Title: Effects of intrathecal ACTH on opiate A algesia in the rat
Abstract: The effects of administration of opiates and ACTH onto the lumbar spinal cord of rats were investigated. ACTH, morphine and β-endorphin were administered to the lumbar spinal cord via chronically implanted spinal catheters. Effects on nociceptive thresholds using the tail-flick test were observed. Intrathecal morphine and β-endorphin caused analgesia whereas effects of intrathecal ACTH were variable. About half the animals showed small increases in tail-flick latency with intrathecal ACTH, the other half showing either decreases in tail-flick latency or no effect. In contrast, intrathecal ACTH consistently reversed the analgesia caused by either intrathecal morphine or β-endorphin. The results are discussed in terms of interactions between ACTH and opiates.
Publication Year: 1982
Publication Date: 1982-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 24
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