.': [1548], '47': [1549], 'Yin': [1552], 'Levin': [1556], 'R,': [1557], 'Assadi': [1558], 'Selective': [1562], 'refractoriness': [1570, 1908], 'determines': [1571], 'post': [1574], 'infarction': [1575], 'reentrant': [1576], 'tachyarrhythmias': [1578], '(VT).': [1579], '161.': [1584], '48': [1585], 'Rosen': [1586], 'MR,': [1587], 'Strauss': [1588], 'HC,': [1589], 'Janse': [1590], 'MJ.': [1591], 'drugs.': [1596], '1277–': [1615], '1286.': [1616], '49': [1617], 'Jalife': [1620, 1648], 'properties': [1629], 'Purkinje': [1633], 'fibers.': [1634], '220:': [1640], '157–': [1641], '166.': [1642], '50': [1643], 'Wasserstrom': [1646], 'JA,': [1647], 'Dantrolene': [1650], 'sodium:': [1651], 'tissues.': [1656], 'Mol': [1658], '1983;': [1661], '15:': [1662], '233–': [1663], '243.': [1664], '51': [1665], 'Sanderson': [1666], 'SWORD': [1669], 'Damocles.': [1671], 'Lancet': [1672, 1944], '348:': [1674], '2–': [1675], '3.': [1676], '52': [1677], 'MC,': [1679, 1710], 'Jiang': [1680], 'Curran': [1682, 1767], 'ME,': [1683, 1768], 'Keating': [1684, 1769], 'MT.': [1685], 'mechanistic': [1687], 'between': [1689], 'an': [1690, 1693], 'inherited': [1691], 'acquired': [1694], 'arrhythmia:': [1696], 'encodes': [1698], 'channel.': [1702, 1785], '81:': [1705], '299–': [1706], '307.': [1707], '53': [1708], 'NK.': [1712], 'Delayed': [1713], 'is': [1718], 'composed': [1719], 'two': [1721], '260:': [1732], 'H393–': [1733], 'H399.': [1734], '54': [1735], 'clofilium': [1746], 'IKs,': [1750], 'component': [1753], 'rectifier.': [1758], 'A209.': [1763], '55': [1764], 'Spector': [1765], 'PS,': [1766], 'MT,': [1770], 'HERG,': [1778], 'Open-channel': [1786], 'methanesulfonanilides.': [1789], '499–': [1794], '503.': [1795], '56': [1796], 'DS,': [1798], 'David': [1799], 'BC,': [1800], 'KJ.': [1802], 'In': [1805], 'highly': [1813], 'selective': [1814], 'A107.': [1823], '57': [1824], 'Vanoli': [1825, 1856], 'E,': [1826, 1857], 'Hull': [1827, 1858], 'SSJ,': [1828, 1859], 'Jackman': [1829], 'WM,': [1830], 'Bussey': [1831], 'JD,': [1832], 'Foreman': [1833, 1862], 'RD,': [1834, 1863], 'Schwartz': [1835, 1864], 'Combined': [1837], 'enhances': [1843], 'arrhythmogenic': [1845], 'sympathetic': [1848, 1882], 'stimulation.': [1849], '58': [1855], 'Adamson': [1860], 'PB,': [1861], 'acute': [1878], 'ischemia': [1879], 'enhanced': [1881], 'activity.': [1883], '847–': [1889], '854.': [1890], '59': [1891], 'Wade-Whittaker': [1892], 'Sansone': [1894], 'DL,': [1895], 'Erickson': [1896], 'BK.': [1897], '(AZ)': [1902], 'dofetilide': [1904], '(DO)': [1905], 'ferret.': [1911], 'A64.': [1916], '60': [1917], 'Waldo': [1918], 'AL,': [1919], 'Camm': [1920], 'de': [1922], 'Ruyter': [1923], 'd-sotalol': [1929], 'mortality': [1931], 'patients': [1933], 'dysfunction': [1937], 'recent': [1939], 'remote': [1941], '236:': [1946], '7–': [1947], '12.': [1948], '61': [1949], 'Yang': [1950], 'Wathen': [1952], 'MS,': [1953], 'Felipe': [1954], 'Tamkun': [1956], 'MM,': [1957], 'Snyders': [1958], 'DJ,': [1959], 'Roden': [1960], 'DM.': [1961], 'mRNA': [1967], 'cultured': [1969], 'myocytes': [1972], '(AT-1': [1973], 'cells).': [1974], '75:': [1978], '870–': [1979], '878.': [1980], '62': [1981], 'Yao': [1982, 2016], 'Tseng': [1984, 2018], 'G.': [1985, 2019], 'can': [1988], 'prolong': [1989], 'shorten': [1991], 'Dependence': [2000], 'Ca,': [2005], 'Na': [2007], 'Electrophysiol': [2011], '63': [2015], 'K': [2026], 'Special': [2033], 'Issue:': [2034], '176A.': [2035], '64': [2036], 'Yu': [2037], 'Pelosi': [2039], 'SS,': [2040], 'Calcagno': [2041], 'MA': [2042], '(inventors);': [2043], 'Norwich': [2044], 'Eaton': [2045], 'Pharmaceuticals': [2046], '(assignee).': [2047], '4-Oxocyclic': [2048], 'ureas': [2049], 'useful': [2050], 'antifibrillatory': [2054], 'agents.': [2055], 'U.S.': [2056], 'Pat.': [2057], '5,462,940,': [2058], '1995.': [2059], '65': [2060], 'Zhang': [2061], 'ZH,': [2062], 'Boutjdir': [2063], 'El-Sherif': [2067], 'N.': [2068], 'Mechanisms': [2069], 'use-independent': [2071], 'drug,': [2078], 'repolarization': [2085], 'Citing': [2099], 'Literature': [2100], 'Volume15,': [2101], 'Issue2June': [2102], '1997Pages': [2103], 'ReferencesRelatedInformation': [2105]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2076862565', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-09T09:08:01.280513', 'created_date': '2016-06-24'}