Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2075699988', 'doi': 'https://doi.org/10.7326/0003-4819-124-6-199603150-00016', 'title': 'Induction of Adrenal Suppression by Megestrol Acetate', 'display_name': 'Induction of Adrenal Suppression by Megestrol Acetate', 'publication_year': 1996, 'publication_date': '1996-03-15', 'ids': {'openalex': 'https://openalex.org/W2075699988', 'doi': 'https://doi.org/10.7326/0003-4819-124-6-199603150-00016', 'mag': '2075699988', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8597331'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-124-6-199603150-00016', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076923664', 'display_name': 'Sheldon S. Stoffer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sheldon S. Stoffer', 'raw_affiliation_strings': ['Mayo Clinic Rochester-MN'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic Rochester-MN', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5031408556', 'display_name': 'Jesse C. Krakauer', 'orcid': 'https://orcid.org/0000-0003-0519-4185'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jesse C. Krakauer', 'raw_affiliation_strings': ['Mayo Clinic Rochester-MN'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic Rochester-MN', 'institution_ids': ['https://openalex.org/I1330342723']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.645533, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 78}, 'biblio': {'volume': '124', 'issue': '6', 'first_page': '613', 'last_page': '613'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12421', 'display_name': 'Adrenal Hormones and Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12421', 'display_name': 'Adrenal Hormones and Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10832', 'display_name': 'Pituitary Gland Disorders and Treatments', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/megestrol', 'display_name': 'Megestrol', 'score': 0.8290875}, {'id': 'https://openalex.org/keywords/discontinuation', 'display_name': 'Discontinuation', 'score': 0.633778}], 'concepts': [{'id': 'https://openalex.org/C2780723184', 'wikidata': 'https://www.wikidata.org/wiki/Q6808975', 'display_name': 'Megestrol acetate', 'level': 3, 'score': 0.96505535}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.94089776}, {'id': 'https://openalex.org/C2779320873', 'wikidata': 'https://www.wikidata.org/wiki/Q410513', 'display_name': 'Megestrol', 'level': 4, 'score': 0.8290875}, {'id': 'https://openalex.org/C2778715236', 'wikidata': 'https://www.wikidata.org/wiki/Q55622662', 'display_name': 'Discontinuation', 'level': 2, 'score': 0.633778}, {'id': 'https://openalex.org/C2777910003', 'wikidata': 'https://www.wikidata.org/wiki/Q1707292', 'display_name': 'Asymptomatic', 'level': 2, 'score': 0.5655108}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5279918}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.46787736}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.37180018}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.14339611}], 'mesh': [{'descriptor_ui': 'D000309', 'descriptor_name': 'Adrenal Insufficiency', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D008535', 'descriptor_name': 'Megestrol', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D010913', 'descriptor_name': 'Pituitary-Adrenal System', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000309', 'descriptor_name': 'Adrenal Insufficiency', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008535', 'descriptor_name': 'Megestrol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008535', 'descriptor_name': 'Megestrol', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D019290', 'descriptor_name': 'Megestrol Acetate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010913', 'descriptor_name': 'Pituitary-Adrenal System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-124-6-199603150-00016', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8597331', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/2', 'score': 0.51, 'display_name': 'Zero hunger'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2434621457', 'https://openalex.org/W2413630402', 'https://openalex.org/W2412727001', 'https://openalex.org/W2212242295', 'https://openalex.org/W2090683022', 'https://openalex.org/W2080633114', 'https://openalex.org/W2077459672', 'https://openalex.org/W2064408249', 'https://openalex.org/W2051866058', 'https://openalex.org/W1987458731'], 'abstract_inverted_index': {'Letters15': [0], 'March': [1, 325, 346], '1996Induction': [2], 'of': [3, 84, 93, 124, 131, 158, 164, 180, 206, 239, 311, 356], 'Adrenal': [4], 'Suppression': [5], 'by': [6, 30, 43, 58, 183, 353], 'Megestrol': [7], 'AcetateCharles': [8], 'L.': [9, 20, 271], 'Loprinzi,': [10, 21, 272], 'MD,': [11, 14, 200], 'Rafael': [12, 33, 274], 'Fonseca,': [13, 34, 275], 'and': [15, 46, 62, 76, 114, 155, 241, 267, 299, 316, 336], 'Michael': [16, 47, 277], 'D.': [17, 48, 278], 'Jensen,': [18, 49, 279], 'MDCharles': [19], 'MDMayo': [22, 35, 50], 'Clinic;': [23, 36, 51, 282], 'Rochester,': [24, 37, 52, 283], 'MN': [25, 38, 53, 284], '55905Search': [26, 39, 54], 'for': [27, 40, 55, 319], 'more': [28, 41, 56], 'papers': [29, 42, 57], 'this': [31, 44, 59], 'author,': [32, 45], 'authorAuthor,': [60], 'Article,': [61, 266], 'Disclosure': [63, 268], 'Informationhttps://doi.org/10.7326/0003-4819-124-6-199603150-00016': [64], 'SectionsAboutFull': [65], 'TextPDF': [66], 'ToolsAdd': [67], 'to': [68, 136], 'favoritesDownload': [69], 'CitationsTrack': [70], 'CitationsPermissions': [71], 'ShareFacebookTwitterLinkedInRedditEmail': [72], 'TO': [73], 'THE': [74], 'EDITOR:Leinung': [75], 'colleagues': [77], '[1]': [78], 'provided': [79], 'the': [80, 125, 132, 210], 'first': [81], 'convincing': [82], 'report': [83], 'a': [85, 121], 'patient': [86], 'who': [87], 'became': [88], 'Addisonian': [89, 159], 'after': [90], 'abrupt': [91, 162], 'discontinuation': [92, 163], 'therapy': [94, 167], 'with': [95, 120, 161, 188, 303, 308], 'megestrol': [96, 106, 143, 153, 165, 184, 207, 244, 296, 312], 'acetate.': [97, 144], 'It': [98], 'has': [99], 'been': [100, 170], 'well': [101], 'established': [102], 'that': [103], 'patients': [104, 141, 187, 307], 'receiving': [105, 142, 152], 'acetate': [107, 166, 185, 208, 297], 'have': [108, 168], 'markedly': [109], 'suppressed': [110], 'serum': [111], 'cortisol': [112], 'levels': [113], 'decreased': [115], 'adrenocorticotropic': [116], 'hormone': [117], 'levels,': [118], 'consistent': [119], 'central': [122], 'suppression': [123, 130, 182], 'pituitary-adrenal': [126, 133, 212], 'axis': [127, 134], '[2].': [128], 'This': [129], 'appears': [135], 'be': [137], 'asymptomatic': [138], 'in': [139, 186, 246, 305], 'most': [140], 'Patients': [145], 'generally': [146], 'do': [147], 'not': [148, 169], 'become': [149], 'Cushingoid': [150], 'while': [151], 'acetate,': [154, 313], 'previous': [156], 'episodes': [157], 'crises': [160], 'reported': [171], '...References1.': [172], 'Leinung': [173], 'MC,': [174], 'Liporace': [175], 'R,': [176], 'Miller': [177], 'CH.': [178], 'Induction': [179], 'adrenal': [181, 293, 301], 'AIDS.': [189], 'Ann': [190], 'Intern': [191], 'Med.': [192], '1995;': [193], '122:843-5.': [194], 'Google': [195, 219, 263], 'Scholar2.': [196], 'Loprinzi': [197, 227], 'CL,': [198, 228], 'Jensen': [199], 'Jiang': [201], 'NS,': [202], 'Schaid': [203], 'DJ.': [204], 'Effect': [205], 'on': [209], 'human': [211], 'axis.': [213], 'Mayo': [214, 281], 'Clinic': [215], 'Proc.': [216], '1992;': [217], '67:1160-2.': [218], 'Scholar3.': [220], 'Rowland': [221], 'KM,': [222], 'Jett': [223], 'JR,': [224], 'Jung': [225], 'SH,': [226], 'Washburn': [229], 'HJ,': [230], 'Shaw': [231], 'EG.': [232], 'Phase': [233], 'III': [234], 'randomized': [235], 'double-blind': [236], 'placebo-controlled': [237], 'trial': [238], 'cisplatin': [240], 'etoposide': [242], 'plus': [243], 'acetate/placebo': [245], 'extensive': [247], 'stage': [248], 'small': [249], 'cell': [250], 'lung.': [251], 'A': [252], 'North': [253], 'Central': [254], 'Cancer': [255], 'Treatment': [256], 'Group': [257], 'Study.': [258], 'Proc': [259], 'ASCO.': [260], '1994;': [261], '13:330.': [262], 'Scholar': [264], 'Author,': [265], 'InformationAuthors:': [269], 'Charles': [270], 'MD;': [273, 276], 'MDAffiliations:': [280], '55905': [285], 'PreviousarticleNextarticle': [286], 'Advertisement': [287], 'FiguresReferencesRelatedDetails': [288], 'Metrics': [289], 'Cited': [290], 'byMegestrol': [291], 'acetate—associated': [292], 'insufficiencyAssociation': [294], 'between': [295], 'treatment': [298], 'symptomatic': [300], 'insufficiency': [302], 'hypogonadism': [304], 'male': [306], 'cancerA': [309], 'comparison': [310], 'nandrolone': [314], 'decanoate': [315], 'dietary': [317], 'counselling': [318], 'HIV': [320], 'associated': [321], 'weight': [322], 'loss': [323], '15': [324, 340, 345], '1996Volume': [326], '124,': [327], 'Issue': [328, 343], '6Page:': [329], '613KeywordsAdrenocorticotropic': [330], 'hormoneBreast': [331], 'cancerCancer': [332], 'treatmentClinical': [333], 'trialsCorticosteroid': [334], 'therapyCortisolDrugsLung': [335], 'intrathoracic': [337], 'tumorsToxicity': [338], 'ePublished:': [339], 'August': [341], '2000': [342], 'Published:': [344], '1996': [347, 352], 'Copyright': [348], '&': [349], 'PermissionsCopyright': [350], '©': [351], 'American': [354], 'College': [355], 'Physicians.': [357], 'All': [358], 'Rights': [359], 'Reserved.PDF': [360], 'downloadLoading': [361], '...': [362]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2075699988', 'counts_by_year': [], 'updated_date': '2024-12-07T19:01:05.373450', 'created_date': '2016-06-24'}