Publication Information

{'id': 'https://openalex.org/W2076789610', 'doi': 'https://doi.org/10.1021/bi9021878', 'title': 'Binding of Munc18-1 to Synaptobrevin and to the SNARE Four-Helix Bundle', 'display_name': 'Binding of Munc18-1 to Synaptobrevin and to the SNARE Four-Helix Bundle', 'publication_year': 2010, 'publication_date': '2010-01-26', 'ids': {'openalex': 'https://openalex.org/W2076789610', 'doi': 'https://doi.org/10.1021/bi9021878', 'mag': '2076789610', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20102228', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2834481'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi9021878', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2834481?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013686582', 'display_name': 'Yi Xu', 'orcid': 'https://orcid.org/0000-0003-2720-0005'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yi Xu', 'raw_affiliation_strings': ['Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390'], 'affiliations': [{'raw_affiliation_string': 'Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029195697', 'display_name': 'Lijing Su', 'orcid': 'https://orcid.org/0000-0003-1533-0988'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lijing Su', 'raw_affiliation_strings': ['Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390'], 'affiliations': [{'raw_affiliation_string': 'Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065106268', 'display_name': 'Josep Rizo', 'orcid': 'https://orcid.org/0000-0003-1773-8311'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Josep Rizo', 'raw_affiliation_strings': ['Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390'], 'affiliations': [{'raw_affiliation_string': 'Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390', 'institution_ids': ['https://openalex.org/I867280407']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.852, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 99, 'citation_normalized_percentile': {'value': 0.999874, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '49', 'issue': '8', 'first_page': '1568', 'last_page': '1576'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10691', 'display_name': 'Retinal Development and Disorders', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/synaptobrevin', 'display_name': 'Synaptobrevin', 'score': 0.7548783}, {'id': 'https://openalex.org/keywords/helix-bundle', 'display_name': 'Helix bundle', 'score': 0.55204165}], 'concepts': [{'id': 'https://openalex.org/C2777029164', 'wikidata': 'https://www.wikidata.org/wiki/Q82452579', 'display_name': 'Synaptobrevin', 'level': 5, 'score': 0.7548783}, {'id': 'https://openalex.org/C203087120', 'wikidata': 'https://www.wikidata.org/wiki/Q372229', 'display_name': 'Helix bundle', 'level': 3, 'score': 0.55204165}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5340983}, {'id': 'https://openalex.org/C2778134712', 'wikidata': 'https://www.wikidata.org/wiki/Q1047307', 'display_name': 'Bundle', 'level': 2, 'score': 0.5070939}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.34000587}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28757828}, {'id': 'https://openalex.org/C47701112', 'wikidata': 'https://www.wikidata.org/wiki/Q735188', 'display_name': 'Protein structure', 'level': 2, 'score': 0.19169846}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18835852}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.14622125}, {'id': 'https://openalex.org/C148785051', 'wikidata': 'https://www.wikidata.org/wiki/Q671136', 'display_name': 'Synaptic vesicle', 'level': 4, 'score': 0.054469436}, {'id': 'https://openalex.org/C130316041', 'wikidata': 'https://www.wikidata.org/wiki/Q189206', 'display_name': 'Vesicle', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C159985019', 'wikidata': 'https://www.wikidata.org/wiki/Q181790', 'display_name': 'Composite material', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D051938', 'descriptor_name': 'Munc18 Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D051938', 'descriptor_name': 'Munc18 Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050683', 'descriptor_name': 'R-SNARE Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D050683', 'descriptor_name': 'R-SNARE Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050600', 'descriptor_name': 'SNARE Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050600', 'descriptor_name': 'SNARE Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D020816', 'descriptor_name': 'Amino Acid Motifs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009682', 'descriptor_name': 'Magnetic Resonance Spectroscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051938', 'descriptor_name': 'Munc18 Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017433', 'descriptor_name': 'Protein Structure, Secondary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050683', 'descriptor_name': 'R-SNARE Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050600', 'descriptor_name': 'SNARE Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013050', 'descriptor_name': 'Spectrometry, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi9021878', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2834481', 'pdf_url': 'https://europepmc.org/articles/pmc2834481?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834481', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20102228', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2834481', 'pdf_url': 'https://europepmc.org/articles/pmc2834481?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1544228065', 'https://openalex.org/W170382783', 'https://openalex.org/W1822252127', 'https://openalex.org/W1964383093', 'https://openalex.org/W1966364658', 'https://openalex.org/W1969841566', 'https://openalex.org/W1971016259', 'https://openalex.org/W1976479871', 'https://openalex.org/W1976535934', 'https://openalex.org/W1997239951', 'https://openalex.org/W1999213641', 'https://openalex.org/W2000142886', 'https://openalex.org/W2000302106', 'https://openalex.org/W2002701489', 'https://openalex.org/W2006897184', 'https://openalex.org/W2009639277', 'https://openalex.org/W2015974998', 'https://openalex.org/W2021285837', 'https://openalex.org/W2021373590', 'https://openalex.org/W2023907596', 'https://openalex.org/W2031212561', 'https://openalex.org/W2036635245', 'https://openalex.org/W2037485019', 'https://openalex.org/W2040866860', 'https://openalex.org/W2046198495', 'https://openalex.org/W2052999464', 'https://openalex.org/W2061387029', 'https://openalex.org/W2063487710', 'https://openalex.org/W2064757060', 'https://openalex.org/W2067354100', 'https://openalex.org/W2069695739', 'https://openalex.org/W2075402444', 'https://openalex.org/W2095474817', 'https://openalex.org/W2098744542', 'https://openalex.org/W2120360272', 'https://openalex.org/W2125335261', 'https://openalex.org/W2127017351', 'https://openalex.org/W2127061791', 'https://openalex.org/W2139266146', 'https://openalex.org/W2151825535', 'https://openalex.org/W2153569460', 'https://openalex.org/W2154100802', 'https://openalex.org/W2157452565', 'https://openalex.org/W2161367731', 'https://openalex.org/W2170117855', 'https://openalex.org/W2170349574'], 'related_works': ['https://openalex.org/W4387497383', 'https://openalex.org/W4327565020', 'https://openalex.org/W2948807893', 'https://openalex.org/W2778153218', 'https://openalex.org/W2748952813', 'https://openalex.org/W2737740661', 'https://openalex.org/W2375292076', 'https://openalex.org/W2155273871', 'https://openalex.org/W2028076297', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': {'Sec1/Munc18': [0], '(SM)': [1], 'proteins': [2], 'and': [3, 36, 42, 60, 73, 101, 107, 141, 157, 182, 235], 'soluble': [4], 'N-ethylmaleimide': [5], 'sensitive': [6], 'factor': [7], 'attachment': [8], 'protein': [9, 68], 'receptors': [10], '(SNAREs)': [11], 'form': [12], 'part': [13], 'of': [14, 121, 164, 174, 199, 228, 232], 'the': [15, 37, 75, 81, 103, 143, 153, 161, 171, 178, 188, 197, 211, 250], 'core': [16], 'intracellular': [17], 'membrane': [18, 29, 39, 115, 245], 'fusion': [19, 214, 246], 'machinery,': [20], 'but': [21, 117], 'it': [22], 'is': [23, 61, 194], 'unclear': [24], 'how': [25], 'they': [26], 'cooperate': [27], 'in': [28, 221, 236, 244, 247], 'fusion.': [30, 64], 'The': [31, 65], 'synaptic': [32], 'vesicle': [33], 'SNARE': [34, 48, 58, 76, 104, 144, 179, 201], 'synaptobrevin': [35, 100, 140, 183, 193], 'plasma': [38], 'SNAREs': [40], 'syntaxin-1': [41, 72, 82, 175], 'SNAP-25': [43], 'assemble': [44], 'into': [45], 'a': [46, 52, 219, 226, 240], 'tight': [47], 'complex': [49, 77], 'that': [50, 85, 95, 108, 135, 166, 204], 'includes': [51], 'four-helix': [53, 105, 145, 180], 'bundle': [54, 106, 181], 'formed': [55], 'by': [56], 'their': [57], 'motifs': [59], 'key': [62], 'for': [63, 88, 114, 184], 'neuronal': [66], 'SM': [67], 'Munc18-1': [69, 96, 136, 165, 185, 189, 208, 238], 'binds': [70, 98, 138, 167], 'to': [71, 74, 99, 102, 139, 142, 159, 168], 'through': [78], 'interactions': [79, 110, 123, 148, 234], 'with': [80, 177, 249], 'N-terminal': [83, 172], 'region': [84, 173], 'are': [86], 'critical': [87], 'neurotransmitter': [89, 223], 'release.': [90], 'It': [91], 'has': [92, 124], 'been': [93, 126], 'proposed': [94], 'also': [97], 'such': [109], 'might': [111], 'be': [112], 'crucial': [113], 'fusion,': [116], 'definitive,': [118], 'direct': [119], 'evidence': [120], 'these': [122], 'not': [125], 'described.': [127], 'Using': [128], 'diverse': [129], 'biophysical': [130], 'approaches,': [131], 'we': [132], 'now': [133], 'demonstrate': [134], 'indeed': [137], 'bundle.': [146], 'Both': [147], 'have': [149], 'similar': [150], 'affinities': [151], '(in': [152], 'low': [154], 'micromolar': [155], 'range)': [156], 'appear': [158], 'involve': [160], 'same': [162], 'cavity': [163], 'syntaxin-1.': [169], 'Correspondingly,': [170], 'competes': [176], 'binding.': [186], 'Importantly,': [187], 'binding': [190], 'site': [191, 212], 'on': [192], 'located': [195], 'at': [196, 210], 'C-terminus': [198], 'its': [200], 'motif,': [202], 'suggesting': [203], 'this': [205], 'interaction': [206], 'places': [207], 'right': [209], 'where': [213], 'occurs.': [215], 'These': [216], 'results': [217], 'suggest': [218], 'model': [220], 'which': [222, 237], 'release': [224], 'involves': [225], 'sequence': [227], 'three': [229], 'different': [230], 'types': [231], 'Munc18-1-SNARE': [233], 'plays': [239], 'direct,': [241], 'active': [242], 'role': [243], 'cooperation': [248], 'SNAREs.': [251]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2076789610', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-10T11:43:10.135864', 'created_date': '2016-06-24'}