Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2076367236', 'doi': 'https://doi.org/10.1200/jco.2010.31.1175', 'title': 'Unraveling the Molecular Pathophysiology of Myelodysplastic Syndromes', 'display_name': 'Unraveling the Molecular Pathophysiology of Myelodysplastic Syndromes', 'publication_year': 2011, 'publication_date': '2011-01-11', 'ids': {'openalex': 'https://openalex.org/W2076367236', 'doi': 'https://doi.org/10.1200/jco.2010.31.1175', 'mag': '2076367236', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21220588', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3969457'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1200/jco.2010.31.1175', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S15137598', 'display_name': 'Journal of Clinical Oncology', 'issn_l': '0732-183X', 'issn': ['0732-183X', '1527-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3969457?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062180760', 'display_name': 'Rafael Bejar', 'orcid': 'https://orcid.org/0000-0002-5603-4598'}, 'institutions': [{'id': 'https://openalex.org/I4210157861', 'display_name': 'Harvard Stem Cell Institute', 'ror': 'https://ror.org/04kj1hn59', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I4210157861']}, {'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rafael Bejar', 'raw_affiliation_strings': ["From Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston; Harvard Stem Cell Institute, Cambridge, MA; and Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY."], 'affiliations': [{'raw_affiliation_string': "From Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston; Harvard Stem Cell Institute, Cambridge, MA; and Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY.", 'institution_ids': ['https://openalex.org/I4210157861', 'https://openalex.org/I1283280774', 'https://openalex.org/I136199984', 'https://openalex.org/I4210117453', 'https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025660159', 'display_name': 'Ross L. Levine', 'orcid': 'https://orcid.org/0000-0002-7884-1905'}, 'institutions': [{'id': 'https://openalex.org/I4210157861', 'display_name': 'Harvard Stem Cell Institute', 'ror': 'https://ror.org/04kj1hn59', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I4210157861']}, {'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}, {'id': 'https://openalex.org/I4210161994', 'display_name': 'Dana-Farber Brigham Cancer Center', 'ror': 'https://ror.org/05rgrbr06', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I4210117453', 'https://openalex.org/I4210161994', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I4210097513', 'display_name': "Women's Hospital", 'ror': 'https://ror.org/00raa0r66', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097513', 'https://openalex.org/I4210114445']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ross Levine', 'raw_affiliation_strings': ["From Brigham and Women's Hospital and Dana-Farber Cancer Institute,", "From Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston; Harvard Stem Cell Institute, Cambridge, MA; and Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY.", 'Harvard Medical School, Boston; Harvard Stem Cell Institute, Cambridge, MA; and', "Women's Hospital, Karp Research Building, CHRB 05.211, 1 Blackfan Cir, Boston, MA 02115;"], 'affiliations': [{'raw_affiliation_string': "From Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston; Harvard Stem Cell Institute, Cambridge, MA; and Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY.", 'institution_ids': ['https://openalex.org/I4210157861', 'https://openalex.org/I1283280774', 'https://openalex.org/I136199984', 'https://openalex.org/I4210117453', 'https://openalex.org/I1334819555']}, {'raw_affiliation_string': "From Brigham and Women's Hospital and Dana-Farber Cancer Institute,", 'institution_ids': ['https://openalex.org/I4210161994', 'https://openalex.org/I1283280774', 'https://openalex.org/I4210117453']}, {'raw_affiliation_string': 'Harvard Medical School, Boston; Harvard Stem Cell Institute, Cambridge, MA; and', 'institution_ids': ['https://openalex.org/I4210157861', 'https://openalex.org/I136199984']}, {'raw_affiliation_string': "Women's Hospital, Karp Research Building, CHRB 05.211, 1 Blackfan Cir, Boston, MA 02115;", 'institution_ids': ['https://openalex.org/I4210097513']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070668676', 'display_name': 'Benjamin L. Ebert', 'orcid': 'https://orcid.org/0000-0003-0197-5451'}, 'institutions': [{'id': 'https://openalex.org/I4210157861', 'display_name': 'Harvard Stem Cell Institute', 'ror': 'https://ror.org/04kj1hn59', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I4210157861']}, {'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}, {'id': 'https://openalex.org/I48633490', 'display_name': 'Mass General Brigham', 'ror': 'https://ror.org/04py2rh25', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Benjamin L. Ebert', 'raw_affiliation_strings': ["From Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston; Harvard Stem Cell Institute, Cambridge, MA; and Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY.", 'Partners HealthCare'], 'affiliations': [{'raw_affiliation_string': "From Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston; Harvard Stem Cell Institute, Cambridge, MA; and Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY.", 'institution_ids': ['https://openalex.org/I4210157861', 'https://openalex.org/I1283280774', 'https://openalex.org/I136199984', 'https://openalex.org/I4210117453', 'https://openalex.org/I1334819555']}, {'raw_affiliation_string': 'Partners HealthCare', 'institution_ids': ['https://openalex.org/I48633490']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 8, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.971, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 304, 'citation_normalized_percentile': {'value': 0.998282, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '29', 'issue': '5', 'first_page': '504', 'last_page': '515'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11628', 'display_name': 'Myeloproliferative Neoplasms: Diagnosis and Treatment', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780817109', 'wikidata': 'https://www.wikidata.org/wiki/Q954625', 'display_name': 'Myelodysplastic syndromes', 'level': 3, 'score': 0.68235093}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.6634835}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.51960224}, {'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.4941781}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.45579278}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.45130974}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44166124}, {'id': 'https://openalex.org/C2779282312', 'wikidata': 'https://www.wikidata.org/wiki/Q1956561', 'display_name': 'Myeloid', 'level': 2, 'score': 0.43459886}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.39852303}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3943914}, {'id': 'https://openalex.org/C2780007613', 'wikidata': 'https://www.wikidata.org/wiki/Q546523', 'display_name': 'Bone marrow', 'level': 2, 'score': 0.3542472}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.31573555}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.31460243}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.20727143}], 'mesh': [{'descriptor_ui': 'D009190', 'descriptor_name': 'Myelodysplastic Syndromes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001853', 'descriptor_name': 'Bone Marrow', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001853', 'descriptor_name': 'Bone Marrow', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002869', 'descriptor_name': 'Chromosome Aberrations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016158', 'descriptor_name': 'Genes, p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009190', 'descriptor_name': 'Myelodysplastic Syndromes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009190', 'descriptor_name': 'Myelodysplastic Syndromes', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1200/jco.2010.31.1175', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S15137598', 'display_name': 'Journal of Clinical Oncology', 'issn_l': '0732-183X', 'issn': ['0732-183X', '1527-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3969457', 'pdf_url': 'https://europepmc.org/articles/pmc3969457?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969457', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21220588', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3969457', 'pdf_url': 'https://europepmc.org/articles/pmc3969457?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.71, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 142, 'referenced_works': ['https://openalex.org/W1004685331', 'https://openalex.org/W11426206', 'https://openalex.org/W128877445', 'https://openalex.org/W140845169', 'https://openalex.org/W1489375841', 'https://openalex.org/W1493823666', 'https://openalex.org/W1851609974', 'https://openalex.org/W187238933', 'https://openalex.org/W1929762568', 'https://openalex.org/W1963736125', 'https://openalex.org/W1965868565', 'https://openalex.org/W1966001673', 'https://openalex.org/W1966530560', 'https://openalex.org/W1969821131', 'https://openalex.org/W1970390241', 'https://openalex.org/W1972297113', 'https://openalex.org/W1972475837', 'https://openalex.org/W1972527095', 'https://openalex.org/W1974079495', 'https://openalex.org/W1979627226', 'https://openalex.org/W1981965189', 'https://openalex.org/W1983602304', 'https://openalex.org/W1983611328', 'https://openalex.org/W1986987869', 'https://openalex.org/W1988633385', 'https://openalex.org/W1991753383', 'https://openalex.org/W1991766825', 'https://openalex.org/W1993185007', 'https://openalex.org/W1993670794', 'https://openalex.org/W1995675594', 'https://openalex.org/W1997127542', 'https://openalex.org/W1997184614', 'https://openalex.org/W1997629459', 'https://openalex.org/W1998598673', 'https://openalex.org/W1999813105', 'https://openalex.org/W2001048486', 'https://openalex.org/W2001103347', 'https://openalex.org/W2004029643', 'https://openalex.org/W2004730826', 'https://openalex.org/W2005458309', 'https://openalex.org/W2006534695', 'https://openalex.org/W2010572463', 'https://openalex.org/W2011723750', 'https://openalex.org/W2012847858', 'https://openalex.org/W2016055354', 'https://openalex.org/W2016420793', 'https://openalex.org/W2016531290', 'https://openalex.org/W2017203219', 'https://openalex.org/W2018240559', 'https://openalex.org/W2019828567', 'https://openalex.org/W2020008959', 'https://openalex.org/W2020160910', 'https://openalex.org/W2023761285', 'https://openalex.org/W2024373518', 'https://openalex.org/W2025391163', 'https://openalex.org/W2028053531', 'https://openalex.org/W2028442715', 'https://openalex.org/W2031720246', 'https://openalex.org/W2032703975', 'https://openalex.org/W2034477988', 'https://openalex.org/W2035543326', 'https://openalex.org/W2039234691', 'https://openalex.org/W2043216151', 'https://openalex.org/W2045204068', 'https://openalex.org/W2046140083', 'https://openalex.org/W2046417042', 'https://openalex.org/W2057867563', 'https://openalex.org/W2061653945', 'https://openalex.org/W2068989596', 'https://openalex.org/W2072713007', 'https://openalex.org/W2073608176', 'https://openalex.org/W2073872690', 'https://openalex.org/W2080452140', 'https://openalex.org/W2082627145', 'https://openalex.org/W2083707526', 'https://openalex.org/W2083900845', 'https://openalex.org/W2084104969', 'https://openalex.org/W2084778800', 'https://openalex.org/W2084830740', 'https://openalex.org/W2084944550', 'https://openalex.org/W2085033687', 'https://openalex.org/W2092329569', 'https://openalex.org/W2093845572', 'https://openalex.org/W2094186176', 'https://openalex.org/W2097743943', 'https://openalex.org/W2097838967', 'https://openalex.org/W2100791643', 'https://openalex.org/W2101151637', 'https://openalex.org/W2102899429', 'https://openalex.org/W2105090556', 'https://openalex.org/W2106194243', 'https://openalex.org/W2107398329', 'https://openalex.org/W2107715878', 'https://openalex.org/W2107874457', 'https://openalex.org/W2108002997', 'https://openalex.org/W2108664872', 'https://openalex.org/W2109673299', 'https://openalex.org/W2111737305', 'https://openalex.org/W2113371461', 'https://openalex.org/W2113736257', 'https://openalex.org/W2114492363', 'https://openalex.org/W2114549720', 'https://openalex.org/W2115400483', 'https://openalex.org/W2118771330', 'https://openalex.org/W2119001905', 'https://openalex.org/W2120686569', 'https://openalex.org/W2120815309', 'https://openalex.org/W2121533623', 'https://openalex.org/W2125597344', 'https://openalex.org/W2126817554', 'https://openalex.org/W2127209416', 'https://openalex.org/W2129119273', 'https://openalex.org/W2131558552', 'https://openalex.org/W2133838758', 'https://openalex.org/W2134061682', 'https://openalex.org/W2137573050', 'https://openalex.org/W2142047303', 'https://openalex.org/W2144310197', 'https://openalex.org/W2144770839', 'https://openalex.org/W2147370638', 'https://openalex.org/W2148033929', 'https://openalex.org/W2150611172', 'https://openalex.org/W2151958425', 'https://openalex.org/W2152496375', 'https://openalex.org/W2154725061', 'https://openalex.org/W2157155777', 'https://openalex.org/W2160494819', 'https://openalex.org/W2162540931', 'https://openalex.org/W2162619595', 'https://openalex.org/W2163240777', 'https://openalex.org/W2163355013', 'https://openalex.org/W2166506757', 'https://openalex.org/W2167134612', 'https://openalex.org/W2169172058', 'https://openalex.org/W2288307011', 'https://openalex.org/W2406071845', 'https://openalex.org/W2558731861', 'https://openalex.org/W2585970811', 'https://openalex.org/W269059671', 'https://openalex.org/W4231499941', 'https://openalex.org/W4238966960', 'https://openalex.org/W4248363598'], 'related_works': ['https://openalex.org/W4380318195', 'https://openalex.org/W4366603091', 'https://openalex.org/W2901503434', 'https://openalex.org/W2485141070', 'https://openalex.org/W2411374999', 'https://openalex.org/W2083798468', 'https://openalex.org/W2064665154', 'https://openalex.org/W2032502279', 'https://openalex.org/W2012639655', 'https://openalex.org/W2008978345'], 'abstract_inverted_index': {'Somatically': [0], 'acquired': [1], 'genetic': [2, 70, 142], 'abnormalities': [3, 31, 71], 'lead': [4], 'to': [5, 24, 35, 134], 'the': [6, 44, 82, 103, 119, 138, 150, 153, 162], 'salient': [7], 'features': [8], 'that': [9, 53], 'define': [10], 'myelodysplastic': [11], 'syndromes': [12], '(MDS):': [13], 'clonal': [14], 'hematopoiesis,': [15], 'aberrant': [16, 61], 'differentiation,': [17, 96], 'peripheral': [18], 'cytopenias,': [19], 'and': [20, 60, 100, 128, 132, 157, 161], 'risk': [21], 'of': [22, 46, 64, 69, 78, 84, 89, 118, 137, 141, 144, 152, 171], 'progression': [23], 'acute': [25], 'myeloid': [26], 'leukemia.': [27], 'Although': [28], 'specific': [29], 'karyotypic': [30], 'have': [32, 42], 'been': [33], 'linked': [34], 'MDS': [36, 73, 114, 145], 'for': [37, 164], 'decades,': [38], 'more': [39], 'recent': [40], 'findings': [41], 'demonstrated': [43], 'importance': [45], 'mutations': [47], 'within': [48], 'individual': [49, 111], 'genes,': [50], 'focal': [51], 'alterations': [52, 108], 'are': [54], 'not': [55], 'apparent': [56], 'by': [57], 'standard': [58], 'cytogenetics,': [59], 'epigenetic': [62], 'regulation': [63], 'gene': [65], 'expression.': [66], 'The': [67], 'spectrum': [68], 'in': [72, 81, 102, 110, 121], 'implicates': [74], 'a': [75], 'wide': [76], 'range': [77], 'molecular': [79, 169], 'mechanisms': [80], 'pathogenesis': [83], 'these': [85], 'disorders,': [86], 'including': [87], 'activation': [88], 'tyrosine': [90], 'kinase': [91], 'signaling,': [92], 'genomic': [93], 'instability,': [94], 'impaired': [95], 'altered': [97], 'ribosome': [98], 'function,': [99], 'changes': [101], 'bone': [104], 'marrow': [105], 'microenvironment.': [106], 'Specific': [107], 'present': [109], 'patients': [112], 'with': [113, 125, 168], 'may': [115], 'explain': [116], 'much': [117], 'heterogeneity': [120], 'clinical': [122], 'phenotype': [123], 'associated': [124], 'this': [126], 'disease': [127], 'can': [129], 'predict': [130], 'prognosis': [131], 'response': [133], 'therapy.': [135], 'Elucidation': [136], 'full': [139], 'complement': [140], 'causes': [143], 'promises': [146], 'profound': [147], 'insight': [148], 'into': [149], 'biology': [151], 'disease,': [154], 'improved': [155], 'classification': [156], 'prognostic': [158], 'scoring': [159], 'schemes,': [160], 'potential': [163], 'novel': [165], 'targeted': [166], 'therapies': [167], 'predictors': [170], 'response.': [172]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2076367236', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 27}, {'year': 2016, 'cited_by_count': 23}, {'year': 2015, 'cited_by_count': 20}, {'year': 2014, 'cited_by_count': 25}, {'year': 2013, 'cited_by_count': 50}, {'year': 2012, 'cited_by_count': 53}], 'updated_date': '2024-12-13T18:35:00.321705', 'created_date': '2016-06-24'}