Publication Information

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'hypertrophy,': [87, 304, 897, 1247, 1325, 1743, 2020], 'release': [88], 'vesicles,': [92], 'alterations': [94, 754], 'in': [95, 190, 209, 309, 459, 486, 499, 516, 536, 545, 557, 569, 596, 610, 620, 636, 678, 684, 700, 723, 742, 746, 755, 769, 816, 828, 835, 842, 861, 867, 880, 894, 910, 918, 928, 931, 959, 990, 1008, 1060, 1074, 1089, 1099, 1102, 1111, 1141, 1204, 1266, 1290, 1293, 1348, 1379, 1442, 1532, 1626, 1639, 1661, 1685, 1699, 1827, 1836, 1867, 1875, 1916, 1936, 1979, 2236, 2245, 2274], 'production': [96, 160, 1716], 'proteins,': [100, 2349, 2383], 'prior': [101, 1940], 'mineralization': [103], 'replacement': [105], 'by': [106, 144, 444, 583, 601, 645, 927, 972, 1491, 1676, 1727, 1766, 1785, 1794, 2000, 2149, 2183, 2198, 2270, 2366, 2423], 'bone.': [107], 'As': [108, 446, 1312, 2140], 'progress': [110], 'toward': [111], 'terminal': [112, 229, 1034], 'differentiation,': [113], 'morphological,': [114], 'biosynthetic': [116], 'occur.': [118], 'Proliferating': [119], 'exit': [121, 986], 'cell': [123, 1683], 'cycle': [124], 'become': [126, 996], 'flattened': [127], 'before': [128, 686], 'fully': [129], 'maturing': [130], 'into': [131, 288, 1610, 2429], 'round,': [132], 'hypertrophic': [133, 164, 631, 646, 1127, 1309, 1662, 1851], 'secrete': [136, 1703, 1720], 'organize': [138], 'matrix,': [142], 'characterized': [143, 971], 'high': [145, 1100], 'levels': [146, 152, 1056, 1762], 'alkaline': [148], 'phosphatase': [149], '(ALP),': [150], 'diminished': [151, 1140], 'collagens': [154], 'type': [155, 167, 1052, 1456, 2053, 2056, 2064, 2074, 2127, 2189, 2216, 2225, 2339, 2342, 2374], 'II': [156, 2057, 2075, 2190, 2226], 'IX,': [158], 'new': [163, 358, 454, 1944], 'chondrocyte-specific': [165], 'product,': [166], 'X': [168, 1053, 1457], 'collagen.1-3': [169], 'addition': [171, 1618], 'normal': [173, 546, 1846], 'formation': [175, 356, 458, 485, 1201], 'during': [176, 945, 1094, 1282, 1436], 'development': [177, 947, 1019], 'skeleton,': [180], 'process': [182, 254, 688], 'endochondral': [184, 260, 466, 586, 960, 1165, 1227, 1339, 2435], 'ossification': [185, 836], 'has': [186, 218, 346, 1334, 1594], 'also': [187, 285, 329, 494, 1084, 1373, 1475, 1971, 2124, 2309, 2323], 'been': [188, 238, 347, 400, 476, 510, 732, 1335, 1596, 2041, 2359], 'implicated': [189], 'fracture': [191], 'repair': [192, 214], 'such': [194], 'pathologic': [195], 'processes': [196], 'as': [197, 276, 633, 635, 1152, 1262, 1275, 1725, 2007, 2135, 2361], 'osteoarthritis': [198], 'ectopic': [200, 1850], 'formation.': [202, 468, 727, 1167, 2437], 'fundamental': [204], 'importance': [205, 696], 'chondrocyte': [207, 242, 281, 303, 896, 905, 1161, 1246, 1324, 1366, 1464, 1485, 1558, 2305, 2431], 'maturation': [208, 906, 1073, 1415, 1437, 1486, 1600, 1648, 1679], 'led': [219], 'intense': [221], 'investigation': [222], 'factors': [226, 236, 249, 299, 1435], 'regulate': [228, 241], 'differentiation': [230, 326, 334, 424, 1035], 'chondrocytes.': [232, 647, 1663, 1922], 'Although': [233, 380, 1512], 'have': [237, 399, 405, 474, 508, 731, 781, 893, 1692, 1824, 2040, 2088, 2163, 2358, 2377, 2400, 2416], 'indentified': [239], 'maturation,': [243, 1454], 'remains': [245], 'unclear': [246], 'how': [247, 289], 'these': [248, 710, 968, 1070, 1147, 1432, 1644, 2425], 'interact': [250, 306, 2071], 'coordinate': [252], 'leading': [255, 2384], 'elongation': [258], 'ossification.': [261, 1228], 'issue,': [264], 'Grismud': [265, 1425], 'colleagues': [267, 1427], 'propose': [268], 'role': [270, 717, 891, 915, 1088], 'for': [271, 542, 563, 594, 806, 875, 916, 1409, 1551, 1863, 2081, 2091, 2159, 2209, 2303, 2380, 2434], 'morphogenetic': [273], 'protein-6': [274], '(BMP-6)': [275], 'positive': [278, 890, 1656], 'regulator': [279, 1244, 1278], 'maturation.': [282, 1511, 1545], 'Their': [283], 'report': [284, 1765], 'provides': [286], 'insight': [287], 'parathyroid': [290], 'hormone-related': [291], 'protein': [292, 1109], '(PTHrP)': [293], 'indian': [295], 'hedgehog,': [296], 'other': [297, 868, 1542, 2034, 2314], 'known': [300, 348, 818, 1597], 'modulate': [302], 'may': [305, 665, 1671, 1988, 2099], 'BMP-6': [308, 642, 653, 807, 821, 854, 866, 879, 1300, 1384, 1479, 1502, 1524, 1564, 1576, 1604, 1653, 1667, 1731, 1741, 2005, 2150, 2237, 2282], 'plate.': [312, 1371, 1419], 'BMPs': [313, 350, 451, 544, 556, 595, 699, 892, 1406], 'belong': [314], 'transforming': [317], 'factor-β': [319], '(TGF-β)': [320], 'superfamily': [321], 'secreted': [323, 2405], 'polypeptides,': [327], 'includes': [330, 415], 'activins,': [331], 'factors,': [335], 'Mullerian': [337], 'inhibiting': [338], 'substance.4,': [339], '5': [340], 'For': [341], 'over': [342], '30': [343], 'years,': [344], 'capable': [352, 1049], 'inducing': [354, 2304], 'when': [362], 'implanted': [363], 'extraskeletally.6': [364], 'However,': [365, 526, 823, 2211], 'was': [367, 847, 859, 925, 1237, 1525, 1792, 1865, 1873, 2132], 'not': [368, 1771, 1895, 1989, 2230, 2265, 2332], 'until': [369, 1760], '1988': [370], 'three': [372, 1433, 2347], 'proteins': [375, 1253, 1260], 'involved': [376, 1265], '(BMP2–4)': [377], 'were': [378, 970], 'cloned.7': [379], 'their': [381, 384, 447, 1521, 1552], 'name': [382, 448], 'stresses': [383], 'critical': [385, 2302], 'impact': [386, 409, 414], 'skeletal': [389, 570, 790, 845, 869], 'system,': [390], 'more': [391, 539, 733, 1188], 'than': [392, 410, 2120], '20': [393], 'members': [394, 2035, 2093], 'BMP': [397, 500, 530, 729, 764, 1620, 1745, 2066, 2096, 2161, 2188, 2205, 2243, 2315, 2373], 'family': [398, 765], 'identified': [401, 1261, 2360], 'determined': [403], 'broader': [407], 'biological': [408, 2105], 'just': [411], 'skeletogenesis.': [412], 'This': [413, 1882, 1943, 2263], 'establishment': [416], 'basic': [418], 'embryonic': [419, 558, 598, 702, 946, 1194, 1268], 'patterning': [420, 703, 1281], 'nearly': [426], 'all': [427, 475, 509], 'body': [428], 'systems': [429, 438], 'cardiovascular,': [432], 'gastrointestinal,': [433], 'respiratory,': [434], 'nervous,': [435], 'urogenital': [437], 'integument': [441], '(see': [442], 'review': [443], 'Hogan).7': [445], 'implies,': [449], 'most': [450, 662, 1993], 'can': [452, 1569, 1887, 2123], 'initiate': [453], 'cascade': [461], 'events': [463], 'reminiscent': [464], 'BMP-2,': [469, 503, 564, 576, 2082], 'BMP-4,': [470, 504, 565, 577, 2083], 'BMP-5,': [471], 'BMP-7': [473, 507, 568, 607, 778, 2113], 'shown': [477, 511, 1336, 2042], 'possess': [479], 'ability': [481, 1398, 1539, 1665], 'promote': [483], 'vivo.4,': [487], '8-10': [488], 'Additional': [489], 'evidence': [490, 1590, 1616], 'cultured': [492, 517, 1061, 2276], 'cells': [493, 1075, 1579, 1718, 1796, 1810, 1892], 'point': [495, 1085, 1149, 2144], 'considerable': [497], 'overlap': [498], 'function;': [501], 'recombinant': [502], 'BMP-6,': [505, 566, 578, 1516], 'induce': [513, 1402, 1528, 1541, 1669], 'both': [514, 611, 1041, 1130, 1393, 1403, 1845, 1917, 2006, 2255], 'hypertrophy': [515, 993, 1162, 1367, 1559, 1568, 1712, 1759, 1954, 2012], 'osteogenesis': [520], 'from': [521, 529, 1496, 1807, 1831, 1927, 1978], 'mesenchymal': [522], 'stem': [523], 'cells.5,': [524], '11': [525], 'information': [527, 714, 1945], 'derived': [528], 'localization': [531, 1082], 'studies': [532, 930, 1083, 1784], 'null': [534, 676, 779, 804], 'mutations': [535, 677], 'mice': [537, 780, 939, 952, 969, 1007], 'suggests': [538, 1946], 'specific': [540, 844, 2157], 'roles': [541, 562, 2158], 'individual': [543], 'temporal': [549], 'spatial': [551], 'patterns': [552, 593, 864], 'expression': [554, 592, 851, 863, 1110, 1138, 1477, 1531, 1660, 1987, 2184, 2260], 'mouse': [559, 599, 1832], 'forelimbs': [560], 'support': [561, 1906], 'formation,': [571], 'multiple': [573], 'BMPs,': [574, 1514, 2032], 'BMP-7,': [580], 'produced': [582], 'undergoing': [585], 'ossification.12-16': [587], 'Recent': [588, 2153], 'detailed': [589], 'analysis': [590, 934], 'humerus': [600], 'Solloway': [602], 'et': [603, 1232, 1342, 1690, 1729, 1768, 1787, 1822, 2002, 2142, 2272], 'al.16': [604], 'show': [605, 1016, 1174, 1221], 'expressed': [609, 1289], 'proliferating': [612, 1847, 1868, 1877, 1921, 1932], 'perichondrum,': [616], 'BMP-4': [617, 681], 'found': [619, 860], 'transition': [624], 'zone': [625, 989, 1840], 'immediately': [626, 1123], 'adjacent': [627, 1124, 1307, 1957], 'mature': [630, 1143], 'well': [634], 'perichondrium,': [638], 'while': [639, 2398], 'BMP-2': [640, 651, 679, 719, 858], 'coexpressed': [644], 'coexpression': [649], 'consistent': [655, 1224], 'hypothesis': [658], 'physiologically': [661, 1994], 'active': [663, 2173, 2242, 2291], 'forms': [664], 'be': [666, 1488, 1672, 1733, 1991, 2319], 'heterodimers': [667], 'BMP-2/6': [669], 'BMP-2/7.17': [671], 'Mice': [672, 801, 1168], 'bred': [673], 'homozygous': [675, 937], 'die': [682], 'early': [683, 701, 850, 1193, 1267], 'embryogenesis,': [685], 'skeletogenesis': [690, 827], 'occurs.18,': [691], '19': [692], 'While': [693, 1040, 1997], 'emphasizing': [694], 'some': [698], 'morphogenesis,': [705], 'lethality': [707], 'means': [708], 'mutants': [711], 'cannot': [712], 'contribute': [713], 'about': [715, 2403, 2420], 'BMP-': [721], '4': [722], 'Other': [728], 'knockouts': [730], 'enlightening.': [734], 'Loss': [735], 'function': [737], 'mutation': [738, 761, 805], 'BMP-5': [740], 'results': [741, 768], 'short': [743], 'ears,': [744], 'defects': [745, 786, 815], 'sternum': [748], 'ribs,': [750], 'relatively': [752, 774, 788, 1256, 1814], 'minor': [753, 789], 'appendicular': [757, 771], 'skeleton,20,': [758], '21': [759], 'whereas': [760], 'member': [766], 'GDF-5': [767], 'shortened': [770, 979], 'unaffected': [775], 'axial': [776], 'skeleton.22': [777], 'severe': [782, 1189], 'kidney': [783], 'eye': [785], 'but': [787, 1184], 'pattern': [791, 2268], 'abnormalities': [792, 958], 'rib': [795], 'cage,': [796], 'skull,': [797], 'hindlimbs.23,': [799], '24': [800], 'carrying': [802], 'viable': [809], 'fertile': [811], 'no': [813], 'overt': [814], 'tissues': [817], 'express': [820], 'mRNA.16': [822], 'careful': [824], 'examination': [825], 'late': [829], 'gestation': [830], 'embryos': [831, 2248], 'showed': [832, 940, 1912], 'delay': [834, 1953], 'sternum.': [839], 'defect': [841], 'element': [846], 'attributed': [848], 'only': [853, 1066], 'within': [855, 1117, 1330, 1368, 1416], 'sternum;': [857], 'overlapping': [862], 'elements': [870], 'might': [872, 1894, 2219], 'functionally': [873], 'compensate': [874], 'loss': [877], 'rest': [882], 'skeleton.': [885], 'contrast': [887], 'promoting': [895], 'PTHrP': [898, 917, 936, 944, 1004, 1010, 1027, 1042, 1067, 1081, 1096, 1137, 1151, 1182, 1217, 1236, 1350, 1394, 1404, 1447, 1474, 1495, 1509, 1536, 1555, 1635, 1709, 1739, 1778, 1819, 1914, 1939], 'acts': [899, 1390], 'slow': [901, 1711, 1715], 'rate': [903, 1159, 1364, 2018], 'maintain': [908], 'proliferative': [912, 988, 1839, 1891, 1968], 'state.': [913], 'A': [914], 'modulating': [919], 'proliferation': [920], 'suggested': [926, 1789], 'vitro': [929], '1993.25': [932], 'Subsequently,': [933], 'knockout': [938], 'absence': [942, 2222], 'causes': [948], 'chondrodysplasias,': [949], 'dying': [953], 'shortly': [954], 'after': [955], 'birth': [956], 'formation.26,': [962], '27': [963], 'plates': [966, 1835, 1843], 'disorganized': [974], 'columnar': [975], 'architecture': [976], 'proliferative/resting': [980], 'zone,': [981], 'indicating': [982], 'prematurely': [985], 'order': [991], 'subsequently': [995], 'calcified.': [997], 'An': [998], 'opposite': [999, 1197], 'effect': [1000, 1198], 'seen': [1002, 1180, 1203, 1313, 2269], 'overexpression.': [1005], 'Transgenic': [1006], 'overexpression': [1011, 1315, 1318, 1376, 2167, 2213], 'targeted': [1013], 'delayed': [1017, 1226], 'an': [1021, 2008, 2136], 'accumulation': [1022], 'prehypertrophic': [1024, 1963], 'chondrocytes,28': [1025], 'treatment': [1028], 'murine': [1030], 'limb': [1031, 1283], 'explants': [1032], 'blocks': [1033], 'chondrocytes.29': [1039], 'fibroblast': [1044], 'factor-2': [1046], '(FGF-2)': [1047], 'reducing': [1051], 'collagen': [1054, 1458], 'mRNA': [1055, 1459, 1522, 1915], 'ALP': [1058, 1461], 'activity': [1059], 'avian': [1062], 'cephalic': [1063], 'sternal': [1064, 1440, 1934, 2179], 'chondrocytes,': [1065, 1869, 2277, 2413], 'could': [1068, 1487, 1503], 'decrease': [1069], 'parameters': [1071, 1452, 1543], 'had': [1077], 'undergone': [1078], 'further': [1079, 2100], 'maturation.30': [1080], 'maintaining': [1090], 'phenotype': [1093, 1176, 1223], 'present': [1098, 1866], 'concentrations': [1101], 'fetal': [1103], 'postnatal': [1105], 'cartilage,': [1107, 1291], 'concentrated': [1116], 'thin': [1119], 'layer': [1120], 'zone.31': [1128], 'regions,': [1136], 'animal.32': [1144], 'All': [1145], 'data': [1148, 1830, 1926, 2288], 'major': [1154], 'factor': [1155], 'diminishes': [1157], 'subsequent': [1164], 'lack': [1170], 'PTH/PTHrP': [1172, 1854], 'receptor': [1173, 1862, 1872, 2049, 2076, 2111, 2129, 2147, 2191, 2218, 2235, 2254, 2299], 'similar': [1177], 'knockouts,': [1183], 'effects': [1186, 1483, 1507, 2106, 2426], 'lead': [1191, 2220], 'death.': [1195], 'patients': [1205], "Jansen's": [1207], 'metaphyseal': [1208], 'chondroplasia,': [1209], 'naturally': [1211], 'occurring,': [1212], 'activating': [1213], 'mutant': [1214, 2174], 'receptor.33': [1218], 'These': [1219, 1546, 2086], 'individuals': [1220], '1996,': [1230], 'Vortkamp': [1231, 1341], 'al.29': [1233], 'proposed': [1234, 1345, 1693], 'downstream': [1239], 'mediator': [1240, 1657], 'another': [1242], 'negative': [1243, 1358, 1696, 2170, 2187, 2200], 'Indian': [1248], 'hedgehog': [1249, 1252, 1272], '(Ihh).': [1250], 'small': [1257], 'group': [1258], 'signaling': [1263, 2080, 2206, 2337, 2363, 2406], 'molecules': [1264, 2364, 2407], 'patterning,': [1269], 'sonic': [1271], '(Shh)': [1273], 'serving': [1274], 'key': [1277], 'anterior–posterior': [1280], 'related': [1286], 'Ihh': [1287, 1320, 1329, 1353, 1378, 1389, 1400, 1608, 1623, 1638, 1659, 1670, 1747, 1751, 1761, 1806, 1864, 1886, 2257], 'colocalizes': [1298], 'postproliferative': [1305, 1701], 'cells.29,': [1310], '34': [1311], 'PTHrP,': [1317, 1755], 'or': [1321, 1674], 'Shh': [1322], 'delays': [1323], 'misexpression': [1327], 'chick': [1332, 1381, 1933, 2178, 2247], 'wingbud': [1333], 'disrupt': [1338], 'ossification.29': [1340], 'al.': [1343], 'therefore': [1344, 1632], 'model': [1347], 'reciprocally': [1351], 'inhibits': [1352], 'expression,': [1354, 1385, 1523, 1624, 1748], 'thus': [1355], 'forming': [1356], 'feedback': [1359, 1641, 1697, 1737, 1950], 'loop': [1360, 1642, 1698, 1951], 'moderate': [1362], 'They': [1372, 1444, 1631], 'demonstrated': [1374], 'developing': [1380, 2246], 'wings': [1382], 'blocked': [1383], 'argues': [1387, 2203], 'upstream': [1391], 'BMP.': [1396, 1584], 'would': [1407, 1732, 1803, 1883, 2279], 'allow': [1408], 'tightly': [1411], 'controlled': [1412], 'progression': [1413], 'issue': [1422], 'JBMR,': [1424], 'explore': [1428], 'relationship': [1430], 'chicken': [1439], 'culture.': [1443], 'confirm': [1445], 'able': [1449, 1518], 'inhibit': [1451], 'induction,': [1460], 'activity,': [1462], 'increased': [1463, 1913], 'size,': [1465], 'decreased': [1467, 1754], 'proliferation.': [1468], 'addition,': [1470, 1586, 1924], 'they': [1471], 'demonstrate': [1472], 'abolishes': [1476], 'mRNA.': [1480], 'inhibitory': [1482, 1506], 'rapidly': [1489], 'reversed': [1490], 'removal': [1493], 'cultures': [1498], 'furthermore,': [1500], 'exogenous': [1501, 1583], 'circumvent': [1504], 'many': [1513, 2023], 'autoregulate': [1520], 'unable': [1526], 'its': [1529, 1538, 1899, 2030], 'own': [1530], 'presence': [1534, 1628], 'despite': [1537, 1571], 'observations': [1547], 'form': [1548], 'basis': [1550], 'conclusion': [1553], 'suppression': [1556, 1573], 'occurs': [1560], 'via': [1561, 2284], 'inhibition': [1562, 1636], 'levels,': [1565], 'proceed': [1570], 'PTHrP-induced': [1572], 'endogenous': [1575], 'if': [1577], 'provided': [1581], 'authors': [1588, 1614], 'ascorbate,': [1592], 'long': [1595, 1815], 'accelerate': [1599], 'chondrocytes,35-37': [1602], 'increases': [1603, 1706], 'expression.': [1605, 1820], 'Where': [1606], 'does': [1607, 1770, 2229, 2264], 'fit': [1609, 2266], 'picture?': [1612], 'induces': [1621, 2259], 'high-level': [1622], 'even': [1625], 'PTHrP.': [1630, 2262], 'conclude': [1633], 'two': [1645, 1956, 2063], 'inhibitors': [1646], 'indirect': [1650, 1675], 'direct': [1673], 'increasing': [1677, 1687], 'state': [1680], 'turn': [1686], 'Ihh.': [1688, 1721], 'Kronenberg': [1689], 'al.38': [1691], 'local': [1695], 'Ihh,': [1704], 'secretion': [1707], 'thereby': [1714], 'Under': [1722], 'scenario': [1724], 'modified': [1726], 'Grimsrud': [1728, 1767, 2001, 2141, 2271], 'al.,39': [1730], 'added': [1734], 'system:': [1738], 'suppresses': [1740, 1746], 'low': [1744, 1750], 'leads': [1752], 'BMP-induced': [1758], 'rise.': [1763], 'al.39': [1769, 2003, 2143, 2273], 'address': [1772], 'question': [1774], 'where': [1776], 'produced.': [1780], 'situ': [1782, 1828, 1980], 'hybridization': [1783, 1829, 1981], 'Lee': [1786], 'al.31': [1788], 'synthesized': [1793], 'perichondrial': [1795], 'close': [1797], 'surfaces,': [1801], 'argue': [1804, 2280], 'must': [1811], 'travel': [1812], 'distance': [1816], 'activate': [1818, 2409], 'Chung': [1821], 'al.40': [1823], 'recently': [1825], 'presented': [1826], 'chimeric': [1833], 'contained': [1844], 'lacking': [1853], 'receptor.': [1855], 'nonchimeric': [1857], 'plates,': [1859], 'Patched': [1861], 'up-regulated': [1874], 'chimeras.': [1881], 'imply': [1884], 'signal': [1888], 'nearby': [1890], 'need': [1896], 'make': [1898], 'way': [1900], 'perichondrium.': [1904], 'hypothesis,': [1909], 'chimeras': [1911], 'perichondrium': [1919], 'unpublished': [1925], 'our': [1928], 'laboratory': [1929], 'indicate': [1930], 'culture': [1937], 'produce': [1938], 'hypertrophy.': [1942, 2210, 2306], 'Ihh–PTHrP': [1949], 'involves': [1955], 'populations': [1958], 'cells,': [1960], 'Ihh-producing': [1962], 'PTHrP-producing': [1967], 'cells.': [1969], 'It': [1970, 2307, 2321, 2368], 'highlights': [1972], 'one': [1973, 2073], 'complications': [1976], 'arising': [1977], 'studies:': [1982], 'site': [1984], 'maximal': [1986], 'necessarily': [1990, 2231], 'relevant': [1995], 'region.': [1996], 'paper': [1999], 'implicates': [2004], 'autocrine': [2009], 'inducer': [2010], 'modulator': [2015], 'there': [2021, 2312], 'unanswered': [2024], 'questions': [2025], 'concerning': [2026], 'mechanism': [2028], 'action.': [2031, 2238], 'like': [2033], 'TGF-β': [2038], 'superfamily,': [2039], 'transduce': [2044], 'signals': [2045], 'through': [2046, 2338], 'transmembrane': [2047], 'heteromeric': [2048], 'complexes': [2050], 'consisting': [2051], 'I': [2054, 2065, 2128, 2217, 2375], 'serine/threonine': [2058], 'kinase': [2059], 'receptors.41': [2060], 'vertebrates,': [2062], 'receptors': [2067, 2087, 2162, 2244, 2316, 2376], '(BMPR-IA': [2068], 'BMPR-IB)': [2070], 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