Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2076014943', 'doi': 'https://doi.org/10.1002/dvdy.10501', 'title': 'Sonic hedgehog patterning in chick neural plate is antagonized by a Wnt3‐like signal', 'display_name': 'Sonic hedgehog patterning in chick neural plate is antagonized by a Wnt3‐like signal', 'publication_year': 2004, 'publication_date': '2004-01-28', 'ids': {'openalex': 'https://openalex.org/W2076014943', 'doi': 'https://doi.org/10.1002/dvdy.10501', 'mag': '2076014943', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14991707'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/dvdy.10501', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.10501', 'source': {'id': 'https://openalex.org/S104993753', 'display_name': 'Developmental Dynamics', 'issn_l': '1058-8388', 'issn': ['1058-8388', '1097-0177'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.10501', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007820719', 'display_name': 'Christie P. Robertson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christie P. Robertson', 'raw_affiliation_strings': ['Department of Biological Structure, Program in Neurobiology and Behavior, and Center for Developmental Biology, University of Washington, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Structure, Program in Neurobiology and Behavior, and Center for Developmental Biology, University of Washington, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059969701', 'display_name': 'Michelle Braun', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michelle M. Braun', 'raw_affiliation_strings': ['Department of Biological Structure, Program in Neurobiology and Behavior, and Center for Developmental Biology, University of Washington, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Structure, Program in Neurobiology and Behavior, and Center for Developmental Biology, University of Washington, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033672356', 'display_name': 'Henk Roelink', 'orcid': 'https://orcid.org/0000-0002-5260-3634'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Henk Roelink', 'raw_affiliation_strings': ['Department of Biological Structure, Program in Neurobiology and Behavior, and Center for Developmental Biology, University of Washington, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Structure, Program in Neurobiology and Behavior, and Center for Developmental Biology, University of Washington, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4020, 'currency': 'USD', 'value_usd': 4020, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.76, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 33, 'citation_normalized_percentile': {'value': 0.699389, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '229', 'issue': '3', 'first_page': '510', 'last_page': '519'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling in Development and Cancer', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling in Development and Cancer', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10268', 'display_name': 'Notch Signaling Pathway in Development and Disease', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt Signaling in Development and Disease', 'score': 0.9818, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neural-cell', 'display_name': 'Neural cell', 'score': 0.67973244}, {'id': 'https://openalex.org/keywords/hedgehog-signaling', 'display_name': 'Hedgehog Signaling', 'score': 0.622244}, {'id': 'https://openalex.org/keywords/wnt-signaling', 'display_name': 'Wnt Signaling', 'score': 0.594917}, {'id': 'https://openalex.org/keywords/notch-signaling', 'display_name': 'Notch Signaling', 'score': 0.548648}, {'id': 'https://openalex.org/keywords/floor-plate', 'display_name': 'Floor plate', 'score': 0.548425}, {'id': 'https://openalex.org/keywords/neural-fold', 'display_name': 'Neural fold', 'score': 0.49398977}, {'id': 'https://openalex.org/keywords/cell-fate-determination', 'display_name': 'Cell fate determination', 'score': 0.45910668}, {'id': 'https://openalex.org/keywords/neural-development', 'display_name': 'Neural development', 'score': 0.4296619}], 'concepts': [{'id': 'https://openalex.org/C2776637008', 'wikidata': 'https://www.wikidata.org/wiki/Q14860072', 'display_name': 'Sonic hedgehog', 'level': 3, 'score': 0.940482}, {'id': 'https://openalex.org/C2780594696', 'wikidata': 'https://www.wikidata.org/wiki/Q1127402', 'display_name': 'Neural tube', 'level': 3, 'score': 0.9193855}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8338535}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.7565403}, {'id': 'https://openalex.org/C2778539099', 'wikidata': 'https://www.wikidata.org/wiki/Q6120', 'display_name': 'Hedgehog', 'level': 3, 'score': 0.69574195}, {'id': 'https://openalex.org/C2992459734', 'wikidata': 'https://www.wikidata.org/wiki/Q43054', 'display_name': 'Neural cell', 'level': 3, 'score': 0.67973244}, {'id': 'https://openalex.org/C197849852', 'wikidata': 'https://www.wikidata.org/wiki/Q2314823', 'display_name': 'Neural plate', 'level': 4, 'score': 0.6738317}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5720633}, {'id': 'https://openalex.org/C78577261', 'wikidata': 'https://www.wikidata.org/wiki/Q3391691', 'display_name': 'Floor plate', 'level': 2, 'score': 0.548425}, {'id': 'https://openalex.org/C88498014', 'wikidata': 'https://www.wikidata.org/wiki/Q14859918', 'display_name': 'Hedgehog signaling pathway', 'level': 3, 'score': 0.49819493}, {'id': 'https://openalex.org/C103607123', 'wikidata': 'https://www.wikidata.org/wiki/Q7002059', 'display_name': 'Neural fold', 'level': 5, 'score': 0.49398977}, {'id': 'https://openalex.org/C163952510', 'wikidata': 'https://www.wikidata.org/wiki/Q5058196', 'display_name': 'Cell fate determination', 'level': 4, 'score': 0.45910668}, {'id': 'https://openalex.org/C461258', 'wikidata': 'https://www.wikidata.org/wiki/Q1345738', 'display_name': 'Neural development', 'level': 3, 'score': 0.4296619}, {'id': 'https://openalex.org/C140530291', 'wikidata': 'https://www.wikidata.org/wiki/Q1225063', 'display_name': 'Dorsum', 'level': 2, 'score': 0.4132949}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.41213614}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.38117707}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.37554836}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.29077512}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.21381897}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.13860112}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.0574134}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.04368937}], 'mesh': [{'descriptor_ui': 'D009432', 'descriptor_name': 'Neural Crest', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D009432', 'descriptor_name': 'Neural Crest', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002642', 'descriptor_name': 'Chick Embryo', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017403', 'descriptor_name': 'In Situ Hybridization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009432', 'descriptor_name': 'Neural Crest', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010802', 'descriptor_name': 'Phylogeny', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051153', 'descriptor_name': 'Wnt Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060508', 'descriptor_name': 'Wnt3 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/dvdy.10501', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.10501', 'source': {'id': 'https://openalex.org/S104993753', 'display_name': 'Developmental Dynamics', 'issn_l': '1058-8388', 'issn': ['1058-8388', '1097-0177'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/14991707', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/dvdy.10501', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.10501', 'source': {'id': 'https://openalex.org/S104993753', 'display_name': 'Developmental Dynamics', 'issn_l': '1058-8388', 'issn': ['1058-8388', '1097-0177'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W1541821200', 'https://openalex.org/W1548186657', 'https://openalex.org/W1585922331', 'https://openalex.org/W1611895582', 'https://openalex.org/W1839239664', 'https://openalex.org/W1887141904', 'https://openalex.org/W1892599478', 'https://openalex.org/W1901649215', 'https://openalex.org/W1963807253', 'https://openalex.org/W1968707675', 'https://openalex.org/W1972023230', 'https://openalex.org/W1972727772', 'https://openalex.org/W1974080870', 'https://openalex.org/W1975035795', 'https://openalex.org/W1977814055', 'https://openalex.org/W1978039987', 'https://openalex.org/W1982087641', 'https://openalex.org/W1982482145', 'https://openalex.org/W1987047126', 'https://openalex.org/W1989194294', 'https://openalex.org/W1991821425', 'https://openalex.org/W1992865216', 'https://openalex.org/W1999921847', 'https://openalex.org/W2000015384', 'https://openalex.org/W2001910980', 'https://openalex.org/W2006047257', 'https://openalex.org/W2017920584', 'https://openalex.org/W2021103771', 'https://openalex.org/W2022154218', 'https://openalex.org/W2026649263', 'https://openalex.org/W2033291406', 'https://openalex.org/W2033870866', 'https://openalex.org/W2040773128', 'https://openalex.org/W2044094920', 'https://openalex.org/W2048675800', 'https://openalex.org/W2048994813', 'https://openalex.org/W2049859215', 'https://openalex.org/W2051788298', 'https://openalex.org/W2052648973', 'https://openalex.org/W2059614045', 'https://openalex.org/W2092880556', 'https://openalex.org/W2104789206', 'https://openalex.org/W2111334408', 'https://openalex.org/W2111350290', 'https://openalex.org/W2125635238', 'https://openalex.org/W2131820556', 'https://openalex.org/W2138526982', 'https://openalex.org/W2140034535', 'https://openalex.org/W2142951125', 'https://openalex.org/W2155099799', 'https://openalex.org/W2162405663', 'https://openalex.org/W2165622092', 'https://openalex.org/W2183111316', 'https://openalex.org/W2184947876', 'https://openalex.org/W4246054925'], 'related_works': ['https://openalex.org/W4390053972', 'https://openalex.org/W4285139494', 'https://openalex.org/W2503071417', 'https://openalex.org/W2283619593', 'https://openalex.org/W2103168913', 'https://openalex.org/W2096548029', 'https://openalex.org/W2087835271', 'https://openalex.org/W2071507443', 'https://openalex.org/W1975477239', 'https://openalex.org/W1972107716'], 'abstract_inverted_index': {'Abstract': [0], 'Sonic': [1], 'hedgehog': [2], '(Shh)': [3], 'patterns': [4], 'the': [5, 9, 14, 30, 34, 46, 56, 60, 75, 85], 'dorsal‐ventral': [6], 'axis': [7], 'of': [8, 16, 36, 44, 67, 74, 88], 'neural': [10, 18, 24, 79, 97, 104], 'tube': [11, 105], 'by': [12], 'promoting': [13], 'differentiation': [15, 35], 'ventral': [17], 'cell': [19, 122], 'types': [20], 'while': [21], 'suppressing': [22], 'dorsal': [23], 'fates.': [25], 'Other': [26], 'signals': [27, 57, 109], 'impinge': [28], 'upon': [29], 'Shh': [31, 61, 76], 'response,': [32], 'biasing': [33], 'a': [37, 94, 117], 'cell.': [38], 'Three': [39], 'dorsally': [40], 'expressed': [41, 49], 'transforming': [42], 'Wnts,': [43], 'which': [45], 'most': [47], 'broadly': [48], 'is': [50, 91], 'Wnt3': [51, 90], ',': [52], 'may': [53, 114], 'be': [54], 'among': [55], 'that': [58, 65, 84, 102], 'influence': [59], 'response.': [62], 'We': [63], 'demonstrate': [64], 'activation': [66], 'Wnt': [68, 118], 'signaling': [69], 'results': [70, 100], 'in': [71, 78, 96], 'an': [72], 'inhibition': [73], 'response': [77, 119], 'tissue.': [80], 'Additionally,': [81], 'we': [82], 'show': [83], 'expression': [86], 'pattern': [87], 'chick': [89], 'consistent': [92], 'with': [93], 'role': [95], 'patterning.': [98], 'These': [99], 'indicate': [101], 'differentiating': [103], 'cells,': [106], 'besides': [107], 'integrating': [108], 'from': [110], 'Hedgehogs': [111], 'and': [112], 'BMPs,': [113], 'also': [115], 'incorporate': [116], 'to': [120], 'make': [121], 'fate': [123], 'decisions.': [124], 'Developmental': [125], 'Dynamics': [126], '229:510–519,': [127], '2004.': [128], '©': [129], '2004': [130], 'Wiley‐Liss,': [131], 'Inc.': [132]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2076014943', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-09-19T23:41:29.543964', 'created_date': '2016-06-24'}