Abstract LB-66: Results of two phase I multicenter trials of AZD5363, an inhibitor of AKT1, 2 and 3: Biomarker and early clinical evaluation in Western and Japanese patients with advanced solid tumors .

Name: Work Video:
Duration: 3 min 30 s
Udai Banerji; Malcolm Ranson; Jan H.M. Schellens; Taito Esaki; Emma Dean; Andrea Zivi; Ruud van der Noll; Paul K. Stockman; Marcelo Marotti; Michelle D. Garrett; Barry R. Davies; Paul Elvin; Andrew Hastie; Peter Lawrence; Sy Amy Cheung; Christine Stephens; Kenji Tamura
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'events,': [171], 'note,': [173], 'hyperglycemia,': [175], 'rash,': [176], 'diarrhea.': [178], 'PK': [180, 379], 'suggests': [182], 'proportional': [185], 'increase': [186, 268], 'Cmax': [188], 'AUC.': [190], 'Exposures': [191], 'achieved': [192], 'at': [193, 322, 367], 'doses': [194, 217], 'above': [206], 'are': [207, 301], 'consistent': [208, 271, 383], 'seen': [211, 222], 'xenograft': [213], 'models.': [214, 388], 'described,': [218], 'target': [219], 'engagement': [220], 'as': [223], 'evidenced': [224], 'by': [225, 405], 'changes': [227], 'normal': [229], '(&amp;gt;50%': [231], 'reduction': [232, 250, 255], 'pPRAS40': [234, 252], '7/10': [236], 'samples': [247, 300], '30-50%': [249], '&amp;gt;30%': [254], 'pGSK3β': [257], 'platelet': [259], 'rich': [260], 'plasma).': [261], 'Importantly,': [262], '7/9': [263], 'paired': [264], 'biopsies': [265], 'showed': [266, 377], 'pAKT': [270], 'non': [274], 'allosteric': [275], 'inhibition': [276], 'AKT.': [278], 'Investigation': [279], 'another': [281], 'bid,': [286], 'on/5': [289], 'treatment,': [292], 'ongoing.': [294, 302], 'Exploratory': [295], 'mutation': [296], 'analyses': [297], 'partial': [304], 'responses': [305, 390], 'observed,': [307], 'one': [308, 315], 'endometrioid': [309, 351], 'cancer': [310, 352], 'ovary': [313, 354], 'cervical': [316], 'cancer,': [317], '400': [328], '(7/7),': [331], 'respectively.': [332], 'Mutation': [333], 'either': [335], 'AKT1': [336], 'or': [337], 'PIK3CA': [338], 'identified': [340], 'from': [344], 'patients.': [346], 'A': [347], 'further': [348], 'patient,': [349], '(PIK3CA': [355], 'mutation),': [356], 'stable': [358], 'disease': [359], '(SD)': [360], '156': [362], 'days.': [363], 'Conclusions:': [364], 'administered': [366], 'generally': [373], 'well': [374], 'preclinical': [387], 'Partial': [389], 'noted': [392], 'mutations': [396], 'driving': [397], 'PI3K': [399], 'pathway.': [400], 'Footnote:': [401], 'discovered': [404], 'AstraZeneca': [406], 'subsequent': [407], 'collaboration': [409, 415], 'Astex': [411], 'Therapeutics': [412], '(and': [413], 'its': [414], 'Institute': [418], 'Cancer': [420, 423, 514, 524], 'Research': [421, 424], 'Technology': [425], 'Ltd).': [426], 'Citation': [427], 'Format:': [428], 'Udai': [429], 'Banerji,': [430], 'Malcolm': [431], 'Ranson,': [432], 'Jan': [433], 'HM': [434], 'Schellens,': [435], 'Taito': [436], 'Esaki,': [437], 'Emma': [438], 'Dean,': [439], 'Andrea': [440], 'Zivi,': [441], 'Ruud': [442], 'van': [443], 'der': [444], 'Noll,': [445], 'Paul': [446, 457], 'K.': [447], 'Stockman,': [448], 'Marcelo': [449], 'Marotti,': [450], 'Michelle': [451], 'D.': [452], 'Garrett,': [453], 'Barry': [454], 'R.': [455], 'Davies,': [456], 'Elvin,': [458], 'Andrew': [459], 'Hastie,': [460], 'Peter': [461], 'Lawrence,': [462], 'SY': [463], 'Amy': [464], 'Cheung,': [465], 'Christine': [466], 'Stephens,': [467], 'Kenji': [468], 'Tamura.': [469], 'Results': [470], 'two': [472], 'multicenter': [475], 'trials': [476], 'AZD5363,': [478], '3:': [485], 'Biomarker': [486], 'early': [488], 'clinical': [489], 'evaluation': [490], 'advanced': [497], 'solid': [498], 'tumors': [499], '.': [500], '[abstract].': [501], 'In:': [502], 'Proceedings': [503], '104th': [506], 'Annual': [507], 'Meeting': [508], 'American': [511], 'Association': [512], 'Research;': [515], '2013': [516], 'Apr': [517], '6-10;': [518], 'Washington,': [519], 'DC.': [520], 'Philadelphia': [521], '(PA):': [522], 'AACR;': [523], 'Res': [525], '2013;73(8': [526], 'Suppl):Abstract': [527], 'nr': [528], 'LB-66.': [529], 'doi:10.1158/1538-7445.AM2013-LB-66': [530]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2074897569', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-08T13:14:01.116194', 'created_date': '2016-06-24'}
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