Publication Information

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4328, 4338, 4343, 4378, 4385, 4399, 4408, 4423, 4466], 'extracellular': [10, 237, 471], 'amyloid-β': [11, 238, 474], '(Aβ)': [12, 239, 475], 'deposits,': [13, 240], 'and': [14, 81, 107, 174, 215, 218, 241, 308, 334, 401, 442, 445, 477, 525, 537, 542, 557, 586, 629, 720, 780, 814, 817, 880, 903, 957, 1051, 1072, 1089, 1149, 1278, 1317, 1335, 1360, 1401, 1423, 1439, 1454, 1479, 1535, 1549, 1683, 1692, 1704, 1721, 1756, 1780, 1798, 1815, 1837, 1849, 1863, 1905, 1941, 1973, 2129, 2164, 2166, 2314, 2385, 2407, 2415, 2440, 2461, 2498, 2537, 2588, 2612, 2622, 2647, 2717, 2741, 2766, 2821, 2859, 2866, 2876, 2882, 2918, 2981, 3040, 3066, 3075, 3148, 3224, 3236, 3244, 3257, 3267, 3339, 3359, 3379, 3483, 3512, 3535, 3558, 3572, 3642, 3651, 3756, 3773, 3850, 3897, 3912, 3935, 3965, 3984, 3995, 4024, 4029, 4048, 4054, 4074, 4111, 4222, 4233, 4275, 4406, 4455, 4497], 'neurofibrillary': [15, 184, 242, 411, 478, 545, 621, 650, 842, 1043, 1083, 2014, 2529, 2897, 4237, 4267, 4296, 4424, 4467], 'lesions,': [16, 243], 'which': [17, 244, 822, 870, 3543], 'consist': [18, 245], 'intracellular': [20, 247, 482, 2672], 'aggregates': [21, 248, 483, 692], 'hyperphosphorylated': [23, 250, 485, 690, 2845], 'tau': [24, 33, 50, 58, 95, 119, 122, 148, 154, 183, 194, 221, 251, 260, 277, 285, 322, 346, 349, 375, 381, 410, 421, 448, 486, 541, 587, 628, 654, 691, 805, 811, 829, 846, 973, 979, 991, 1009, 1050, 1158, 1184, 1768, 1813, 1937, 2481, 2536, 2597, 2660, 2673, 2830, 2846, 2891, 2990, 3034, 3046, 3242, 3250, 3310, 3326, 3354, 3362, 3392, 3402, 3409, 3433, 3462, 3562, 3612, 3658, 3791, 3812, 3838, 3918, 3923, 3943, 4042, 4065, 4083, 4274, 4300, 4320, 4331, 4365, 4380, 4386, 4410, 4428, 4471], 'protein.': [25, 252], 'To': [26, 115, 253, 342, 967, 1553, 1766, 2252, 2326, 2608], 'study': [27, 117, 254, 344, 793, 868, 987, 4217], 'the': [28, 56, 63, 73, 78, 88, 180, 193, 197, 206, 209, 216, 255, 283, 290, 300, 305, 315, 407, 420, 424, 433, 436, 443, 520, 560, 694, 791, 797, 887, 890, 893, 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2194, 2333, 2493, 2531, 2592, 2617, 2656, 2683, 2825, 2849, 2900, 2910, 2922, 2933, 2985, 3036, 3048, 3195, 3428, 3431, 3453, 3496, 3566, 3628, 3667, 3845, 3855, 3860, 3866, 3900, 4014, 4020, 4032, 4044, 4051, 4067, 4086, 4119, 4194, 4225, 4269, 4298, 4325, 4390, 4426, 4469], 'vivo': [30, 257, 578, 4226], 'induction': [31, 96, 258, 323, 772, 949, 971, 989, 1527, 3140, 3407, 3427, 3460, 3493, 3521, 3550, 3659, 3748, 4085, 4235, 4377, 4384], 'pathology,': [34, 261, 974, 3624, 4387], 'dilute': [35, 262, 717, 4340], 'brain': [36, 69, 100, 263, 296, 327, 521, 591, 722, 800, 897, 1013, 1293, 1559, 1772, 2044, 2172, 2179, 2268, 2386, 2421, 2618, 2856, 2877, 3082, 3222, 3346, 3498, 3573, 3629, 3647, 3788, 3861, 3997, 4327, 4363], 'extracts': [37, 101, 264, 328, 723, 801, 1294, 1405, 3383, 3698], 'from': [38, 102, 139, 265, 329, 366, 1309, 1322, 1436, 1986, 2102, 2367, 3058, 3220, 3501, 3585, 3597, 3633, 4358], 'aged': [39, 103, 108, 266, 330, 335, 1425, 3228, 3587, 3599], 'Aβ-depositing': [40, 267, 3063], 'APP23': [41, 128, 141, 268, 355, 368, 983, 1203, 1417, 3064, 3081, 3320, 3382, 3466, 3524, 3588, 3797, 3806, 3871, 3964, 3968, 4120, 4197, 4346], 'transgenic': [42, 51, 111, 123, 142, 155, 269, 278, 338, 350, 369, 382, 624, 655, 734, 812, 830, 847, 980, 984, 1046, 1087, 1105, 1197, 1204, 1246, 1418, 1445, 1914, 2477, 2532, 2627, 3230, 3792, 3798, 3818, 3877, 3967, 4157, 4198, 4270, 4301, 4332, 4345, 4360, 4411, 4429, 4472], 'mice': [43, 106, 112, 124, 135, 145, 156, 270, 333, 339, 351, 362, 372, 383, 625, 656, 813, 848, 981, 985, 1047, 1088, 1097, 1106, 1154, 1171, 1178, 1198, 1205, 1266, 1845, 2479, 2533, 2593, 2628, 2651, 2671, 2690, 2714, 2737, 2754, 2776, 2826, 2935, 2986, 3004, 3023, 3065, 3281, 3290, 3304, 3387, 3778, 3793, 3807, 3822, 3872, 3888, 3903, 3919, 4089, 4099, 4271, 4302, 4333, 4430, 4473], 'were': [44, 113, 125, 271, 340, 352, 1094, 1098, 1199, 1267, 1295, 1367, 1390, 1406, 1452, 1463, 1617, 1647, 1709, 1714, 1749, 1775, 1790, 1833, 1846, 1851, 1870, 1926, 1984, 2000, 2051, 2174, 2181, 2226, 2270, 2423, 2434, 2629, 2718, 2743, 2893, 2905, 3056, 3260, 3282, 3291, 3418, 3614, 3783, 3794, 3945, 4011, 4103], 'intracerebrally': [45, 272, 826], 'infused': [46, 189, 273, 416, 827], 'young': [48, 275, 808, 3272, 4329], 'B6/P301L': [49, 110, 121, 153, 276, 337, 348, 380, 809, 978, 1086, 1096, 1196, 1444, 2643, 2650, 2670, 2713, 3003, 3022, 3229, 3277, 3302, 3369, 3432, 3600, 3790, 3804, 3819, 3869, 3878, 3917, 3962, 4068, 4330, 4361], 'mice.': [52, 129, 279, 356, 2667, 3279, 3435, 3799, 3880, 3970], 'Six': [53, 280], 'months': [54, 281, 2487, 2709, 2733, 3014, 3285, 3295, 3892, 3907], 'after': [55, 282, 1385, 3692, 4396], 'infusion,': [57, 284], 'pathology': [59, 149, 195, 286, 376, 422, 588, 806, 992, 1010, 2482, 2661, 3035, 3311, 3363, 3426, 3563, 3813, 3839, 3924, 4066, 4084, 4321], 'was': [60, 97, 287, 324, 825, 878, 899, 1332, 1338, 1349, 1355, 1363, 1381, 1433, 1547, 1739, 1822, 2138, 2211, 2300, 2395, 2680, 2764, 3232, 3252, 3364, 3373, 3403, 3564, 3626, 3767, 3774, 3864, 3882, 3974, 4036, 4078, 4218, 4501], 'induced': [61, 288, 657, 849, 3322, 3366, 3561, 3627, 3942, 4013, 4041, 4303, 4324, 4431, 4474], 'injected': [64, 291, 879, 911, 3262, 3329, 3384, 3664, 3784, 4487, 4499], 'hippocampus': [65, 292, 1318, 2073, 2092, 2357, 2406, 3266, 3330, 3455, 3985, 4025, 4407], 'but': [66, 293, 687, 3371, 3645, 3858, 4349], 'also': [67, 294, 803, 976, 1200, 1434, 2860, 3365, 3494, 3547, 3677], 'regions': [70, 297, 2045, 2180, 3430, 3499, 3630, 3657, 3863], 'well': [71, 298], 'beyond': [72, 299], 'injection': [74, 89, 301, 316, 715, 891, 3316, 3343, 3503, 3618, 3635, 3682, 4337], 'sites': [75, 302, 2034], 'such': [76, 303, 3505, 3637, 4070], 'as': [77, 304, 1488, 1711, 2342, 2930, 3506, 3638, 4071, 4504], 'entorhinal': [79, 306, 2104, 2155, 2864, 3508, 3640, 3847, 3933, 4022], 'cortex': [80, 307, 2105, 2113, 2163, 3270, 3509, 3569, 3641, 3934, 4023, 4405], 'amygdala,': [82, 309, 2165, 2414, 3644, 4392], 'areas': [83, 159, 310, 386, 1878, 3050, 4060], 'neuronal': [85, 312], 'projection': [86, 313], 'to': [87, 151, 314, 378, 535, 562, 683, 865, 883, 986, 1007, 1594, 1620, 1650, 1728, 1810, 1884, 1936, 1965, 1976, 2098, 2109, 2117, 2125, 2134, 2144, 2151, 2158, 2168, 2187, 2213, 2246, 2264, 2272, 2363, 2373, 2381, 2391, 2401, 2410, 2417, 2442, 2485, 2613, 2631, 2663, 2688, 2720, 2731, 2770, 2887, 2896, 3012, 3089, 3096, 3192, 3274, 3293, 3469, 3485, 3527, 3536, 3552, 3662, 3673, 3680, 3769, 3815, 3851, 3874, 3926, 4063, 4116, 4220, 4374], 'site.': [90, 317], 'No': [91, 318, 1378, 3560, 3611], 'or': [92, 319, 1384, 1954, 3348, 3787, 4080, 4356], 'only': [93, 320, 3032, 4081, 4389], 'modest': [94, 321, 4082], 'observed': [98, 325, 3615], 'when': [99, 326, 2724, 3288], 'nontransgenic': [104, 331, 1090, 1428, 3069, 3345, 3386, 3593, 4353], 'control': [105, 332, 1190, 3070, 3821, 3879, 4354], 'tau-depositing': [109, 336], 'infused.': [114, 341], 'further': [116, 343], 'Aβ-induced': [118, 345], 'lesions': [120, 222, 347, 449, 2892, 3047, 3243, 3355, 3410, 3613, 3944, 4010, 4043], 'crossed': [126, 353, 3795], 'Although': [130, 357], 'Aβ': [131, 162, 172, 177, 190, 200, 213, 358, 389, 399, 404, 417, 427, 440, 518, 585, 824, 877, 894, 1077, 1555, 1730, 2331, 3085, 3688, 3703, 4232, 4371, 4490, 4500], 'deposition': [132, 359, 1074, 2332, 2674, 3324, 3463, 3704, 3981, 4006, 4050], 'double-transgenic': [134, 144, 361, 371, 3803, 3868, 3887, 3902, 4088], 'did': [136, 363, 904, 3005, 3350, 3388, 3699, 3808, 3955], 'not': [137, 364, 688, 905, 2681, 3006, 3306, 3351, 3374, 3389, 3646, 3700, 3706, 3809, 3824, 3859, 3895, 3921, 3956, 4061, 4350], 'differ': [138, 365], 'single': [140, 152, 367, 379, 2204, 3817, 3876, 3915, 3966, 4336], 'mice,': [143, 370, 4069], 'revealed': [146, 373, 581, 2652, 3031, 3084, 3519], 'increased': [147, 374, 3811], 'compared': [150, 377, 2662, 3095, 3468, 3484, 3526, 3551, 3814, 3873], 'predominately': [157, 384], 'high': [161, 388, 872, 4092, 4493], 'plaque': [163, 390, 4093], 'load.': [164, 391], 'The': [165, 186, 392, 413, 504, 550, 1352, 1460, 1545, 1736, 1819, 1923, 2178, 2191, 4215], 'present': [166, 393, 792, 4216], 'results': [167, 394, 1062, 4118], 'suggest': [168, 395, 1063, 4369], 'that': [169, 188, 396, 415, 461, 512, 528, 713, 1064, 2749, 3299, 3397, 4319, 4370], 'both': [170, 397, 1065], 'extract-derived': [171, 398], 'species': [173, 400], 'deposited': [175, 402], 'fibrillary': [176, 403, 875, 1076, 4488], 'can': [178, 191, 405, 418, 1078, 4322], 'induce': [179, 406, 804, 1008, 1079, 3352, 3390], 'formation': [181, 408, 543, 1081], 'pathology.': [185, 412, 1084, 4381], 'observation': [187, 414], 'trigger': [192, 419], 'absence': [198, 425], 'deposits': [201, 214, 428, 441, 472, 885, 908, 3393, 4102], 'provides': [202, 429], 'an': [203, 430, 523, 582, 1069, 1343, 1424, 2229, 3067, 3215, 3218, 3227, 3586, 3598, 4375], 'explanation': [204, 431], 'for': [205, 432, 1172, 1342, 1373, 1476, 1485, 1865, 1994, 2035, 2217, 2257, 2345, 2446, 2636, 3405, 3544, 3687, 3884], 'discrepancy': [207, 434], 'between': [208, 435, 584, 2483, 2496, 3960, 4231, 4448], 'neuroanatomical': [210, 437], 'location': [211, 438], 'development': [217, 444, 2658], 'spreading': [219, 446], 'brain.': [226, 453, 2902, 3053], '(AD)': [456], 'is': [457, 462, 522, 776, 953, 1531, 1592, 2495, 2701, 3144, 3190, 3481, 3752, 4372], 'a': [458, 530, 871, 1270, 1298, 1415, 1442, 1598, 1717, 1794, 2203, 2206, 2233, 2241, 2247, 2428, 2437, 2471, 2632, 2653, 2684, 2841, 2937, 3018, 3196, 3674, 3834, 3852, 3937, 3975, 4037, 4091, 4106, 4229, 4335, 4339, 4344, 4359, 4409, 4492], 'neurodegenerative': [459], 'disorder': [460], 'pathologically': [463], 'characterized': [464], 'by': [465, 658, 778, 850, 955, 993, 1100, 1396, 1408, 1533, 2005, 2016, 2277, 2296, 2452, 2726, 2907, 2919, 3146, 3332, 3411, 3420, 3443, 3464, 3754, 3841, 3992, 4105, 4304, 4334, 4351, 4432, 4475], 'composed': [469, 480], 'peptide,': [476], 'tangles,': [479, 1147, 2586, 2819, 2979], 'protein.1Goedert': [487], 'M': [488, 617, 736, 766, 770, 913, 943, 947, 1039, 1120, 1125, 1127, 1145, 1215, 1235, 1239, 1491, 1521, 1525, 1567, 1586, 1590, 1673, 1889, 1899, 1901, 2525, 2559, 2564, 2566, 2584, 2792, 2797, 2799, 2817, 2952, 2957, 2959, 2977, 3104, 3134, 3138, 3165, 3184, 3188, 3712, 3742, 3746, 4126, 4146, 4150, 4177, 4185, 4187, 4263], 'Spillantini': [489], 'MG': [490], 'A': [491, 601, 748, 925, 998, 1023, 1135, 1237, 1503, 1663, 2509, 2574, 2807, 2967, 3074, 3116, 3338, 3724, 3911, 4148, 4179, 4181, 4247, 4382], 'century': [492], 'disease.Science.': [495], '2006;': [496, 782, 959, 1537, 3150, 3758], '314:': [497], '777-781Crossref': [498], 'PubMed': [499, 567, 634, 665, 704, 785, 857, 962, 1056, 1164, 1260, 1540, 1611, 1697, 1920, 2082, 2542, 2603, 2836, 2996, 3153, 3209, 3761, 4171, 4210, 4280, 4311, 4439, 4482], 'Scopus': [500, 568, 635, 666, 705, 786, 858, 963, 1057, 1165, 1261, 1541, 1612, 1698, 2083, 2543, 2604, 2837, 2997, 3154, 3210, 3762, 4172, 4211, 4281, 4312, 4440, 4483], '(1677)': [501], 'Google': [502, 570, 637, 668, 707, 788, 860, 965, 1059, 1167, 1263, 1543, 1614, 1700, 1921, 2028, 2085, 2545, 2606, 2839, 2999, 3156, 3212, 3764, 4174, 4213, 4283, 4314, 4442, 4485], 'Scholar': [503, 571, 708, 789, 861, 966, 1060, 1168, 1264, 1544, 1615, 1701, 1922, 2029, 2086, 2201, 2607, 2840, 3000, 3213, 3765, 4214, 4315, 4443, 4486], 'amyloid': [505, 551, 730, 884, 907, 1243, 1911, 3801, 3832, 3953, 3980, 3989, 4005, 4049, 4101, 4154, 4192], 'cascade': [506, 531], 'hypothesis': [507, 552], 'AD': [509, 2901], 'pathogenesis': [510], 'holds': [511], 'accumulation': [513], 'polymerized': [515], 'forms': [516], 'early': [524], 'critical': [526], 'event': [527], 'triggers': [529], 'events': [533], 'leading': [534], 'hyperphosphorylation': [536], 'somatodendritic': [538], 'segregation': [539], 'tangles.2Hardy': [546], 'J': [547, 593, 615, 640, 645, 738, 764, 832, 837, 915, 941, 1015, 1037, 1109, 1113, 1133, 1493, 1519, 1661, 1679, 2501, 2523, 2548, 2552, 2572, 2781, 2785, 2805, 2941, 2945, 2965, 3106, 3132, 3714, 3740, 4200, 4239, 4261, 4286, 4291, 4414, 4419, 4457, 4462], 'Selkoe': [548], 'DJ': [549], 'disease:': [555], 'progress': [556], 'problems': [558], 'on': [559, 1782, 1872, 2777, 2936], 'road': [561], 'therapeutics.Science.': [563], '2002;': [564, 1917], '297:': [565], '353-356Crossref': [566], '(11263)': [569], 'Consistent': [572], 'this': [574, 866, 969, 3372, 3927], 'view,': [575], 'previous': [576, 819, 3102, 3710, 4117, 4224], 'studies': [579, 820, 2621, 4227, 4451], 'have': [580, 711, 2336, 3305, 4317], 'interaction': [583], 'vulnerable': [590], 'regions.3Lewis': [592, 1014], 'Dickson': [594, 1016, 1140, 2502, 2579, 2812, 2972, 4240], 'DW': [595, 1017, 1141, 2503, 2580, 2813, 2973, 4241], 'Lin': [596, 1018, 1136, 2504, 2575, 2808, 2968, 4242], 'WL': [597, 1019, 1137, 2505, 2576, 2809, 2969, 4243], 'Chisholm': [598, 1020, 2506, 4244], 'L': [599, 609, 673, 1021, 1031, 1887, 1897, 2055, 2507, 2517, 4245, 4255], 'Corral': [600, 1022, 1134, 2508, 2573, 2806, 2966, 4246], 'Jones': [602, 1024, 2510, 4248], 'G': [603, 1025, 1667, 1675, 2190, 2511, 4249], 'Yen': [604, 1026, 1138, 2512, 2577, 2810, 2970, 4250], 'SH': [605, 1027, 1139, 2513, 2578, 2811, 2971, 4251], 'Sahara': [606, 1028, 2514, 4252], 'N': [607, 1029, 2515, 4253], 'Skipper': [608, 1030, 2516, 4254], 'Yager': [610, 1032, 2518, 4256], 'D': [611, 750, 927, 1033, 1213, 1505, 1575, 2519, 3118, 3173, 3557, 3726, 4124, 4257], 'Eckman': [612, 1034, 2520, 4258], 'C': [613, 744, 921, 1035, 1211, 1219, 1231, 1499, 1577, 2521, 3112, 3175, 3256, 3358, 3720, 4122, 4130, 4142, 4259], 'Hardy': [614, 1036, 1132, 2522, 2571, 2804, 2964, 4260], 'Hutton': [616, 1038, 1144, 2524, 2583, 2816, 2976, 4262], 'McGowan': [618, 1040, 1110, 2526, 2549, 2782, 2942, 4264], 'E': [619, 746, 923, 1041, 1111, 1501, 1569, 1677, 2527, 2550, 2783, 2943, 3114, 3167, 3722, 4028, 4265], 'Enhanced': [620, 1042, 2528, 4266], 'degeneration': [622, 1044, 2530, 2909, 4268], 'expressing': [626, 1048, 1155, 1206, 2534, 2594, 2827, 2987, 4272], 'mutant': [627, 1049, 1156, 1209, 2535, 2595, 2828, 2988, 4273], 'APP.Science.': [630, 1052, 2538, 4276], '2001;': [631, 662, 854, 1053, 2539, 4277, 4308, 4436, 4479], '293:': [632, 663, 855, 1054, 2540, 4278, 4309, 4437, 4480], '1487-1491Crossref': [633, 1055, 2541, 4279], '(1295)': [636, 1058, 2544, 4282], 'Scholar,': [638, 669, 2546, 3157, 4175, 4284], '4Götz': [639, 4285], 'Chen': [641, 833, 4287, 4415, 4458], 'F': [642, 834, 1891, 2009, 4288, 4416, 4459], 'van': [643, 835, 1580, 3178, 4289, 4417, 4460], 'Dorpe': [644, 836, 4290, 4418, 4461], 'Nitsch': [646, 838, 4292, 4420, 4463], 'RM': [647, 839, 4293, 4421, 4464], 'Formation': [648, 840, 4294, 4422, 4465], 'tangles': [651, 843, 2898, 4297, 4425, 4468], 'P301l': [653, 845, 4299, 4427, 4470], 'Abeta': [659, 680, 851, 1591, 3189, 4305, 4433, 4476], '42': [660, 852, 4306, 4434, 4477], 'fibrils.Science.': [661, 853, 4307, 4435, 4478], '1491-1495Crossref': [664, 856, 4310, 4438, 4481], '(1299)': [667, 859, 4313, 4441, 4484], '5Oddo': [670], 'S': [671, 742, 919, 1221, 1497, 1573, 3110, 3171, 3718, 4132], 'Billings': [672], 'Kesslak': [674], 'JP': [675], 'Cribbs': [676], 'DH': [677], 'LaFerla': [678], 'FM': [679], 'immunotherapy': [681], 'leads': [682], 'clearance': [684], 'early,': [686], 'late,': [689], 'via': [693], 'proteasome.Neuron.': [695], '2004;': [696, 1608, 3206], '43:': [697], '321-332Abstract': [698], 'Full': [699, 701, 4205, 4207], 'Text': [700, 702, 4206, 4208], 'PDF': [703, 4209], '(739)': [706], 'Previously': [709], 'we': [710, 794, 975, 2335], 'shown': [712, 4318], 'intracerebral': [714], 'Aβ-containing': [718, 799, 1070, 3413, 3697, 4341], 'human': [719, 1207, 1729, 3249, 3401], 'murine': [721], 'induces': [724], 'cerebral': [725, 774, 951, 1529, 1603, 3142, 3201, 3750], 'amyloidosis': [726], 'young,': [728], 'predepositing': [729], 'precursor': [731, 1244, 1912, 4155], 'protein': [732, 1245, 1913, 2847, 4156], '(APP23)': [733], 'mice.6Meyer-Luehmann': [735], 'Coomaraswamy': [737, 914, 1492, 3105, 3713], 'Bolmont': [739, 916, 1494, 3107, 3715], 'T': [740, 917, 1495, 3108, 3716], 'Kaeser': [741, 918, 1496, 3109, 3717], 'Schaefer': [743, 920, 1498, 3111, 3719], 'Kilger': [745, 922, 1500, 3113, 3721], 'Neuenschwander': [747, 924, 1502, 3115, 3723], 'Abramowski': [749, 926, 1212, 1504, 1574, 3117, 3172, 3725, 4123], 'Frey': [751, 928, 1226, 1506, 3119, 3727, 4137], 'P': [752, 758, 929, 935, 1117, 1143, 1227, 1507, 1513, 1565, 2556, 2582, 2789, 2815, 2949, 2975, 3120, 3126, 3163, 3474, 3532, 3580, 3728, 3734, 4138], 'Jaton': [753, 930, 1508, 3121, 3729], 'AL': [754, 931, 1509, 3122, 3730], 'Vigouret': [755, 932, 1510, 3123, 3731], 'JM': [756, 933, 1511, 3124, 3732], 'Paganetti': [757, 934, 1228, 1512, 3125, 3733, 4139], 'Walsh': [759, 936, 1514, 3127, 3735], 'DM': [760, 937, 1515, 3128, 3736], 'Mathews': [761, 938, 1516, 1587, 3129, 3185, 3737], 'PM': [762, 939, 1517, 1588, 3130, 3186, 3738], 'Ghiso': [763, 940, 1518, 3131, 3739], 'Staufenbiel': [765, 942, 1238, 1520, 1585, 1672, 1898, 3133, 3183, 3741, 4149, 4184], 'Walker': [767, 944, 1522, 1896, 3135, 3743], 'LC': [768, 945, 1523, 3136, 3744], 'Jucker': [769, 946, 1234, 1524, 1589, 1900, 3137, 3187, 3745, 4145, 4186], 'Exogenous': [771, 948, 1526, 3139, 3747], 'beta-amyloidogenesis': [775, 952, 1530, 3143, 3751], 'governed': [777, 954, 1532, 3145, 3753], 'agent': [779, 956, 1534, 3147, 3755], 'host.Science.': [781, 958, 1536, 3149, 3757], '313:': [783, 960, 1538, 3151, 3759], '1781-1784Crossref': [784, 961, 1539, 3152, 3760], '(802)': [787, 964, 1542, 3155, 3763], 'In': [790, 1997, 2668, 2871, 3341, 3655, 3931, 4059, 4097], 'examined': [795], 'whether': [796, 3781], 'same': [798, 2339], 'would': [802], 'mutated': [810], 'thus': [815], 'confirm': [816, 4221], 'expand': [818, 4223], 'synthetic': [823, 876, 4400, 4489], 'mice.4Götz': [831], 'However,': [862, 3666, 3826, 4444], 'contrast': [864, 3342], 'latter': [867, 4001], 'concentration': [873, 902, 4494], 'gave': [881], 'rise': [882], 'host': [888, 3289], 'at': [889, 900, 1173, 1456, 1466, 1481, 1939, 2183, 2637, 3689, 3827, 4491], 'site,': [892, 3504], 'extract': [898, 1071, 1432, 2619, 3083, 3219, 3321, 3347, 3450, 3467, 3525, 3584, 3596, 4342, 4357], 'low': [901, 2184], 'form': [906], 'host.6Meyer-Luehmann': [912], 'complement': [968], 'exogenous': [970], 'crossbred': [977, 1201], '(genetic)': [994], 'expression': [995, 3399], 'APP/Aβ.': [997], 'similar': [999, 2769, 2895, 2929, 3775, 4115, 4383], 'cross': [1000], 'breeding': [1001], 'strategy': [1002], 'has': [1003, 4393], 'previously': [1004, 1489, 2932], 'been': [1005, 4394], 'reported': [1006], 'selected': [1012], 'Our': [1061], 'infusion': [1067, 2620, 3694, 4398], 'Heterozygous': [1085], 'wild-type': [1091, 3592], 'littermate': [1092, 1429, 3071, 3820], 'controls': [1093], 'used.': [1095, 3233], 'obtained': [1099, 1985], 'backcrossing': [1101], 'original': [1103, 2665, 2772], 'P301L': [1104, 1187, 2476, 2626, 2666, 2775, 2934], '(JNPL3': [1107], 'mice)7Lewis': [1108], 'Rockwood': [1112, 2551, 2784, 2944], 'Melrose': [1114, 2553, 2786, 2946], 'H': [1115, 2554, 2787, 2947], 'Nacharaju': [1116, 2555, 2788, 2948], 'Van': [1118, 2557, 2790, 2950], 'Slegtenhorst': [1119, 2558, 2791, 2951], 'Gwinn-Hardy': [1121, 2560, 2793, 2953], 'K': [1122, 1131, 1225, 1579, 2561, 2570, 2794, 2803, 2954, 2963, 3177, 4136], 'Paul': [1123, 2562, 2795, 2955], 'Murphy': [1124, 2563, 2796, 2956], 'Baker': [1126, 2565, 2798, 2958], 'Yu': [1128, 2567, 2800, 2960], 'X': [1129, 2568, 2801, 2961], 'Duff': [1130, 2569, 2802, 2962], 'Davies': [1142, 2581, 2814, 2974], 'Neurofibrillary': [1146, 2585, 2818, 2978], 'amyotrophy': [1148, 2587, 2820, 2980], 'progressive': [1150, 2589, 2822, 2982], 'motor': [1151, 2590, 2823, 2983], 'disturbance': [1152, 2591, 2824, 2984], '(P301L)': [1157, 2596, 2829, 2989], 'protein.Nat': [1159, 2598, 2831, 2991], 'Genet.': [1160, 2599, 2832, 2992], '2000;': [1161, 2600, 2833, 2993], '25:': [1162, 2601, 2834, 2994], '402-405Crossref': [1163, 2602, 2835, 2995], '(1160)': [1166, 2605, 2838, 2998], 'C57BL/6J': [1170, 2633], 'least': [1174, 2638], 'seven': [1175, 2159, 2639], 'generations.': [1176], 'JNPL3': [1177], 'express': [1179], 'shortest': [1181, 3247], 'four-repeat': [1182], '(4R0N)': [1183], 'mutation': [1188], 'under': [1189], 'mouse': [1193, 1247, 1420, 1447, 1599, 3197, 3231, 3589, 3601, 4158, 4347, 4362, 4412], 'prion': [1194], 'promoter.': [1195], 'KM670/671NL': [1208], 'APP.8Sturchler-Pierrat': [1210], 'Duke': [1214, 4125], 'Wiederhold': [1216, 1894, 4127], 'KH': [1217, 1895, 4128], 'Mistl': [1218, 4129], 'Rothacher': [1220, 4131], 'Ledermann': [1222, 4133], 'B': [1223, 1241, 1665, 4134, 4152, 4183], 'Burki': [1224, 1578, 3176, 4135], 'PA': [1229, 4140], 'Waridel': [1230, 4141], 'Calhoun': [1232, 1888, 4143], 'ME': [1233, 4144], 'Probst': [1236, 4147, 4180], 'Sommer': [1240, 4151, 4182], 'Two': [1242, 4153], 'models': [1248, 4159], 'Alzheimer': [1250, 4161], 'disease-like': [1251, 4162], 'pathology.Proc': [1252, 4163], 'Natl': [1253, 4164], 'Acad': [1254, 2022, 4165], 'Sci': [1255, 2023, 4166], 'USA.': [1256, 4167], '1997;': [1257, 1694, 4168], '94:': [1258, 4169], '13287-13292Crossref': [1259, 4170], '(1265)': [1262, 4173], 'Host': [1265, 1844], 'anesthetized': [1268], 'mixture': [1271], 'ketamine': [1273], '(10': [1274], 'mg/kg': [1275, 1281], 'body': [1276, 1282], 'weight)': [1277, 1283], 'xylazine': [1279], '(20': [1280, 2263], 'saline.': [1285], 'Unilateral': [1286], 'stereotaxic': [1287], 'injections': [1288], '2.5': [1290], 'μl': [1291], 'placed': [1296], '5-μl': [1299], 'Hamilton': [1300], 'syringe': [1301], 'into': [1302, 3263, 3385, 4402], 'right': [1304, 3265], 'neocortex': [1305, 1413, 1909, 2369, 3060, 3983], '(A/P,': [1306, 1319], '−2.5': [1307, 1320, 2107], 'mm': [1308, 1321, 2097, 2101, 2108, 2116, 2124, 2133, 2362, 2366, 2372, 2380, 2390], 'bregma;': [1310, 1323], 'L,': [1311, 1324], '−2.0': [1312, 1325], 'mm;': [1313, 1326], 'D/V,': [1314, 1327], '−0.8': [1315], 'mm)': [1316, 2137, 2394], '−1.8': [1328], 'mm).': [1329], 'Injection': [1330], 'speed': [1331], '1.25': [1333], 'μl/minute,': [1334], 'needle': [1337, 3771], 'kept': [1339], 'place': [1341], 'additional': [1344, 3216], '3': [1345, 2732], 'minutes': [1346, 1487], 'before': [1347], 'it': [1348], 'slowly': [1350], 'withdrawn.': [1351], 'surgical': [1353], 'area': [1354, 2040, 2294, 2298, 2450, 3441], 'cleaned': [1356], 'sterile': [1358, 1470], 'saline,': [1359], 'incision': [1362], 'sutured.': [1364], 'Operated': [1365], 'animals': [1366], 'monitored': [1368], 'weekly': [1369], 'their': [1371, 2722], 'cages': [1372], 'signs': [1374, 2744, 3044], 'behavioral': [1376], 'changes.': [1377], 'seizure': [1379], 'activity': [1380], 'apparent': [1382, 2682], 'during': [1383], 'infusion.': [1387], 'All': [1388, 2224, 3280, 3415], 'experiments': [1389], 'compliance': [1392], 'protocols': [1394], 'approved': [1395], 'local': [1398], 'animal': [1399], 'care': [1400], 'use': [1402], 'committee.': [1403], 'Brain': [1404, 1431, 2193, 3054], 'prepared': [1407, 1435, 3057], 'first': [1409], 'dissecting': [1410], 'out': [1411], '24-month-old': [1416], 'female': [1419, 1427, 1446, 2478, 2669, 2712, 3278, 3303, 3886], '(APP23': [1421], 'extract)': [1422], 'matched': [1426], 'control.': [1430], 'brainstem': [1438, 2130, 3041], 'diencephalon': [1440, 3225], '21.5-month-old': [1443], '(B6/P301L': [1448], 'extract).': [1449], 'Tissue': [1450], 'samples': [1451, 1616, 1774], 'frozen': [1453, 1551], 'stored': [1455], '−80°C': [1457], 'until': [1458], 'use.': [1459], 'tissue': [1461], 'pieces': [1462], 'then': [1464, 1648], 'homogenized': [1465], '10%': [1467, 1651, 1783], '(w/v)': [1468, 1632, 1637, 1643], 'phosphate-buffered': [1471], 'saline': [1472], '(PBS),': [1473], 'vortexed,': [1474], 'sonicated': [1475], '5': [1477, 1486], 'seconds,': [1478], 'centrifuged': [1480], '3000': [1482], '×': [1483, 3451, 3805, 3870, 3963], 'g': [1484], 'described.6Meyer-Luehmann': [1490], 'supernatant': [1546], 'recovered': [1548], 'immediately': [1550], '(−80°C).': [1552], 'determine': [1554, 1767], 'levels': [1556, 1769, 3086], 'homogenates,9Herzig': [1560], 'MC': [1561, 3159], 'Winkler': [1562, 3160], 'DT': [1563, 3161], 'Burgermeister': [1564, 3162], 'Pfeifer': [1566, 3164], 'Kohler': [1568, 3166], 'Schmidt': [1570, 3168], 'SD': [1571, 3169], 'Danner': [1572, 3170], 'Sturchler-Pierrat': [1576, 3174], 'Duinen': [1581, 3179], 'SG': [1582, 3180], 'Maat-Schieman': [1583, 3181], 'ML': [1584, 3182], 'targeted': [1593, 3191], 'vasculature': [1596, 3194], 'model': [1600, 3198], 'hereditary': [1602, 3200], 'hemorrhage': [1604, 3202], 'amyloidosis.Nat': [1606, 3204], 'Neurosci.': [1607, 1916, 3205], '7:': [1609, 3207], '954-960Crossref': [1610, 3208], '(341)': [1613, 3211], 'diluted': [1618], '1': [1619, 2730], '4': [1621], 'sample': [1623, 1778], 'buffer': [1624, 1779, 1860], '[0.48': [1625], 'mol/L': [1626, 1629, 1654], 'Bis-Tris,': [1627], '0.21': [1628], 'Bicine,': [1630], '1.32%': [1631], 'sodium': [1633, 1656, 1784, 1858], 'dodecyl': [1634, 1657, 1785], 'sulfate,': [1635], '20%': [1636], 'sucrose,': [1638], '3.33%': [1639], '(v/v)': [1640], '2-mercaptoethanol,': [1641], '0.0053%': [1642], 'bromophenol': [1644], 'blue].': [1645], 'Samples': [1646], 'subjected': [1649], 'Bicine-Tris': [1652], '8': [1653], 'urea': [1655], 'sulfate-polyacrylamide': [1658, 1786], 'gel': [1659], 'electrophoresis.10Wiltfang': [1660], 'Smirnov': [1662], 'Schnierstein': [1664], 'Kelemen': [1666], 'Matthies': [1668], 'U': [1669], 'Klafki': [1670], 'HW': [1671], 'Huther': [1674], 'Ruther': [1676], 'Kornhuber': [1678], 'Improved': [1680], 'electrophoretic': [1681], 'separation': [1682, 4039], 'immunoblotting': [1684], 'beta-amyloid': [1686], '(A': [1687], 'beta)': [1688], 'peptides': [1689], '1-40,': [1690], '1-42,': [1691], '1-43.Electrophoresis.': [1693], '18:': [1695], '527-532Crossref': [1696], '(122)': [1699], 'Synthetic': [1702], 'Aβ1-40': [1703, 3094], '1-42': [1705], '(Bachem,': [1706], 'Bubendorf,': [1707], 'Switzerland)': [1708, 1953], 'used': [1710, 2337], 'controls.': [1712], 'Proteins': [1713, 1789], 'transferred': [1715, 1792], 'onto': [1716, 1758, 1793, 1839], 'polyvinylidene': [1718, 1795], 'difluoride': [1719, 1796], 'membrane': [1720, 1797], 'probed': [1722, 1799], 'monoclonal': [1724, 1801, 1928], 'antibody': [1725, 1738, 1802, 1821, 1930, 1945, 1964, 1975], '6E10': [1726], 'specific': [1727, 1935], '(diluted': [1731, 1804], '1:500;': [1732], 'Covance,': [1733], 'Emeryville,': [1734], 'CA).': [1735, 1747, 2289], 'secondary': [1737, 1820], 'horseradish': [1740, 1823], 'peroxidase-conjugated': [1741, 1824], 'goat': [1742], 'anti-mouse': [1743], 'IgG': [1744, 1827], '(Chemicon,': [1745], 'Temecula,': [1746], 'Bands': [1748, 1832], 'visualized': [1750, 1834], 'using': [1751, 1835, 2074, 2232, 2278, 2302], 'SuperSignal': [1752, 1836], '(Pierce,': [1753], 'Rockford,': [1754], 'IL)': [1755], 'developed': [1757, 1838, 3308], 'Kodak': [1759, 1840], 'X-OMAT': [1760, 1841], 'AR': [1761, 1842], 'film': [1762], '(Eastman-Kodak,': [1763], 'Rochester,': [1764], 'NY).': [1765], 'homogenates,': [1773], 'dissolved': [1776], 'run': [1781], 'Tris-tricine': [1787], 'gels.': [1788], 'electrophoretically': [1791], 'HT7': [1803], '1:1000,': [1805], 'recognizes': [1806], 'amino': [1807], 'acids': [1808], '159': [1809], '163': [1811], 'phosphorylated': [1814, 1938], 'nonphosphorylated': [1816], 'epitopes;': [1817], 'Pierce).': [1818], 'sheep': [1825], 'anti-rabbit': [1826], '(NA931;': [1828], 'Amersham-Biosciences,': [1829], 'Uppsala,': [1830], 'Sweden).': [1831], 'film.': [1843], 'deeply': [1847], 'anesthetized,': [1848], 'they': [1850, 3782], 'perfused': [1852], 'transcardially': [1853], '4%': [1855], 'paraformaldehyde': [1856], 'phosphate': [1859], '(pH': [1861], '7.4)': [1862], 'processed': [1864], 'paraffin': [1866, 1875], 'embedding.': [1867], 'Immunohistological': [1868], 'stainings': [1869], 'done': [1871], '5-μm': [1873], 'coronal': [1874], 'sections': [1876, 1999, 2146, 2403], 'throughout': [1877, 3327], 'interest': [1880, 2047], '(see': [1881, 2624], 'quantification),': [1882], 'according': [1883, 2186], 'standard': [1885], 'procedures.11Bondolfi': [1886], 'Ermini': [1890], 'Kuhn': [1892], 'HG': [1893], 'Amyloid-associated': [1902], 'neuron': [1903], 'loss': [1904], 'gliogenesis': [1906], 'mice.J': [1915], '22:': [1918], '515-522Crossref': [1919], 'following': [1924], 'antibodies': [1925, 1983], 'used:': [1927], 'AT8': [1929, 2678, 3334, 3843], '(1:1000;': [1931, 1947, 1956, 1978], 'Innogenetics,': [1932], 'Gent,': [1933], 'Belgium)': [1934], 'ser-202': [1940], 'thr-205;': [1942], 'polyclonal': [1943, 1963, 1974], 'anti-Aβ': [1944], 'NT12': [1946], 'courtesy': [1948, 1957], 'P.': [1950], 'Paganetti,': [1951], 'Basel,': [1952], 'DW6': [1955], 'D.': [1959], 'Walsh,': [1960], 'Dublin,': [1961], 'UK);': [1962], 'GFAP': [1966], '(1:20,000;': [1967], 'Sigma': [1968], 'Aldrich,': [1969], 'St.': [1970], 'Louis,': [1971], 'MO);': [1972], 'Iba-1': [1977], 'Wako,': [1979], 'Neuss,': [1980], 'Germany).': [1981], 'Secondary': [1982], 'Vector': [1987], 'Laboratories,': [1988], 'Burlingame,': [1989], 'CA': [1990], '(Vectastain': [1991], 'ABC': [1992], 'kits),': [1993], 'peroxidase': [1995], 'staining.': [1996], 'addition': [1998], 'stained': [2001], 'histologically': [2002], 'silver-impregnation': [2004], 'Gallyas': [2007], 'protocol.12Gallyas': [2008], 'Silver': [2010], 'staining': [2011, 2221, 3445], 'changes': [2015, 2904], 'means': [2017], 'physical': [2019], 'development.Acta': [2020], 'Morphol': [2021], 'Hung.': [2024], '1971;': [2025], '19:': [2026], '1-8PubMed': [2027], 'For': [2030], 'selection': [2031], 'sampling': [2033, 2049, 2209, 2341, 2431], 'estimation': [2037, 2060], 'tau-immunopositive': [2039, 2297], 'fraction': [2041, 2299], 'stereological': [2048, 2059, 2340], 'rules': [2050], 'applied.13West': [2052], 'MJ': [2053], 'Slomianka': [2054], 'Gundersen': [2056], 'HJ': [2057], 'Unbiased': [2058], 'total': [2063], 'number': [2064], 'neurons': [2066, 2851], 'subdivisions': [2069], 'rat': [2072], 'optical': [2076], 'fractionator.Anat': [2077], 'Rec.': [2078], '1991;': [2079], '231:': [2080], '482-497Crossref': [2081], '(2643)': [2084], 'Every': [2087], '72nd': [2088], 'section': [2089, 2354], 'through': [2090, 2147, 2153, 2160, 2170, 2355, 2404, 2412, 2419], '(from': [2093, 2358], 'positions': [2094, 2359], 'AP': [2095, 2099, 2118, 2126, 2135, 2360, 2364, 2374, 2382, 2392], '−1.0': [2096, 2115, 2123, 2361, 2371, 2379], '−4.0': [2100, 2110, 2132, 2365, 2375, 2389], 'bregma),': [2103, 2368], '(AP': [2106, 2114, 2122, 2131, 2370, 2378, 2388], 'mm),': [2111, 2120, 2128, 2376, 2384], 'sensorimotor': [2112, 2162, 3568], '−3.5': [2119, 2127, 2383], 'amygdala': [2121, 2377, 2867, 2875, 3514, 3546, 3669, 3857, 3994, 4034], '−5.0': [2136], 'immunostained': [2139, 2396], 'AT8.': [2141], 'Therefore,': [2142, 2399], 'eight': [2143], 'nine': [2145], 'hippocampus,': [2149, 2863, 3849, 3936], 'four': [2150, 2400, 2411], 'five': [2152, 2402], 'cortex,': [2156, 2865, 3848, 4076], 'six': [2157], 'two': [2167, 2418, 4450], 'three': [2169, 2409], 'stem': [2173, 2387, 2422, 2857, 2878, 3223, 3574, 3648, 3862], 'analyzed': [2175, 2424, 3283], 'per': [2176, 2267, 2425], 'animal.': [2177, 2426], 'delineated': [2182], 'magnification': [2185], 'cytoarchitectural': [2188], 'criteria.14Paxinos': [2189], 'Mouse': [2192], 'Stereotaxic': [2195], 'Coordinates.': [2196], 'Academic': [2197], 'Press,': [2198], 'New': [2199], 'York2001Google': [2200], 'Within': [2202, 2729], 'section,': [2205], 'systematic': [2207, 2429], 'random': [2208, 2430], 'scheme': [2210], 'performed': [2212, 2301], 'capture': [2214], 'video': [2215], 'images': [2216, 2225, 2256, 2262, 2266, 2276, 2433], 'measurement': [2218], 'AT8-positive': [2220, 2258, 2349, 3444], '(percent': [2222], 'area).': [2223], 'captured': [2227, 2435], '×40': [2230], 'objective': [2231, 2439], 'Zeiss': [2234], 'Axioskop': [2235], 'microscope': [2236], '(Zeiss,': [2237], 'Göttingen,': [2238], 'Germany)': [2239], 'motorized': [2242], 'x-y-z': [2243], 'stage': [2244, 2750], 'coupled': [2245], 'Sony': [2248], 'CCD-IRIS': [2249], 'color': [2250, 2261], 'camera.': [2251], 'analyze': [2253], 'individual': [2255], 'burden,': [2259], '24-bit': [2260], '50': [2265], 'region)': [2269], 'converted': [2271, 2441], '8-bit': [2273, 2443], 'gray': [2274, 2444], 'scale': [2275, 2445], 'conversion': [2279], 'algorithms': [2280], 'associated': [2281], 'Adobe': [2283], 'Photoshop': [2284], 'CS': [2285], '(Adobe,': [2286], 'San': [2287], 'Jose,': [2288], 'Calculation': [2290], 'percent': [2293, 2449, 3440], 'occupied': [2295, 2451, 3442], 'public': [2304], 'domain': [2305], 'NIH': [2306], 'ImageJ.': [2307], 'Statistical': [2308, 2455], 'analysis': [2309, 2311, 2456, 2458, 3422, 3438, 3447, 3950], 'included': [2310, 2457], 'variance': [2313, 2460], 'posthoc': [2315, 2462, 3478], 'testing': [2316, 2463], 'help': [2319, 2466], 'Statistica': [2321, 2468], '5.0': [2322], '(StatSoft,': [2323], 'Tulsa,': [2324], 'OK).': [2325], 'assess': [2327], 'burden': [2329], 'brains,': [2334], 'described': [2343, 2931, 4395], 'above': [2344], 'assessment': [2347], 'deposits.': [2350], 'Briefly,': [2351], 'every': [2352], '144th': [2353], '−5.5': [2393], 'DW6.': [2398], 'neocortex,': [2408], 'one': [2416], 'Using': [2427], 'scheme,': [2432], '×20': [2438], 'calculating': [2447], 'Aβ-immunoreactive': [2453], 'pixels.': [2454], '5.0.': [2469], 'On': [2470], 'mixed': [2472, 2779, 2938], 'C57BL/DBA2/SW': [2473], 'background,': [2474], 'heterozygous': [2475, 3002, 3276], 'develop': [2480, 3922, 4064], '7': [2484], '11': [2486, 2497, 3292], 'age,': [2489, 2692, 2711, 2756, 3300], 'whereas': [2490], 'onset': [2492], 'males': [2494], '15': [2499], 'months.3Lewis': [2500], '7Lewis': [2547], 'minimize': [2609, 2614], 'immunological': [2610], 'consequences': [2611], 'genetic': [2615, 2634, 2939], 'variability': [2616, 3978], 'cross-breeding': [2623], 'below),': [2625], 'backcrossed': [2630], 'background': [2635], 'times': [2640], '(thereafter': [2641], 'termed': [2642], 'mice;': [2644], 'see': [2645], 'Materials': [2646], 'Methods).': [2648], 'Surprisingly,': [2649], 'substantial': [2654, 2842], 'delay': [2655], '(assessed': [2675, 3331, 3840], 'phosphorylation-dependent': [2677, 3333, 3842], 'antibody)': [2679, 3844], 'group': [2685, 2752, 3019], '11-': [2687], '12-month-old': [2689], '(mean': [2691, 2755], '11.5': [2693], '±': [2694, 2758, 3025, 3890, 3905], '0.3': [2695], 'months;': [2696, 2760, 3027], 'n': [2697, 2761, 3028], '=': [2698, 2762, 3029, 3472, 3530, 3578], '5;': [2699], 'indicated': [2700, 3480], 'SEM)': [2703, 3482], '(Figure': [2704, 2868, 2879, 3072, 3098, 3254, 3312, 3356, 3377, 3394, 3423, 3649, 3684, 3929, 3947, 4007, 4026, 4057, 4095], '1,': [2705, 2869, 2880, 3313], 'A–E).': [2706, 3314], 'At': [2707, 2748, 3298], '∼18': [2708], 'became': [2715], 'symptomatic': [2716], 'unable': [2719], 'spread': [2721], 'hindlimbs': [2723], 'lifted': [2725], 'tail.': [2728], 'onset,': [2736], 'showed': [2738, 3548], 'weight': [2739], 'loss,': [2740], 'there': [2742, 3973, 4035, 4077], 'dystonic': [2746], 'posture.': [2747], 'another': [2751], '19.8': [2757], '0.6': [2759], '6)': [2763, 3030], 'sacrificed': [2765], 'analyzed.': [2767], 'Neuropathologically,': [2768], 'report': [2773], 'background,7Lewis': [2780], 'amount': [2843], 'accumulated': [2848], 'affected': [2850], 'spinal': [2854, 2873, 2916, 3038], 'cord,': [2855, 2874], 'nuclei,': [2858], 'F–J).': [2870], 'I': [2881], 'J),': [2883], 'majority': [2885], '(∼80': [2886], '90%)': [2888], 'these': [2890, 3416, 3941], 'Gallyas-positive': [2894, 3946], 'found': [2899, 3565], 'These': [2903, 4367], 'followed': [2906, 3991], 'axonal': [2908], 'descending': [2911], 'fiber': [2912], 'tracts': [2913], 'cord': [2917, 3039], 'neurogenic': [2920], 'atrophy': [2921], 'skeletal': [2923], 'muscles': [2924], '(not': [2925, 4113], 'shown),': [2926, 3707], 'all': [2927, 3777, 4098], 'overall': [2928], 'background.7Lewis': [2940], 'Male': [3001], 'show': [3007], 'any': [3008, 3353, 3391, 3690, 3702, 3958], 'clinical': [3009], 'symptoms': [3010], 'up': [3011, 3925], '30': [3013], 'age.': [3016, 3297], 'Consistently,': [3017], '27-month-old': [3021], '(26.5': [3024], '1.1': [3026], 'little': [3033], 'no': [3043, 4004, 4079], 'other': [3049], 'homogenates': [3055], 'aged,': [3062], 'aged-matched': [3068], '2,': [3073, 3255], 'B).': [3076, 3340], 'Western': [3077, 3237], 'blotting': [3078], '∼1': [3088], '10': [3090], 'ng/μl': [3091], 'more': [3093], 'Aβ1-42': [3097, 4401], '2D)': [3099], 'consistent': [3100, 3708], 'findings.6Meyer-Luehmann': [3103], '9Herzig': [3158], 'As': [3214], 'control,': [3217], 'By': [3234], 'immunohistochemistry': [3235], 'blotting,': [3238], 'presence': [3240], '4-repeat': [3248], 'isoform': [3251], 'demonstrated': [3253], 'D).': [3258], 'Extracts': [3259], 'unilaterally': [3261], 'overlying': [3268], 'somatosensory': [3269, 4075, 4404], '(5-': [3273], '6-month-old)': [3275], '6': [3284], 'later,': [3286], 'ie,': [3287], '12': [3294], 'uninjected': [3301], 'yet': [3307], 'significant': [3309, 3376, 3459, 3520, 3831], 'Intracerebral': [3315], 'Aβ-rich': [3319], 'robust': [3323, 3835, 4107], 'antibody;': [3335], 'Figure': [3336, 3380, 3605, 3652, 3909], '3,': [3337, 3357], 'PBS': [3349, 3470, 3528, 3553, 3786], 'E).': [3360], 'Modest': [3361], 'extract,': [3370, 4355], 'statistically': [3375], '3D': [3378], '4A).': [3381], '3F),': [3395], 'indicating': [3396], 'necessary': [3404], 'extracts.': [3414, 3789], 'observations': [3417, 4368], 'supported': [3419], 'quantitative': [3421], '4A).Figure': [3424], '4Tau': [3425], 'various': [3429], 'tg': [3434], 'A:': [3436], 'Stereological': [3437, 3949], '(two-way': [3446], 'variance,': [3449], 'hemisphere)': [3452], '(HPS)': [3456], 'confirms': [3457], '(+n': [3471, 3529], '5/group;': [3473, 3579], '<': [3475, 3490, 3533, 3541, 3555], '0.0001;': [3476], 'Newmann-Keuls': [3477], 'tests;': [3479], 'contralateral': [3487, 3538, 3679], 'site': [3488, 3539, 3619, 3683], '(*P': [3489, 3540], '0.0001).': [3491], 'Tau': [3492, 3623, 4009], 'occurred': [3495, 3678], 'some': [3497, 3549], 'away': [3500, 3632], '(ENT)': [3510], '(B)': [3511], '(AMG)': [3515], '(C).': [3516], 'Analysis': [3517], 'again': [3518], '5/group,': [3531], '0.0001)': [3534], '0.05),': [3542], '(P': [3554], '0.001).': [3556], 'E:': [3559], '(CTX)': [3570], '(D)': [3571], '(BS)': [3575], '(E)': [3576], '(n': [3577], '>': [3581], '0.05).': [3582], 'APP23,': [3583], 'brain;': [3590], 'WT,': [3591], 'extract;': [3594], 'P301L,': [3595], 'brain.View': [3602], 'Large': [3603], 'Image': [3604], 'ViewerDownload': [3606], 'Hi-res': [3607], 'image': [3608], 'Download': [3609], '(PPT)': [3610], 'around': [3616], 'neocortex.': [3622], 'however,': [3625, 3972, 4031], 'farther': [3631], 'sites,': [3636], '3A': [3650], '4,': [3653], 'B–E).': [3654], 'most': [3656], 'appeared': [3660], 'confined': [3661], 'hemisphere.': [3665], 'induction,': [3671], 'albeit': [3672, 4388], 'lesser': [3675], 'degree,': [3676], '4C).': [3685], 'Immunostaining': [3686], 'time': [3691, 3829], 'reveal': [3701, 3957], '(data': [3705], 'studies.6Meyer-Luehmann': [3711], 'Gliosis': [3766], 'limited': [3768], 'track': [3772], 'among': [3776], 'independent': [3779], 'Before': [3800], 'deposition,': [3802, 3833], 'exhibit': [3810], '(results': [3823], 'shown).': [3825], 'increase': [3836], 'lower': [3853], 'extent': [3854], 'noted': [3865], 'This': [3881], 'true': [3883], '(21.6': [3889], '0.9': [3891], 'old;': [3893, 3908], 'data': [3894], 'shown)': [3896, 4114], 'particularly': [3898], 'appreciable': [3899], 'male': [3901, 3916, 3969], '(27.6': [3904], '0.7': [3906], '5,': [3910, 4027], 'C)': [3913], 'because': [3914], 'do': [3920], 'age': [3928], '5B).': [3930], 'subset': [3938], '(∼50%)': [3939], '5I).': [3948], 'load': [3954, 4094], 'differences': [3959, 4447], 'double': [3961], 'Notably,': [3971], 'great': [3976], 'region-specific': [3977], 'revealing': [3986], 'highest': [3988], 'load,': [3990], 'stem,': [3998], 'showing': [4002], 'virtually': [4003], '5D).': [4008], 'typically': [4012], 'vicinity': [4016], 'congophilic': [4018, 4100], 'plaques': [4019, 4193], 'F);': [4030], 'clear': [4038], 'basolateral': [4046], 'part': [4047], 'dorso-': [4053], 'ventrolateral': [4055], 'parts': [4056], '5H).': [4058], 'prone': [4062], 'piriform': [4073], 'despite': [4090], '5G).': [4096], 'surrounded': [4104], 'activation': [4108], 'microglia': [4110, 4190], 'astroglia': [4112], 'mice.8Sturchler-Pierrat': [4121], '15Stalder': [4176], 'Phinney': [4178], 'Association': [4188], 'brains': [4195], 'mice.Am': [4199], 'Pathol.': [4201], '1999;': [4202], '154:': [4203], '1673-1684Abstract': [4204], '(274)': [4212], 'undertaken': [4219], 'demonstrating': [4228], 'link': [4230], 'pathology.3Lewis': [4238], 'We': [4316], 'be': [4323], 'brain,': [4348], 'PBS,': [4352], 'lesions.': [4366], 'key': [4373], 'effective': [4376], 'model.4Götz': [4413], 'several': [4445], 'important': [4446], 'emerge.': [4452], '1)': [4453], 'Gotz': [4454], 'colleagues4Götz': [4456], '(1': [4495], 'μg/μl),': [4496], 'readily': [4502], 'detectable': [4503]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2076482846', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 22}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 18}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2025-01-13T02:20:12.900750', 'created_date': '2016-06-24'}