Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin

Name: Work Video:
Duration: 3 min 30 s
Jeffrey E. Galvin; Mark E. Hemric; Kent E. Ward; Madeleine W. Cunningham
{'id': 'https://openalex.org/W2075460902', 'doi': 'https://doi.org/10.1172/jci7132', 'title': 'Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin', 'display_name': 'Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin', 'publication_year': 2000, 'publication_date': '2000-07-15', 'ids': {'openalex': 'https://openalex.org/W2075460902', 'doi': 'https://doi.org/10.1172/jci7132', 'mag': '2075460902', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10903337', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/314302'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci7132', 'pdf_url': 'http://www.jci.org/articles/view/7132/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/7132/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111966516', 'display_name': 'Jeffrey E. Galvin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I49332381', 'display_name': 'University of Oklahoma Health Sciences Center', 'ror': 'https://ror.org/0457zbj98', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I49332381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey E. Galvin', 'raw_affiliation_strings': ["Department of Microbiology and Immunology, and. Department of Pediatric Cardiology, Children's Heart Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA."], 'affiliations': [{'raw_affiliation_string': "Department of Microbiology and Immunology, and. Department of Pediatric Cardiology, Children's Heart Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.", 'institution_ids': ['https://openalex.org/I49332381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020907549', 'display_name': 'Mark E. Hemric', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mark E. Hemric', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, and'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104069264', 'display_name': 'Kent E. Ward', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I49332381', 'display_name': 'University of Oklahoma Health Sciences Center', 'ror': 'https://ror.org/0457zbj98', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I49332381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kent Ward', 'raw_affiliation_strings': ["Department of Pediatric Cardiology, Children's Heart Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatric Cardiology, Children's Heart Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA", 'institution_ids': ['https://openalex.org/I49332381']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024828248', 'display_name': 'Madeleine W. Cunningham', 'orcid': 'https://orcid.org/0000-0001-8122-728X'}, 'institutions': [{'id': 'https://openalex.org/I49332381', 'display_name': 'University of Oklahoma Health Sciences Center', 'ror': 'https://ror.org/0457zbj98', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I49332381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Madeleine W. Cunningham', 'raw_affiliation_strings': ['University of Oklahoma Health Sciences Center#TAB#'], 'affiliations': [{'raw_affiliation_string': 'University of Oklahoma Health Sciences Center#TAB#', 'institution_ids': ['https://openalex.org/I49332381']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 9.377, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 229, 'citation_normalized_percentile': {'value': 0.999935, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '106', 'issue': '2', 'first_page': '217', 'last_page': '224'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11153', 'display_name': 'Streptococcal Infections and Treatments', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11153', 'display_name': 'Streptococcal Infections and Treatments', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11688', 'display_name': 'Microbial infections and disease research', 'score': 0.9797, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/heavy-meromyosin', 'display_name': 'Heavy meromyosin', 'score': 0.45286483}], 'concepts': [{'id': 'https://openalex.org/C2779814568', 'wikidata': 'https://www.wikidata.org/wiki/Q58345', 'display_name': 'Laminin', 'level': 3, 'score': 0.60917616}, {'id': 'https://openalex.org/C195616568', 'wikidata': 'https://www.wikidata.org/wiki/Q128711', 'display_name': 'Epitope', 'level': 3, 'score': 0.59318775}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.51185125}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4750495}, {'id': 'https://openalex.org/C2776193487', 'wikidata': 'https://www.wikidata.org/wiki/Q32846', 'display_name': 'Basement membrane', 'level': 2, 'score': 0.4569126}, {'id': 'https://openalex.org/C102091540', 'wikidata': 'https://www.wikidata.org/wiki/Q5695264', 'display_name': 'Heavy meromyosin', 'level': 3, 'score': 0.45286483}, {'id': 'https://openalex.org/C6997183', 'wikidata': 'https://www.wikidata.org/wiki/Q271727', 'display_name': 'Myosin', 'level': 2, 'score': 0.44282}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42997462}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.4141559}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.3834447}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33085644}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.32946125}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.31245768}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.28763533}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.15449393}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.12871668}], 'mesh': [{'descriptor_ui': 'D003602', 'descriptor_name': 'Cytotoxicity, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006351', 'descriptor_name': 'Heart Valves', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007797', 'descriptor_name': 'Laminin', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D009205', 'descriptor_name': 'Myocarditis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D012214', 'descriptor_name': 'Rheumatic Heart Disease', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000117', 'descriptor_name': 'Acetylglucosamine', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000117', 'descriptor_name': 'Acetylglucosamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004797', 'descriptor_name': 'Enzyme-Linked Immunosorbent Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018604', 'descriptor_name': 'Epitope Mapping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006351', 'descriptor_name': 'Heart Valves', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007797', 'descriptor_name': 'Laminin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018716', 'descriptor_name': 'Molecular Mimicry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009205', 'descriptor_name': 'Myocarditis', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D009205', 'descriptor_name': 'Myocarditis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009218', 'descriptor_name': 'Myosins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D009218', 'descriptor_name': 'Myosins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D012214', 'descriptor_name': 'Rheumatic Heart Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012214', 'descriptor_name': 'Rheumatic Heart Disease', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci7132', 'pdf_url': 'http://www.jci.org/articles/view/7132/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc314302', 'pdf_url': 'https://europepmc.org/articles/pmc314302?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314302', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://digitalcommons.liberty.edu/bio_chem_fac_pubs/107', 'pdf_url': 'https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=1106&context=bio_chem_fac_pubs', 'source': {'id': 'https://openalex.org/S4377196585', 'display_name': 'Scholars Crossing (Liberty University)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I67789559', 'host_organization_name': 'Liberty University', 'host_organization_lineage': ['https://openalex.org/I67789559'], 'host_organization_lineage_names': ['Liberty University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10903337', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci7132', 'pdf_url': 'http://www.jci.org/articles/view/7132/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.75, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W121744710', 'https://openalex.org/W1496559392', 'https://openalex.org/W1521848483', 'https://openalex.org/W1522111211', 'https://openalex.org/W1555305661', 'https://openalex.org/W1563142381', 'https://openalex.org/W1563981780', 'https://openalex.org/W1567286786', 'https://openalex.org/W1652305702', 'https://openalex.org/W168785140', 'https://openalex.org/W1802519508', 'https://openalex.org/W1832431561', 'https://openalex.org/W1833207062', 'https://openalex.org/W1878446582', 'https://openalex.org/W1934058025', 'https://openalex.org/W1981685027', 'https://openalex.org/W1982839428', 'https://openalex.org/W1990264812', 'https://openalex.org/W1990659956', 'https://openalex.org/W1991987854', 'https://openalex.org/W1997639129', 'https://openalex.org/W2001975672', 'https://openalex.org/W2005584412', 'https://openalex.org/W2009251691', 'https://openalex.org/W2031741525', 'https://openalex.org/W2036530348', 'https://openalex.org/W2056535660', 'https://openalex.org/W2068284042', 'https://openalex.org/W2070854264', 'https://openalex.org/W2095180364', 'https://openalex.org/W2095991005', 'https://openalex.org/W2099614431', 'https://openalex.org/W2115583525', 'https://openalex.org/W2129003337', 'https://openalex.org/W2129645761', 'https://openalex.org/W2131166082', 'https://openalex.org/W2139292873', 'https://openalex.org/W2142316029', 'https://openalex.org/W2144664678', 'https://openalex.org/W2149677358', 'https://openalex.org/W2149870842', 'https://openalex.org/W2166534473', 'https://openalex.org/W2169799272', 'https://openalex.org/W2330754517', 'https://openalex.org/W2407392001', 'https://openalex.org/W2418439902'], 'related_works': ['https://openalex.org/W2418217717', 'https://openalex.org/W2380145641', 'https://openalex.org/W2088661214', 'https://openalex.org/W2070100383', 'https://openalex.org/W2058567144', 'https://openalex.org/W2029408488', 'https://openalex.org/W1974641637', 'https://openalex.org/W1966992690', 'https://openalex.org/W1749945299', 'https://openalex.org/W1573412678'], 'abstract_inverted_index': {'Anti-streptococcal': [0], 'antibodies': [1, 162], 'cross-reactive': [2, 161], 'with': [3, 15, 51, 63, 121, 132, 152], 'N-acetyl-βD-glucosamine': [4], '(GlcNAc)': [5], 'and': [6, 49, 55, 95, 108, 171], 'myosin': [7, 71], 'are': [8], 'present': [9], 'in': [10, 22, 82, 163], 'the': [11, 64, 92, 122, 133, 147, 158, 169, 175], 'sera': [12], 'of': [13, 60, 84, 115, 149, 174], 'patients': [14], 'rheumatic': [16, 39, 164], 'fever': [17], '(RF).': [18], 'However,': [19], 'their': [20], 'role': [21], 'tissue': [23], 'injury': [24, 167], 'is': [25], 'not': [26], 'clear.': [27], 'In': [28], 'this': [29], 'study,': [30], 'we': [31], 'show': [32], 'that': [33, 141, 160], 'anti-GlcNAc/anti-myosin': [34], 'mAb': [35, 61, 77, 116, 150], '3.B6': [36, 62, 78, 117, 151], 'from': [37], 'a': [38], 'carditis': [40, 165], 'patient': [41], 'was': [42, 66, 118], 'cytotoxic': [43], 'for': [44], 'human': [45, 52, 69, 85, 153], 'endothelial': [46], 'cell': [47], 'lines': [48], 'reacted': [50], 'valvular': [53], 'endothelium': [54, 170], 'underlying': [56, 172], 'basement': [57], 'membrane.': [58], 'Reactivity': [59], 'valve': [65, 134], 'inhibited': [67, 146], 'by': [68], 'cardiac': [70, 86], '>': [72, 74], 'laminin': [73, 137], 'GlcNAc.': [75], 'The': [76], 'epitopes': [79], 'were': [80], 'localized': [81], 'fragments': [83], 'myosin,': [87], 'including': [88], 'heavy': [89], 'meromyosin': [90, 98], '(HMM),': [91], 'S1': [93], 'subfragment,': [94], 'two': [96], 'light': [97], '(LMM)': [99], 'peptides': [100], 'containing': [101], 'amino': [102], 'acid': [103], 'sequences': [104], 'KEALISSLTRGKLTYTQQ': [105], '(LMM': [106, 110], '1)': [107], 'SERVQLLHSQNTSLINQK': [109], '33).': [111], 'A': [112, 136], 'novel': [113], 'feature': [114], 'its': [119, 130], 'reactivity': [120, 131, 148], 'extracellular': [123], 'matrix': [124, 173], 'protein': [125], 'laminin,': [126], 'which': [127], 'may': [128], 'explain': [129], 'surface.': [135], 'A-chain': [138], 'peptide': [139], '(HTQNT)': [140], 'includes': [142], 'homology': [143], 'to': [144], 'LMM33': [145], 'valve.': [154, 176], 'These': [155], 'data': [156], 'support': [157], 'hypothesis': [159], 'cause': [166], 'at': [168]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2075460902', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-14T22:05:37.477135', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
