Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2074220343', 'doi': 'https://doi.org/10.1002/(sici)1521-4141(199908)29:08<2367::aid-immu2367>3.0.co;2-3', 'title': 'Blocking CD40 – CD154 and CD80/CD86 – CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production', 'display_name': 'Blocking CD40 – CD154 and CD80/CD86 – CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production', 'publication_year': 1999, 'publication_date': '1999-08-01', 'ids': {'openalex': 'https://openalex.org/W2074220343', 'doi': 'https://doi.org/10.1002/(sici)1521-4141(199908)29:08<2367::aid-immu2367>3.0.co;2-3', 'mag': '2074220343', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10458748'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/(sici)1521-4141(199908)29:08<2367::aid-immu2367>3.0.co;2-3', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-4141%28199908%2929%3A08%3C2367%3A%3AAID-IMMU2367%3E3.0.CO%3B2-3', 'source': {'id': 'https://openalex.org/S126191069', 'display_name': 'European Journal of Immunology', 'issn_l': '0014-2980', 'issn': ['0014-2980', '1521-4141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-4141%28199908%2929%3A08%3C2367%3A%3AAID-IMMU2367%3E3.0.CO%3B2-3', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5039085121', 'display_name': 'Stefaan Van Gool', 'orcid': 'https://orcid.org/0000-0002-8102-5968'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'S W Van Gool', 'raw_affiliation_strings': ['Laboratory of Experimental Immunology, Catholic University of Leuven, Leuven, Belgium. [email protected]'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Experimental Immunology, Catholic University of Leuven, Leuven, Belgium. [email protected]', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051290752', 'display_name': 'Jan Vermeiren', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J Vermeiren', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082964755', 'display_name': 'Khadija Rafiq', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'K Rafiq', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5097616347', 'display_name': 'Katrien Lorr', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'K Lorr', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053330965', 'display_name': 'M de Boer', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M de Boer', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016803288', 'display_name': 'Jan Ceuppens', 'orcid': 'https://orcid.org/0000-0003-4502-2679'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J L Ceuppens', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4120, 'currency': 'USD', 'value_usd': 4120, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.013, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 67, 'citation_normalized_percentile': {'value': 0.846642, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '29', 'issue': '8', 'first_page': '2367', 'last_page': '2375'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11020', 'display_name': 'Natural Killer Cells in Immunity', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11020', 'display_name': 'Natural Killer Cells in Immunity', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'Regulatory T Cell Development and Function', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunobiology of Dendritic Cells', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cd80', 'display_name': 'CD80', 'score': 0.8680236}, {'id': 'https://openalex.org/keywords/cd86', 'display_name': 'CD86', 'score': 0.81392413}, {'id': 'https://openalex.org/keywords/cd154', 'display_name': 'CD154', 'score': 0.78922606}, {'id': 'https://openalex.org/keywords/priming', 'display_name': 'Priming (agriculture)', 'score': 0.49772456}, {'id': 'https://openalex.org/keywords/antigen-presentation', 'display_name': 'Antigen Presentation', 'score': 0.460317}], 'concepts': [{'id': 'https://openalex.org/C2778297628', 'wikidata': 'https://www.wikidata.org/wiki/Q5009843', 'display_name': 'CD80', 'level': 5, 'score': 0.8680236}, {'id': 'https://openalex.org/C2781101188', 'wikidata': 'https://www.wikidata.org/wiki/Q5009846', 'display_name': 'CD86', 'level': 4, 'score': 0.81392413}, {'id': 'https://openalex.org/C148125776', 'wikidata': 'https://www.wikidata.org/wiki/Q1622348', 'display_name': 'CD28', 'level': 4, 'score': 0.7970865}, {'id': 'https://openalex.org/C2779234475', 'wikidata': 'https://www.wikidata.org/wiki/Q14897851', 'display_name': 'CD154', 'level': 5, 'score': 0.78922606}, {'id': 'https://openalex.org/C39347974', 'wikidata': 'https://www.wikidata.org/wiki/Q21135811', 'display_name': 'CD40', 'level': 4, 'score': 0.6900151}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.61058795}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.59428734}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.55972487}, {'id': 'https://openalex.org/C81444415', 'wikidata': 'https://www.wikidata.org/wiki/Q7243535', 'display_name': 'Priming (agriculture)', 'level': 3, 'score': 0.49772456}, {'id': 'https://openalex.org/C129374314', 'wikidata': 'https://www.wikidata.org/wiki/Q909381', 'display_name': 'Interleukin 21', 'level': 4, 'score': 0.46762758}, {'id': 'https://openalex.org/C67662055', 'wikidata': 'https://www.wikidata.org/wiki/Q1047791', 'display_name': 'Antigen-presenting cell', 'level': 4, 'score': 0.41946378}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.4000609}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.38879773}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.38303083}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.20602235}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.18887153}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.063601315}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C100701293', 'wikidata': 'https://www.wikidata.org/wiki/Q193838', 'display_name': 'Germination', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015703', 'descriptor_name': 'Antigens, CD', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017635', 'descriptor_name': 'Clonal Anergy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018796', 'descriptor_name': 'Immunoconjugates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000069594', 'descriptor_name': 'Abatacept', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019138', 'descriptor_name': 'Antibodies, Blocking', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019138', 'descriptor_name': 'Antibodies, Blocking', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015703', 'descriptor_name': 'Antigens, CD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000943', 'descriptor_name': 'Antigens, Differentiation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000943', 'descriptor_name': 'Antigens, Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018122', 'descriptor_name': 'B7-1 Antigen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018122', 'descriptor_name': 'B7-1 Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051940', 'descriptor_name': 'B7-2 Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019013', 'descriptor_name': 'CD40 Antigens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019013', 'descriptor_name': 'CD40 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023201', 'descriptor_name': 'CD40 Ligand', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060908', 'descriptor_name': 'CTLA-4 Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003602', 'descriptor_name': 'Cytotoxicity, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007378', 'descriptor_name': 'Interleukins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007378', 'descriptor_name': 'Interleukins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D007519', 'descriptor_name': 'Isoantigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008213', 'descriptor_name': 'Lymphocyte Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007959', 'descriptor_name': 'Lymphocyte Culture Test, Mixed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/(sici)1521-4141(199908)29:08<2367::aid-immu2367>3.0.co;2-3', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-4141%28199908%2929%3A08%3C2367%3A%3AAID-IMMU2367%3E3.0.CO%3B2-3', 'source': {'id': 'https://openalex.org/S126191069', 'display_name': 'European Journal of Immunology', 'issn_l': '0014-2980', 'issn': ['0014-2980', '1521-4141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10458748', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/(sici)1521-4141(199908)29:08<2367::aid-immu2367>3.0.co;2-3', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-4141%28199908%2929%3A08%3C2367%3A%3AAID-IMMU2367%3E3.0.CO%3B2-3', 'source': {'id': 'https://openalex.org/S126191069', 'display_name': 'European Journal of Immunology', 'issn_l': '0014-2980', 'issn': ['0014-2980', '1521-4141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1507996597', 'https://openalex.org/W1524274652', 'https://openalex.org/W1525020553', 'https://openalex.org/W1525199620', 'https://openalex.org/W1589504620', 'https://openalex.org/W1597390649', 'https://openalex.org/W1626920792', 'https://openalex.org/W1635113215', 'https://openalex.org/W1651822094', 'https://openalex.org/W1660250134', 'https://openalex.org/W1806817428', 'https://openalex.org/W1960538598', 'https://openalex.org/W1970483076', 'https://openalex.org/W1990098795', 'https://openalex.org/W1990334085', 'https://openalex.org/W1995980770', 'https://openalex.org/W1999481925', 'https://openalex.org/W1999711156', 'https://openalex.org/W2002789309', 'https://openalex.org/W2004777690', 'https://openalex.org/W2008304542', 'https://openalex.org/W2009417025', 'https://openalex.org/W2012120883', 'https://openalex.org/W2023006000', 'https://openalex.org/W2025332550', 'https://openalex.org/W2028446411', 'https://openalex.org/W2040250565', 'https://openalex.org/W2054083392', 'https://openalex.org/W2062994475', 'https://openalex.org/W2063480372', 'https://openalex.org/W2068872972', 'https://openalex.org/W2076707911', 'https://openalex.org/W2077389439', 'https://openalex.org/W2084072841', 'https://openalex.org/W2086219463', 'https://openalex.org/W2087039285', 'https://openalex.org/W2088593885', 'https://openalex.org/W2089262366', 'https://openalex.org/W2099748840', 'https://openalex.org/W2106531897', 'https://openalex.org/W2118061894', 'https://openalex.org/W2121497416', 'https://openalex.org/W2125341443', 'https://openalex.org/W2125547273', 'https://openalex.org/W2126845096', 'https://openalex.org/W2128409610', 'https://openalex.org/W2136421587', 'https://openalex.org/W2140944306', 'https://openalex.org/W2145473252', 'https://openalex.org/W2150278877', 'https://openalex.org/W2155229523', 'https://openalex.org/W2164224564', 'https://openalex.org/W2168931543', 'https://openalex.org/W2412227245', 'https://openalex.org/W2470947009', 'https://openalex.org/W4210657423', 'https://openalex.org/W4248034314', 'https://openalex.org/W4285719527', 'https://openalex.org/W4313342469'], 'related_works': ['https://openalex.org/W2347860539', 'https://openalex.org/W2086708956', 'https://openalex.org/W2068757729', 'https://openalex.org/W2049298095', 'https://openalex.org/W2034945808', 'https://openalex.org/W2026268116', 'https://openalex.org/W1986344484', 'https://openalex.org/W1985394960', 'https://openalex.org/W1979857953', 'https://openalex.org/W1565185006'], 'abstract_inverted_index': {'Although': [0], 'CD28': [1, 15, 159], 'triggering': [2], 'provides': [3], 'an': [4], 'important': [5], 'co-stimulatory': [6], 'signal': [7], 'to': [8, 33, 187, 194], 'T': [9, 82, 163, 167, 200], 'cells,': [10], 'blocking': [11, 60, 66, 150], 'the': [12, 39, 46, 56, 88, 125, 129, 140, 148, 152, 183], 'CD80/CD86': [13, 157], '–': [14, 41, 154, 158], 'interaction': [16, 43, 160], 'with': [17, 79], 'CTLA-4lg': [18, 49], 'fusion': [19], 'protein': [20], 'is': [21], 'not': [22], 'sufficient': [23], 'for': [24], 'tolerance': [25], 'induction': [26], 'in': [27, 30, 69, 87, 124], 'vivo': [28], 'or': [29], 'vitro.': [31], 'According': [32], 'more': [34], 'recent': [35], 'data,': [36], 'interruption': [37], 'of': [38, 48, 58, 71, 90, 98, 107, 131, 136, 151, 181, 189, 197], 'CD40': [40, 153], 'CD154': [42, 155], 'might': [44], 'complement': [45], 'effect': [47], 'and': [50, 93, 111, 114, 156, 193], 'induce': [51], 'graft': [52], 'acceptance.': [53], 'We': [54, 145], 'studied': [55], 'effects': [57], 'a': [59, 96], 'anti-CD40': [61, 94], 'monoclonal': [62], 'antibody': [63], '(mAb)': [64], 'and/or': [65], 'anti-CD80/anti-CD86': [67], 'mAb': [68], 'cultures': [70], 'human': [72], 'peripheral': [73], 'blood': [74], 'mononuclear': [75], 'cells': [76, 83, 172], '(PBMC)': [77], 'stimulated': [78], 'allogeneic': [80, 162], 'PBMC.': [81], 'activated': [84], 'by': [85, 105, 174], 'alloantigens': [86], 'presence': [89], 'anti-CD80,': [91], 'anti-CD86': [92], 'entered': [95], 'state': [97], 'alloantigen-specific': [99, 143], 'non-responsiveness': [100], 'as': [101], 'evidenced': [102], 'upon': [103], 'restimulation': [104, 120, 141], 'lack': [106], 'proliferation,': [108], 'cytotoxic': [109], 'activity,': [110], 'IL-2,': [112], 'IL-5': [113], 'IL-13': [115], 'production.': [116], 'IFN-γ': [117], 'production': [118, 130], 'during': [119, 139, 161], 'was': [121, 133], 'less': [122], 'than': [123], 'control': [126], 'cultures,': [127], 'while': [128], 'IL-10': [132], 'enhanced.': [134], 'Addition': [135], 'recombinant': [137], 'IL-2': [138], 'rescued': [142], 'activity.': [144], 'conclude': [146], 'that': [147], 'simultaneous': [149], 'cell': [164, 168, 191], 'activation': [165], 'induces': [166], 'anergy.': [169], 'Since': [170], 'anergic': [171], 'induced': [173], 'this': [175], 'treatment': [176], 'still': [177], 'produce': [178], 'high': [179], 'levels': [180], 'IL-10,': [182], 'latter': [184], 'could': [185], 'contribute': [186], 'modulation': [188], 'antigen-presenting': [190], 'activity': [192], 'bystander': [195], 'suppression': [196], 'residual': [198], 'reactive': [199], 'cells.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2074220343', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-01T03:31:24.990269', 'created_date': '2016-06-24'}