Title: Combinatorial Mutasynthesis of Flavonoid Analogues from Acrylic Acids in Microorganisms
Abstract: Flavonoids are plant secondary metabolites often used as nutraceutical supplements, but a growing number of unnatural flavonoids are being investigated as therapeutic agents. Cultures of Saccharomyces cerevisiae expressing recombinant flavonoid enzymes, including 4-coumaroyl:CoA ligase (4CL), chalcone synthase (CHS), chalcone isomerase (CHI), and flavanone 3β-hydroxylase (FHT), produced novel flavanones and dihydroflavonols when fed with a number of aromatic acrylic acids. The flavonoid network also exhibited broad substrate specificity by converting muconic acid into a unique polypropanoid.
Publication Year: 2007
Publication Date: 2007-04-21
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 58
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