Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2074814223', 'doi': 'https://doi.org/10.1161/circresaha.111.246504', 'title': 'Zebrafish in the Study of Early Cardiac Development', 'display_name': 'Zebrafish in the Study of Early Cardiac Development', 'publication_year': 2012, 'publication_date': '2012-03-15', 'ids': {'openalex': 'https://openalex.org/W2074814223', 'doi': 'https://doi.org/10.1161/circresaha.111.246504', 'mag': '2074814223', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22427324', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3329892'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.111.246504', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.246504', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.246504', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028481056', 'display_name': 'Jiandong Liu', 'orcid': 'https://orcid.org/0000-0003-0035-3570'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jiandong Liu', 'raw_affiliation_strings': ['From the Department of Biochemistry and Biophysics (J.L., D.Y.R.S.), Program in Developmental and Stem Cell Biology (D.Y.R.S.), and the Cardiovascular Research Institute (J.L., D.Y.R.S.), University of California, San Francisco, CA.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Biochemistry and Biophysics (J.L., D.Y.R.S.), Program in Developmental and Stem Cell Biology (D.Y.R.S.), and the Cardiovascular Research Institute (J.L., D.Y.R.S.), University of California, San Francisco, CA.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5089780494', 'display_name': 'Didier Y. R. Stainier', 'orcid': 'https://orcid.org/0000-0002-0382-0026'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Didier Y.R. Stainier', 'raw_affiliation_strings': ['From the Department of Biochemistry and Biophysics (J.L., D.Y.R.S.), Program in Developmental and Stem Cell Biology (D.Y.R.S.), and the Cardiovascular Research Institute (J.L., D.Y.R.S.), University of California, San Francisco, CA.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Biochemistry and Biophysics (J.L., D.Y.R.S.), Program in Developmental and Stem Cell Biology (D.Y.R.S.), and the Cardiovascular Research Institute (J.L., D.Y.R.S.), University of California, San Francisco, CA.', 'institution_ids': ['https://openalex.org/I180670191']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.069, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 136, 'citation_normalized_percentile': {'value': 0.659813, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '110', 'issue': '6', 'first_page': '870', 'last_page': '874'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11677', 'display_name': 'Congenital heart defects research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11677', 'display_name': 'Congenital heart defects research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10300', 'display_name': 'Congenital Heart Disease Studies', 'score': 0.9872, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12018', 'display_name': 'Coronary Artery Anomalies', 'score': 0.9565, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/heart-development', 'display_name': 'Heart development', 'score': 0.7932553}, {'id': 'https://openalex.org/keywords/cardiovascular-physiology', 'display_name': 'Cardiovascular physiology', 'score': 0.4349968}], 'concepts': [{'id': 'https://openalex.org/C2776878037', 'wikidata': 'https://www.wikidata.org/wiki/Q169444', 'display_name': 'Zebrafish', 'level': 3, 'score': 0.9704488}, {'id': 'https://openalex.org/C62425271', 'wikidata': 'https://www.wikidata.org/wiki/Q14819288', 'display_name': 'Heart development', 'level': 4, 'score': 0.7932553}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.69228065}, {'id': 'https://openalex.org/C40692019', 'wikidata': 'https://www.wikidata.org/wiki/Q815547', 'display_name': 'Morphogenesis', 'level': 3, 'score': 0.4899339}, {'id': 'https://openalex.org/C2781121885', 'wikidata': 'https://www.wikidata.org/wiki/Q425517', 'display_name': 'Retinoic acid', 'level': 3, 'score': 0.4509886}, {'id': 'https://openalex.org/C183683566', 'wikidata': 'https://www.wikidata.org/wiki/Q5038741', 'display_name': 'Cardiovascular physiology', 'level': 2, 'score': 0.4349968}, {'id': 'https://openalex.org/C89611455', 'wikidata': 'https://www.wikidata.org/wiki/Q6804646', 'display_name': 'Mechanism (biology)', 'level': 2, 'score': 0.4271729}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.4140557}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.40441373}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.33805344}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.33228654}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.21005252}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16238755}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.12907377}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.092160106}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.07625094}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C111472728', 'wikidata': 'https://www.wikidata.org/wiki/Q9471', 'display_name': 'Epistemology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D023421', 'descriptor_name': 'Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.111.246504', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.246504', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3329892', 'pdf_url': 'https://europepmc.org/articles/pmc3329892?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329892', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22427324', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.111.246504', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.246504', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1554463652', 'https://openalex.org/W1963577861', 'https://openalex.org/W1966563415', 'https://openalex.org/W1980362465', 'https://openalex.org/W1988893964', 'https://openalex.org/W1991375522', 'https://openalex.org/W1992697273', 'https://openalex.org/W1994142299', 'https://openalex.org/W1995946981', 'https://openalex.org/W2002732720', 'https://openalex.org/W2022733476', 'https://openalex.org/W2025855348', 'https://openalex.org/W2029817525', 'https://openalex.org/W2033033141', 'https://openalex.org/W2060726822', 'https://openalex.org/W2065171831', 'https://openalex.org/W2070779001', 'https://openalex.org/W2073615403', 'https://openalex.org/W2074380279', 'https://openalex.org/W2075401648', 'https://openalex.org/W2078115867', 'https://openalex.org/W2081558031', 'https://openalex.org/W2086413921', 'https://openalex.org/W2091732296', 'https://openalex.org/W2093360631', 'https://openalex.org/W2102927207', 'https://openalex.org/W2103724167', 'https://openalex.org/W2106636692', 'https://openalex.org/W2115798328', 'https://openalex.org/W2153361555', 'https://openalex.org/W2155321073', 'https://openalex.org/W2155651653', 'https://openalex.org/W2164619944', 'https://openalex.org/W2181479036', 'https://openalex.org/W2411710211'], 'related_works': ['https://openalex.org/W4362641123', 'https://openalex.org/W2770805947', 'https://openalex.org/W2741887047', 'https://openalex.org/W2150627711', 'https://openalex.org/W2118467593', 'https://openalex.org/W2097440061', 'https://openalex.org/W2074814223', 'https://openalex.org/W1973515414', 'https://openalex.org/W1970408590', 'https://openalex.org/W1964506754'], 'abstract_inverted_index': {'Heart': [0], 'development': [1, 45, 83, 112, 134], 'is': [2, 113], 'a': [3, 22, 30, 86, 99], 'complex': [4], 'process': [5], 'that': [6, 81, 124, 128], 'involves': [7], 'cell': [8], 'specification': [9, 57], 'and': [10, 18, 40, 46, 50, 58, 139, 144, 155], 'differentiation,': [11], 'as': [12, 14, 29], 'well': [13], 'elaborate': [15], 'tissue': [16], 'morphogenesis': [17], 'remodeling,': [19], 'to': [20, 34, 70, 94], 'generate': [21], 'functional': [23], 'organ.': [24], 'The': [25], 'zebrafish': [26, 110, 138], 'has': [27], 'emerged': [28], 'powerful': [31], 'model': [32], 'system': [33], 'unravel': [35], 'the': [36, 59, 62, 71, 106, 114, 117, 125, 130, 148, 151], 'basic': [37], 'genetic,': [38], 'molecular,': [39], 'cellular': [41], 'mechanisms': [42, 127], 'of': [43, 61, 108, 116, 150], 'cardiac': [44, 56, 75, 96, 111], 'function.': [47], 'We': [48], 'summarize': [49], 'discuss': [51], 'recent': [52, 103], 'discoveries': [53], 'on': [54], 'early': [55, 109], 'identification': [60, 115], 'second': [63, 118, 131, 152], 'heart': [64, 82, 119, 132, 153], 'field': [65, 133, 154], 'in': [66, 105], 'zebrafish.': [67], 'In': [68], 'addition': [69], 'inductive': [72], 'signals': [73], 'regulating': [74], 'specification,': [76], 'these': [77], 'studies': [78, 122], 'have': [79], 'shown': [80], 'also': [84], 'requires': [85], 'repressive': [87], 'mechanism': [88], 'imposed': [89], 'by': [90], 'retinoic': [91], 'acid': [92], 'signaling': [93], 'select': [95], 'progenitors': [97], 'from': [98], 'multipotent': [100], 'population.': [101], 'Another': [102], 'advance': [104], 'study': [107], 'field.': [120], 'These': [121], 'suggest': [123], 'molecular': [126], 'regulate': [129], 'are': [135], 'conserved': [136], 'between': [137], 'other': [140], 'vertebrates': [141], 'including': [142], 'mammals': [143], 'provide': [145], 'insight': [146], 'into': [147], 'evolution': [149], 'its': [156], 'derivatives.': [157]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2074814223', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 17}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 11}], 'updated_date': '2024-12-13T18:06:29.968361', 'created_date': '2016-06-24'}