Publication Information

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170, 197, 208, 252, 325, 344, 348, 407, 421, 448, 602, 663, 2173, 2395, 3575, 3636, 3746, 3764, 3844, 3915, 3921, 4591, 5247, 5347, 5350, 5367, 5531, 5566, 5583, 5706, 5768, 5855, 5895, 5919, 5974, 5983], 'pathogenesis,': [24, 198], 'and': [25, 71, 105, 152, 199, 245, 279, 326, 416, 457, 467, 490, 535, 599, 665, 716, 729, 744, 759, 774, 793, 804, 809, 919, 1191, 1330, 1425, 1581, 1584, 1596, 1599, 1602, 1701, 1706, 1722, 1825, 1870, 2054, 2061, 2096, 2165, 2356, 2443, 2459, 2543, 2601, 2689, 2718, 2722, 2742, 2882, 2944, 3019, 3037, 3211, 3426, 3429, 3436, 3583, 3597, 3610, 3684, 3719, 3734, 3762, 3797, 3860, 3918, 3925, 4024, 4061, 4134, 4165, 4219, 4314, 4320, 4388, 4433, 4498, 4567, 4593, 4637, 4655, 4673, 4686, 4737, 4770, 4816, 4955, 4969, 4982, 5115, 5140, 5238, 5455, 5548, 5591, 5634, 5642, 5761, 5775, 5784, 5797, 5913, 5985], 'reduction': [26, 200], 'levels': [29, 203, 571, 574, 671, 933, 1237, 1250, 1583, 1604, 1912, 1986, 2439, 3450, 3799, 3939, 5100, 5137, 5241, 5375, 5550, 5600], 'should': [30, 204, 672, 4587, 4692], 'prove': [31, 205], 'beneficial': [32, 206, 675, 3431], 'for': [33, 68, 77, 111, 207, 242, 251, 285, 443, 660, 712, 741, 814, 929, 1436, 1717, 2159, 2345, 2598, 2607, 2683, 2696, 3025, 3032, 3574, 3619, 3679, 4293, 4590, 4602, 4683, 4709, 4764, 4784, 4813, 4958, 5702, 5894, 5938, 5954, 5982], 'treatment.': [35, 209, 3576, 5957], 'generation': [37, 70, 211, 244, 715, 918, 3761, 4479], 'is': [38, 66, 84, 212, 240, 258, 381, 679, 710, 738, 746, 779, 920, 924, 945, 1257, 1410, 1715, 1908, 2021, 2155, 2188, 2320, 2337, 2596, 2602, 2694, 3030, 3414, 3568, 3614, 3722, 3743, 4039, 4049, 4181, 4393, 4482, 4490, 4550, 4561, 4634, 4811, 4844, 4929, 5128, 5344, 5386, 5571, 5608, 5742, 5754, 5765, 5780, 5943, 5961], 'initiated': [39, 213], 'by': [40, 47, 214, 221, 413, 427, 748, 781, 1712, 3854, 4051, 4563, 4695, 4932, 5184, 5193], 'proteolysis': [41, 215], 'precursor': [44, 218, 361], 'protein': [45, 219, 689, 751, 1256, 4329, 5114], '(APP)': [46, 220], 'β-secretase': [49, 62, 223, 236, 810, 957, 1189, 1441, 2186, 2605], 'enzyme': [50, 83, 224, 257, 708], 'BACE1.': [51, 225, 4299, 4696], 'Bace1': [52, 226, 2737, 3044, 3141, 3412, 3772, 3798, 5638], 'knockout': [53, 227], '(Bace1–/–)': [54, 228], 'mice': [55, 95, 229, 269, 2026, 2196, 2403, 2451, 2466, 2713, 2751, 2879, 2950, 2956, 3213, 4836], 'have': [56, 230, 454, 1867, 2175, 2328, 2723, 4756, 4781, 4960], 'validated': [57, 231], 'BACE1': [58, 65, 125, 148, 232, 239, 299, 322, 705, 734, 915, 941, 1235, 1255, 1324, 1409, 1445, 1573, 1589, 1714, 1920, 2066, 2148, 2163, 2318, 2350, 2595, 2731, 3029, 3402, 3419, 3449, 3567, 3581, 3584, 3602, 3605, 3632, 3670, 3721, 3733, 3754, 3864, 3937, 4018, 4027, 4048, 4067, 4169, 4180, 4213, 4223, 4249, 4272, 4308, 4333, 4378, 4392, 4434, 4549, 4585, 4631, 4726, 4739, 4785, 4808, 4810, 4919, 4938, 4959, 4975, 4978, 5072, 5099, 5109, 5120, 5136, 5176, 5198, 5205, 5240, 5359, 5374, 5384, 5395, 5446, 5480, 5534, 5541, 5599, 5627, 5670, 5673, 5704, 5748, 5790, 5798, 5876, 5885, 5911, 5926, 5939, 5949, 5971], 'as': [59, 144, 233, 318, 2057, 2062, 2145, 4500, 4974, 5111, 5845], 'authentic': [61, 235], 'vivo.': [64, 238, 4026], 'essential': [67, 241, 711, 2597], 'represents': [72, 246], 'suitable': [74, 248], 'drug': [75, 249, 927, 3572, 3841, 4603, 5920], 'target': [76, 250, 928, 3573], 'therapy,': [79, 253], 'especially': [80, 254], 'because': [81, 255], 'this': [82, 116, 137, 256, 290, 311, 1525, 4336, 4559, 4718, 5169, 5992], 'up-regulated': [85, 259, 2023], 'AD.': [87, 261, 677, 940, 3621, 5164, 5203, 5579], 'However,': [88, 262, 3028, 5361, 5880], 'although': [89, 263, 450, 1524, 1694, 1865, 3720], 'initial': [90, 122, 264, 296], 'data': [91, 265, 2192, 2343, 2679, 4486, 4730, 5776, 5932], 'indicated': [92, 266, 2193], 'that': [93, 131, 163, 267, 305, 337, 495, 507, 582, 949, 1430, 2194, 2317, 2594, 2691, 3625, 3661, 3687, 3848, 4266, 4488, 4495, 4640, 4641, 4671, 4789, 4822, 4842, 5098, 5108, 5116, 5196, 5573, 5624, 5744, 5778, 5785, 5945, 5963], 'Bace1–/–': [94, 268, 2025, 2183, 2195, 3212, 4835], 'lack': [96, 270, 2197, 2452], 'an': [97, 271, 757, 805, 901, 946, 2058, 2063, 3215, 3846, 4183, 4712, 5353, 5699], 'overt': [98, 272], 'phenotype,': [99, 273], 'BACE1-mediated': [101, 275], 'processing': [102, 276, 4198], 'APP': [104, 278, 376, 433, 593, 719, 737, 815, 1437, 2093, 2405, 2551, 2881, 4138, 4197, 4489, 4928, 5186, 5191], 'other': [106, 280, 1320, 4260, 4643, 4936, 5365], 'substrates': [107, 281, 4939, 4976, 5073, 5121], 'may': [108, 282, 584, 3421, 3587, 3728, 3849, 4136, 4194, 4290, 4721, 4804, 5178], 'be': [109, 283, 410, 673, 3022, 3144, 3396, 3459, 3850, 4794, 5458, 5594, 5676, 5864, 5952], 'important': [110, 284, 4682, 5935], 'specific': [112, 286, 451, 2330, 2744, 3033, 4220, 4838, 5119, 5588], 'biological': [113, 287], 'processes.': [114, 288], 'In': [115, 289, 2397, 3712, 4045, 4390, 5958], 'minireview,': [117, 291], 'topics': [118, 292], 'range': [119, 293], 'from': [120, 294, 681, 1538, 1686, 3042, 4649, 4660, 4806], 'identification': [123, 159, 297, 333, 4966], 'to': [126, 300, 397, 409, 509, 573, 667, 722, 908, 2140, 2146, 2178, 2339, 2399, 2512, 2618, 2726, 2748, 3021, 3399, 3458, 3600, 3667, 3801, 3809, 3920, 4056, 4139, 4215, 4297, 4334, 4484, 4758, 4963, 5079, 5202, 5457, 5474, 5482, 5533, 5577, 5596, 5646, 5863, 5899, 5928], 'fundamental': [128, 302], 'knowledge': [129, 303], 'gaps': [130, 304], 'remain': [132, 306, 441, 3665], 'our': [134, 308, 5873, 5923], 'understanding': [135, 309, 3407, 5874, 5924, 5965], 'protease.': [138, 312], 'We': [139, 313], 'address': [140, 164, 314, 338, 5381], 'pertinent': [141, 315], 'questions': [142, 316], 'such': [143, 317, 2342, 3663, 4790, 5614, 5844, 5892], 'putative': [145, 319, 3445, 4937, 5071], 'causes': [146, 320, 1334], 'elevation': [149, 323, 5385, 5396, 5447, 5799, 5972], 'discuss': [153, 327], 'why,': [154, 328], 'nine': [155, 329, 3612], 'years': [156, 330], 'since': [157, 331], 'BACE1,': [161, 335, 1821, 3593, 4710, 4765, 5194], 'treatments': [162, 336], 'underlying': [166, 340, 439, 5970], 'pathological': [167, 341, 505, 5757], 'mechanisms': [168, 342, 3660, 5969], 'still': [172, 346], 'lacking.': [173, 347], '2The': [349], 'abbreviations': [350], 'used': [351, 2177, 2725], 'are:': [352], 'AD,': [353, 489, 5760], 'disease;': [355], 'FAD,': [356], 'familial': [357, 424], 'AD;': [358], 'APP,': [359, 684, 785, 4924], 'protein;': [362], 'PS,': [363], 'presenilin;': [364], 'TBI,': [365, 5592], 'traumatic': [366], 'brain': [367, 669, 1261, 1980, 2441, 2446, 2456, 2608, 2900, 5248], 'injury;': [368], 'Aβ,': [369, 541, 1693, 2457], 'β-protein;': [371], 'APPs,': [372], 'secreted': [373], 'APP;': [374], 'AICD,': [375], 'intracellular': [377, 4144], 'domain;': [378], 'Tg,': [379], 'transgenic.': [380], 'most': [383, 1914], 'common': [384, 2747], 'form': [385, 538, 723], 'dementia,': [387], 'afflicting': [388], 'over': [389], '29': [390], 'million': [391], 'people': [392], 'worldwide,': [393], 'figure': [395], 'anticipated': [396], 'rise': [398, 3802], 'exponentially': [399], 'within': [400, 786, 1454], 'decades.': [401], 'Although': [402, 1703, 2190, 3622, 4179, 4248, 4473, 4548, 4728, 4917, 5165, 5468, 5565], 'etiology': [404, 5567, 5990], 'remains': [405, 3457, 5173, 5478, 5568, 5862], 'enigmatic,': [406, 5569], 'appears': [408, 3430], 'brought': [411], 'about': [412], 'both': [414, 1720, 4021, 5453, 5545], 'genetic': [415, 530], 'non-genetic': [417], 'factors.': [418], '∼5%': [419], 'cases': [422, 5172], '(FAD),': [425], 'caused': [426, 4837, 5183], 'autosomal': [428], 'dominant': [429], 'mutations': [430, 2887], 'either': [432, 1333], 'or': [434, 567, 1984, 2464, 5388, 5402, 5840, 5851, 5856], 'PS': [436], 'genes.': [437], 'The': [438, 807, 1254, 3604, 3669, 4630, 4965, 5445, 5666], 'cause(s)': [440, 5167], 'elusive': [442], 'majority': [445], 'sporadic': [447, 3620, 5171], 'cases,': [449], 'risk': [452, 3916, 5348, 5368, 5584], 'factors': [453, 3917, 5369, 5746], 'been': [455, 2176, 2724], 'identified': [456, 2329], 'include': [458], 'aging,': [459, 5587], 'apolipoprotein': [461], 'E4': [462], 'allele,': [463], 'certain': [464, 5846], 'vascular': [465, 3929, 5589, 5849], 'diseases,': [466], 'TBI': [468, 3924, 5635, 5852], '(1Cole': [469, 603, 1541, 1605, 1724, 2098, 3940, 4147, 4199, 4274, 4571, 4941, 4986, 5083, 5145, 5249, 5551, 5681], 'S.L.': [470, 604, 1542, 1606, 1725, 2099, 2244, 2793, 2855, 2905, 2987, 3941, 4148, 4200, 4275, 4572, 4942, 4987, 5084, 5146, 5250, 5552, 5682], 'Vassar': [471, 605, 1391, 1543, 1607, 1726, 1847, 2002, 2041, 2100, 2231, 2497, 2530, 2643, 2813, 2837, 2866, 2925, 2969, 2998, 3096, 3126, 3942, 4105, 4149, 4201, 4276, 4461, 4573, 4861, 4943, 4988, 5085, 5147, 5251, 5433, 5510, 5553, 5654, 5683, 5729], 'R.': [472, 606, 693, 818, 836, 959, 977, 1061, 1065, 1120, 1263, 1281, 1392, 1462, 1480, 1544, 1608, 1620, 1638, 1727, 1804, 1840, 1848, 1922, 1940, 1995, 2003, 2042, 2068, 2101, 2113, 2232, 2272, 2278, 2498, 2531, 2644, 2812, 2814, 2838, 2863, 2867, 2924, 2926, 2970, 2995, 2999, 3097, 3127, 3179, 3361, 3548, 3695, 3943, 4069, 4106, 4150, 4202, 4277, 4458, 4462, 4574, 4862, 4902, 4944, 4989, 5086, 5148, 5252, 5302, 5312, 5430, 5434, 5507, 5511, 5554, 5655, 5684, 5726, 5730], 'Mol.': [473, 607, 695, 1045, 1366, 1545, 1609, 1728, 2102, 2308, 3282, 3944, 4071, 4151, 4203, 4278, 4575, 4945, 4990, 5087, 5149, 5253, 5555, 5685], 'Neurodegener.': [474, 608, 1546, 1610, 1729, 2103, 3945, 4152, 4204, 4279, 4576, 4946, 4991, 5088, 5150, 5254, 5556, 5686], '2007;': [475, 609, 1547, 1611, 1730, 2104, 2870, 3002, 3554, 3789, 3946, 4153, 4205, 4280, 4365, 4465, 4577, 4947, 4992, 5089, 5151, 5255, 5437, 5514, 5557, 5687, 5733, 5825], '2:': [476, 610, 1548, 1612, 1731, 2105, 3830, 3947, 4154, 4206, 4281, 4578, 4948, 4993, 5090, 5152, 5256, 5558, 5688], '22Crossref': [477, 611, 1549, 1613, 1732, 2106, 3831, 3948, 4155, 4207, 4282, 4579, 4949, 4994, 5091, 5153, 5257, 5559, 5689], 'PubMed': [478, 523, 556, 612, 649, 700, 869, 895, 1010, 1051, 1114, 1153, 1180, 1229, 1314, 1372, 1404, 1513, 1550, 1568, 1614, 1671, 1733, 1764, 1790, 1816, 1860, 1901, 1973, 2015, 2086, 2107, 2135, 2238, 2313, 2388, 2432, 2504, 2587, 2656, 2785, 2820, 2847, 2873, 2932, 2979, 3005, 3079, 3109, 3136, 3206, 3251, 3288, 3331, 3388, 3494, 3520, 3562, 3654, 3707, 3792, 3832, 3906, 3949, 3974, 4007, 4076, 4120, 4156, 4208, 4243, 4283, 4373, 4412, 4430, 4468, 4527, 4545, 4580, 4625, 4750, 4874, 4912, 4950, 4995, 5025, 5062, 5092, 5154, 5233, 5258, 5276, 5296, 5337, 5440, 5517, 5560, 5661, 5690, 5736, 5833], 'Scopus': [479, 524, 557, 613, 650, 701, 870, 896, 1011, 1052, 1115, 1154, 1181, 1230, 1315, 1373, 1405, 1514, 1551, 1569, 1615, 1672, 1734, 1765, 1791, 1817, 1861, 1902, 1974, 2016, 2050, 2087, 2108, 2136, 2239, 2389, 2433, 2505, 2539, 2588, 2657, 2786, 2821, 2848, 2874, 2933, 2980, 3006, 3080, 3110, 3137, 3207, 3252, 3289, 3332, 3389, 3495, 3521, 3563, 3655, 3708, 3793, 3833, 3907, 3950, 3975, 4008, 4077, 4121, 4157, 4209, 4244, 4284, 4374, 4413, 4469, 4528, 4581, 4626, 4751, 4875, 4913, 4951, 4996, 5026, 5063, 5093, 5155, 5234, 5259, 5277, 5297, 5338, 5441, 5518, 5561, 5662, 5691, 5737, 5834], '(365)': [480, 614, 1552, 1616, 1735, 2109, 3951, 4158, 4210, 4285, 4582, 4952, 4997, 5094, 5156, 5260, 5562, 5692], 'Google': [481, 526, 559, 615, 652, 703, 872, 898, 1013, 1054, 1117, 1156, 1183, 1232, 1317, 1375, 1407, 1516, 1553, 1571, 1617, 1674, 1736, 1767, 1793, 1819, 1863, 1904, 1976, 2018, 2052, 2089, 2110, 2138, 2241, 2314, 2391, 2435, 2507, 2541, 2590, 2659, 2788, 2823, 2850, 2876, 2935, 2982, 3008, 3082, 3112, 3139, 3209, 3254, 3291, 3334, 3391, 3497, 3523, 3565, 3657, 3710, 3795, 3835, 3909, 3952, 3977, 4010, 4079, 4123, 4159, 4211, 4246, 4286, 4376, 4415, 4431, 4471, 4530, 4546, 4583, 4628, 4753, 4877, 4915, 4953, 4998, 5028, 5065, 5095, 5157, 5236, 5261, 5279, 5299, 5340, 5443, 5520, 5563, 5664, 5693, 5739, 5836], 'Scholar).': [482, 527, 560, 653, 704, 1184, 1233, 1318, 1408, 1517, 1572, 1675, 1820, 1905, 2019, 2090, 2508, 2660, 2877, 2936, 3009, 3140, 3392, 3566, 3711, 3836, 3910, 4011, 4124, 4160, 4212, 4247, 4287, 4377, 4472, 4547, 4584, 4629, 4916, 5066, 5096, 5158, 5341, 5444, 5564, 5665, 5694, 5837], 'Several': [483, 1676], 'major': [484, 2604, 4511], 'pathologies': [485, 3435], 'observed': [487, 2547, 2947, 5245, 5766], 'hypothesis': [493, 2686], 'states': [494], 'plays': [497], 'critical': [499, 658, 2157, 4812], 'early': [500, 2191, 3152, 3452, 5700], 'role,': [501], 'triggering': [502], 'complex': [504, 752, 4029, 4062], 'cascade': [506], 'leads': [508, 5532], 'neurodegeneration': [510, 5796], '(2Golde': [511], 'T.E.': [512], 'Dickson': [513], 'D.': [514, 620, 643, 1018, 1067, 1095, 1103, 1165, 1339, 1755, 2034, 2260, 2286, 2523, 3155, 3159, 3185, 3337, 3341, 3367, 3538, 3648, 4896, 5324], 'Hutton': [515], 'M.': [516, 637, 864, 1005, 1069, 1087, 1205, 1209, 1309, 1382, 1390, 1508, 1556, 1666, 1770, 1846, 1968, 2001, 2044, 2119, 2230, 2274, 2282, 2288, 2496, 2533, 2632, 2642, 2805, 2826, 2834, 2853, 2857, 2861, 2917, 2958, 2966, 2985, 2989, 2993, 3085, 3095, 3115, 3123, 3177, 3359, 3528, 3542, 3544, 3644, 3815, 3868, 3992, 4082, 4108, 4351, 4353, 4420, 4444, 4456, 4535, 4850, 4860, 5001, 5007, 5043, 5310, 5318, 5416, 5428, 5493, 5505, 5712, 5724, 5811, 5813], 'Curr.': [517, 4233, 4743], 'Res.': [519], '2006;': [520, 646, 2817, 2844, 2929, 2976, 3133, 3903, 4004, 4747, 5022], '3:': [521], '421-430Crossref': [522], '(124)': [525], 'A': [528, 5903], 'strong': [529, 3616, 3740], 'correlation': [531], 'exists': [532], 'between': [533, 2094, 5795], 'FAD': [534, 562, 2408, 2886, 5182], 'neurotoxic': [537], 'fibrillogenic': [540, 578], 'Aβ42': [542, 565, 570, 583, 661, 670, 5476, 5528, 5539], '(3Glabe': [543], 'C.G.': [544], 'J.': [545, 694, 842, 846, 860, 884, 983, 987, 1001, 1075, 1083, 1093, 1105, 1169, 1199, 1218, 1287, 1291, 1305, 1393, 1486, 1490, 1504, 1644, 1648, 1662, 1811, 1849, 1897, 1946, 1950, 1964, 2004, 2038, 2075, 2129, 2130, 2218, 2246, 2302, 2377, 2484, 2527, 2582, 2780, 2801, 2807, 2815, 2842, 2859, 2913, 2919, 2927, 2974, 2991, 3074, 3131, 3157, 3195, 3246, 3261, 3326, 3339, 3377, 3489, 3551, 3638, 3640, 3649, 3703, 3821, 3827, 3888, 3968, 4070, 4090, 4109, 4425, 4440, 4463, 4540, 4620, 5051, 5223, 5412, 5435, 5489, 5512, 5656, 5708, 5731], 'Biol.': [546, 885, 1219, 1394, 1850, 2005, 2076, 2378, 3196, 3378, 3552, 4110, 4234, 5052], 'Chem.': [547, 886, 1220, 1395, 1851, 2006, 2077, 2379, 3197, 3379, 3553, 4111, 4746, 5053], '2008;': [548], '283:': [549], '29639-29643Abstract': [550], 'Full': [551, 553, 890, 892, 1224, 1226, 1399, 1401, 1565, 1785, 1787, 1855, 1857, 2010, 2012, 2081, 2083, 2383, 2385, 2651, 2653, 3104, 3106, 3201, 3203, 3383, 3385, 3557, 3559, 4115, 4117, 4238, 4240, 4368, 4370, 4869, 4871, 4907, 4909, 5057, 5059, 5228, 5230, 5828, 5830], 'Text': [552, 554, 891, 893, 1225, 1227, 1400, 1402, 1566, 1786, 1788, 1856, 1858, 2011, 2013, 2082, 2084, 2384, 2386, 2652, 2654, 3105, 3107, 3202, 3204, 3384, 3386, 3558, 3560, 4116, 4118, 4239, 4241, 4369, 4371, 4870, 4872, 4908, 4910, 5058, 5060, 5229, 5231, 5829, 5831], 'PDF': [555, 894, 1228, 1403, 1567, 1789, 1859, 2014, 2085, 2387, 2655, 3108, 3205, 3387, 3561, 4119, 4242, 4372, 4873, 4911, 5061, 5232, 5832], '(653)': [558], 'Pre-symptomatic': [561], 'patients': [563], 'exhibit': [564, 595, 1193, 1830, 3214, 4251], 'elevations': [566, 568], 'relative': [572], 'less': [577, 1194, 4638], 'peptide,': [579], 'Aβ40,': [580], 'indicating': [581], 'initiate': [585, 5854], 'pathophysiology.': [586], 'Patients': [587], 'with': [588, 900, 1416, 1679, 2406, 2462, 2706, 2884, 3146, 3295, 3635, 4258, 4332, 4436, 4553, 4666, 4761, 4880, 5208, 5449, 5613], 'additional': [589, 4657], 'copies': [590], 'gene': [594, 3618, 3633], 'total': [596], 'overproduction': [598], 'develop': [600, 2445, 2513, 2626, 2665, 4759], 'early-onset': [601], 'Scholar,': [616, 873, 1014, 1055, 1118, 1157, 1376, 1554, 1618, 1737, 1768, 1794, 2111, 2242, 2789, 2824, 2851, 2983, 3083, 3113, 3255, 3335, 3498, 3524, 3953, 3978, 4080, 4416, 4531, 4999, 5029, 5262, 5280, 5300], '4Rovelet-Lecrux': [617], 'A.': [618, 627, 629, 635, 1167, 1176, 1747, 1774, 2115, 2803, 2915, 3902, 4003, 5011, 5333], 'Hannequin': [619], 'Raux': [621], 'G.': [622, 862, 1003, 1044, 1091, 1161, 1307, 1365, 1506, 1664, 1810, 1966, 2117, 2248, 2298, 2427, 2571, 2769, 3063, 3235, 3263, 3315, 3478, 3886, 3982, 4104, 4228, 4341, 4608, 4894, 5290, 5801], 'Le': [623], 'Meur': [624], 'N.': [625, 1073, 1079, 3279, 3874, 5050], 'Laquerriere': [626], 'Vital': [628], 'Dumanchin': [630], 'C.': [631, 1026, 1042, 1347, 1363, 1739, 1745, 1776, 1887, 2127, 2366, 2419, 3187, 3369, 4232, 5018, 5020], 'Feuillette': [632], 'S.': [633, 822, 824, 832, 840, 844, 963, 965, 973, 981, 985, 1057, 1101, 1163, 1175, 1211, 1267, 1269, 1277, 1285, 1289, 1386, 1466, 1468, 1476, 1484, 1488, 1624, 1626, 1634, 1642, 1646, 1809, 1838, 1891, 1926, 1928, 1936, 1944, 1948, 1993, 2206, 2210, 2294, 2304, 2417, 2423, 2472, 2476, 2795, 2907, 3165, 3347, 3550, 3872, 3901, 4002, 4096, 4098, 4349, 4452, 4612, 4614, 4900, 5009, 5217, 5332, 5424, 5501, 5720, 5809], 'Brice': [634], 'Vercelletto': [636], 'Dubas': [638], 'F.': [639, 858, 999, 1303, 1502, 1660, 1962, 2425, 3642, 3826, 3893, 3988, 3990, 4888, 5035], 'Frebourg': [640], 'T.': [641, 854, 995, 1213, 1299, 1498, 1656, 1958, 2565, 2763, 3057, 3161, 3229, 3309, 3343, 3472, 3823, 3890, 4100, 4450, 4890, 4898, 5033, 5314, 5422, 5499, 5653, 5718], 'Campion': [642], 'Nat.': [644, 2233, 2499, 3515], 'Genet.': [645, 2309], '38:': [647], '24-26Crossref': [648], '(973)': [651], 'Data': [654, 4669], 'point': [655], 'toward': [656], 'etiology,': [664], 'strategies': [666, 4296], 'lower': [668], 'therapeutically': [674], 'formed': [680], 'endoproteolysis': [682], 'type': [686, 1412], '1': [687, 1413], 'membrane': [688, 1414, 1540, 4185], '(Fig.': [690], '1)': [691, 709], '(5Vassar': [692, 4068], 'Neurosci.': [696, 1047, 1368, 2234, 2500, 2583, 2781, 2816, 2843, 2928, 2975, 3075, 3132, 3247, 3284, 3327, 3490, 3516, 4072, 4426, 4464, 4541, 5436, 5513, 5657, 5732], '2004;': [697, 2648, 3101, 3704, 4073, 4866, 5225, 5334], '23:': [698, 2845, 2977, 3134, 4074], '105-114Crossref': [699, 4075], '(303)': [702, 4078], '(β-site': [706], 'APP-cleaving': [707], 'initiating': [713], 'cleaves': [717, 800, 1520, 2092, 4920], 'Asp+1': [720, 1691, 1721], 'residue': [721], 'N': [726], 'terminus,': [727], 'APPsβ,': [728, 1579, 1594, 2458], 'C-terminal': [731, 795, 4170, 4309], 'fragment,': [732], 'C99.': [733], 'cleavage': [735, 763, 783, 905, 1438, 4694, 5117, 5192], 'prerequisite': [740], 'γ-secretase-mediated': [742], 'cleavage,': [743], 'C99': [745, 2460], 'proteolyzed': [747], 'γ-secretase': [749], '(a': [750], 'containing': [753], 'PS),': [754], 'which': [755, 790, 2625, 4193, 4702, 5189, 5536], 'generates': [756, 4064], 'AICD': [758], 'Aβ.': [760], 'This': [761], 'imprecise': [762], 'produces': [764], 'variants,': [766], 'including': [767, 3611, 4301, 5586], 'those': [768, 3678], 'ending': [769], 'at': [770, 1248, 1439, 1449, 1690, 1698, 1719, 1910, 2697, 3803, 5544, 5934], 'residues': [771, 1682, 4654, 4663, 4691], '40': [772], '(Aβ40)': [773], '42': [775], '(Aβ42).': [776], 'formation': [778, 2600, 5144], 'precluded': [780], 'α-secretase': [782, 2060], 'domain,': [789, 4060], 'liberates': [791], 'APPsα': [792, 1586, 1601], 'fragment': [796], 'C83.': [797], 'γ-Secretase': [798], 'then': [799], 'C83,': [801], 'forming': [802], 'p3': [803], 'AICD.': [806], 'α-': [808], 'moieties': [811], 'can': [812, 1527, 3769, 3935, 5200, 5593, 5636, 5675], 'compete': [813], 'substrate': [816], '(6Vassar': [817, 958, 1262, 1461, 1921], 'Bennett': [819, 960, 1264, 1463, 1621, 1923, 2207, 2473, 4093], 'B.D.': [820, 961, 1265, 1378, 1464, 1622, 1836, 1924, 1991, 2208, 2474, 4094], 'Babu-Khan': [821, 962, 1266, 1465, 1623, 1837, 1925, 1992, 2209, 2475], 'Kahn': [823, 964, 1268, 1385, 1467, 1625, 1927, 2205, 2471, 4095], 'Mendiaz': [825, 966, 1270, 1469, 1627, 1929, 4087], 'E.A.': [826, 967, 1271, 1470, 1628, 1930, 2634, 3087, 4088, 4852], 'Denis': [827, 968, 1272, 1379, 1471, 1629, 1931, 2211, 2477, 4083], 'P.': [828, 834, 969, 975, 1081, 1097, 1273, 1279, 1380, 1472, 1478, 1630, 1636, 1806, 1932, 1938, 2212, 2415, 2478, 2799, 2911, 3181, 3191, 3363, 3373, 3878, 4084, 4446, 5016, 5048, 5322, 5418, 5495, 5714], 'Teplow': [829, 970, 1274, 1383, 1473, 1557, 1631, 1756, 1777, 1933, 2124], 'D.B.': [830, 877, 971, 1140, 1275, 1384, 1474, 1558, 1632, 1757, 1778, 1934, 2125], 'Ross': [831, 972, 1276, 1475, 1633, 1935, 4097], 'Amarante': [833, 974, 1278, 1477, 1635, 1937], 'Loeloff': [835, 976, 1280, 1479, 1637, 1839, 1939, 1994], 'Luo': [837, 978, 1282, 1481, 1639, 1941], 'Y.': [838, 979, 1283, 1482, 1640, 1875, 1881, 1885, 1889, 1942, 2028, 2202, 2220, 2421, 2468, 2486, 2517, 3955, 4086, 4359, 4442, 5326, 5414, 5491, 5710, 5819], 'Fisher': [839, 980, 1284, 1483, 1641, 1943], 'Fuller': [841, 982, 1286, 1485, 1643, 1945, 4089], 'Edenson': [843, 984, 1288, 1487, 1645, 1947], 'Lile': [845, 986, 1290, 1489, 1647, 1949], 'Jarosinski': [847, 988, 1292, 1491, 1649, 1951], 'M.A.': [848, 989, 1293, 1492, 1650, 1879, 1952, 2032, 2521, 3961], 'Biere': [849, 990, 1294, 1493, 1651, 1953], 'A.L.': [850, 991, 1295, 1494, 1652, 1954], 'Curran': [851, 992, 1296, 1495, 1653, 1843, 1955, 1998], 'E.': [852, 993, 1297, 1496, 1654, 1844, 1956, 1999, 2797, 2909, 3171, 3265, 3353, 3504, 3514, 3876, 4454, 5426, 5503, 5722], 'Burgess': [853, 994, 1298, 1497, 1655, 1957, 4099], 'Louis': [855, 996, 1300, 1387, 1499, 1657, 1841, 1959, 1996, 2223, 2489], 'J.-C.': [856, 997, 1301, 1388, 1500, 1658, 1842, 1960, 1997, 2224, 2490], 'Collins': [857, 998, 1302, 1501, 1659, 1961], 'Treanor': [859, 1000, 1304, 1503, 1661, 1963], 'Rogers': [861, 1002, 1306, 1505, 1663, 1965, 4103], 'Citron': [863, 1004, 1308, 1389, 1507, 1665, 1845, 1967, 2000, 2043, 2229, 2495, 2532, 2641, 2833, 2860, 2965, 2992, 3094, 3122, 4107, 4455, 4859, 5006, 5309, 5427, 5504, 5723], 'Science.': [865, 1006, 1310, 1509, 1667, 1969, 2428, 4621, 5021], '1999;': [866, 1007, 1048, 1111, 1150, 1311, 1369, 1510, 1668, 1970], '286:': [867, 1008, 1312, 1511, 1669, 1971], '735-741Crossref': [868, 1009, 1313, 1512, 1670, 1972], '(3308)': [871, 1012, 1316, 1515, 1673, 1975], '7Skovronsky': [874], 'D.M.': [875, 1034, 1355], 'Moore': [876], 'Milla': [878], 'M.E.': [879, 1124, 1148, 2072, 2292], 'Doms': [880], 'R.W.': [881], 'Lee': [882, 2273, 2578, 2776, 3070, 3242, 3322, 3485, 3541, 4419, 4534], 'V.M.': [883], '2000;': [887, 1177, 1396, 1852, 2007, 4112, 4622], '275:': [888, 1397, 1853, 2008, 4113], '2568-2575Abstract': [889], '(297)': [897], 'Scholar),': [899, 1864, 1977, 2315, 2542, 2591, 3210, 3292, 3658, 3796, 4432, 4754, 4878, 4954, 5237, 5740], 'increase': [902, 3751, 4195, 4722], 'one': [904], 'event': [906], 'leading': [907, 5473], 'decrease': [910], 'other.': [913], 'As': [914, 1443, 3393, 3738, 4799, 5342], 'initiates': [916], 'putatively': [921], 'rate-limiting,': [922], 'it': [923, 3394, 5570, 5607, 5741, 5942, 5960], 'prime': [926, 3570], 'lowering': [930], 'cerebral': [931, 3759], 'treatment': [936, 1592, 5896, 5984], 'and/or': [937, 4177, 4271, 5081, 5242, 5376, 5601], 'prevention': [938], '(memapsin': [942], '2,': [943], 'Asp2)': [944], 'aspartic': [947, 4652], 'protease': [948, 1415, 1526, 4132, 4163, 4256, 4560], 'exhibits': [950, 1187], 'all': [951, 2453, 2952], 'previously': [953], 'determined': [954], 'characteristics': [955], '8Hussain': [1015], 'I.': [1016, 1085, 1215, 1337, 1751, 2270, 3787, 3819, 3870, 4230], 'Powell': [1017, 1338], 'Howlett': [1019, 1340], 'D.R.': [1020, 1341, 2575, 2773, 3067, 3239, 3319, 3482, 3884, 4226], 'Tew': [1021, 1342], 'D.G.': [1022, 1343, 2252], 'Meek': [1023, 1344], 'T.D.': [1024, 1345], 'Chapman': [1025, 1346, 2414], 'Gloger': [1027, 1348], 'I.S.': [1028, 1349], 'Murphy': [1029, 1350], 'K.E.': [1030, 1351, 2266], 'Southan': [1031, 1352], 'C.D.': [1032, 1353], 'Ryan': [1033, 1354], 'Smith': [1035, 1356], 'T.S.': [1036, 1357, 1772], 'Simmons': [1037, 1358], 'D.L.': [1038, 1359, 2577, 2775, 3069, 3241, 3321, 3484, 4404, 4519, 5213], 'Walsh': [1039, 1360], 'F.S.': [1040, 1361], 'Dingwall': [1041, 1362, 4231], 'Christie': [1043, 1364, 4227], 'Cell.': [1046, 1367, 3283], '14:': [1049, 1370, 1563], '419-427Crossref': [1050, 1371], '(1001)': [1053, 1374], '9Sinha': [1056], 'Anderson': [1058, 2245, 3529], 'J.P.': [1059, 3530], 'Barbour': [1060], 'Basi': [1062, 2247], 'G.S.': [1063], 'Caccavello': [1064], 'Davis': [1066], 'Doan': [1068], 'Dovey': [1070], 'H.F.': [1071], 'Frigon': [1072, 2257], 'Hong': [1074], 'Jacobson-Croak': [1076], 'K.': [1077, 2262, 2264, 2413, 2563, 2761, 3055, 3163, 3173, 3189, 3227, 3307, 3345, 3355, 3371, 3470, 3540, 3693, 3785, 5037, 5039, 5286, 5304], 'Jewett': [1078], 'Keim': [1080], 'Knops': [1082], 'Lieberburg': [1084, 1214, 1750], 'Power': [1086, 2281], 'Tan': [1088], 'H.': [1089, 1126, 1798, 1877, 2036, 2216, 2300, 2482, 2525, 2557, 2567, 2638, 2755, 2765, 2791, 2832, 2903, 2964, 3049, 3059, 3091, 3121, 3221, 3231, 3301, 3311, 3464, 3474, 3963, 3984, 4856, 4892, 5041, 5211, 5264, 5320], 'Tatsuno': [1090, 2297], 'Tung': [1092], 'Schenk': [1094, 1754, 2285], 'Seubert': [1096], 'Suomensaari': [1098], 'S.M.': [1099, 3257, 3779], 'Wang': [1100, 1803, 1874], 'Walker': [1102], 'Zhao': [1104, 2858, 2990], 'McConlogue': [1106, 1216, 2305], 'L.': [1107, 1201, 1203, 1207, 1217, 2222, 2306, 2488, 2810, 2828, 2922, 2960, 3117, 3167, 3349, 3506, 3526, 3646, 3817, 3882, 4460, 4606, 5316, 5432, 5509, 5728], 'John': [1108], 'V.': [1109, 3959, 4102, 4742], 'Nature.': [1110, 1149, 1760], '402:': [1112, 1151], '537-540Crossref': [1113], '(1482)': [1116], '10Yan': [1119], 'Bienkowski': [1121, 2073, 2249], 'M.J.': [1122, 2074, 2250, 2374], 'Shuck': [1123, 2071, 2291], 'Miao': [1125], 'Tory': [1127], 'M.C.': [1128, 5221, 5270], 'Pauley': [1129], 'A.M.': [1130], 'Brashler': [1131], 'J.R.': [1132], 'Stratman': [1133], 'N.C.': [1134], 'Mathews': [1135], 'W.R.': [1136], 'Buhl': [1137], 'A.E.': [1138, 2376], 'Carter': [1139], 'Tomasselli': [1141], 'A.G.': [1142], 'Parodi': [1143], 'L.A.': [1144, 3275], 'Heinrikson': [1145], 'R.L.': [1146], 'Gurney': [1147], '533-537Crossref': [1152], '(1339)': [1155], '11Lin': [1158], 'X.': [1159, 1873, 1893, 3965, 3980, 4610, 5308], 'Koelsch': [1160, 4607], 'Wu': [1162, 4611], 'Downs': [1164], 'Dashti': [1166], 'Tang': [1168, 4619], 'Proc.': [1170, 3896, 3997, 5327], 'Natl.': [1171, 3897, 3998, 5328], 'Acad.': [1172, 3898, 3999, 5329], 'Sci.': [1173, 3899, 4000, 5330], 'U.': [1174, 3183, 3365, 3900, 4001, 5331], '97:': [1178], '1456-1460Crossref': [1179], '(740)': [1182], 'Neural': [1185, 3969], 'tissue': [1186], 'maximal': [1188], 'activity,': [1190, 4133, 4164, 4254, 4984, 5671], 'astrocytes': [1192], 'activity': [1195, 1448, 2187, 3403, 3691, 3866, 4019, 4224, 4273, 4380, 5177, 5199, 5206, 5243, 5377], 'than': [1196, 5460], 'neurons': [1197, 1245], '(12Zhao': [1198], 'Paganini': [1200], 'Mucke': [1202], 'Gordon': [1204], 'Refolo': [1206], 'Carman': [1208], 'Sinha': [1210, 2293, 3549], 'Oltersdorf': [1212], '1996;': [1221, 1782, 2380, 2429], '271:': [1222, 2381], '31407-31411Abstract': [1223], '(81)': [1231], 'Accordingly,': [1234], 'mRNA': [1236, 1907, 1989, 3938], 'highest': [1239], 'brain,': [1241, 2185, 3714, 3747], 'being': [1242, 1452], 'enriched': [1243], 'but': [1246], 'found': [1247], 'low': [1249, 1911, 1983], 'resting': [1252], 'glia.': [1253], 'abundant': [1258], 'human': [1260, 1915, 1978, 2172], 'Like': [1319], 'pepsin': [1321], 'family': [1322, 4330, 4644], 'members,': [1323], 'has': [1325, 1446, 2149, 4599, 4703, 4711, 4825, 5877, 5897, 5917], 'two': [1326], 'active': [1327, 1428, 4632, 4679], 'site': [1328, 1429, 4476, 4633, 4680], 'motifs,': [1329], 'mutation': [1331, 2410], 'inactivity': [1335], '(8Hussain': [1336], '13Bennett': [1377], 'Haniu': [1381], '37712-37717Abstract': [1398], '(240)': [1406], 'single': [1418, 2707], 'transmembrane': [1419], 'domain': [1420, 4128], 'near': [1421], 'its': [1422, 4175, 5648, 5867], 'C': [1423], 'terminus': [1424], 'luminal': [1427], 'provides': [1431], 'correct': [1433], 'topological': [1434], 'orientation': [1435], 'site.': [1442], 'predicted,': [1444], 'optimal': [1447], 'pH': [1450], '4.5,': [1451], 'localized': [1453], 'acidic': [1455], 'compartments': [1456], 'secretory': [1459, 4043], 'pathway': [1460, 4400, 4570], 'β-Secretase': [1518], 'efficiently': [1519], 'only': [1521], 'membrane-bound': [1522], 'substrates,': [1523], 'tolerate': [1528], 'changes': [1529, 5357, 5611], 'distance': [1532], 'cleaved': [1535, 4930, 5781], 'peptide': [1536, 4824], 'bond': [1537], '14Citron': [1555], 'Selkoe': [1559, 1758, 1779], 'D.J.': [1560, 1759, 1780], 'Neuron.': [1561, 1781, 2647, 3100, 4364, 4865, 4903, 5824], '1995;': [1562], '661-670Abstract': [1564], '(233)': [1570], 'transfection': [1574], 'APP-overexpressing': [1576], 'cells': [1577], 'elevates': [1578, 1600, 5789], 'C99,': [1580, 1595], 'reduces': [1585, 3843], 'levels.': [1587], 'Conversely,': [1588], 'antisense': [1590], 'oligonucleotide': [1591], 'inhibits': [1593], 'production': [1598, 4016, 4515, 4820], 'C83': [1603], '6Vassar': [1619], 'species': [1678, 1696, 1708], 'different': [1680], 'N-terminal': [1681], 'exist.': [1683], 'isolated': [1685], 'plaques': [1687, 2515, 4502, 5487], 'predominantly': [1688, 3723, 4931], 'begins': [1689], 'minor': [1695], 'begin': [1697], 'Val–3,': [1699], 'Ile–6,': [1700], 'Glu+11.': [1702], 'Val–3': [1705], 'Ile–6': [1707], 'not': [1710, 2022, 2664, 3422, 4130, 5841], 'generated': [1711], 'β-secretase,': [1713], 'responsible': [1716, 2606, 2695, 3024], 'cleaving': [1718], 'Glu+11': [1723], '15Haass': [1738], 'Schlossmacher': [1740], 'M.G.': [1741], 'Hung': [1742], 'A.Y.': [1743], 'Vigo-Pelfrey': [1744, 2365], 'Mellon': [1746], 'Ostaszewski': [1748], 'B.L.': [1749], 'Koo': [1752], 'E.H.': [1753], '1992;': [1761], '359:': [1762], '322-325Crossref': [1763], '(1763)': [1766], '16Citron': [1769], 'Diehl': [1771], 'Capell': [1773, 2114], 'Haass': [1775, 2126, 5019], '17:': [1783], '171-179Abstract': [1784], '(82)': [1792], '17Gouras': [1795], 'G.K.': [1796], 'Xu': [1797, 2570, 2768, 3062, 3234, 3314, 3477], 'Jovanovic': [1799], 'J.N.': [1800], 'Buxbaum': [1801], 'J.D.': [1802], 'Greengard': [1805], 'Relkin': [1807], 'N.R.': [1808], 'Neurochem.': [1812, 2131], '1998;': [1813], '71:': [1814], '1920-1925Crossref': [1815], '(106)': [1818], 'on': [1822, 1827, 2733, 4732, 5988], 'chromosome': [1823, 1828], '11q23.2,': [1824], 'BACE2,': [1826], '21q22.3,': [1829], '64%': [1831], 'amino': [1832], 'acid': [1833, 4303, 4653], 'similarity': [1834], '(18Bennett': [1835, 1990], '20647-20651Abstract': [1854, 2009], '(257)': [1862, 2017, 5064], 'they': [1866], 'distinct': [1868], 'regulation': [1869, 5542], 'function': [1871, 2152, 4886, 4979], '(19Sun': [1872], 'Qing': [1876, 3962, 3983], 'Christensen': [1878, 3960], 'Liu': [1880, 1892, 2035, 2275, 2524, 3545], 'Zhou': [1882, 3956, 3985], 'W.': [1883, 1895, 2214, 2276, 2480, 2830, 2962, 3119, 3546, 3957, 3967, 3986, 3996], 'Tong': [1884], 'Xiao': [1886], 'Huang': [1888, 3993], 'Zhang': [1890, 2037, 2217, 2483, 2526, 4617], 'Song': [1894, 3966, 3995], 'FASEB': [1896, 3702], '2005;': [1898, 2584, 2782, 3076, 3198, 3248, 3328, 3380, 3491, 3517, 3829, 3971, 5054, 5658], '19:': [1899], '739-749Crossref': [1900], '(110)': [1903], 'BACE': [1906], 'expressed': [1909], 'peripheral': [1916], 'tissues,': [1917, 4927], 'yet': [1918, 5898], 'unlike': [1919], 'whole': [1979], 'expresses': [1981], 'very': [1982], 'undetectable': [1985], 'BACE2': [1988, 2020, 2091], '(20Luo': [2027, 2516], 'Bolon': [2029, 2203, 2469, 2518], 'B.': [2030, 2121, 2204, 2470, 2519, 3194, 3376, 3697, 4448, 5005, 5014, 5046, 5420, 5497, 5716], 'Damore': [2031, 2520], 'Fitzpatrick': [2033, 2522], 'Yan': [2039, 2225, 2491, 2528, 5311], 'Q.': [2040, 2226, 2492, 2529], 'Neurobiol.': [2045, 2534, 2868, 3000], 'Dis.': [2046, 2535, 2869, 3001], '2003;': [2047, 2536, 3285, 3651, 4409, 4524, 4904], '4:': [2048, 2236, 2502, 2537], '81-88Crossref': [2049, 2538], '(153)': [2051, 2540], 'Scholar)': [2053, 2139, 2392, 2436, 5521], 'functions': [2055, 4957, 5110], 'more': [2056, 2325, 4635, 5459], 'alternative': [2059], 'antagonist': [2064], '(21Yan': [2067], 'Munzner': [2069], 'J.B.': [2070, 2370], '2001;': [2078, 2235, 2310, 2501, 4235], '276:': [2079], '34019-34027Abstract': [2080], '(148)': [2088], 'Phe+19': [2095], 'Phe+20': [2097], '22Fluhrer': [2112], 'Westmeyer': [2116], 'Willem': [2118], 'Hartung': [2120], 'Condron': [2122], 'M.M.': [2123], 'Walter': [2128, 3820, 3887], '2002;': [2132, 4427, 4542, 5273, 5293], '81:': [2133], '1011-1020Crossref': [2134], '(100)': [2137], 'abolish': [2141], 'production.': [2143, 5540], 'Knowledge': [2144], 'whether': [2147, 5382, 5839], 'vital': [2151], 'vivo': [2154, 2688, 3405, 4481], 'importance': [2158], 'development': [2161, 3811, 4604, 4734, 5978], 'inhibitors,': [2164, 4786], 'mouse': [2166, 2184], 'models': [2167, 5454], 'recapitulating': [2168], 'key': [2169, 5756], 'features': [2170], 'pathology': [2174, 2741, 5451], 'examine': [2179], 'this.': [2180], 'Notably,': [2181, 2937, 5204, 5580], 'abolished.': [2189], 'any': [2198], 'adverse': [2199], 'phenotype': [2200, 3217], '(23Luo': [2201, 2467], 'Fan': [2213, 2479], 'Kha': [2215, 2481], 'Gong': [2219, 2485], 'Martin': [2221, 2487], 'Richards': [2227, 2493], 'W.G.': [2228, 2494], '231-232Crossref': [2237, 2503], '(951)': [2240, 2506], '24Roberds': [2243], 'Branstetter': [2251], 'Chen': [2253, 3533], 'K.S.': [2254, 3534], 'Freedman': [2255, 3535], 'S.B.': [2256, 3536], 'N.L.': [2258], 'Games': [2259, 3537], 'Hu': [2261], 'Johnson-Wood': [2263, 3539], 'Kappenman': [2265], 'Kawabe': [2267], 'T.T.': [2268], 'Kola': [2269], 'Kuehn': [2271], 'Motter': [2277, 3547], 'Nichols': [2279], 'N.F.': [2280], 'Robertson': [2283], 'D.W.': [2284], 'Schoor': [2287], 'Shopp': [2289], 'G.M.': [2290], 'Svensson': [2295], 'K.A.': [2296], 'Tintrup': [2299], 'Wijsman': [2301], 'Wright': [2303], 'Hum.': [2307], '10:': [2311], '1317-1324Crossref': [2312], 'suggesting': [2316, 4841], 'absence': [2319, 4831, 5403], 'well': [2321], 'tolerated': [2322], 'vivo,': [2324, 4391], 'recent': [2326, 5931], 'studies': [2327], 'Bace1–/–-associated': [2331], 'phenotypes': [2332], '(discussed': [2333, 4338], 'below).': [2334, 5379], 'Further': [2335], 'research': [2336], 'required': [2338, 3031, 5953], 'determine': [2340], 'what': [2341], 'mean': [2344], 'clinical': [2347, 5889], 'use': [2348, 3842, 5890], 'inhibitors': [2351, 4586, 4740], 'future.': [2354], 'Fibrillar': [2355], 'soluble': [2357, 2616, 2692], 'oligomeric': [2358], 'forms': [2360, 2454], '(25Kuo': [2361], 'Y.M.': [2362], 'Emmerling': [2363], 'M.R.': [2364], 'Kasunic': [2367], 'T.C.': [2368], 'Kirkpatrick': [2369], 'Murdoch': [2371], 'G.H.': [2372], 'Ball': [2373], 'Roher': [2375], '4077-4081Abstract': [2382], '(555)': [2390], 'accumulate': [2393], 'contrast': [2398], 'wild-type': [2400], 'mice,': [2401, 2624, 2670], 'Tg': [2402, 2552, 2708, 2712, 2750], 'overexpressing': [2404], 'Swedish': [2409, 5187], '(Tg2576)': [2411], '(26Hsiao': [2412], 'Nilsen': [2416], 'Eckman': [2418], 'Harigaya': [2420], 'Younkin': [2422, 2635, 2639, 3088, 3092, 4853, 4857], 'Yang': [2424, 4354, 5305, 5814], 'Cole': [2426, 2792, 2854, 2904, 2986], '274:': [2430], '99-103Crossref': [2431], '(3700)': [2434], 'produce': [2437, 3729], 'robust': [2438], 'age-dependently': [2444], 'plaques.': [2448], 'Bace1–/–·Tg2576': [2449, 2509, 2668], 'bigenic': [2450, 2669], 'compared': [2461], 'Bace1+/–·Tg2576': [2463], 'Bace1+/+·Tg2576': [2465], 'animals': [2510], 'fail': [2511], 'similar': [2544], 'findings': [2545, 3623], 'were': [2546, 2629, 2951], 'another': [2549], 'Bace1-deficient': [2550], 'model': [2553], '(27Laird': [2554, 2752, 3046, 3218, 3298, 3461], 'F.M.': [2555, 2753, 3047, 3219, 3299, 3462], 'Cai': [2556, 2754, 3048, 3220, 3300, 3463, 3989, 5319], 'Savonenko': [2558, 2756, 3050, 3222, 3302, 3465], 'A.V.': [2559, 2757, 3051, 3223, 3303, 3466], 'Farah': [2560, 2758, 3052, 3224, 3304, 3467], 'M.H.': [2561, 2759, 3053, 3225, 3305, 3468], 'He': [2562, 2760, 3054, 3226, 3306, 3469, 3981], 'Melnikova': [2564, 2762, 3056, 3228, 3308, 3471], 'Wen': [2566, 2764, 3058, 3230, 3310, 3473], 'Chiang': [2568, 2766, 3060, 3232, 3312, 3475], 'H.C.': [2569, 2767, 3061, 3233, 3313, 3476], 'Koliatsos': [2572, 2770, 3064, 3236, 3316, 3479, 4405, 4520], 'V.E.': [2573, 2771, 3065, 3237, 3317, 3480, 4406, 4521], 'Borchelt': [2574, 2772, 3066, 3238, 3318, 3481, 4895], 'Price': [2576, 2774, 3068, 3240, 3320, 3483, 4403, 4518, 5323], 'H.K.': [2579, 2777, 3071, 3243, 3323, 3486, 5031], 'Wong': [2580, 2778, 3072, 3244, 3324, 3487, 5321], 'P.C.': [2581, 2779, 3073, 3245, 3325, 3488], '25:': [2585, 2783, 3077, 3249, 3329, 3492, 5659], '11693-11709Crossref': [2586, 2784, 3078, 3250, 3330, 3493], '(454)': [2589, 2787, 3081, 3253, 3333, 3496], 'unequivocally': [2592], 'proving': [2593], 'generation.': [2610], 'To': [2611, 5380], 'analyze': [2612], 'contribution': [2614], 'memory': [2619, 2627, 2703, 2720, 2745, 2891, 3035, 3427, 4839, 4848], 'dysfunction,': [2620], 'young': [2621], 'pre-plaque': [2622], 'Tg2576': [2623, 2673], 'impairments,': [2628, 4840], 'examined': [2630], '(28Ohno': [2631, 4849], 'Sametsky': [2633, 3086, 4851], 'L.H.': [2636, 3089, 4854], 'Oakley': [2637, 2831, 2963, 3090, 3120, 4855], 'S.G.': [2640, 3093, 4858], 'Disterhoft': [2645, 2806, 2839, 2864, 2918, 2971, 2996, 3098, 3128, 4863], 'J.F.': [2646, 2840, 2865, 2972, 2997, 3099, 3129, 4864], '41:': [2649, 3102, 4867], '27-33Abstract': [2650, 3103, 4868], '(459)': [2658, 3111, 4876], 'Memory': [2661], 'deficits': [2662, 2721, 2746, 2940], 'did': [2663], 'Aβ-deficient': [2667], 'whereas': [2671, 5672], 'Aβ-overproducing': [2672], 'monogenics': [2674], 'exhibited': [2675, 2888], 'florid': [2676], 'deficits.': [2677, 2704, 3438], 'These': [2678], 'provide': [2680, 4291], 'direct': [2681], 'evidence': [2682], 'indicate': [2690, 3624, 4487, 4670], 'least': [2698], 'some': [2699], 'aspects': [2700], 'AD-related': [2702], 'Compared': [2705], 'models,': [2709], 'APP/PS1': [2710, 2749], 'double': [2711], 'show': [2714, 5777], 'accelerated': [2715], 'accumulation': [2717], 'AD-associated': [2719], 'investigate': [2727], 'consequences': [2729, 3409, 3927], 'ablation': [2732], 'established': [2734], 'pathology.': [2736, 3765], 'deletion': [2738], 'abolished': [2739], 'prevented': [2743], '29Oakley': [2790], 'Logan': [2794, 2906, 4451, 5423, 5500, 5719], 'Maus': [2796, 2908, 4453, 5425, 5502, 5721], 'Shao': [2798, 2910, 4445, 5417, 5494, 5713], 'Craft': [2800, 2912], 'Guillozet-Bongaarts': [2802, 2914], 'Ohno': [2804, 2916], 'Van': [2808, 2920, 3824, 3891], 'Eldik': [2809, 2921], 'Berry': [2811, 2862, 2923, 2994, 4457, 5429, 5506, 5725], '26:': [2818, 2871, 2930, 3003], '10129-10140Crossref': [2819, 2931], '(2003)': [2822, 2934], '30Ohno': [2825, 3114], 'Chang': [2827, 2959, 3116], 'Tseng': [2829, 2961, 3118], 'Klein': [2835, 2967, 3124], 'W.L.': [2836, 2968, 3125], 'Eur.': [2841, 2973, 3130], '251-260Crossref': [2846, 2978, 3135], '(227)': [2849, 2981, 3138], '31Ohno': [2852, 2984], 'Yasvoina': [2856, 2988, 4443, 5415, 5492, 5711], '134-145Crossref': [2872, 3004], '(245)': [2875, 3007], '5XFAD': [2878, 2949], 'coexpressing': [2880], 'PS1': [2883], 'five': [2885], 'aggressive': [2889], 'pathology,': [2890, 2939], 'deficits,': [2892, 5622], 'and,': [2893], 'unusually,': [2894], 'significant': [2895, 3730, 5366, 5582], 'neuronal': [2896, 2945, 3026, 3725, 4885, 4918, 4983, 5772], 'loss': [2897, 2946, 5753], 'AD-sensitive': [2899], 'regions': [2901], '(29Oakley': [2902], 'hippocampus-dependent': [2942], 'learning,': [2943], 'rescued': [2953], 'Bace1–/–/5XFAD': [2955], '(30Ohno': [2957], 'Thus,': [3010], 'peptides': [3012, 4494], 'involved': [3014, 4845, 5075, 5390], 'age-associated': [3016], 'cognitive': [3017, 3437], 'impairments': [3018], 'appear': [3020, 3800, 5645], 'ultimately': [3023], 'death.': [3027], 'hippocampal': [3034], 'processes,': [3036], 'potential': [3038], 'mechanism-based': [3039, 4802], 'toxicities': [3040, 4803], 'result': [3041, 4805], 'complete': [3043, 4807, 4830], 'inhibition': [3045, 5786], '28Ohno': [3084], 'deficiency': [3142, 5641], 'might': [3143, 3756, 5351, 5625], 'associated': [3145, 5612], 'higher': [3148], 'mortality': [3149], 'rate': [3150], 'life': [3153], '(32Dominguez': [3154], 'Tournoy': [3156, 3338], 'Hartmann': [3158, 3340], 'Huth': [3160, 3342], 'Cryns': [3162, 3344], 'Deforce': [3164, 3346], 'Serneels': [3166, 3348], 'Camacho': [3168, 3350], 'I.E.': [3169, 3351], 'Marjaux': [3170, 3352], 'Craessaerts': [3172, 3354], 'Roebroek': [3174, 3356], 'A.J.': [3175, 3259, 3357], 'Schwake': [3176, 3358], "D'Hooge": [3178, 3360], 'Bach': [3180, 3362], 'Kalinke': [3182, 3364], 'Moechars': [3184, 3366], 'Reiss': [3188, 3370], 'Saftig': [3190, 3372, 5015, 5047], 'De': [3192, 3374, 5012, 5044], 'Strooper': [3193, 3375, 5013, 5045], '280:': [3199, 3381, 5055], '30797-30806Abstract': [3200, 3382], '(296)': [3208, 3390], 'emotional': [3216], '33Harrison': [3256], 'Harper': [3258], 'Hawkins': [3260], 'Duddy': [3262], 'Grau': [3264], 'Pugh': [3266], 'P.L.': [3267], 'Winter': [3268], 'P.H.': [3269], 'Shilliam': [3270], 'C.S.': [3271], 'Hughes': [3272], 'Z.A.': [3273], 'Dawson': [3274], 'Gonzalez': [3276], 'M.I.': [3277], 'Upton': [3278], 'Pangalos': [3280], 'M.N.': [3281], '24:': [3286], '646-655Crossref': [3287], '(138)': [3290], 'appearing': [3293], 'hyperactive,': [3294], 'enhanced': [3296, 4252, 5762], 'locomotion': [3297], '32Dominguez': [3336], 'would': [3395], 'nearly': [3397], 'impossible': [3398], 'completely': [3400], 'suppress': [3401, 4131], 'therapeutically,': [3406], 'partial': [3411, 3418], 'inactivation': [3413, 3420], 'critically': [3415], 'important.': [3416], 'Indeed,': [3417, 4506, 4828, 4934, 5922], 'affect': [3423, 5637], 'normal': [3424, 3590, 4817, 4847], 'learning': [3425], 'processes': [3428], 'reducing': [3433], 'Aβ-associated': [3434], 'Whether': [3439], 'there': [3440], 'differences': [3442], 'benefit': [3446, 4589], 'adjusting': [3448], 'during': [3451, 3736, 5132, 5782, 5859], 'versus': [3453], 'later': [3454], 'stages': [3456], 'clarified': [3460], '34Singer': [3499], 'O.': [3500, 4418, 4533], 'Marr': [3501], 'R.A.': [3502, 5651], 'Rockenstein': [3503], 'Crews': [3505], 'Coufal': [3507], 'N.G.': [3508], 'Gage': [3509], 'F.H.': [3510], 'Verma': [3511], 'I.M.': [3512], 'Masliah': [3513], '8:': [3518], '1343-1349Crossref': [3519], '(361)': [3522], '35McConlogue': [3525], 'Buttini': [3527], 'Brigham': [3531], 'E.F.': [3532], 'Zeller': [3543], '282:': [3555], '26326-26334Abstract': [3556], '(255)': [3564], 'therapeutic': [3571, 4295], 'Understanding': [3577], 'control': [3579, 4311], 'expression': [3582, 3755, 3773], 'cell': [3585, 5407], 'biology': [3586], 'illuminate': [3588], 'identify': [3594], 'disease-associated': [3595], 'mechanisms,': [3596], 'suggest': [3598], 'approaches': [3599], 'inhibit': [3601, 4298, 4693], 'therapeutically.': [3603], 'gene,': [3606], 'spanning': [3607], '∼30': [3608], 'kb': [3609], 'exons,': [3613], 'candidate': [3617], 'polymorphisms': [3626], 'exon': [3628], '5': [3629], 'associate': [3634], '(36Clarimon': [3637], 'Bertranpetit': [3639], 'Calafell': [3641], 'Boada': [3643], 'Tarraga': [3645], 'Comas': [3647], 'Neurol.': [3650, 4408, 4523, 5272, 5292], '250:': [3652], '956-961Crossref': [3653], '(39)': [3656], 'clear': [3659, 5944], 'underlie': [3662], 'associations': [3664], 'hard': [3666], 'identify.': [3668], 'promoter': [3671, 3865], 'contains': [3672], 'multiple': [3673, 5574, 5745], 'transcription': [3674], 'factor-binding': [3675], 'sites': [3676, 3804, 4512], '(including': [3677], 'interferon-γ,': [3680], 'peroxisome': [3681, 3857], 'proliferator-activated': [3682, 3858], 'receptor-γ,': [3683], 'hypoxia-inducible': [3685], 'factor-1)': [3686], 'likely': [3688, 4510, 5743, 5962], 'influence': [3689, 4174], 'transcriptional': [3690, 5547], '(37Sambamurti': [3692], 'Kinsey': [3694], 'Maloney': [3696], 'Ge': [3698], 'Y.W.': [3699], 'Lahiri': [3700], 'D.K.': [3701], '18:': [3705], '1034-1036Crossref': [3706], '(156)': [3709], 'glia': [3715, 3727], 'significantly': [3716], 'outnumber': [3717], 'neurons,': [3718], 'protein,': [3726, 4186], 'amounts': [3731], 'inflammation.': [3737], 'inflammatory': [3741], 'reaction': [3742], 'present': [3744], 'even': [3748], 'slight': [3750], 'glial': [3753, 3806], 'substantially': [3757], 'impact': [3758, 5373], 'exacerbate': [3763], 'Certain': [3766], 'pro-inflammatory': [3767], 'molecules': [3768, 4688], 'elevate': [3770, 3936, 5747], 'astrocytic': [3771], '(38Cho': [3774], 'H.J.': [3775], 'Kim': [3776, 3782], 'S.K.': [3777], 'Jin': [3778], 'Hwang': [3780], 'E.M.': [3781], 'Y.S.': [3783], 'Huh': [3784], 'Mook-Jung': [3786], 'Glia.': [3788], '55:': [3790], '253-262Crossref': [3791], '(89)': [3794], 'activation': [3807, 3855, 5764], 'prior': [3808], 'plaque': [3810], '(39Heneka': [3812], 'M.T.': [3813, 3895], 'Sastre': [3814], 'Dumitrescu-Ozimek': [3816, 3881], 'Dewachter': [3818, 3869], 'Klockgether': [3822, 3889], 'Leuven': [3825, 3892], 'Neuroinflamm.': [3828], '(239)': [3834], 'Interestingly,': [3837, 3923], 'long-term': [3838], 'nonsteroidal': [3839], 'anti-inflammatory': [3840], 'risk,': [3845], 'effect': [3847], 'mediated': [3851], 'part': [3853], 'receptor-γ': [3859], 'subsequent': [3861], 'repression': [3862], '(40Sastre': [3867], 'Rossner': [3871], 'Bogdanovic': [3873], 'Rosen': [3875], 'Borghgraef': [3877], 'Evert': [3879], 'B.O.': [3880], 'Thal': [3883], 'Landreth': [3885], 'Heneka': [3894], '103:': [3904, 4005], '443-448Crossref': [3905], '(347)': [3908], 'Specific': [3911], 'stressful': [3912, 5104, 5842], 'events': [3913, 5472], 'link': [3919], 'pathogenesis.': [3922], 'cellular': [3926, 5610], '(e.g.': [3931, 4262, 5616], 'hypoxia,': [3932, 5617, 5630], 'oxidative': [3933, 5618, 5631], 'stress)': [3934], '41Tong': [3954], 'Fung': [3958], 'Sun': [3964], 'Transm.': [3970], '112:': [3972], '455-469Crossref': [3973], '(197)': [3976], '42Sun': [3979], 'Dobie': [3987], 'Staufenbiel': [3991], 'L.E.': [3994], '18727-18732Crossref': [4006], '(463)': [4009], 'Furthermore,': [4012, 4697, 5067], 'hypoxia': [4013], 'increases': [4014, 5207, 5538], 'via': [4017], 'up-regulation': [4020], 'vitro': [4023], 'undergoes': [4028, 4190], 'regulation.': [4030], 'Following': [4031], 'synthesis': [4032], 'endoplasmic': [4035], 'reticulum,': [4036], 'immature': [4037], 'pro-BACE1': [4038, 4135], 'transported': [4040, 4394], 'through': [4041], 'pathway.': [4044], 'Golgi,': [4047, 4384], 'processed': [4050], 'furin-like': [4053], 'proprotein': [4054], 'convertase': [4055], 'remove': [4057], 'propeptide': [4059, 4127], 'glycosylation': [4063], 'mature': [4065], '70-kDa': [4066], '43Haniu': [4081], 'Young': [4085], 'Hui': [4091], 'J.O.': [4092], 'Katta': [4101], '21099-21106Abstract': [4114], '(209)': [4122], 'Unusually,': [4125], 'does': [4129], 'cleave': [4137], 'generate': [4140], 'potentially': [4142, 4173, 5372], 'toxic': [4143], 'pool': [4146], 'Glycosylation': [4161], 'affects': [4162], 'palmitoylation': [4166], 'tail': [4171], 'could': [4172, 5370], 'localization': [4176, 4316, 5481], 'trafficking.': [4178], 'considered': [4182], 'integral': [4184], 'small': [4188, 4687], 'fraction': [4189], 'ectodomain': [4191], 'shedding,': [4192], 'amyloidogenic': [4196], 'localizes': [4214], 'cholesterol-rich': [4216], 'lipid': [4217], 'rafts,': [4218], 'lipids': [4221], 'stimulate': [4222], '(44Riddell': [4225], 'Hussain': [4229], '11:': [4236], '1288-1293Abstract': [4237], '(270)': [4245], 'homodimers': [4250], 'catalytic': [4253, 4651], 'interacts': [4257], 'several': [4259, 4935, 5581], 'proteins': [4261], 'reticulon/Nogo': [4263], 'proteins,': [4264], 'SorLA/LR11)': [4265], 'modulate': [4267], 'BACE1-APP': [4269], 'interaction': [4270], 'Such': [4288], 'interactions': [4289], 'clues': [4292], 'Signals,': [4300], 'cluster-dileucine': [4304], 'motif': [4305], 'tail,': [4310], 'trafficking': [4313], 'subcellular': [4315, 4475], 'protease,': [4319], 'members': [4321], 'GGA': [4324], '(Golgilocalized': [4325], 'γ-ear-containing': [4326], 'ADP-ribosylation': [4327], 'factor-binding)': [4328], 'interact': [4331], 'regulate': [4335], 'process': [4337], 'below)': [4339], '(45Tesco': [4340, 5800], 'Koh': [4342, 5802], 'Y.H.': [4343, 5803], 'Kang': [4344, 5804], 'E.L.': [4345, 5805], 'Cameron': [4346, 5806], 'A.N.': [4347, 5003, 5807], 'Das': [4348, 5808], 'Sena-Esteves': [4350, 5810], 'Hiltunen': [4352, 5812], 'S.H.': [4355, 5815], 'Zhong': [4356, 5816], 'Z.': [4357, 5817], 'Shen': [4358, 5325, 5818], 'Simpkins': [4360, 5820], 'J.W.': [4361, 5821], 'Tanzi': [4362, 5822], 'R.E.': [4363, 5823], '54:': [4366, 5826], '721-737Abstract': [4367, 5827], '(306)': [4375, 5835], 'enzymatic': [4379], 'resides': [4381], 'trans-Golgi': [4386], 'network,': [4387], 'endosomes.': [4389], 'down': [4395], 'axons': [4396], 'perforant': [4399], '(46Sheng': [4401, 4516], 'J.G.': [4402, 4517], 'Exp.': [4407, 4522], '184:': [4410, 4525], '1053-1057Crossref': [4411, 4526], '(49)': [4414, 4529], '47Lazarov': [4417, 4532], 'Peterson': [4421, 4536], 'D.A.': [4422, 4537], 'Sisodia': [4423, 4538, 4899], 'S.S.': [4424, 4539], '22:': [4428, 4543], '9785-9793Crossref': [4429, 4544], 'co-localizes': [4435], 'presynaptic': [4437, 5483], 'markers': [4438], '(48Zhao': [4439, 5411, 5488, 5707], 'Fu': [4441, 5413, 5490, 5709], 'Hitt': [4447, 5419, 5496, 5715], "O'Connor": [4449, 5421, 5498, 5652, 5717], 'Binder': [4459, 5431, 5508, 5727], '27:': [4466, 5438, 5515, 5734], '3639-3649Crossref': [4467, 5439, 5516, 5735], '(307)': [4470, 5442, 5519, 5738], 'difficult': [4483], 'asses,': [4485], 'metabolized': [4491], 'into': [4492], 'released': [4497], 'deposited': [4499], 'around': [4503, 5485], 'nerve': [4504], 'terminals.': [4505], 'axon': [4507], 'terminals': [4508], 'relatively': [4551], 'stable,': [4552], 'half-life': [4555], '∼9': [4557], 'h,': [4558], 'degraded': [4562], 'endoproteolysis,': [4564], 'lysosome,': [4566], 'ubiquitin-proteasome': [4569], 'offer': [4588], 'patients,': [4592], 'structural': [4594], 'analysis': [4595], 'BACE1-inhibitor': [4597], 'complexes': [4598], 'proved': [4600], 'useful': [4601], '(49Hong': [4605], 'Lin': [4609], 'Terzyan': [4613], 'Ghosh': [4615], 'A.K.': [4616], 'X.C.': [4618], '290:': [4623], '150-153Crossref': [4624], '(700)': [4627], 'open': [4636], 'hydrophobic': [4639, 4675], 'members.': [4645], 'Four': [4646], 'hydrogen': [4647, 4658], 'bonds': [4648, 4659], '10': [4656], 'various': [4661], 'active-site': [4662], 'made': [4665], 'inhibitor.': [4668], 'Arg296': [4672], 'pocket': [4676], 'binding': [4684], 'substrate,': [4685], 'targeting': [4689], 'these': [4690, 5070, 5696], 'bound': [4699], 'inhibitor': [4700, 5886], '0M99-2,': [4701], 'Ki': [4705], '1.6': [4707], 'nm': [4708], 'unusual': [4713], 'kinked': [4714], 'conformation;': [4715], 'thus,': [4716], 'mimicking': [4717], 'unique': [4719], 'conformation': [4720], 'selectivity': [4724], 'inhibitors.': [4727], 'much': [4729], 'exist': [4731, 4940, 5576], 'peptidomimetic': [4736], 'non-peptidomimetic': [4738], '(50John': [4741], 'Top.': [4744], 'Med.': [4745], '6:': [4748], '569-578Crossref': [4749], '(58)': [4752], 'researchers': [4755], 'struggled': [4757], 'compounds': [4760], 'high': [4762], 'potency': [4763], 'good': [4766], 'blood-brain': [4767], 'barrier': [4768], 'penetration,': [4769], 'appropriate': [4772], 'pharmacokinetic': [4773], 'characteristics.': [4774], 'Nevertheless,': [4775], 'number': [4777, 5363], 'pharmaceutical': [4779], 'companies': [4780], 'advanced': [4782, 5466], 'programs': [4783], 'providing': [4787], 'encouragement': [4788], 'therapeutics': [4791, 5893], 'will': [4792, 5951, 5975], 'eventually': [4793], 'available': [4795], 'clinic.': [4798], 'discussed': [4800], 'previously,': [4801], 'inhibition.': [4809], 'generation,': [4815], 'neural': [4818], 'indicates': [4821, 5522], 'physiological': [4826, 4956, 5936], 'function(s).': [4827], 'consistent': [4879], 'involvement': [4882], 'regular': [4884], '(51Kamenetz': [4887], 'Tomita': [4889], 'Hsieh': [4891], 'Seabrook': [4893], 'Iwatsubo': [4897], 'Malinow': [4901], '37:': [4905], '925-937Abstract': [4906], '(1285)': [4914], 'proportion': [4922], 'non-neuronal': [4926], 'α-secretase.': [4933], 'recently': [4961], 'begun': [4962], 'emerge.': [4964], 'neuregulin-1': [4968], 'sodium': [4971], 'channel': [4972], 'β-subunit': [4973], 'implicates': [4977], 'myelination': [4981], 'respectively': [4985], '52Willem': [5000], 'Garratt': [5002], 'Novak': [5004], 'Kaufmann': [5008], 'Rittger': [5010], 'Birchmeier': [5017], '314:': [5023], '664-666Crossref': [5024], '(608)': [5027], '53Wong': [5030], 'Sakurai': [5032], 'Oyama': [5034], 'Kaneko': [5036], 'Wada': [5038], 'Miyazaki': [5040], 'Kurosawa': [5042], 'Nukina': [5049], '23009-23017Abstract': [5056], 'many': [5068], 'response': [5078], 'stress': [5080, 5644], 'injury': [5082], 'Given': [5097, 5930], 'elevated': [5102, 5135, 5197, 5239, 5703], 'under': [5103, 5678], 'conditions,': [5105, 5590], 'indications': [5106], 'stress-response': [5113], 'facilitates': [5122], 'recovery': [5123], 'after': [5124], 'acute': [5125], 'stress/injury.': [5126], 'It': [5127], 'also': [5129, 5371, 5668], 'hypothesized': [5130], 'that,': [5131], 'chronic': [5133], 'stress/injury,': [5134], 'become': [5138, 5900], 'pathogenic': [5139], 'facilitate': [5141], 'harmful': [5142], 'Excessive': [5159], 'deposition': [5161, 5477, 5529], 'occurs': [5162, 5543], 'unknown,': [5174], 'increased': [5175, 5475, 5878], 'play': [5179], 'role.': [5181], 'mutation,': [5188], 'enhances': [5190, 5771], 'suggests': [5195], 'lead': [5201], 'age': [5209], '(54Fukumoto': [5210], 'Rosene': [5212], 'Moss': [5214], 'M.B.': [5215], 'Raju': [5216], 'Hyman': [5218, 5267], 'B.T.': [5219, 5268], 'Irizarry': [5220, 5269], 'Am.': [5222], 'Pathol.': [5224], '164:': [5226], '719-725Abstract': [5227], '(251)': [5235], '55Fukumoto': [5263], 'Cheung': [5265], 'B.S.': [5266], 'Arch.': [5271], '59:': [5274], '1381-1389Crossref': [5275], '(599)': [5278], '56Holsinger': [5281], 'R.M.': [5282], 'McLean': [5283], 'C.A.': [5284], 'Beyreuther': [5285], 'Masters': [5287], 'C.L.': [5288], 'Evin': [5289], 'Ann.': [5291], '51:': [5294], '783-786Crossref': [5295], '(494)': [5298], '57Li': [5301], 'Lindholm': [5303], 'L.B.': [5306], 'Yue': [5307], 'Beach': [5313], 'Sue': [5315], 'Sabbagh': [5317], '101:': [5335], '3632-3637Crossref': [5336], '(445)': [5339], 'aging': [5343], 'biggest': [5346], 'factor,': [5349], 'reflect': [5352], 'exaggeration': [5354], 'age-related': [5356], 'activity.': [5360, 5602], '(see': [5378], 'passively': [5387], 'actively': [5389], 'progression,': [5393], 'presence': [5399], '(5XFAD': [5400], 'mice)': [5401, 5405], '(Tg2576': [5404], 'death': [5408], 'was': [5409], 'analyzed': [5410], 'correlated': [5448], 'appeared': [5456], 'passive': [5462], 'end': [5463], 'product': [5464], 'neurodegeneration.': [5467], 'sequence': [5470], 'undetermined,': [5479], 'structures': [5484], 'positive': [5524], 'feedback': [5525], 'loop,': [5526], 'whereby': [5527], 'elevation,': [5535], 'further': [5537, 5964], 'post-transcriptional': [5549], 'plausible': [5572], 'triggers': [5575], 'cause': [5578, 5626], 'factors,': [5585], 'linked': [5595], 'alterations': [5597], 'On': [5603], 'molecular': [5605, 5968], 'level,': [5606], 'conditions': [5615, 5680, 5843], 'stress,': [5619, 5632], 'energy': [5620, 5640], 'metabolism': [5621], 'inflammation)': [5623], 'elevation.': [5628], 'Whereas': [5629, 5695], 'inflammation,': [5633], 'transcription,': [5639], 'metabolic': [5643], 'alter': [5647], 'translation': [5649], '(58Velliquette': [5650], '10874-10883Crossref': [5660], '(211)': [5663], 'microenvironment': [5667], 'impacts': [5669], 'stability': [5674], 'affected': [5677], 'ischemic': [5679], 'observations': [5697], 'support': [5698], 'throughout': [5749], 'progression.': [5751], 'Neuronal': [5752], 'feature': [5758], 'caspase': [5763], 'Apoptosis': [5770], 'levels,': [5774, 5791], 'GGA3': [5779, 5788], 'apoptosis': [5783], 'revealing': [5792], 'connection': [5794], 'Clearly,': [5838], 'types': [5847], 'actually': [5853], 'deleteriously': [5857], 'contribute': [5858], 'progression': [5861], 'determined.': [5865], 'Since': [5866], 'discovery': [5868], 'almost': [5869], 'decade': [5871], 'ago,': [5872], 'significantly.': [5879], 'despite': [5881], 'promising': [5882], 'news': [5883], 'development,': [5887], 'routine': [5888], 'reality.': [5902], 'combination': [5904], 'technical': [5906], 'difficulties,': [5907], 'complexity': [5909], 'biology,': [5912], 'multifarious': [5914], 'pathogenesis': [5916], 'slowed': [5918], 'development.': [5921], 'continues': [5927], 'evolve.': [5929], 'hinting': [5933], 'roles': [5937], '(and': [5940], 'APP),': [5941], 'careful': [5946], 'titration': [5947], 'dosage': [5950], 'effective': [5955], 'safe': [5956], 'addition,': [5959], 'enhance': [5976], 'novel': [5980], 'therapies': [5981], 'shed': [5986], 'light': [5987], 'devastating': [5993], 'disease.': [5994]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2075604126', 'counts_by_year': [{'year': 2024, 'cited_by_count': 20}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 24}], 'updated_date': '2024-12-13T11:37:26.932373', 'created_date': '2016-06-24'}