A Model for Ku Heterodimer Assembly and Interaction with DNA

Name: Work Video:
Duration: 3 min 30 s
Jingsong Wang; Xingwen Dong; Westley H. Reeves
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2757, 2798, 2879, 2899, 2946, 3032, 3092, 3140, 3166, 3173, 3196, 3271, 3278, 3285, 3409, 3415, 3419, 3432, 3471, 3476, 3491, 3525, 3578, 3591, 3677, 3705, 3743, 3749, 3768, 3806, 3839, 3853, 3886, 3891, 3943, 3966, 4009, 4011, 4050, 4093, 4178, 4218, 4249, 4256, 4264, 4331, 4383, 4412], '70-': [5, 186], 'and': [6, 29, 148, 187, 210, 329, 378, 449, 461, 536, 559, 660, 673, 678, 693, 927, 1058, 1071, 1114, 1125, 1139, 1164, 1169, 1182, 1235, 1252, 1283, 1359, 1409, 1456, 1508, 1570, 1603, 1666, 1679, 1691, 1721, 1742, 1755, 1761, 1775, 1794, 1898, 1915, 1944, 2044, 2092, 2210, 2229, 2238, 2267, 2286, 2452, 2463, 2528, 2655, 2746, 2815, 2911, 2971, 3014, 3142, 3175, 3230, 3486, 3614, 3630, 3721, 3877, 3989, 4018, 4057, 4064, 4227, 4253, 4267, 4366], '80-kDa': [7, 188], 'subunits,': [8, 189], 'is': [9, 49, 190, 230, 450, 553, 665, 978, 2104, 2256, 2276, 2334, 2377, 2412, 2893, 3108, 3224, 3265, 3521, 3531, 4114, 4308, 4410, 4422], 'DNA': [11, 16, 23, 70, 118, 130, 151, 157, 172, 179, 192, 197, 204, 251, 299, 311, 332, 338, 353, 360, 455, 606, 663, 688, 691, 699, 909, 911, 937, 975, 1053, 1072, 1081, 1086, 1097, 1785, 1804, 1890, 1908, 1932, 2076, 2096, 3189, 3207, 3215, 3254, 3268, 3296, 3307, 3364, 3390, 3457, 3468, 3488, 3581, 3589, 3609, 3646, 3711, 3753, 3766, 3803, 3819, 3836, 3850, 3894, 3952, 3971, 3975, 4006, 4014, 4182, 4240, 4251], 'end-binding': [12, 193], 'factor': [13, 194], 'critical': [14, 195], 'for': [15, 55, 128, 196, 236, 309, 1293, 1372, 1442, 1669, 1895, 1923, 1984, 2046, 2107, 2279, 2318, 2380, 2405, 2436, 3088, 3182, 3523, 3533, 3740, 3817, 4310, 4424], 'repair.': [17, 198, 689], 'Two': [18, 199, 2056], 'domains': [19, 101, 200, 282, 946, 2072, 2907, 2965, 3124, 3165, 3490, 4016, 4255], 'p70': [21, 78, 99, 202, 259, 280, 659, 697, 917, 1057, 1168, 1248, 1455, 2060, 2103, 2173, 2189, 2290, 2449, 2494, 2504, 2527, 2541, 2574, 2593, 2672, 2710, 2733, 2745, 2762, 2902, 2958, 2993, 2998, 3035, 3052, 3122, 3141, 3167, 3185, 3238, 3272, 3341, 3359, 3396, 3492, 3598, 3651, 3751, 3854, 3985, 3990, 4001, 4013, 4085, 4226, 4339, 4427], 'mediate': [22, 203, 4223, 4336], 'binding,': [24, 71, 205, 252, 910, 913, 938], 'one': [25, 30, 206, 211, 942, 1312, 2068, 3180, 3195], 'on': [26, 31, 207, 212, 980, 1838, 2493, 2808, 2819, 3658], 'the': [27, 32, 47, 65, 98, 104, 146, 149, 208, 213, 228, 246, 279, 285, 327, 330, 383, 656, 670, 701, 767, 817, 824, 894, 903, 944, 981, 1032, 1051, 1079, 1106, 1137, 1224, 1244, 1264, 1373, 1443, 1453, 1655, 1685, 1731, 1767, 1861, 1882, 1899, 1919, 2036, 2059, 2075, 2082, 2087, 2140, 2145, 2204, 2217, 2259, 2269, 2330, 2339, 2352, 2367, 2428, 2457, 2499, 2511, 2516, 2559, 2568, 2597, 2632, 2652, 2660, 2668, 2728, 2740, 2751, 2761, 2795, 2881, 2885, 2896, 2962, 3034, 3051, 3089, 3105, 3120, 3129, 3150, 3162, 3170, 3197, 3242, 3262, 3267, 3282, 3352, 3400, 3412, 3420, 3449, 3466, 3484, 3526, 3576, 3588, 3624, 3659, 3673, 3706, 3741, 3750, 3761, 3802, 3824, 3835, 3845, 3882, 3892, 3944, 4012, 4081, 4084, 4176, 4212, 4230, 4247, 4250, 4261, 4265, 4302, 4380, 4413, 4429], 'C-terminal': [28, 209, 2423, 2500, 2560, 3201, 3245, 3487, 3752, 3763, 3849], 'N-terminal': [33, 214, 1033, 1232, 2418, 3214, 3527], 'portion.': [34, 215], 'The': [35, 216, 408, 581, 626, 916, 1043, 1127, 1166, 1219, 1240, 1545, 1675, 2098, 2137, 2489, 2508, 2835, 2901, 3026, 3184, 3200, 3358, 3634, 3654, 3848, 3889, 3983, 4375], 'latter': [36, 217, 3846], 'must': [37, 52, 218, 233, 1035], 'dimerize': [38, 219], 'with': [39, 76, 94, 220, 257, 275, 387, 423, 1120, 1151, 1184, 1311, 1506, 1549, 1572, 1605, 1684, 1702, 1735, 1792, 1842, 1867, 1874, 1904, 1947, 2062, 2109, 2172, 2187, 2222, 2281, 2289, 2306, 2320, 2346, 2450, 2544, 2577, 2704, 2714, 2813, 2942, 2969, 2973, 2991, 3024, 3039, 3057, 3079, 3113, 3169, 3179, 3220, 3275, 3337, 3374, 3386, 3399, 3596, 3602, 3649, 3735, 3939, 4021, 4118, 4225, 4260, 4301, 4338, 4349, 4373, 4417, 4426], 'p80': [40, 68, 92, 125, 221, 249, 273, 306, 661, 704, 807, 825, 906, 921, 1037, 1059, 1066, 1170, 1246, 1260, 1268, 1421, 1457, 1680, 2066, 2110, 2149, 2181, 2218, 2263, 2451, 2520, 2529, 2545, 2563, 2578, 2598, 2647, 2705, 2715, 2721, 2736, 2747, 2799, 2816, 2838, 2947, 3040, 3068, 3131, 3143, 3174, 3243, 3279, 3286, 3401, 3453, 3463, 3520, 3579, 3592, 3615, 3635, 3737, 3769, 3797, 3813, 3843, 4023, 4094, 4119, 4219, 4257, 4332, 4362, 4384], 'in': [41, 59, 69, 135, 162, 222, 240, 250, 316, 343, 392, 432, 452, 687, 700, 762, 816, 823, 907, 936, 1038, 1068, 1116, 1144, 1263, 1280, 1303, 1354, 1660, 1730, 1950, 2018, 2095, 2170, 2190, 2258, 2456, 2604, 2636, 2750, 2895, 3069, 3149, 3255, 3301, 3426, 3436, 3444, 3478, 3535, 3584, 3623, 3823, 3919, 4025, 4061, 4116, 4235, 4239, 4244, 4312, 4359, 4428], 'order': [42, 223, 1039], 'to': [43, 103, 111, 156, 224, 284, 292, 337, 420, 662, 683, 812, 901, 1040, 1049, 1230, 1289, 1654, 1757, 1771, 1797, 1860, 2035, 2067, 2074, 2336, 2427, 2438, 2515, 2565, 2649, 2863, 3061, 3128, 3294, 3345, 3424, 3621, 3710, 3800, 3833, 3948, 4005, 4031, 4054, 4175, 4222, 4237, 4335], 'bind': [44, 102, 225, 283, 770, 811, 1036, 1041, 1095, 3126, 3253, 3456, 3622, 4089], 'DNA,': [45, 226, 813, 4043, 4046], 'whereas': [46, 134, 227, 315, 1031, 2308, 3213, 3611], 'former': [48, 229], 'p80-independent.': [50, 231], 'Both': [51, 96, 232, 277], 'be': [53, 234, 421, 2316, 2801, 3001], 'intact': [54, 235, 3762, 3945], 'end': [56, 237, 912, 3208, 3820, 3883, 3909], 'binding': [57, 131, 152, 238, 312, 333, 607, 664, 675, 976, 1054, 1073, 1082, 1796, 1954, 2037, 2077, 2437, 2491, 2513, 3060, 3190, 3209, 3216, 3269, 3300, 3308, 3391, 3418, 3469, 3474, 3489, 3534, 3582, 3590, 3754, 3804, 3821, 3837, 3851, 3884, 3895, 3910, 3942, 3967, 4015, 4183, 4252], 'activity': [58, 239, 2078, 3210, 3217, 3223, 3232, 3270, 3380, 3392, 3470, 3475, 3524, 3583, 3805, 3822, 3838, 3885], 'gel': [60, 136, 241, 317, 368, 763, 1927, 3302, 3479, 3536, 3585, 3625, 3660, 3825], 'shift': [61, 137, 242, 318, 764, 1929, 3303, 3480, 3537, 3586, 3626, 3826], 'assays.': [62, 243], 'To': [63, 244, 2213, 2665, 2738, 3259, 3574, 3901], 'evaluate': [64, 245, 3902], 'role': [66, 247, 686, 904, 2094, 2138, 3890, 4358], 'deletion': [72, 253, 2182, 2530, 2599, 2959, 3239, 3360, 3402, 3593, 3616, 3742], 'mutants': [73, 254, 815, 2183, 2219, 2531, 2600, 2960, 3053, 3240, 3280, 3403, 3421, 3594, 3617, 4363], 'were': [74, 126, 142, 255, 307, 323, 1103, 1173, 1261, 1270, 1309, 1352, 1377, 1514, 1547, 1586, 1652, 1677, 1687, 1699, 1723, 1749, 1858, 1872, 1901, 2014, 2033, 2220, 2240, 2297, 2825, 3016, 3029, 3037, 3135, 3147, 3442, 3914, 4333], 'co-expressed': [75, 256, 2543, 2576, 2703, 2713, 2989, 3022, 3038, 3112, 3274, 3595], 'full-length': [77, 258, 1245, 2188, 2540, 3842, 3984, 4022], 'using': [79, 260, 380, 1276, 1361, 1470, 1693, 1935, 2193, 2203, 2830, 2857, 3440, 3717], 'recombinant': [80, 261, 1220, 1241, 1315, 1349, 1454, 1855, 2194, 3605, 3707], 'baculoviruses.': [81, 262, 2195], 'We': [82, 263, 2640, 3460], 'show': [83, 264], 'by': [84, 178, 265, 359, 1272, 1357, 1588, 1689, 1751, 1803, 1865, 1881, 1911, 2016, 2024, 2176, 2201, 2242, 2300, 2360, 2386, 2410, 2446, 2534, 2827, 2956, 2982, 3003, 3018, 3211, 3226, 3233, 3342, 3384, 3618, 3714, 3879, 3957, 3968, 3981, 3987, 4039, 4229], 'several': [85, 266], 'criteria': [86, 267], 'that': [87, 115, 268, 296, 428, 563, 1089, 2252, 2268, 2341, 2366, 2374, 2558, 2642, 2656, 2727, 2794, 2889, 2939, 3050, 3093, 3119, 3161, 3448, 3462, 3669, 3733, 4000, 4027, 4083, 4305, 4420], 'amino': [88, 121, 139, 269, 302, 320, 924, 2312, 2400, 2415, 2643, 2876, 3227, 3234, 4215], 'acids': [89, 122, 140, 270, 303, 321, 925, 985, 1423, 1429, 1435, 2265, 2274, 2313, 2401, 2416, 2432, 2496, 2506, 2644, 2674, 2877, 2909, 2949, 3204, 3228, 3235, 3747, 3992, 4216, 4329, 4346, 4386], '371–510': [90, 271, 2239, 4217, 4330], 'interact': [93, 274, 2061, 2941, 3168, 4372], 'p70.': [95, 276, 2282, 2321, 2439, 3472, 4374], 'dimerization': [100, 281, 898, 1070, 2091, 2108, 2280, 2319, 2343, 2447, 2633, 2661, 2743, 2891, 2964, 3123, 3145, 3164, 3198, 3219, 3283, 3385, 3427, 3670, 3734, 4224, 4254, 4337, 4414], 'same': [105, 286, 1265, 1732, 1883, 3130, 3151], 'region': [106, 287, 1034, 2272, 2409, 2658, 2797, 3172, 3577, 3830], 'p80,': [108, 289, 2372, 2880, 2970, 2992, 3613], 'but': [109, 290, 761, 2244, 2356, 2388, 2548, 2582, 2588, 2719, 2846, 3366, 3638, 3828, 4368], 'apparently': [110, 291, 2940, 4173], 'separate': [112, 293, 2906], 'sites': [113, 153, 294, 334, 3146, 3309], 'within': [114, 295], 'region.': [116, 297], 'In': [117, 298, 690, 2081, 3010, 4211], 'immunoprecipitation': [119, 300, 692, 1509, 1805, 2202, 2886, 2984, 3297], 'assays,': [120, 138, 301, 319, 696, 765, 1930, 3587], '179–510': [123, 304, 2287, 2304, 2645], 'required': [127, 308, 2106, 2379, 3532, 3816], 'p80-dependent': [129, 147, 310, 328, 3257, 3263, 3389, 3467, 3893], 'p70,': [133, 314, 2307, 2376, 3612], '179–732': [141, 322], 'necessary.': [143, 324], 'Interestingly,': [144, 325], 'both': [145, 326, 1069, 3012, 3306, 3483], 'p80-independent': [150, 331, 974, 1080], 'preferentially': [154, 335, 1084, 3858, 3955, 4004, 4030], 'bound': [155, 336, 1859, 3344, 3363, 3608, 3645, 4029], 'ends,': [158, 339, 1087], 'suggesting': [159, 340, 1088, 2251, 2557, 2793, 3049, 3999], 'model': [161, 342], 'which': [163, 344, 3410], 'single': [165, 346, 1091, 2944], 'may': [168, 349, 899, 1094, 2315, 2800, 3422, 3455, 4354], 'juxtapose': [169, 350], 'two': [170, 351, 920, 933, 1096, 2905, 2963, 3121, 3163, 3188], 'broken': [171, 352], 'ends': [173, 354, 566, 4091], 'physically,': [174, 355], 'facilitating': [175, 356], 'their': [176, 357, 2295, 2454], 'rejoining': [177, 358], 'ligases.': [180, 361], 'double-stranded': [362, 453, 1784, 3951], 'double': [363], 'strand': [364], 'break': [365, 456], 'repair': [366, 457], 'polyacrylamide': [367, 2021], 'electrophoresis': [369, 2017], 'monoclonal': [370, 1367], 'antibody': [371], 'x-ray': [372, 4062], 'cross-complementing.': [373], 'antigen': [375, 1376, 1800], 'was': [376, 418, 1048, 1074, 1134, 1447, 1468, 1595, 1769, 1790, 1801, 1836, 1893, 1909, 1921, 1933, 2174, 2199, 2246, 2325, 2357, 2384, 2521, 2532, 2702, 2748, 2811, 2843, 2953, 2980, 3085, 3287, 3292, 3381, 3393, 3599, 3712, 3815, 3831, 3954, 3963, 4035, 4220], 'identified': [377, 1353, 1688], 'characterized': [379], 'autoantibodies': [381], 'from': [382, 1105, 1136, 1448, 1459, 1465, 1592, 1787, 2765, 3371], 'sera': [384], 'patients': [386], 'systemic': [388], 'autoimmune': [389, 1363], 'diseases': [390], '(reviewed': [391], 'Ref.': [393], '1Reeves': [394], 'W.H.': [395, 568, 613, 749, 956, 996, 1020, 1202, 1328, 1390, 1484, 1528, 1616, 1816, 1996, 2120, 2480, 2618, 2685, 2776, 2922, 3319, 3502, 3779, 3866, 3927, 4102, 4194], 'Wang': [396, 569, 614, 744], 'J.': [397, 482, 521, 543, 570, 593, 615, 709, 745, 750, 779, 884, 948, 957, 988, 997, 1014, 1194, 1203, 1320, 1329, 1382, 1391, 1476, 1485, 1520, 1529, 1608, 1617, 1808, 1817, 1988, 1997, 2112, 2121, 2153, 2158, 2466, 2472, 2481, 2608, 2677, 2686, 2768, 2777, 2914, 2923, 3311, 3320, 3494, 3503, 3547, 3693, 3771, 3780, 3860, 3921, 4096, 4186, 4195, 4319, 4393, 4398], 'Ajmani': [398, 571, 616], 'A.K.': [399, 572, 617], 'Stojanov': [400, 573, 618, 2611], 'L.': [401, 574, 619, 643, 2612], 'Satoh': [402, 575, 620, 1015, 2467, 2615, 3861, 3922, 4097], 'M.': [403, 405, 576, 578, 621, 623, 1016, 2151, 2468, 2616, 3862, 3923, 4098, 4391], 'Zanetti': [404, 577, 622], 'Capra': [406, 579, 624], 'J.D.': [407, 580, 625], 'Antibodies.': [409, 582, 627], 'Harwood': [410, 583, 628], 'Academic': [411, 584, 629], 'Publishers,': [412, 585, 630], 'Amsterdam1997:': [413, 586, 631], '33-84Google': [414, 587, 632], 'Scholar).': [415, 551, 604, 654, 805, 892, 972, 1218, 1344, 1406, 1500, 1544, 1632, 1832, 2012, 2136, 2488, 2628, 3335, 3518, 3573, 3703, 3795, 4079, 4210, 4295, 4327], 'Later,': [416], 'it': [417, 2333, 2589, 3529, 4421], 'shown': [419, 3731, 4221, 4334], 'associated': [422, 1683], 'DNA-dependent': [425], 'protein': [426, 1511, 1600, 1839, 2197, 2903, 3107, 3186, 3708, 3986], 'kinase': [427], 'phosphorylates': [429], 'chromatin-bound': [430], 'proteins': [431, 1228, 1351, 1458, 1464, 1585, 1857, 2233, 3036], 'vitro': [433], '(2Anderson': [434], 'C.W.': [435], 'Lees-Miller': [436], 'S.P.': [437, 541, 863, 4157], 'CRC': [438, 466], 'Crit.': [439, 467], 'Rev.': [440, 468], 'Eukaryotic': [441, 469], 'Gene': [442, 470], 'Exp.': [443, 471, 751], '1992;': [444, 753, 782, 3550], '2:': [445], '283-314PubMed': [446], 'Google': [447, 478, 496, 528, 550, 603, 653, 719, 740, 759, 789, 804, 850, 877, 891, 971, 1011, 1029, 1217, 1343, 1405, 1499, 1543, 1631, 1831, 2011, 2135, 2168, 2487, 2627, 2700, 2791, 2937, 3334, 3517, 3557, 3572, 3702, 3794, 3875, 3936, 4078, 4111, 4144, 4171, 4209, 4294, 4326, 4408, 4446], 'Scholar)': [448, 2169, 2701, 2938, 4409], 'involved': [451, 935, 1067], '(ds)1': [454], '(DSBR),': [458], 'V(D)J': [459, 4058], 'recombination,': [460, 4059], 'isotype': [462], 'switching': [463], '(3Weaver': [464], 'D.T.': [465, 882, 4069, 4317], '1996;': [472, 647, 798, 844, 3566, 4138, 4288, 4440], '6:': [473], '345-375Crossref': [474], 'PubMed': [475, 493, 525, 547, 602, 650, 718, 756, 788, 801, 847, 874, 888, 968, 1008, 1026, 1214, 1340, 1402, 1496, 1540, 1628, 1828, 2008, 2132, 2167, 2624, 2697, 2788, 2934, 3331, 3514, 3556, 3569, 3699, 3791, 3872, 3933, 4075, 4108, 4141, 4168, 4206, 4291, 4323, 4407, 4443], 'Scopus': [476, 494, 526, 548, 651, 738, 757, 802, 848, 875, 889, 969, 1009, 1027, 1215, 1341, 1403, 1497, 1541, 1629, 1829, 2009, 2133, 2625, 2698, 2789, 2935, 3332, 3515, 3570, 3700, 3792, 3873, 3934, 4076, 4109, 4142, 4169, 4207, 4292, 4324, 4444], '(44)': [477], 'Scholar,': [479, 497, 588, 633, 720, 741, 790, 851, 878, 1012, 3558, 4145, 4447], '4Chu': [480], 'G.': [481, 840, 4134, 4284], 'Biol.': [483, 594, 710, 780, 797, 843, 870, 958, 998, 1204, 1330, 1392, 1486, 1530, 1618, 1818, 1998, 2122, 2159, 2687, 2778, 2924, 3321, 3504, 3548, 3565, 3695, 3781, 4137, 4164, 4196, 4287, 4399, 4439], 'Chem.': [484, 595, 711, 781, 959, 999, 1205, 1331, 1393, 1487, 1531, 1619, 1819, 1999, 2123, 2160, 2688, 2779, 2925, 3322, 3505, 3549, 3782, 4197, 4400], '1997;': [485, 871, 885, 2621, 4165, 4320], '272:': [486], '24097-24100Abstract': [487], 'Full': [488, 490, 599, 715, 785, 963, 965, 1003, 1005, 1209, 1211, 1335, 1337, 1397, 1399, 1491, 1493, 1535, 1537, 1623, 1625, 1823, 1825, 2003, 2005, 2127, 2129, 2164, 2692, 2694, 2783, 2785, 2929, 2931, 3326, 3328, 3509, 3511, 3553, 3786, 3788, 4201, 4203, 4404], 'Text': [489, 491, 600, 716, 786, 964, 966, 1004, 1006, 1210, 1212, 1336, 1338, 1398, 1400, 1492, 1494, 1536, 1538, 1624, 1626, 1824, 1826, 2004, 2006, 2128, 2130, 2165, 2693, 2695, 2784, 2786, 2930, 2932, 3327, 3329, 3510, 3512, 3554, 3787, 3789, 4202, 4204, 4405], 'PDF': [492, 601, 717, 787, 967, 1007, 1213, 1339, 1401, 1495, 1539, 1627, 1827, 2007, 2131, 2166, 2696, 2787, 2933, 3330, 3513, 3555, 3790, 4205, 4406], '(219)': [495], '5Casellas': [498], 'R.': [499, 503, 505, 2157, 4397], 'Nussenzweig': [500, 518], 'A.': [501, 507, 515, 828, 855, 2155, 2470, 4122, 4149, 4272, 4395], 'Wuerffel': [502], 'Pelanda': [504], 'Reichlin': [506], 'Suh': [508], 'H.': [509, 637, 857, 4151], 'Qin': [510], 'X.F.': [511], 'Besmer': [512], 'E.': [513, 3681], 'Kenter': [514], 'Rajewsky': [516], 'K.': [517, 952, 992, 1198, 1324, 1386, 1480, 1524, 1612, 1812, 1992, 2116, 2681, 2772, 2918, 3315, 3498, 3775, 4190], 'M.C.': [519], 'EMBO': [520, 542, 883, 4318], '1998;': [522, 544, 960, 1000, 1206, 1332, 1394, 1488, 1532, 1620, 1820, 2000, 2124, 2689, 2780, 2926, 3323, 3506, 3783, 4198], '17:': [523, 545, 872, 4166], '2404-2411Crossref': [524], '(292)': [527], 'Scholar),': [529, 760, 1030, 2792, 3876, 4112, 4172], 'as': [530, 532, 682, 930, 932, 1191, 1317, 1378, 1412, 1517, 1863, 2803, 2995, 2997, 3248, 3348, 3350, 3917], 'well': [531, 931, 2996, 3349], 'telomeric': [533], 'length': [534], 'maintenance': [535], 'silencing': [537], '(6Boulton': [538], 'S.J.': [539], 'Jackson': [540, 862, 4156], '1819-1828Crossref': [546], '(554)': [549], '70-kDa': [557], '(p70)': [558], '∼80-kDa': [560], '(p80)': [561], 'subunits': [562], 'binds': [564, 698, 3765, 4003], 'dsDNA': [565, 3347, 3856, 3959, 4090], '(1Reeves': [567, 612], '7Mimori': [589], 'T.': [590, 706, 776, 861, 3544, 4155], 'Hardin': [591, 707, 777, 3545], 'J.A.': [592, 708, 778, 3546], '1986;': [596, 712], '261:': [597, 713], '10375-10379Abstract': [598, 714], 'Sequence-specific': [605], 'also': [608, 2572, 3066, 3084, 3530, 3671, 3906, 4002, 4028, 4298], 'has': [609, 3187, 3206, 3897], 'been': [610, 3899], 'reported': [611], '8Griffin': [634], 'W.': [635, 3684], 'Torrance': [636], 'Rodda': [638], 'D.J.': [639, 4455], 'Prefontaine': [640], 'G.G.': [641], 'Pope': [642], 'Hache': [644], 'R.J.G.': [645], 'Nature.': [646], '380:': [648], '265-268Crossref': [649], '(197)': [652], 'Defining': [655, 893], 'contribution': [657], 'interest': [667], 'because': [668, 679, 2323, 3299, 4361], 'dual': [671], 'sequence-': [672], 'end-specific': [674], 'uncertainty': [681], 'its': [684, 1795, 2093, 3379], 'precise': [685], 'Southwestern': [694], 'blot': [695, 2855], 'absence': [702], '(7Mimori': [705], '9Allaway': [721], 'G.P.': [722], 'Vivino': [723], 'A.A.': [724], 'Kohn': [725], 'L.D.': [726], 'Notkins': [727], 'A.L.': [728], 'Prabhakar': [729], 'B.S.': [730], 'Biochem.': [731], 'Biophys.': [732], 'Res.': [733], 'Commun.': [734], '1989;': [735, 2161, 3696, 4401], '168:': [736], '747-755Crossref': [737], '(33)': [739], '10Chou': [742], 'C.H.': [743, 1018, 2474, 3864, 3925, 4100], 'Knuth': [746], 'M.W.': [747], 'Reeves': [748, 955, 995, 1019, 1201, 1327, 1389, 1483, 1527, 1615, 1815, 1995, 2119, 2479, 2617, 2684, 2775, 2921, 3318, 3501, 3778, 3865, 3926, 4101, 4193], 'Med.': [752], '175:': [754], '1677-1684Crossref': [755], '(67)': [758], 'only': [766], 'dimer': [768], 'can': [769, 3125, 4088, 4371], '(11Griffith': [771, 3539], 'A.J.': [772, 3540], 'Blier': [773, 3541], 'P.R.': [774, 3542], 'Mimori': [775, 3543], '267:': [783, 3551], '331-338Abstract': [784, 3552], '12Wu': [791, 3559], 'X.': [792, 950, 990, 1196, 1322, 1384, 1478, 1522, 1610, 1810, 1990, 2114, 2610, 2679, 2770, 2916, 3313, 3496, 3560, 3773, 4188, 4434], 'Lieber': [793, 3561, 4435], 'M.R.': [794, 3562, 4436], 'Mol.': [795, 841, 868, 3563, 3694, 4135, 4162, 4285, 4437], 'Cell.': [796, 842, 869, 3564, 4136, 4163, 4286, 4438], '16:': [799, 845, 886, 3567, 4139, 4289, 4321, 4441], '5186-5193Crossref': [800, 3568, 4442], '(110)': [803, 3571, 4445], 'Although': [806], 'alone': [808, 2603, 3110], 'does': [809, 3100], 'not': [810, 2105, 2247, 2277, 2358, 2378, 2389, 2549, 2583, 2591, 2720, 2724, 2871, 3055, 3101, 3116, 3154, 3177, 3632, 3639, 3726, 3898, 4036, 4369], 'DSBR': [814, 4056, 4113, 4311], 'XRCC5': [818], 'complementation': [819], 'group': [820], 'have': [821, 3730], 'defects': [822], 'gene': [826], '(13Errami': [827, 4121, 4271], 'Smider': [829, 4123, 4273], 'V.': [830, 4124, 4274], 'Rathmell': [831, 4125, 4275], 'W.K.': [832, 4126, 4276], 'He': [833, 4127, 4277], 'D.M.': [834, 4128, 4278], 'Hendrickson': [835, 953, 993, 1199, 1325, 1387, 1481, 1525, 1613, 1813, 1993, 2117, 2682, 2773, 2919, 3316, 3499, 3776, 4129, 4191, 4279], 'E.A.': [836, 954, 994, 1200, 1326, 1388, 1482, 1526, 1614, 1814, 1994, 2118, 2683, 2774, 2920, 3317, 3500, 3777, 4130, 4192, 4280], 'Zdzienicka': [837, 4131, 4281], 'M.Z.': [838, 4132, 4282], 'Chu': [839, 4133, 4283], '1519-1526Crossref': [846, 4140, 4290], '(158)': [849, 4143, 4293], '14Singleton': [852, 4146], 'B.K.': [853, 4147], 'Priestley': [854, 4148], 'Steingrimsdottir': [856, 4150], 'Gell': [858, 4152], 'D.': [859, 2614, 4153], 'Blunt': [860, 4154], 'Lehmann': [864, 4158], 'A.R.': [865, 4159], 'Jeggo': [866, 4160], 'P.A.': [867, 4161], '1264-1273Crossref': [873, 4167], '(165)': [876, 4170], '15Jin': [879], 'S.': [880, 4315], 'Weaver': [881, 4316], '6874-6885Crossref': [887, 4322], '(125)': [890, 4325], 'mechanism': [895, 2088], 'p70-p80': [897, 2406], 'help': [900], 'explain': [902, 3881], 'sequence-specific': [908], 'and/or': [914, 1365], 'DSBR.': [915], 'subunit': [918, 4087], 'contains': [919], 'interaction': [922, 945, 2071, 2254, 2501, 2517, 2763, 3413], 'domains,': [923, 3191], '1–115': [926, 2910], '430–482,': [928], 'respectively,': [929], 'regions': [934, 2057], 'each': [939, 3058, 3192, 3408, 3445, 4010], 'partially': [940, 3193, 3739], 'overlapping': [941, 2961, 3194, 3281], '(16Wang': [947, 987, 1193, 1319, 1381, 1475, 1519, 1607, 1807, 1987, 2111, 2676, 2767, 2913, 3310, 3493, 3770, 4185], 'Dong': [949, 989, 1195, 1321, 1383, 1477, 1521, 1609, 1809, 1989, 2113, 2609, 2678, 2769, 2915, 3312, 3495, 3772, 4187], 'Myung': [951, 991, 1197, 1323, 1385, 1479, 1523, 1611, 1811, 1991, 2115, 2680, 2771, 2917, 3314, 3497, 3774, 4189], '273:': [961, 1001, 1207, 1333, 1395, 1489, 1533, 1621, 1821, 2001, 2125, 2690, 2781, 2927, 3324, 3507, 3784, 4199], '842-848Abstract': [962, 1002, 1208, 1334, 1396, 1490, 1534, 1622, 1822, 2002, 2126, 2691, 2782, 2928, 3325, 3508, 3785, 4200], '(68)': [970, 1010, 1216, 1342, 1404, 1498, 1542, 1630, 1830, 2010, 2134, 2699, 2790, 2936, 3333, 3516, 3793, 4208], 'A': [973, 1780, 4342], 'site': [977, 2492, 2514, 2892, 3202, 3264, 3896, 3905, 4184], 'located': [979, 2257, 2894], 'C': [982], 'terminus': [983, 2147, 4382], '(amino': [984, 1422, 1428, 1434, 2264, 2273, 2431, 2495, 2505, 2673, 2908, 2948, 3203, 3746, 3991, 4345, 4385], '536–609)': [986, 3205], '17Wang': [1013], 'Chou': [1017, 2473, 3863, 3924, 4099], 'FEBS': [1021, 3867, 3928, 4103], 'Lett.': [1022, 3868, 3929, 4104], '1994;': [1023, 2484, 3869, 3930, 4105], '351:': [1024, 3870, 3931, 4106], '219-224Crossref': [1025, 3871, 3932, 4107], '(26)': [1028, 3874, 3935, 4110], 'DNA.': [1042], 'goal': [1044], 'this': [1046, 2347, 2408, 2657, 3829, 3904, 4352], 'study': [1047], 'define': [1050, 2667], 'dimerization-dependent': [1052], 'site.': [1055, 1239], 'Using': [1056], 'mutants,': [1060], 'large': [1062], 'central': [1063, 2260, 2897, 3171], 'domain': [1064, 2255, 2430, 2502, 2518, 2662, 2764, 2945, 3284, 3414, 3755, 3764, 3852, 4344], 'identified.': [1075], 'This': [1076], 'site,': [1077, 1083], 'like': [1078, 2373], 'recognized': [1085], 'ends.': [1098], 'K562': [1099, 1466, 1593, 1697, 2753], '(human': [1100], 'erythroleukemia)': [1101], 'cells': [1102, 1190, 1308, 1461, 1467, 1505, 1594, 1698, 2192, 2606, 3372, 4117], 'obtained': [1104, 1135, 3136], 'American': [1107], 'Type': [1108], 'Culture': [1109], 'Collection': [1110], '(ATCC,': [1111], 'Rockville,': [1112], 'MD)': [1113], 'maintained': [1115, 1140], 'RPMI': [1117], '1640': [1118], 'supplemented': [1119, 1150, 1734], '10%': [1121, 1160, 1967], 'fetal': [1122, 1161], 'bovine': [1123, 1162], 'serum': [1124, 1364], 'penicillin/streptomycin.': [1126, 1165], 'Sf9': [1128, 1189, 1307, 1460, 1504, 1695, 2191, 2605], '(Spodoptera': [1129], 'frugiperda': [1130], 'ovary)': [1131], 'cell': [1132, 1355, 1834, 1948, 2754, 4269], 'line': [1133], 'ATCC,': [1138], 'at': [1141, 1657, 1672, 1725, 1777, 1981, 2051, 2851], '27': [1142], '°C': [1143, 1983, 2053], "Grace's": [1145], 'insect': [1146], 'tissue': [1147], 'culture': [1148], 'medium': [1149], '3.3': [1152, 1156], 'g/liter': [1153, 1157], 'TC': [1154], 'yeastolate,': [1155], 'lactalbumin': [1158], 'hydrolyzate,': [1159], 'serum,': [1163], 'human': [1167, 1259, 1362, 1374, 2752], 'cDNAs': [1172, 1269, 1292], 'subcloned': [1174, 1284], 'into': [1175, 1188, 1285, 1295], 'modified': [1177], 'baculovirus': [1178, 1187, 1221, 1296], 'transfer': [1179, 1297], 'vector': [1180], 'pVLB4-mp53': [1181], 'co-transfected': [1183], 'linearized': [1185], 'wild-type': [1186, 3340, 3375, 3597, 3650, 3736], 'described': [1192, 1318, 1379, 1518], 'vectors': [1222], 'direct': [1223], 'expression': [1225, 2198, 2979], 'fused': [1229], 'an': [1231, 1916, 2047, 2253, 2443], 'polyhistidine': [1233, 1444], 'sequence': [1234, 2101, 2143, 2370], 'enterokinase': [1237], 'cleavage': [1238], 'baculoviruses': [1242, 1256, 1316], 'expressing': [1243, 1257], 'or': [1247, 1313, 1462, 1645, 1696, 1848, 2392, 2422, 2552, 2580, 2594, 2717, 2967, 3044, 3111, 3251, 3406, 3643, 3976, 3980, 4047], 'are': [1249, 1411, 2403, 2434, 4258, 4299], 'designated': [1250], 'p80-bv': [1251], 'p70-bv': [1253], 'respectively.': [1254], 'Recombinant': [1255, 2196], 'mutant': [1258, 2420, 2425, 2546, 3106, 3361, 3636], 'constructed': [1262], 'manner.': [1266, 3258], 'Truncated': [1267], 'amplified': [1271], 'polymerase': [1273], 'chain': [1274], 'reaction': [1275], 'primer': [1277], 'pairs': [1278], 'listed': [1279], 'Table': [1281], 'I,': [1282], 'pVLB4-mp53.Table': [1286], 'IPrimers': [1287], 'used': [1288, 1922, 3443], 'amplify': [1290], 'subcloning': [1294], 'vectorsConstructs5′': [1298], 'Primer3′': [1299], 'Primerp80.1–1785′-GCGGATCCATGGTGCGGTCGGGGAATAAG-3′5′-GCGAATTCTCATCTGTCCCCACTTCCATC-3′p80.371–7325′-GCGGATCCGAGGCAGCTGCAGTTGCAC-3′5′-GCGAATTCCGACCTATATCATGTCC-3′p80.179–7325′-GCGGATCCGGAGATGGCCCCTTTCGC-3′5′-GCGAATTCCGACCTATATCATGTCC-3′p80.179–6545′-GCGGATCCGGAGATGGCCCCTTTCGC-3′5′-GCGAATTCTCAGCGCTGCTCTTCTGAAAAC-3′p80.179–5105′-GCGGATCCGGAGATGGCCCCTTTCGC-3′5′-GCGAATTCTCACTGCTGAATTGGGGGTAG-3′p80.179–4005′-GCGGATCCGGAGATGGCCCCTTTCGC-3′5′-GCGAATTCTCATCTTTTGTCATAAGC-3′p80.371–6545′-GCGGATCCGAGGCAGCTGCAGTTGCAC-3′5′-GCGAATTCTCAGCGCTGCTCTTCTGAAAAC-3′p80.371–5105′-GCGGATCCGAGGCAGCTGCAGTTGCAC-3′5′-GCGAATTCTCACTGCTGAATTGGGGGTAG-3′p80.400–7325′-GCGGATCCAGAGCTAATCCTCAAGTC-3′5′-GCGAATTCCGACCTATATCATGTCC-3′p80.400–6545′-GCGGATCCAGAGCTAATCCTCAAGTC-3′5′-GCGAATTCTCAGCGCTGCTCTTCTGAAAAC-3′p80.400–5105′-GCGGATCCAGAGCTAATCCTCAAGTC-3′5′-GCGAATTCTCACTGCTGAATTGGGGGTAG-3′p80.510–6545′-GCGGATCCCAGCATATTTGGAATATGC-3′5′-GCGAATTCTCAGCGCTGCTCTTCTGAAAAC-3′p80.654–7325′-GCGGATCCCGCTTTAACAACTTCCTG-3′5′-GCGAATTCCGACCTATATCATGTCC-3′': [1300], 'Open': [1301], 'table': [1302], 'new': [1305], 'tab': [1306], 'infected': [1310, 3373], 'more': [1314], 'Seventy-two': [1345], 'hours': [1346], 'after': [1347, 2041, 2822, 2840, 3647], 'infection,': [1348], 'lysates': [1356], 'SDS-PAGE': [1358, 1690, 1866], 'immunoblotting': [1360, 1692], 'specific': [1366, 1371, 1441], 'antibodies': [1368], '(mAbs).': [1369], 'mAbs': [1370, 1472, 2030, 2975], 'previously': [1380, 3732], 'Their': [1407], 'isotypes': [1408], 'specificities': [1410], 'follows:': [1413], '162,': [1414, 4234], 'IgG2a': [1415, 1438], 'anti-p70/p80': [1416], 'dimer;': [1417], 'S10B1,': [1418], 'IgG1': [1419, 1426], 'anti-': [1420], '179–371);': [1424], '111,': [1425, 1847], 'anti-p80': [1427, 3004], '610–705);': [1430], 'N3H10,': [1431, 1846, 2243, 3441], 'IgG2b': [1432], 'anti-p70': [1433, 2223], '529–541).': [1436], 'An': [1437], 'murine': [1439, 1471], 'mAb': [1440, 1598, 2206, 2224, 2440, 2537, 2570, 2707, 2758, 2809, 2831, 2858, 3005, 3019, 3064, 3719, 3723, 4233], 'tag': [1445], '(HIS-1)': [1446], 'Sigma.': [1449], 'Immunoblot': [1450], 'analysis': [1451, 2856], 'performed': [1469], '(1:1000': [1473], 'dilution)': [1474], 'Radiolabeling': [1501], 'baculovirus-infected': [1503], '[35S]methionine/cysteine': [1507], 'onto': [1510, 1597], 'A-Sepharose': [1512, 1601, 1840], 'beads': [1513, 1546, 1602, 1656, 1676, 1686, 1841, 1900, 2821], 'carried': [1515, 3915], 'out': [1516, 3916], 'washed': [1548, 1700, 1873, 1902], '1.5': [1550, 2460], 'm': [1551, 1557, 1759, 1773, 2461], 'NaCl': [1552, 1876, 2462], 'NET-Nonidet': [1553, 1877, 1905], 'P-40': [1554, 1878], 'buffer': [1555, 1574, 1704, 1733, 1884, 1955], '(1.5': [1556], 'NaCl,': [1558, 1576, 1715, 1971], '50': [1559, 1577, 1886], 'mm': [1560, 1568, 1578, 1662, 1706, 1711, 1714, 1719, 1737, 1763, 1887, 1957, 1962, 1965, 1970], 'Tris,': [1561, 1579, 1958], 'pH': [1562, 1580, 1664, 1708, 1959], '7.5,': [1563, 1581, 1665, 1960], '0.3%': [1564], 'Nonidet': [1565], 'P-40,': [1566], '2': [1567, 1582, 1726, 1972, 2555, 2586], 'EDTA)': [1569], 'once': [1571], 'NET': [1573], '(0.15m': [1575], 'mmEDTA).': [1583], 'Immunoprecipitated': [1584], 'analyzed': [1587, 2015, 2826], 'SDS-PAGE.': [1589], 'affinity-purified': [1596, 1798, 2807], '162-coated': [1599], 'digested': [1604], 'proteases': [1606], 'Protease': [1633], 'V8': [1634], '(Boehringer': [1635], 'Mannheim),': [1636], 'trypsin-treated': [1637], 'tosylphenylalanyl': [1638], 'chloromethyl': [1639], 'ketone': [1640], '(Millipore': [1641], 'Corp.,': [1642, 1649], 'Freehold,': [1643, 1650], 'NJ),': [1644], 'chymotrypsin': [1646, 2841], '(Worthington': [1647], 'Biochemical': [1648], 'NJ)': [1651], 'added': [1653, 1894, 2034], '2–200': [1658], 'μg/ml': [1659], '10': [1661, 1713, 1762], 'Tris-HCl,': [1663], '2.5': [1667], 'mmCaCl2': [1668], '30': [1670, 1985, 2049], 'min': [1671, 1986, 2040, 2050], '22': [1673, 1982, 2052], '°C.': [1674, 1779], 'washed,': [1678], 'fragments': [1681, 2817, 2865, 3139], 'remaining': [1682], 'S10B1.': [1694], 'briefly': [1701], 'hypotonic': [1703], '(10': [1705, 1956], 'HEPES,': [1707], '7.3,': [1709], '25': [1710], 'KCl,': [1712], '1': [1716, 1739, 1896, 1961, 2185, 2249, 2363, 2395, 2638], 'mmMgCl2,': [1717], '0.1': [1718, 1772], 'EDTA),': [1720], 'pellets': [1722], 'resuspended': [1724], '×': [1727], '108': [1728], 'cells/ml': [1729], '0.5': [1736, 1758], 'dithiothreitol,': [1738, 1963], 'mmphenylmethylsulfonyl': [1740], 'fluoride,': [1741], 'aprotinin': [1743], '(0.3': [1744], 'trypsin': [1745], 'inhibitor': [1746], 'units/ml).': [1747], 'Pellets': [1748], 'lysed': [1750], 'three': [1752], 'freeze-thaw': [1753], 'cycles': [1754], 'adjusted': [1756], 'KCl': [1760, 1774], 'MgCl2.': [1764], 'After': [1765], 'centrifuging,': [1766], 'supernatant': [1768, 1920], 'diluted': [1770], 'stored': [1776], '−80': [1778], '564-base': [1781], 'pair': [1782], 'linear': [1783, 3346, 3950, 3958, 4032], 'fragment': [1786, 2839], 'bacteriophage': [1788], 'λ': [1789], 'radiolabeled': [1791, 1931], '[32P]dATP,': [1793], 'measured': [1802], 'assay': [1806, 3627], 'Briefly,': [1833], 'extract': [1835, 3370], 'immunoprecipitated': [1837, 2539, 2573, 2709], '3': [1843], 'μl': [1844, 1952], 'HIS-1': [1849, 2207, 2535, 3724], 'ascitic': [1850], 'fluid.': [1851], 'Equal': [1852], 'amounts': [1853, 3431], 'beads,': [1862], 'determined': [1864, 3435], 'Coomassie': [1868], 'Blue': [1869], 'staining.': [1870], 'Beads': [1871], '1.5m': [1875], 'buffer,': [1879], 'followed': [1880, 2023], 'containing': [1885, 3451], 'NaCl.': [1888], 'Radiolabeled': [1889], '(25': [1891], 'ng)': [1892], 'h,': [1897], 'again': [1903], 'P-40.': [1906], 'Bound': [1907], 'recovered': [1910], 'proteinase': [1912], 'K': [1913], 'digestion,': [1914], 'aliquot': [1917], 'scintillation': [1924], 'counting.': [1925], 'For': [1926, 2026], 'mobility': [1928], 'purified': [1934, 2029], 'Geneclean': [1937], 'III': [1938], 'kit': [1939], '(Bio': [1940], '101,': [1941], 'Vista,': [1942], 'CA)': [1943], 'then': [1945], 'incubated': [1946, 2045], 'extracts': [1949], '20': [1951], '5': [1964, 2039], 'EDTA,': [1966], 'glycerol,': [1968], '150': [1969], 'μg': [1973], 'closed': [1975, 3969], 'circular': [1976, 3970], 'φX174': [1977, 4040], 'Rf': [1978, 3973, 4041], 'I': [1979, 3974, 4042], 'DNA)': [1980, 3979], 'Samples': [2013], '4%': [2020], 'gel,': [2022], 'autoradiography.': [2025], 'supershift': [2027, 3715], 'experiments,': [2028], '(∼1': [2031], 'μg)': [2032], 'mixture': [2038], 'adding': [2042], 'probe': [2043, 3953], 'additional': [2048], 'before': [2054], 'electrophoresis.': [2055], 'p80.': [2063, 2664, 2900, 3025, 3062, 3080, 3221, 3387, 3416], 'Binding': [2064, 2756, 3704, 4034], 'these': [2070, 3158], 'contributes': [2073, 2564], 'Ku.': [2080], 'present': [2083, 4213], 'study,': [2084, 4214], 'we': [2085, 3729], 'investigated': [2086, 2175, 2522, 3148], 'p80-p70': [2090], 'binding.': [2097, 3183, 4241], 'leucine': [2099, 2141, 2270, 2353, 2368, 4376], 'zipper-like': [2100, 2142, 2271, 2354, 2369, 4377], 'near': [2144, 4379], 'N': [2146, 4381], '(18Yaneva': [2150, 4390], 'Wen': [2152, 4392], 'Ayala': [2154, 4394], 'Cook': [2156, 4396], '264:': [2162, 4402], '13407-13411Abstract': [2163, 4403], 'interactions': [2171, 2296, 4425], 'co-expressing': [2177, 2957, 3071], 'panel': [2179, 3277], '(Fig.': [2184, 2208, 2226, 2248, 2362, 2394, 2523, 2554, 2585, 2833, 2976, 2985, 3007, 3095, 3289, 3355, 3628, 3652, 3661, 3808, 3960, 4340], 'A)': [2186], 'verified': [2200, 2533, 2981, 3713], 'polyhistidine-specific': [2205], '1,B': [2209], 'C,': [2211, 2230], 'HIS).': [2212, 2987], 'detect': [2214, 2864], 'formation,': [2216], 'co-immunoprecipitated': [2221, 2241, 2359, 2385, 3002, 3017, 3067, 3076], 'N3H10': [2225, 2361, 2387, 3065, 3075, 3099], '1,': [2227], 'B': [2228], 'N3H10).': [2231], 'Mutant': [2232, 2349, 2382], '179–732,': [2234, 2294, 2547, 3404, 3637], '179–654,': [2235, 3405, 3641], '179–510,': [2236, 2581, 3407, 3642, 4364], '371–654,': [2237], '179–400': [2245, 2309, 2324, 2584], 'B),': [2250, 2556], 'portion': [2261, 2898, 3745], '371–510),': [2266], '146–178)': [2275], 'essential': [2278, 4309], 'Even': [2283], 'though': [2284, 2399, 3760], '179–654': [2285, 2579], 'dimerized': [2288, 3398], 'less': [2291, 2327, 3458], 'efficiently': [2292, 2328], 'than': [2293, 2329, 2867, 3369], 'visualized': [2298], 'readily': [2299], 'co-immunoprecipitation': [2301, 2741, 3438], 'assay.': [2302], 'Since': [2303, 2873], 'interacted': [2305], 'did': [2310, 2590, 3351], 'not,': [2311], '400–510': [2314, 2402], 'crucial': [2317, 2404, 4357], 'However,': [2322, 3378, 3429, 3796], 'expressed': [2326, 2602, 3109], 'other': [2331], 'constructs,': [2332], 'difficult': [2335], 'completely': [2337], 'exclude': [2338], 'possibility': [2340], 'some': [2342], 'might': [2344], 'occur': [2345], 'construct.': [2348], '1–178': [2350, 2553], 'overlaps': [2351, 2498, 2659, 3411], 'sequence,': [2355], 'C),': [2364, 2587], 'indicating': [2365, 2726, 2888, 3118], 'dimerization.': [2381], '400–732': [2383], '400–510,': [2390, 4370], '510–654,': [2391], '654–732': [2393], 'C).': [2396], 'Thus,': [2397, 3237, 3812], 'even': [2398, 3759], 'dimerization,': [2407, 4360], 'itself': [2411, 3343, 3988], 'insufficient.': [2413], 'Additional': [2414], 'either': [2417], '(e.g.': [2419, 2424], '371–510)': [2421], '400–732)': [2426], '"core"': [2429, 4343], '400–510)': [2433], 'necessary': [2435, 3293], '162': [2441, 2490, 2512, 2538, 2571, 2653, 2670, 2708, 2729, 2759, 2810, 2820, 3720], 'recognizes': [2442, 2875, 3855], 'epitope': [2444, 2730], 'created': [2445], 'prevents': [2453], 'dissociation': [2455], 'presence': [2458], 'detergent': [2464], '(19Wang': [2465], 'Pierani': [2469], 'Schmitt': [2471], 'Stunnenberg': [2475], 'H.G.': [2476], 'Roeder': [2477], 'R.G.': [2478], 'Cell': [2482], 'Sci.': [2483], '107:': [2485], '3223-3233PubMed': [2486], '430–542)': [2497, 2675], '430–482).': [2507], 'relationship': [2509], '2,A–C).': [2524], 'Expression': [2525], 'antibody.': [2536], 'when': [2542, 2575, 2601, 2712, 3021, 3104, 3137, 3395], '371–732,': [2550, 3640], '179–371,': [2551], 'half': [2561], 'formation': [2566, 2650, 4307], 'epitope.': [2569], 'immunoprecipitate': [2592, 3102], 'any': [2595], '(20Wang': [2607], 'Kimpel': [2613], 'Arthritis': [2619], 'Rheum.': [2620], '40:': [2622], '1344-1353Crossref': [2623], '(10)': [2626], 'These': [2629, 4296], 'data': [2630, 3159, 3631, 4297], 'confirm': [2631, 2739], 'studies': [2634, 2883], 'illustrated': [2635, 4243], 'Fig.': [2637, 4245, 4388], 'B.': [2639], 'conclude': [2641, 3461], 'contribute': [2648], 'epitope,': [2654, 2671], 'further': [2666, 2955], 'minimal': [2669], 'mutants.': [2706], '(430–542)': [2711, 2734], '(179–654': [2716], '179–510),': [2718], '(179–400)': [2722], '(data': [2723, 2870, 3115, 3153, 3725], 'shown),': [2725, 3117], 'consists': [2731], 'plus': [2735], '(179–510).': [2737], 'data,': [2742, 2887], 'studied': [2749], 'line.': [2755], 'protects': [2760], 'proteolysis': [2766], 'corresponding': [2796], 'protected,': [2802], 'well.': [2804, 3459], 'treated': [2812], 'proteases,': [2814], 'retained': [2818], 'protease': [2823, 2882], 'treatment': [2824], 'Western': [2828, 2854], 'blotting': [2829], 'S10B1': [2832, 2874], '3).': [2834], 'smallest': [2836], 'bead-associated': [2837], 'digestion': [2842], 'weak,': [2845], 'consistently': [2847], 'visualized,': [2848], 'band': [2849, 3094], 'migrating': [2850], '∼22': [2852], 'kDa.': [2853], '111': [2859, 3006, 3020], '(anti-p80,': [2860], '610–705)': [2861], 'failed': [2862, 3620, 3799], 'smaller': [2866, 3138], '60': [2868], 'kDa': [2869], 'shown).': [2872, 3155, 3633, 3727], '179–371': [2878], 'support': [2884], 'carries': [2904], '430–482)': [2912], '371–510).': [2950], 'Heterodimer': [2951], 'assembly': [2952], 'evaluated': [2954], 'separately': [2966, 3041], 'together': [2968, 3023, 3045], 'immunoprecipitating': [2972], 'anti-Ku': [2974, 3718], '4).': [2977], 'Protein': [2978], 'anti-polyhistidine': [2983, 3722], '4,': [2986, 3008, 3096], 'When': [2988], 'individually': [2990], '(1–433)': [2994], '(430–609)': [2999], 'could': [3000], '111).': [3009], 'addition,': [3011], '1–433': [3013, 3077, 3103], '430–609': [3015, 3083, 3114], 'bands': [3027, 3656], 'intensities': [3028], 'similar': [3030, 3996], 'regardless': [3031], 'whether': [3033, 3903], '(1–433,': [3042], '430–609)': [3043, 3993], '(1–433': [3046], '+': [3047], '430–609),': [3048], 'do': [3054, 3176], 'interfere': [3056], "other's": [3059], 'Anti-p70': [3063], '430–609/p80': [3070], 'lysates.': [3072], 'More': [3073], 'importantly,': [3074], 'along': [3078, 4348], 'Some': [3081], 'free': [3082], 'immunoprecipitated,': [3086], 'accounting': [3087], 'greater': [3090], 'intensity': [3091], 'right': [3097], 'panel).': [3098], 'independently': [3127, 3767, 4092], 'molecule.': [3132], 'Similar': [3133], 'results': [3134], 'carrying': [3144], 'manner': [3152], 'Taken': [3156], 'together,': [3157], 'indicate': [3160], 'compete': [3178], 'another': [3181], 'sites.': [3199], 'itself,': [3212, 3880], 'requires': [3218, 3305, 3482], 'Partial': [3222, 3388], 'exhibited': [3225, 3844], '1–115,': [3229, 3252], 'complete': [3231], '1–542.': [3236], 'lacking': [3241], 'independent': [3244], 'domain,': [3246, 3528, 4415], 'such': [3247], '1–600,': [3249], '1–542,': [3250], 'determine': [3260], 'how': [3261], 'assembled,': [3266], '(1–600)': [3273, 3397], 'tested': [3288], '5).': [3290], 'It': [3291], 'use': [3295], 'assays': [3298, 3304, 3481, 3538, 3716], 'Consistent': [3336, 3601, 3938], 'previous': [3338, 3603, 3940, 4418], 'findings,': [3339, 3604, 3941], 'p70/p80': [3353, 3946], '5,': [3356], 'left).': [3357], '1–600': [3362], 'poorly,': [3365], 'clearly': [3367], 'better': [3368], '(WT)': [3376], 'baculovirus.': [3377], 'enhanced': [3382], 'considerably': [3383], 'conferred': [3394], 'Decreased': [3417], 'relate': [3423], 'differences': [3425], 'efficiency.': [3428], 'comparable': [3430], 'dimers,': [3434], 'preliminary': [3437], 'experiments': [3439, 3913], 'lane,': [3446, 3664], 'arguing': [3447], 'dimers': [3450], 'truncated': [3452], 'constructs': [3454, 4026], '(179–510)': [3464], 'mediates': [3465], 'End': [3473], 'N-': [3485], 'Because': [3519], 'needed': [3522], 'establish': [3575], 'conferring': [3580], 'tested.': [3600], 'efficiently,': [3610], 'themselves': [3619], '6': [3629], '179–400,': [3644], 'dimerizing': [3648], '6).': [3653], 'multiple': [3655], 'visible': [3657], '6,': [3662, 3809], '179–732/p70': [3663, 3709], 'B1,': [3665], 'B2,': [3666], 'B3)': [3667], 'suggest': [3668], 'restores': [3672], 'internal': [3674], 'translocation': [3675], 'property': [3676], '(21de': [3679], 'Vries': [3680], 'van': [3682, 3689], 'Driel': [3683], 'Bergsma': [3685], 'W.G.': [3686], 'Arnberg': [3687], 'A.C.': [3688], 'der': [3690], 'Vliet': [3691], 'P.C.': [3692], '208:': [3697], '65-78Crossref': [3698], '(216)': [3701], 'Paradoxically,': [3728], 'compensates': [3738], '601–609)': [3748], '(p70': [3756], '(1–600),': [3757], 'p70Δ),': [3758], '(179–732)': [3798, 3814], 'restore': [3801, 3834], 'p70Δ': [3807], '179–732/p70Δ': [3810], 'lane).': [3811], 'assay,': [3827], 'insufficient': [3832], 'p70Δ.': [3840], 'Only': [3841], 'effect.': [3847], 'termini': [3857], '(17Wang': [3859, 4095], 'could,': [3878], 'antigen.': [3888], 'defined.': [3900], 'exhibits': [3907], 'preferential': [3908], 'activity,': [3911], 'competition': [3912], 'detailed': [3918], 'Ref.17Wang': [3920], 'Scholar.': [3937], 'inhibited': [3956, 4037], '7).': [3961], 'There': [3962], 'little': [3964], 'inhibition': [3965, 3997], '(φX174': [3972], 'pBKS': [3977, 4044], 'plasmid': [3978, 4045], 'tRNA.': [3982, 4048], 'displayed': [3994], 'pattern,': [3998], 'termini.': [4007], 'Dimerization': [4008], '(p70.430–609': [4017], 'p70.1–542,': [4019], 'respectively)': [4020], 'resulted': [4024], 'dsDNA.': [4033], 'significantly': [4038], 'Deficiency': [4049], 'autoantigen': [4052], 'leads': [4053], 'defective': [4055], 'resulting': [4060], 'sensitivity': [4063], 'severe': [4065], 'combined': [4066], 'immunodeficiency': [4067], '(22Weaver': [4068], 'Adv.': [4070], 'Immunol.': [4071], '1995;': [4072], '58:': [4073], '29-85Crossref': [4074], '(59)': [4077], 'Despite': [4080], 'fact': [4082], 'absent': [4115], 'mutations': [4120], 'due': [4174], 'existence': [4177], 'second,': [4180], 'dimerization-dependent,': [4181], 'recognition': [4228], 'dimer-specific': [4232], 'addition': [4236], 'participating': [4238], 'As': [4242], '8,': [4246], 'locations': [4248], 'consistent': [4259, 4300, 4416], 'DSBR-deficient': [4262], 'phenotypes': [4263], 'XR-V9B': [4266], 'XR-V15B': [4268], 'lines': [4270], 'recent': [4303], 'finding': [4304], 'vivo': [4313], '(15Jin': [4314], 'Amino': [4328], '1).': [4341], '400–510),': [4347], 'sequences': [4350], 'flanking': [4351], 'region,': [4353], 'play': [4355], '371–510,': [4365], '400–732,': [4367], 'motif': [4378], '146–178;': [4387], '8)': [4389], 'outside': [4411], 'observations': [4419], 'dispensable': [4423], 'yeast': [4430], 'two-hybrid': [4431], 'system': [4432], '(12Wu': [4433], '23Cary': [4448], 'R.B.': [4449], 'Chen': [4450, 4454], 'F.': [4451], 'Shen': [4452], 'Z.': [4453], 'Nucleic': [4456], 'Acids': [4457], 'Re': [4458]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2074493289', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-15T07:11:19.277813', 'created_date': '2016-06-24'}
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