Title: Antiandrogen effects on androgen-responsive mammary tumour cells in culture
Abstract: The effect of three antiandrogens, flutamide, hydroxyflutamide and cyproterone acetate on the growth of an androgen responsive mouse mammary tumour cell line has been investigated. These effects have been correlated with binding of the compounds to the androgen receptor. The growth inhibitory activities of hydroxyflutamide and cyproterone acetate are clearly related to their ability to inhibit androgen binding to cytoplasmic and nuclear receptors. Flutamide, however, inhibits cell growth in both the presence and absence of testosterone but does not inhibit DHT binding to the receptor.
Publication Year: 1981
Publication Date: 1981-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 11
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