Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2075643011', 'doi': 'https://doi.org/10.1042/bj20090142', 'title': 'SUMOylation enhances DNA methyltransferase 1 activity', 'display_name': 'SUMOylation enhances DNA methyltransferase 1 activity', 'publication_year': 2009, 'publication_date': '2009-05-19', 'ids': {'openalex': 'https://openalex.org/W2075643011', 'doi': 'https://doi.org/10.1042/bj20090142', 'mag': '2075643011', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19450230'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20090142', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056769099', 'display_name': 'Bongyong Lee', 'orcid': 'https://orcid.org/0000-0003-3134-7093'}, 'institutions': [{'id': 'https://openalex.org/I106165777', 'display_name': 'University of Central Florida', 'ror': 'https://ror.org/036nfer12', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I106165777']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bongyong Lee', 'raw_affiliation_strings': ['Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32826-3227, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32826-3227, U.S.A.', 'institution_ids': ['https://openalex.org/I106165777']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111955781', 'display_name': 'Mark T. Muller', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I106165777', 'display_name': 'University of Central Florida', 'ror': 'https://ror.org/036nfer12', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I106165777']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark\xa0T. Muller', 'raw_affiliation_strings': ['Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32826-3227, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32826-3227, U.S.A.', 'institution_ids': ['https://openalex.org/I106165777']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.126, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 66, 'citation_normalized_percentile': {'value': 0.918299, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '421', 'issue': '3', 'first_page': '449', 'last_page': '461'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11772', 'display_name': 'Genetics and Neurodevelopmental Disorders', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dnmt1', 'display_name': 'DNMT1', 'score': 0.82831204}, {'id': 'https://openalex.org/keywords/dna-methyltransferase', 'display_name': 'DNA methyltransferase', 'score': 0.6248027}], 'concepts': [{'id': 'https://openalex.org/C171350616', 'wikidata': 'https://www.wikidata.org/wiki/Q61506', 'display_name': 'SUMO protein', 'level': 4, 'score': 0.868856}, {'id': 'https://openalex.org/C175211621', 'wikidata': 'https://www.wikidata.org/wiki/Q14907998', 'display_name': 'DNMT1', 'level': 5, 'score': 0.82831204}, {'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.6750809}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.65624124}, {'id': 'https://openalex.org/C2779979206', 'wikidata': 'https://www.wikidata.org/wiki/Q1154602', 'display_name': 'DNA methyltransferase', 'level': 5, 'score': 0.6248027}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.5970867}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.56686217}, {'id': 'https://openalex.org/C91965660', 'wikidata': 'https://www.wikidata.org/wiki/Q415875', 'display_name': 'Methyltransferase', 'level': 4, 'score': 0.50446737}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.47919402}, {'id': 'https://openalex.org/C167227067', 'wikidata': 'https://www.wikidata.org/wiki/Q5113739', 'display_name': 'Chromatin remodeling', 'level': 4, 'score': 0.43482947}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.35652673}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.34614795}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.33570188}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.30167615}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.23294568}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.20762691}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.13053063}], 'mesh': [{'descriptor_ui': 'D004248', 'descriptor_name': 'DNA (Cytosine-5-)-Methyltransferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D025842', 'descriptor_name': 'SUMO-1 Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000076123', 'descriptor_name': 'DNA (Cytosine-5-)-Methyltransferase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004248', 'descriptor_name': 'DNA (Cytosine-5-)-Methyltransferases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004248', 'descriptor_name': 'DNA (Cytosine-5-)-Methyltransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025842', 'descriptor_name': 'SUMO-1 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044763', 'descriptor_name': 'Ubiquitin-Conjugating Enzymes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D044763', 'descriptor_name': 'Ubiquitin-Conjugating Enzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D044763', 'descriptor_name': 'Ubiquitin-Conjugating Enzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20090142', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19450230', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1490231232', 'https://openalex.org/W1521333964', 'https://openalex.org/W1533942477', 'https://openalex.org/W1916132949', 'https://openalex.org/W1966092430', 'https://openalex.org/W1966630923', 'https://openalex.org/W1982453928', 'https://openalex.org/W1985633462', 'https://openalex.org/W1995585583', 'https://openalex.org/W1995623924', 'https://openalex.org/W1998708229', 'https://openalex.org/W2002129512', 'https://openalex.org/W2005311687', 'https://openalex.org/W2031668046', 'https://openalex.org/W2038783223', 'https://openalex.org/W2040257851', 'https://openalex.org/W2048465271', 'https://openalex.org/W2050646440', 'https://openalex.org/W2055171335', 'https://openalex.org/W2059587308', 'https://openalex.org/W2060446375', 'https://openalex.org/W2064268598', 'https://openalex.org/W2068858732', 'https://openalex.org/W2070484728', 'https://openalex.org/W2073534270', 'https://openalex.org/W2082770588', 'https://openalex.org/W2112441454', 'https://openalex.org/W2118810511', 'https://openalex.org/W2121417064', 'https://openalex.org/W2122044343', 'https://openalex.org/W2122778166', 'https://openalex.org/W2129320496', 'https://openalex.org/W2130808015', 'https://openalex.org/W2132554729', 'https://openalex.org/W2134488586', 'https://openalex.org/W2136905998', 'https://openalex.org/W2138079393', 'https://openalex.org/W2138373011', 'https://openalex.org/W2141963489', 'https://openalex.org/W2149557692', 'https://openalex.org/W2162093159', 'https://openalex.org/W2170634115', 'https://openalex.org/W2172298521'], 'related_works': ['https://openalex.org/W4287441772', 'https://openalex.org/W4206856404', 'https://openalex.org/W3084863567', 'https://openalex.org/W2125931439', 'https://openalex.org/W2065044476', 'https://openalex.org/W2055511217', 'https://openalex.org/W2031581570', 'https://openalex.org/W1836451835', 'https://openalex.org/W1534737270', 'https://openalex.org/W1522855936'], 'abstract_inverted_index': {'DNA': [0, 34, 96], 'methylation': [1], 'regulates': [2], 'gene': [3, 66], 'expression': [4], 'through': [5], 'a': [6, 24, 127], 'complex': [7], 'network': [8], 'of': [9, 41, 65, 109, 126], 'protein-protein': [10], 'and': [11, 36, 55, 79, 99, 114], 'protein-DNA': [12], 'interactions': [13], 'in': [14, 27, 57, 61, 97, 112, 115, 132], 'chromatin.': [15, 116], 'The': [16, 44], 'maintenance': [17, 130], 'methylase,': [18], 'DNMT1': [19, 50, 74, 90, 110], '(DNA': [20], 'methyltransferase': [21], '1),': [22], 'is': [23, 31, 53, 75, 91], 'prominent': [25, 128], 'enzyme': [26], 'the': [28, 38, 106, 123], 'process': [29], 'that': [30, 47, 73, 102, 120], 'linked': [32], 'to': [33], 'replication': [35], 'drives': [37], 'heritable': [39], 'nature': [40], 'epigenetic': [42, 129], 'modifications.': [43], 'mechanistic': [45], 'details': [46], 'explain': [48], 'how': [49], 'catalytic': [51], 'action': [52], 'directed': [54], 'regulated': [56], 'chromatin': [58], 'are': [59], 'important': [60], 'our': [62], 'overall': [63], 'understanding': [64], 'control.': [67], 'In': [68], 'this': [69], 'work,': [70], 'we': [71, 80, 100], 'show': [72], 'modified': [76], 'by': [77, 86], 'SUMOylation': [78, 84, 103, 121], 'have': [81], 'mapped': [82], 'these': [83], 'sites': [85], 'defined': [87], 'mutations.': [88], 'SUMOylated': [89], 'catalytically': [92], 'active': [93], 'on': [94], 'genomic': [95], 'vivo': [98], 'find': [101], 'significantly': [104], 'enhances': [105], 'methylase': [107], 'activity': [108, 125], 'both': [111], 'vitro': [113], 'These': [117], 'data': [118], 'suggest': [119], 'modulates': [122], 'endogenous': [124], 'pathway': [131], 'somatic': [133], 'cells.': [134]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2075643011', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-13T15:36:29.108976', 'created_date': '2016-06-24'}