Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2074636644', 'doi': 'https://doi.org/10.1182/blood-2011-10-386052', 'title': 'Platelet Ca2+ responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors: roles for secondary activation of P2X1 receptors and release from intracellular Ca2+ stores', 'display_name': 'Platelet Ca2+ responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors: roles for secondary activation of P2X1 receptors and release from intracellular Ca2+ stores', 'publication_year': 2012, 'publication_date': '2012-04-12', 'ids': {'openalex': 'https://openalex.org/W2074636644', 'doi': 'https://doi.org/10.1182/blood-2011-10-386052', 'mag': '2074636644', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22228626', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3448562'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1182/blood-2011-10-386052', 'pdf_url': 'https://ashpublications.org/blood/article-pdf/119/15/3613/1497503/zh801512003613.pdf', 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://ashpublications.org/blood/article-pdf/119/15/3613/1497503/zh801512003613.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046691338', 'display_name': 'Candice Fung', 'orcid': 'https://orcid.org/0000-0002-4277-3664'}, 'institutions': [{'id': 'https://openalex.org/I153648349', 'display_name': 'University of Leicester', 'ror': 'https://ror.org/04h699437', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I153648349']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'C. Y. Eleanor Fung', 'raw_affiliation_strings': ['Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom;', 'institution_ids': ['https://openalex.org/I153648349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103130908', 'display_name': 'Sarah Jones', 'orcid': 'https://orcid.org/0000-0001-8154-3928'}, 'institutions': [{'id': 'https://openalex.org/I153648349', 'display_name': 'University of Leicester', 'ror': 'https://ror.org/04h699437', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I153648349']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sarah Jones', 'raw_affiliation_strings': ['Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom;', 'institution_ids': ['https://openalex.org/I153648349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5097775044', 'display_name': 'Adwoa Ntrakwah', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I153648349', 'display_name': 'University of Leicester', 'ror': 'https://ror.org/04h699437', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I153648349']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Adwoa Ntrakwah', 'raw_affiliation_strings': ['Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom;', 'institution_ids': ['https://openalex.org/I153648349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086090291', 'display_name': 'Khalid M. Naseem', 'orcid': 'https://orcid.org/0000-0002-3870-8747'}, 'institutions': [{'id': 'https://openalex.org/I69768126', 'display_name': 'Hull York Medical School', 'ror': 'https://ror.org/0003e4m70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I69768126']}, {'id': 'https://openalex.org/I191240316', 'display_name': 'University of Hull', 'ror': 'https://ror.org/04nkhwh30', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I191240316']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Khalid M. Naseem', 'raw_affiliation_strings': ['Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull, Hull, United Kingdom; and'], 'affiliations': [{'raw_affiliation_string': 'Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull, Hull, United Kingdom; and', 'institution_ids': ['https://openalex.org/I69768126', 'https://openalex.org/I191240316']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074848089', 'display_name': 'Richard W. Farndale', 'orcid': 'https://orcid.org/0000-0001-6130-8808'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Richard W. Farndale', 'raw_affiliation_strings': ['Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom,', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048266874', 'display_name': 'Martyn P. Mahaut‐Smith', 'orcid': 'https://orcid.org/0000-0001-5357-2350'}, 'institutions': [{'id': 'https://openalex.org/I153648349', 'display_name': 'University of Leicester', 'ror': 'https://ror.org/04h699437', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I153648349']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Martyn P. Mahaut-Smith', 'raw_affiliation_strings': ['Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom;', 'institution_ids': ['https://openalex.org/I153648349']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5000, 'currency': 'USD', 'value_usd': 5000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.392, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 35, 'citation_normalized_percentile': {'value': 0.862805, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '119', 'issue': '15', 'first_page': '3613', 'last_page': '3621'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11193', 'display_name': 'Molecular Physiology of Purinergic Signalling', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11193', 'display_name': 'Molecular Physiology of Purinergic Signalling', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Thrombosis Mechanisms', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10155', 'display_name': 'Role of Nitric Oxide in Health and Disease', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gpvi', 'display_name': 'GPVI', 'score': 0.7154634}, {'id': 'https://openalex.org/keywords/apyrase', 'display_name': 'Apyrase', 'score': 0.7057456}, {'id': 'https://openalex.org/keywords/protease-activated-receptor', 'display_name': 'Protease-activated receptor', 'score': 0.53256285}, {'id': 'https://openalex.org/keywords/p2x-receptors', 'display_name': 'P2X Receptors', 'score': 0.489719}], 'concepts': [{'id': 'https://openalex.org/C2780573682', 'wikidata': 'https://www.wikidata.org/wiki/Q14905651', 'display_name': 'GPVI', 'level': 4, 'score': 0.7154634}, {'id': 'https://openalex.org/C2779508331', 'wikidata': 'https://www.wikidata.org/wiki/Q24770179', 'display_name': 'Apyrase', 'level': 3, 'score': 0.7057456}, {'id': 'https://openalex.org/C2781128415', 'wikidata': 'https://www.wikidata.org/wiki/Q412050', 'display_name': 'Prostacyclin', 'level': 2, 'score': 0.60192513}, {'id': 'https://openalex.org/C3018697912', 'wikidata': 'https://www.wikidata.org/wiki/Q179217', 'display_name': 'Platelet activation', 'level': 3, 'score': 0.5514317}, {'id': 'https://openalex.org/C149577978', 'wikidata': 'https://www.wikidata.org/wiki/Q24777577', 'display_name': 'Protease-activated receptor', 'level': 4, 'score': 0.53256285}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.52605486}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41601425}, {'id': 'https://openalex.org/C26828662', 'wikidata': 'https://www.wikidata.org/wiki/Q7202248', 'display_name': 'Platelet membrane glycoprotein', 'level': 3, 'score': 0.40968755}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.389491}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.38506097}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37852618}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.37280554}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3726247}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.34830412}, {'id': 'https://openalex.org/C2777292125', 'wikidata': 'https://www.wikidata.org/wiki/Q409166', 'display_name': 'Thrombin', 'level': 3, 'score': 0.22501776}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.13857877}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.091557294}], 'mesh': [{'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010980', 'descriptor_name': 'Platelet Membrane Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D058474', 'descriptor_name': 'Receptors, Purinergic P2X1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051193', 'descriptor_name': 'Toll-Like Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024042', 'descriptor_name': 'Collagen Type I', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D024042', 'descriptor_name': 'Collagen Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055724', 'descriptor_name': 'Electrophysiological Phenomena', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D055724', 'descriptor_name': 'Electrophysiological Phenomena', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042541', 'descriptor_name': 'Intracellular Space', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D042541', 'descriptor_name': 'Intracellular Space', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D042541', 'descriptor_name': 'Intracellular Space', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D042541', 'descriptor_name': 'Intracellular Space', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010980', 'descriptor_name': 'Platelet Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058910', 'descriptor_name': 'Purinergic P2 Receptor Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058910', 'descriptor_name': 'Purinergic P2 Receptor Agonists', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D058910', 'descriptor_name': 'Purinergic P2 Receptor Agonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D058474', 'descriptor_name': 'Receptors, Purinergic P2X1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051193', 'descriptor_name': 'Toll-Like Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1182/blood-2011-10-386052', 'pdf_url': 'https://ashpublications.org/blood/article-pdf/119/15/3613/1497503/zh801512003613.pdf', 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448562', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3448562', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22228626', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1182/blood-2011-10-386052', 'pdf_url': 'https://ashpublications.org/blood/article-pdf/119/15/3613/1497503/zh801512003613.pdf', 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1487192768', 'https://openalex.org/W1549514523', 'https://openalex.org/W1580332368', 'https://openalex.org/W1798325051', 'https://openalex.org/W1818313483', 'https://openalex.org/W1941413983', 'https://openalex.org/W196385150', 'https://openalex.org/W1971004719', 'https://openalex.org/W1971529415', 'https://openalex.org/W1972407011', 'https://openalex.org/W1973657843', 'https://openalex.org/W1976954262', 'https://openalex.org/W1992168784', 'https://openalex.org/W1999393449', 'https://openalex.org/W2014959551', 'https://openalex.org/W2015154214', 'https://openalex.org/W2015678912', 'https://openalex.org/W2024971613', 'https://openalex.org/W2025605461', 'https://openalex.org/W2028048964', 'https://openalex.org/W2038337449', 'https://openalex.org/W2040715593', 'https://openalex.org/W2045291272', 'https://openalex.org/W2045922233', 'https://openalex.org/W2050771850', 'https://openalex.org/W2051106455', 'https://openalex.org/W2055293344', 'https://openalex.org/W2055990711', 'https://openalex.org/W2057605718', 'https://openalex.org/W2058217708', 'https://openalex.org/W2062213947', 'https://openalex.org/W2065258513', 'https://openalex.org/W2075992820', 'https://openalex.org/W2086948789', 'https://openalex.org/W2089032162', 'https://openalex.org/W2095336107', 'https://openalex.org/W2096336546', 'https://openalex.org/W2098739396', 'https://openalex.org/W2107659105', 'https://openalex.org/W2112666227', 'https://openalex.org/W2113934014', 'https://openalex.org/W213009695', 'https://openalex.org/W2133449490', 'https://openalex.org/W2140327830', 'https://openalex.org/W2157415059', 'https://openalex.org/W2157518434', 'https://openalex.org/W2164033349', 'https://openalex.org/W2167069179', 'https://openalex.org/W2182051627', 'https://openalex.org/W2212838299', 'https://openalex.org/W2531107430'], 'related_works': ['https://openalex.org/W4206625358', 'https://openalex.org/W3128389870', 'https://openalex.org/W2581286765', 'https://openalex.org/W2581011975', 'https://openalex.org/W2082403298', 'https://openalex.org/W2079950215', 'https://openalex.org/W2074636644', 'https://openalex.org/W2073590210', 'https://openalex.org/W2061400583', 'https://openalex.org/W1974703721'], 'abstract_inverted_index': {'Inhibition': [0], 'of': [1, 31, 37, 44, 66, 97, 106, 116, 125, 152, 165], 'Ca(2+)': [2, 33, 61, 85, 99, 118, 170, 186], 'mobilization': [3, 187], 'by': [4, 41, 48, 70, 178], 'cyclic': [5], 'nucleotides': [6], 'is': [7, 51], 'central': [8], 'to': [9, 53, 168], 'the': [10, 22, 32, 59, 123, 155, 162], 'mechanism': [11, 177], 'whereby': [12], 'endothelial-derived': [13], 'prostacyclin': [14, 143], 'and': [15, 83, 144], 'nitric': [16, 126], 'oxide': [17], 'limit': [18], 'platelet': [19, 202], 'activation': [20, 105, 115, 176], 'in': [21, 122], 'intact': [23], 'circulation.': [24], 'However,': [25], 'we': [26], 'show': [27], 'that': [28, 101, 192], '∼': [29], '50%': [30], 'response': [34, 62], 'after': [35], 'stimulation': [36], 'glycoprotein': [38], 'VI': [39], '(GPVI)': [40], 'collagen,': [42], 'or': [43, 132, 200], 'Toll-like': [45], '2/1': [46], 'receptors': [47, 68, 167], 'Pam(3)Cys-Ser-(Lys)(4)': [49], '(Pam(3)CSK(4)),': [50], 'resistant': [52], 'prostacyclin.': [54], 'At': [55, 87], 'low': [56], 'agonist': [57, 89], 'concentrations,': [58, 90], 'prostacyclin-resistant': [60], 'was': [63, 94, 139], 'predominantly': [64], 'because': [65, 96], 'P2X1': [67, 149, 166, 190], 'activated': [69], 'ATP': [71, 158], 'release': [72, 100], 'via': [73], 'a': [74, 173], 'phospholipase-C-coupled': [75], 'secretory': [76], 'pathway': [77, 93], 'requiring': [78], 'both': [79], 'protein': [80], 'kinase': [81], 'C': [82, 108], 'cytosolic': [84], 'elevation.': [86], 'higher': [88], 'an': [91], 'additional': [92], 'observed': [95], 'intracellular': [98], 'also': [102, 120], 'depended': [103], 'on': [104], 'phospholipase': [107], 'and,': [109], 'for': [110], 'TLR': [111], '2/1,': [112], 'PI3-kinase.': [113], 'Secondary': [114], 'P2X1-dependent': [117], 'influx': [119], 'persisted': [121], 'presence': [124], 'oxide,': [127], 'delivered': [128], 'from': [129], 'spermine': [130], 'NONOate,': [131], 'increased': [133], 'ectonucleotidase': [134], 'levels': [135], '(apyrase).': [136], 'Surprisingly,': [137], 'apyrase': [138], 'more': [140], 'effective': [141], 'than': [142], 'NO': [145], 'at': [146], 'limiting': [147], 'secondary': [148], 'activation.': [150, 203], 'Dilution': [151], 'platelets': [153, 183], 'reduced': [154], 'average': [156], 'extracellular': [157], 'level': [159], 'without': [160], 'affecting': [161], 'percentage': [163], 'contribution': [164], 'collagen-evoked': [169], 'responses,': [171], 'indicating': [172], 'highly': [174], 'efficient': [175], 'local': [179], 'ATP.': [180], 'In': [181], 'conclusion,': [182], 'possess': [184], 'inhibitor-resistant': [185], 'pathways,': [188], 'including': [189], 'receptors,': [191], 'may': [193], 'be': [194], 'particularly': [195], 'important': [196], 'during': [197], 'early': [198], 'thrombotic': [199], 'immune-dependent': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2074636644', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-11T04:33:27.362503', 'created_date': '2016-06-24'}