Publication Information

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864, 1681, 1750, 2082, 2156, 2354, 2712, 2888, 3410, 4085], 'review': [110], 'diversity': [112], 'lipoxygenase': [114, 124, 333, 355, 363, 398, 417, 453, 692, 929, 1030, 1815, 2159, 2370, 3000, 3300, 3564, 4025, 4097, 4122, 4170, 4215], 'expression': [115, 594, 607, 635], 'will': [116, 2857, 3213, 3243, 3412, 4112], 'highlighted': [118], 'several': [121, 681, 2009], 'facets': [122], 'function': [125, 2345, 3982], 'considered,': [126], 'concluding': [127], 'discussion': [130], 'issues': [132, 4052, 4154], 'related': [133, 700, 962, 4053, 4094, 4106], 'acquisition': [136, 3445, 3517, 3620], 'substrate': [138, 828, 1022, 1757, 2120, 2639, 2651, 2680, 3444, 3504, 3519, 3576, 3590, 3622, 3696, 3984], 'cellular': [141, 3836], 'environment.': [142, 3509], 'Lipoxygenases': [143, 527], 'found': [145, 3049, 3318, 3993], 'widely': [146], 'plants,': [148], 'fungi,': [149], 'animals': [151, 810, 1073, 2416], '(1Grechkin': [152, 1053], 'A.': [153, 377, 469, 499, 1054, 1234, 1393, 1508, 1737, 2584, 2686, 3105, 3475, 3534, 3754, 3963, 4129, 4220, 4250], 'Prog.': [154, 219, 894, 996, 1055], 'Lipid': [155, 220, 895, 997, 1056], 'Res.': [156, 221, 896, 998, 1057], '1998;': [157, 479, 500, 519, 624, 1058, 1276, 1577, 1710, 1741, 2022, 3106, 3403, 3882, 3917, 4066, 4136, 4230, 4251, 4280], '37:': [158, 1059], '317-352Crossref': [159, 1060], 'PubMed': [160, 173, 195, 208, 225, 308, 409, 482, 503, 522, 588, 627, 665, 900, 1002, 1061, 1083, 1093, 1144, 1249, 1284, 1319, 1355, 1397, 1420, 1491, 1512, 1564, 1580, 1622, 1663, 1718, 1744, 1859, 1887, 1924, 1998, 2053, 2188, 2235, 2263, 2280, 2314, 2398, 2553, 2576, 2597, 2628, 2699, 2824, 2969, 3070, 3084, 3109, 3150, 3206, 3365, 3406, 3432, 3488, 3547, 3653, 3728, 3758, 3787, 3885, 3925, 3967, 4074, 4139, 4185, 4233, 4254, 4288], 'Scopus': [161, 174, 196, 209, 226, 309, 391, 410, 483, 504, 523, 589, 628, 666, 901, 1003, 1062, 1084, 1094, 1145, 1250, 1285, 1320, 1356, 1398, 1421, 1492, 1513, 1565, 1581, 1623, 1719, 1745, 1860, 1888, 1925, 1999, 2025, 2054, 2189, 2236, 2281, 2315, 2554, 2577, 2598, 2629, 2700, 2825, 2970, 3071, 3085, 3110, 3151, 3207, 3366, 3433, 3489, 3548, 3654, 3729, 3759, 3788, 3886, 3926, 3968, 4075, 4140, 4186, 4234, 4255, 4289], '(269)': [162, 1063], 'Google': [163, 176, 198, 211, 228, 311, 393, 412, 485, 506, 525, 591, 630, 668, 903, 1005, 1064, 1086, 1096, 1147, 1252, 1287, 1322, 1358, 1400, 1423, 1494, 1515, 1567, 1583, 1625, 1664, 1721, 1747, 1862, 1890, 1927, 2001, 2027, 2056, 2191, 2238, 2264, 2283, 2317, 2399, 2556, 2579, 2600, 2631, 2702, 2827, 2972, 3073, 3087, 3112, 3153, 3209, 3368, 3407, 3435, 3491, 3550, 3656, 3731, 3761, 3790, 3888, 3928, 3970, 4077, 4142, 4188, 4236, 4257, 4291], 'Scholar,': [164, 177, 199, 212, 289, 486, 507, 1495, 1568, 2239, 2265, 2557, 2580, 4237, 4258], '2Gerwick': [165], 'W.H.': [166, 267, 3077], 'Biochim.': [167, 202, 476, 1853, 1992, 2047, 2182, 2274, 2963, 3078, 3359, 3426, 4227], 'Biophys.': [168, 203, 477, 1854, 1993, 2048, 2183, 2275, 2964, 3079, 3360, 3427, 3881, 4228], 'Acta.': [169, 204, 478, 1855, 1994, 2049, 2184, 2276, 2965, 3080, 3361, 3428, 4229], '1994;': [170, 189, 1316, 1352, 3064, 3081, 3362, 3755], '1211:': [171, 3082], '243-255Crossref': [172, 3083], '(93)': [175, 3086], '3De': [178], 'Petrocellis': [179, 3054], 'L.': [180, 1700, 3055], 'Di': [181, 3056], 'Marzo': [182, 3057], 'V.': [183, 3058], 'Prostaglandins': [184, 3059], 'Leukotrienes': [185, 3060], 'Essent.': [186, 3061], 'Fatty': [187, 3062], 'Acids.': [188, 3063], '51:': [190, 3065], '215-229Abstract': [191, 3066], 'Full': [192, 660, 662, 1279, 1281, 1486, 1488, 1559, 1561, 1617, 1619, 1660, 1713, 1715, 1884, 2260, 2395, 3067, 3145, 3147, 3782, 3784, 3920, 3922, 4069, 4071, 4283, 4285], 'Text': [193, 661, 663, 1280, 1282, 1487, 1489, 1560, 1562, 1618, 1620, 1661, 1714, 1716, 1885, 2261, 2396, 3068, 3146, 3148, 3783, 3785, 3921, 3923, 4070, 4072, 4284, 4286], 'PDF': [194, 664, 1283, 1490, 1563, 1621, 1662, 1717, 1886, 2262, 2397, 3069, 3149, 3786, 3924, 4073, 4287], '(49)': [197, 1321, 3072], '4Funk': [200], 'C.D.': [201, 515, 1991, 2046, 3913, 4276], '1996;': [205, 1509, 1995, 2050, 2573, 3142, 3203], '1304:': [206, 1996, 2051], '65-84Crossref': [207, 1997, 2052], '(238)': [210, 2000, 2055], '5Yamamoto': [213], 'S.': [214, 498, 889, 991, 1382, 1392, 1507, 2181, 2273, 3104, 3714, 3753, 3962, 4249], 'Suzuki': [215, 890, 992], 'H.': [216, 303, 383, 891, 993, 1643, 1706, 1877, 2243, 2306, 2958, 3401, 3716, 4268], 'Ueda': [217, 892, 994, 2176, 2268], 'N.': [218, 893, 995, 1137, 1236, 1312, 2177, 2269, 4178], '1997;': [222, 305, 657, 897, 999, 1080, 1090, 1921, 1958, 2311, 2594, 2625, 2696, 2821, 3485, 3544, 3779, 4182], '36:': [223, 898, 1000], '23-41Crossref': [224, 899, 1001], '(101)': [227, 902, 1004, 1399], 'Scholar).': [229, 394, 526, 592, 669, 1006, 1097, 1148, 1253, 1359, 1401, 1516, 1584, 1665, 1748, 1863, 1891, 1928, 1961, 2002, 2028, 2057, 2192, 2284, 2318, 2400, 2632, 2703, 2828, 2973, 3113, 3154, 3369, 3436, 3492, 3551, 3657, 3732, 3889, 3929, 3971, 4078, 4143, 4189, 4292], 'The': [230, 670, 687, 795, 959, 1254, 1517, 1811, 2029, 2107, 2422, 2455, 2492, 2653, 2704, 2746, 2865, 2919, 2974, 3020, 3257, 3510, 3797, 3828, 4020, 4144], 'suitable': [231], 'substrates': [232, 253, 803, 3294, 3331, 3383, 3416], 'polyunsaturated': [234], 'acids': [236, 249, 2290, 2328, 3188, 3235, 3315, 4127], 'containing': [237, 2446], 'series': [239, 1825], 'cis': [241, 4040], 'double': [242, 2941, 4041], 'bonds.': [243], 'These': [244, 252, 905, 3293], 'essential': [247, 3678], 'humans.': [251], 'present': [256], 'most': [258, 801, 960, 1159, 3494], 'bacteria': [259], '(cyanobacteria': [260], 'some': [262, 531, 985, 1529], 'marine': [263], 'species': [264], 'excepted': [265], '(6Gerwick': [266], 'Bernart': [268], 'M.W.': [269], 'Attaway': [270], 'D.H.': [271, 1415, 2230], 'Zaborsky': [272], 'O.R.': [273], 'Marine': [274], 'Bio/Technology,': [275], 'Volume': [276], 'I:': [277], 'Pharmaceutical': [278], 'Bioactive': [280], 'Natural': [281], 'Products.': [282], 'Plenum': [283], 'Publishing': [284], 'Corp.,': [285], 'New': [286], 'York1993:': [287], '101-152Google': [288], '7Watanabe': [290], 'K.': [291, 301, 1465, 1538, 1596, 3393], 'Ishikawa': [292], 'C.': [293, 381, 579, 2308, 4060, 4133], 'Ohtsuka': [294], 'I.': [295, 1384, 2304], 'Kamata': [296], 'M.': [297, 299, 385, 471, 577, 645, 1477, 1550, 1608, 1649, 2249, 3351, 3646, 3708, 4222, 4262], 'Tomita': [298], 'Yazawa': [300], 'Muramatsu': [302], 'Lipids.': [304, 405, 1416, 1740, 2231], '32:': [306], '975-978Crossref': [307], '(22)': [310], 'Scholar)),': [312], 'yeast': [314, 336, 3948], 'also': [315, 343, 596, 987, 2153, 2377, 3046, 3413], 'lack': [316], 'necessary': [318, 3901], 'desaturases': [319], 'for': [320, 848, 1122, 1412, 1519, 1522, 1941, 2161, 2224, 2331, 2339, 2366, 2380, 2511, 2708, 3164, 3299, 3420, 3570, 3679, 3905, 3989, 3994, 4309, 4314], 'their': [321, 877, 2034, 4207], 'synthesis.': [322], 'accord': [324], 'absence': [327], 'substrate,': [329, 760], 'there': [330, 447, 851, 3554, 3606, 4011], 'no': [332, 350, 1982, 2635, 3157, 3556, 3793], 'genome': [337], '(Saccharomyces': [338], 'cerevisiae),': [339], 'absent': [344], 'from': [345, 424, 830, 1018, 2882, 3447, 3578, 3807], 'typical': [346, 360, 3224, 4121], 'prokaryotes.': [347], 'definitive': [351, 2648], 'account': [352, 3163], 'insects,': [357], 'although': [358, 762, 1676, 3902], 'arachidonic': [361, 777, 2709, 2883, 3689, 3812], 'acid-derived': [362], '(hydroxyeicosatetraenoic': [365], '(HETE)1)': [367], 'identified': [369, 439, 3944], 'primitive': [372], 'insect': [373], 'Thermobia': [374], 'domestica': [375], '(8Ragab': [376], 'Durand': [378], 'J.': [379, 583, 654, 1139, 1273, 1348, 1378, 1480, 1553, 1611, 1654, 2254, 2389, 2561, 2960, 3139, 3647, 3776, 3914, 4063, 4277], 'Bitsch': [380], 'Chap': [382], 'Rigaud': [384], 'Insect': [386], 'Biochem.': [387, 584, 1879, 1919, 3880], '1991;': [388, 1657, 1881, 2185, 2257, 2277], '21:': [389], '321-326Crossref': [390], '(13)': [392], 'unicellular': [401], 'Chlorella': [402], '(9Zimmerman': [403], 'D.C.': [404], '1973;': [406], '8:': [407], '264-266Crossref': [408], '(56)': [411], 'Scholar)': [413, 631, 1065, 3210, 3762, 3791], 'partial': [416], 'cDNA': [418], 'sequence': [419, 743, 3123, 3874, 3896, 4108], 'data': [422, 1531], 'bases': [423], 'slime': [426], 'mold': [427], 'Dictyostelium': [428], 'discoideum.': [429], 'Higher': [430], 'plants': [431, 805, 2005, 2302, 3075], 'contain': [432, 3115], 'multiple': [433], 'at': [436, 779, 841, 988, 1204, 2471, 2874, 2926, 3222, 3464, 3853], 'least': [437, 3854], 'eight': [438], 'soybean,': [441], 'Glycine': [442], 'max.': [443], 'mouse': [446, 1638, 2211], 'seven': [449], 'genes': [450], 'express': [452], 'proteins,': [454], 'five': [456], 'homologues': [457, 735], '(and': [458], 'expressed': [460, 529], 'pseudogene)': [461], 'characterized': [463, 1010], 'humans': [465, 945, 3092], '(10Krieg': [466, 4217], 'P.': [467, 575, 1702, 3720, 3952, 4218], 'Kinzig': [468, 4219], 'Heidt': [470, 4221], 'Marks': [472, 1652, 2252, 4223], 'F.': [473, 1244, 1653, 2253, 4224], 'Fürstenberger': [474, 4225], 'G.': [475, 1475, 1548, 1606, 1641, 1733, 2241, 3399, 4226], '1391:': [480, 4231], '7-12Crossref': [481, 4232], '(51)': [484, 4235], '11Boeglin': [487, 4238], 'W.E.': [488, 619, 651, 3094, 3134, 4239], 'Kim': [489, 646, 3095, 4240], 'R.B.': [490, 647, 3096, 4241], 'Brash': [491, 652, 2387, 3097, 4179, 4242], 'A.R.': [492, 653, 2388, 3098, 3132, 4180, 4243], 'Proc.': [493, 1387, 1502, 3099, 3748, 3957, 4244], 'Natl.': [494, 1349, 1388, 1503, 3100, 3749, 3958, 4245], 'Acad.': [495, 1314, 1389, 1504, 1956, 3101, 3750, 3959, 4246], 'Sci.': [496, 1315, 1390, 1505, 1880, 2021, 3102, 3751, 3960, 4247], 'U.': [497, 1391, 1506, 3103, 3752, 3961, 4248], '95:': [501, 3107, 3651, 4252], '6744-6749Crossref': [502, 3108, 4253], '(148)': [505, 3111, 4256], '12Sun': [508], 'D.': [509, 581, 1232, 3395, 3773, 4260], 'Elsea': [510, 4271], 'S.H.': [511, 4272], 'Patel': [512, 4273], 'P.I.': [513, 4274], 'Funk': [514, 2619, 2815, 3912, 4275], 'Cytogenet.': [516], 'Cell': [517, 3658], 'Genet.': [518, 2624, 2820], '81:': [520], '79-82Crossref': [521], '(21)': [524], 'plant': [532, 675, 816, 1051, 1936, 1944, 3023, 3127, 4104], 'animal': [534, 677, 2072, 2351, 2374, 3025, 3129], 'tissues': [535, 875], 'high': [537, 1724, 2369], 'levels;': [538], 'they': [539], 'constitute': [540], 'few': [542], 'percent': [543], 'soybeans,': [548], '15-lipoxygenase': [551], '(15-LOX)': [552], 'represents': [553, 1154, 4086], 'one': [554, 855, 2007, 2099, 3009, 3600], 'main': [557], 'proteins': [558, 2402, 2423, 3933], 'besides': [559], 'hemoglobin': [560], 'rabbit': [562, 2540], 'reticulocytes': [563], 'during': [564, 2121, 2849], 'anemia': [565], '(13Rapoport': [566], 'S.M.': [567, 1850, 3423], 'Schewe': [568, 1851, 3424], 'T.': [569, 1645, 1852, 1875, 2175, 2245, 2267, 3397, 3425], 'Wiesner': [570], 'R.': [571, 2569, 2586, 2688, 3391, 3477, 3536, 4172], 'Halangk': [572], 'W.': [573, 1467, 1540, 1598, 1731, 1735, 2559], 'Ludwig': [574], 'Janicke-Hohne': [576], 'Tannert': [578], 'Klatt': [580], 'Eur.': [582], '1979;': [585], '96:': [586, 3965], '545-561Crossref': [587], '(230)': [590], 'more': [598, 853, 2228, 2780, 3275, 4201], 'subtle': [599, 2012, 3171], 'low': [601, 1691, 1904, 2875], 'level,': [602], 'cell-specific': [606], 'specific': [609, 1016, 2912, 2940], 'isozymes': [610, 2897, 3325], 'soybean': [612, 705, 2537, 2605, 2741, 2747, 2866, 2896, 3321], 'leaves': [613], '(14Stephenson': [614], 'L.C.': [615], 'Bunker': [616], 'T.W.': [617], 'Dubbs': [618], 'Grimes': [620], 'H.D.': [621], 'Plant': [622, 4134], 'Physiol.': [623], '116:': [625], '923-933Crossref': [626], '(38)': [629], 'discrete': [634, 1196], 'distinct': [637, 739, 907], 'mammalian': [640, 716, 821, 868, 925, 1838, 2900, 3378, 3470, 3601, 4002, 4110, 4197], 'skin': [641, 1639], '(e.g.': [642, 1948, 2204, 2383], 'Ref.': [643, 1949, 2384], '15Jisaka': [644], 'Nanney': [648], 'L.B.': [649], 'Boeglin': [650, 3133], 'Biol.': [655, 1079, 1274, 1481, 1554, 1612, 1655, 2255, 2390, 2593, 2695, 3140, 3484, 3543, 3777, 3915, 4064, 4278], 'Chem.': [656, 1275, 1482, 1555, 1613, 1656, 1738, 2256, 2391, 3141, 3778, 3916, 4065, 4279], '272:': [658, 3780], '24410-24416Abstract': [659], '(98)': [667], 'phylogenetic': [671], 'tree': [672], 'separates': [673], 'forms': [680, 2878], 'subgroups': [682], 'within': [683], 'each': [684, 728], 'kingdom': [685], '(Fig.1).': [686], 'formation': [688, 2199], 'necessarily': [696, 3297], 'associated': [697, 1752, 3286], 'closely': [699, 961], 'sequences.': [701], 'example,': [703, 849, 2367], 'L-1': [706, 2742, 2867, 2906, 3322], 'enzyme,': [707, 2981], '15-LOX,': [709], 'has': [710, 1260, 1527, 1589, 1682, 1897, 2346, 2657, 3734, 3991], 'only': [711, 724, 1586, 1636, 2039, 2162, 2879], '25%': [712], 'identity': [713, 726], 'any': [715, 2647, 3995], '15-lipoxygenase,': [717, 2872], 'two': [720, 2166, 4039], 'human': [721, 1099, 2064, 2215], '15-LOX': [722, 1840, 1895, 2068, 2143, 2542, 2655, 3379], 'share': [723, 741], '35%': [725], 'other.': [729], 'By': [730, 2193, 3370], 'contrast,': [731, 2194, 3371], 'close': [733], 'functional': [734], 'across': [736], 'species,': [737], 'forming': [738, 3038], 'subgroups,': [740], '70–95%': [742], 'identity.': [744], 'practical': [746], 'usage': [747], 'based': [750], 'on': [751, 758, 1208, 1264, 1296, 1457, 1532, 2637, 2650, 2772, 3380, 3700, 4017, 4032, 4165], 'specificity': [753, 3175], 'enzyme': [756, 954, 963, 978, 1896, 2173, 2508, 2876, 2936, 3342, 3411, 4091, 4164], 'acting': [757], 'its': [759, 1227, 1796, 1842, 2071, 2674, 3266, 3274, 3614, 3848, 4027], 'can': [764, 846, 1728, 2217], 'become': [765, 2037, 2329], 'slightly': [766], 'awkward,': [767], 'it': [768, 1677, 2665, 3316], 'conveys': [769], 'simple': [771], 'useful': [773], 'message.': [774], '12-LOX': [775, 856, 887, 1408], 'oxygenates': [776], 'carbon-12,': [780], 'when': [782, 850, 2501], 'necessary,': [783], 'stereoconfiguration': [785], 'specified': [787], '(12': [788], 'R-LOX': [789], '12': [791, 1173, 1294], 'S-LOX': [792], '(Scheme': [793], 'FS1)).': [794], 'differing': [796], 'chain': [797, 2407], 'lengths': [798], 'common': [802, 3125], '(linoleate,': [806], 'linolenate,': [807], '18-carbon)': [808], '(arachidonate,': [811], '20-carbon)': [812], 'result': [813, 2858], '13-LOX': [817], 'corresponding': [818, 2736], '15-LOX;': [822], '"count"': [826], 'carbons': [829], 'tail': [832, 3268], 'end': [833, 1036, 1152], 'chain,': [836], 'both': [838, 2749], 'react': [839], 'ω-6': [843], 'position.': [844], 'Complications': [845], 'arise,': [847], 'than': [854, 1449], 'same': [859, 1894, 2980, 2985, 3117, 3338], 'species.': [860, 941], 'To': [861], 'get': [862], 'around': [863, 1836], 'problem,': [865], 'currently': [866], '12-lipoxygenases': [869], 'named': [871], 'after': [872], 'prototypical': [874], 'occurrence': [878], '(hence,': [879], 'platelet,': [881], 'leukocyte,': [882], 'epidermal': [884], 'type': [885, 927, 974, 2066, 2141, 2207, 2902, 3376], '(5Yamamoto': [888, 990], 'Scholar)).': [904], 'by': [909, 1011, 1170, 2085, 2731, 2932, 3237, 3252, 3386, 3525, 3584], 'sequence,': [910, 3864], 'catalytic': [911, 2444, 3594], 'activities,': [912], 'function.': [914], 'Some': [915, 1042], 'mixture': [920, 1762, 2076], 'products,': [922, 2943], 'e.g.': [923], 'reticulocyte': [926, 1839, 2065, 2140, 2541, 2654, 2901, 3375], 'catalyzes': [930, 980], 'C-12': [931, 982], 'C-15': [933, 989], 'oxygenation,': [934], 'relative': [937], 'proportions': [938], 'varying': [939], 'among': [940, 3050], 'rabbits': [943], 'major': [947], '15-HPETE,': [950, 2922], 'hence': [952], 'designated': [956, 2667], '15-LOX.': [958, 2904], 'rat,': [966], 'mouse,': [967], 'pig,': [968], 'cow': [970], 'leukocyte': [973, 3604, 3702], '12-LOX,': [976, 2209], 'mainly': [981, 2098, 3628], 'oxygenation': [983, 2286, 2890, 2942, 3017, 3308], 'This': [1007, 2133, 2727], 'usually': [1009, 2495], '(Fig.2).': [1023], 'Two': [1024], 'subcategories': [1025], 'recognized': [1027, 1157], 'either': [1032, 3808], 'intermediate': [1034], 'pathway.': [1041], 'examples': [1043, 1463], 'jasmonic': [1045], 'aldehyde': [1048], 'biosynthesis': [1049, 3681], 'leukotriene': [1067, 1128, 3680, 3737, 3805], 'lipoxin': [1069], 'vertebrate': [1072], '(16Samuelsson': [1074], 'B.': [1075, 1339, 1372, 2563, 2571, 3954], 'Adv.': [1076], 'Exp.': [1077], 'Med.': [1078, 1140], '433:': [1081], '1-7Crossref': [1082], '(9)': [1085], 'Scholar,17Serhan': [1087], 'C.N.': [1088], 'Prostaglandins.': [1089], '53:': [1091], '107-137Crossref': [1092], '(225)': [1095], 'beings,': [1100], 'activation': [1101, 1333, 4167], '5-LOX': [1104, 1125, 3626, 3664, 3699, 3839, 3856], 'leukocytes': [1106], 'produces': [1107, 1760], 'leukotrienes': [1109], 'lipid-peptide': [1112], 'conjugates': [1113], 'dihydroxyeicosanoids': [1115], 'provoke': [1116], 'bronchoconstriction': [1117], 'inflammation.': [1119], 'Current': [1120], 'medications': [1121], 'asthma': [1123], 'include': [1124], 'inhibitors': [1126], 'antagonists': [1130], '(18Drazen': [1131], 'J.M.': [1132, 2015], 'Israel': [1133], 'E.': [1134, 1572, 1647, 2247, 2588, 2614, 2690, 2810, 3479, 3538, 3712], "O'Byrne": [1135], 'P.M.': [1136], 'Engl.': [1138], '1999;': [1141, 3964], '340:': [1142], '197-206Crossref': [1143], '(775)': [1146], 'Synthesis': [1149], 'best': [1156, 3021], 'firmly': [1160], 'established': [1161], 'lipoxygenases.': [1164], 'An': [1165, 1438, 1962, 2343, 3890], 'example': [1166], '12-HETE': [1168, 1225, 1366, 1442], 'platelet': [1172, 1407, 1427, 1454, 2206], 'S-LOX.': [1174], 'Numerous': [1175], 'biological': [1176, 3334], 'activities': [1177, 1533], 'ascribed': [1179, 2349], 'individual': [1181], 'HETEs': [1182, 1536, 1670], 'HPETEs,': [1184], 'weight': [1187], 'evidence': [1189, 1362, 3558, 3608, 3851, 4013], 'now': [1190, 3035], 'suggests': [1191], 'act': [1194, 1229, 1327], 'molecules.': [1198], 'Here': [1199], 'actions': [1201, 1263], 'mediated': [1203], 'cell': [1206, 1297, 1329, 1458, 1778, 1832, 1847, 1869, 1988, 3842, 4018], 'surface': [1207, 1330, 2718, 2771, 2787], 'receptors': [1209, 1526], 'channels,': [1211], 'HETE': [1214], 'bioactivity': [1215], 'evident': [1217, 2038], 'nanomolar': [1220], 'range.': [1221], 'modulating': [1223], 'neurotransmission,': [1224], 'derivatives': [1228, 1667], 'fast': [1230, 1450], '(19Piomelli': [1231], 'Volterra': [1233], 'Dale': [1235], 'Siegelbaum': [1237], 'S.A.': [1238, 2582, 2684, 3473, 3532], 'Kandel': [1239], 'E.R.': [1240], 'Schwartz': [1241], 'J.H.': [1242], 'Belardetti': [1243], 'Nature.': [1245], '1987;': [1246, 2392], '328:': [1247], '38-43Crossref': [1248], '(531)': [1251], '5-HETE': [1255], 'oxidation': [1256, 1689, 1902], '5-oxo-eicosatetraenoic': [1258], 'instant': [1261], 'receptor-mediated': [1262], 'calcium': [1265], 'fluxes': [1266], "(20O'Flaherty": [1267], 'J.T.': [1268, 2567], 'Taylor': [1269, 1379], 'J.S.': [1270], 'Thomas': [1271], 'M.J.': [1272, 3640], '273:': [1277, 3918, 4067, 4281], '32535-32541Abstract': [1278], '(47)': [1286], 'Scholar),': [1288, 1323, 1424, 1626, 2601, 3074, 3088, 3408], 'potent': [1291], 'effects': [1292, 1797, 4160], 'S-HETE': [1295, 1588, 1629], 'adhesion,': [1298], 'activity': [1300, 1591, 3372, 3795], 'linked': [1301], 'metastasis': [1303], 'prostate': [1305], 'carcinoma': [1306], '(21Tang': [1307], 'D.G.': [1308, 1497], 'Honn': [1309, 1346, 1385, 1500], 'K.V.': [1310, 1347, 1386, 1501], 'Ann.': [1311], 'Y.': [1313, 2179, 2271], '744:': [1317], '199-215Crossref': [1318], 'considered': [1325], 'through': [1328, 3520], 'kinase': [1336], 'C': [1337, 2473, 3466], '(22Liu': [1338], 'Maher': [1340], 'R.J.': [1341], 'Hannun': [1342, 1375], 'Y.A.': [1343, 1376], 'Porter': [1344], 'A.T.': [1345], 'Cancer': [1350], 'Inst.': [1351], '86:': [1353], '1145-1150Crossref': [1354], '(105)': [1357], 'G-protein-coupled': [1365], 'melanoma': [1369], 'cells': [1370, 3823], '(23Liu': [1371], 'Khan': [1373], 'W.A.': [1374], 'Timar': [1377], 'J.D.': [1380], 'Lundy': [1381], 'Butovich': [1383], '1995;': [1394, 1483, 1556, 1614, 3650], '92:': [1395], '9323-9327Crossref': [1396], 'It': [1402, 2087, 2151, 2842, 2885, 3733, 4079], 'striking': [1404], 'how': [1405, 2638], 'keeps': [1409], 'making': [1410], 'hours': [1413], '(24Hwang': [1414, 2229], '1982;': [1417, 2232], '17:': [1418, 2233], '845-847Crossref': [1419, 2234], '(16)': [1422, 2237], 'whereas': [1425], 'cyclooxygenase': [1428, 4111], 'generates': [1429], 'short': [1431], 'burst': [1432], 'inactivated.': [1437], 'inference': [1439], 'modulate': [1444, 2031], 'longer': [1445], 'term': [1446], 'events': [1447], 'rather': [1448], 'responses': [1451], 'such': [1452], 'aggregation.': [1455], 'Effects': [1456], 'differentiation': [1459, 1989], 'survival': [1461], '(25Yu': [1464, 1537, 1595], 'Bayona': [1466, 1539, 1597], 'Kallen': [1468, 1541, 1599], 'C.B.': [1469, 1542, 1600], 'Harding': [1470, 1543, 1601], 'H.P.': [1471, 1544, 1602], 'Ravera': [1472, 1545, 1603], 'C.P.': [1473, 1546, 1604], 'McMahon': [1474, 1547, 1605], 'Brown': [1476, 1549, 1607], 'Lazar': [1478, 1551, 1609], 'M.A.': [1479, 1552, 1610], '270:': [1484, 1557, 1615], '23975-23983Abstract': [1485, 1558, 1616], '(646)': [1493, 1566, 1624], '26Tang': [1496], 'Chen': [1498, 1705, 4263], 'Y.Q.': [1499], '93:': [1510, 1711], '5241-5246Crossref': [1511], '(328)': [1514], 'search': [1518], 'natural': [1520, 1634], 'ligands': [1521, 3120], 'orphan': [1524], 'nuclear': [1525, 3615, 3634, 3667, 3703, 3872, 3906, 3941], 'produced': [1528], 'provocative': [1530], '27Sørensen': [1569], 'H.N.': [1570], 'Treuter': [1571], 'Gustafsson': [1573], 'J.-A.': [1574], 'Vitam.': [1575], 'Horm.': [1576], '54:': [1578, 1922], '121-166Crossref': [1579], '(52)': [1582], 'Yet,': [1585], '8': [1587, 1628, 2916, 2948, 2998, 3197], 'submicromolar': [1590], 'PPAR-reporter': [1593], 'assays': [1594], 'known': [1631, 3022, 3158], '(28Fürstenberger': [1640], 'Hagedorn': [1642, 2242], 'Jacobi': [1644, 2244], 'Besemfelder': [1646, 2246], 'Stephan': [1648, 2248], 'Lehmann': [1650, 2250], 'W.D.': [1651, 2251], '266:': [1658, 2258], '15738-15745Abstract': [1659, 2259], 'Linoleate': [1666], 'other': [1669, 1970, 2895, 3122, 3764, 3996, 4001], 'significantly': [1672], 'weaker': [1673], 'PPAR': [1674], 'ligands,': [1675], 'argued': [1679], 'potential': [1683, 1843, 2362, 3438, 4208], 'physiological': [1684, 2041, 3225], 'significance': [1685], 'relation': [1687], 'density': [1692, 1905], 'lipoprotein': [1693, 3511, 3529], 'initiation': [1696, 1912], 'atherosclerosis': [1698, 1914], '(29Nagy': [1699], 'Tontonoz': [1701], 'Alvarez': [1703], 'J.G.A.': [1704], 'Evans': [1707], 'R.M.': [1708], 'Cell.': [1709, 4135], '229-240Abstract': [1712], '(1612)': [1720], 'Scholar);': [1722], 'certainly,': [1723], 'concentrations': [1725], 'hydroxylinoleates': [1727], 'accumulate': [1729], '(30Jira': [1730], 'Spiteller': [1732], 'Carson': [1734], 'Schramm': [1736], 'Phys.': [1739], '91:': [1742, 3404, 3756], '1-11Crossref': [1743], '(118)': [1746], 'Typically': [1749], 'metabolism': [1754, 4118], 'esterified': [1756, 2291, 3415], 'often': [1759], 'hydroperoxy': [1764, 1789], '(Fig.': [1766, 2429, 2453, 2478], '2).': [1767], 'Here,': [1768], 'objective': [1770, 2094], 'physical': [1774], 'change': [1780, 3172], 'peroxide': [1782, 4166], 'tone,': [1783], 'structure': [1786, 1802, 2656, 2795], '(a)': [1799], 'perturbing': [1800], 'membrane': [1801, 1818, 3250, 3348, 3508, 3580, 3616, 3668, 3676, 3704, 4015], '(b)': [1804], 'provoking': [1805], 'secondary': [1806], 'oxygenations': [1807], '(enzyme-catalyzed': [1808], 'peroxidation).': [1810], 'concept': [1812], 'could': [1816], 'peroxidize': [1817], 'lipids': [1819], 'thus': [1821], 'help': [1822, 4315], 'programmed': [1827], 'was': [1833, 3317, 3900], 'originally': [1834], 'developed': [1835], 'role': [1844, 1940, 2035, 3561], 'red': [1846], 'maturation': [1848, 1865], '(31Rapoport': [1849, 3422], '1986;': [1856, 3429], '864:': [1857, 3430], '471-495Crossref': [1858, 3431], '(117)': [1861, 3434], 'Keratinocyte': [1864], 'lens': [1867], 'epithelial': [1868], 'development': [1870, 1986, 2382], 'offer': [1871], 'similar': [1872, 3461], 'possibilities': [1873], '(32Schewe': [1874], 'Kühn': [1876, 2305, 3400], 'Trends': [1878], '16:': [1882], '369-373Abstract': [1883], '(63)': [1889], 'Subsequently,': [1892], 'been': [1898, 2348, 3992], 'implicated': [1899, 2295], 'lipoprotein,': [1906], 'key': [1908], 'event': [1909], '(33Feinmark': [1915], 'S.J.': [1916], 'Cornicelli': [1917], 'J.A.': [1918, 3706, 3771], 'Pharmacol.': [1920], '953-959Crossref': [1923], '(39)': [1926], 'Similar': [1929], 'concepts': [1930], 'have': [1931, 2403, 2424, 2750, 3189, 3244, 4004], 'evolved': [1932], 'independently': [1933], 'literature': [1937], 'where': [1938], 'senescence': [1945], 'proposed': [1947], '34Hung': [1950], 'K.T.': [1951], 'Kao': [1952], 'C.H.': [1953], 'Bot.': [1954], 'Bull.': [1955], 'Sin.': [1957], '38:': [1959, 2023], '85-89Google': [1960], 'issue': [1963], 'here,': [1964], 'ascribing': [1967], 'lipoxygenases,': [1971, 3495, 3572], 'fact': [1974], 'gene': [1976], 'knockout': [1977], 'experiments': [1978], 'mice': [1980], 'indicate': [1981], 'obvious': [1983], 'problems': [1984], '(4Funk': [1990, 2045], 'Similarly,': [2003], 'transgenic': [2004], 'lacking': [2006], 'exhibit': [2011], '(35Narvel': [2014], 'Fehr': [2016], 'W.R.': [2017], 'Welke': [2018], 'G.A.': [2019, 3356], 'Crop': [2020], '926-928Crossref': [2024], '(26)': [2026], 'events,': [2032], 'under': [2040, 2061, 2437], 'pathological': [2043], 'stress': [2044], 'As': [2058, 2480, 3552], 'mentioned': [2059], 'earlier': [2060], '"Nomenclature,"': [2062], '(15-LOX-1)': [2069], 'counterparts': [2073], '12-HPETE': [2078], '15-HPETE.': [2080], 'Is': [2081], 'imperfect': [2083, 2108], 'catalysis': [2084, 2122, 2512, 4055], 'design?': [2086], 'hard': [2089], 'imagine': [2091], 'small': [2103], 'amount': [2104], 'another.': [2106], 'fit': [2109], 'active': [2112, 2506, 2853, 2986, 3006], 'site': [2113, 2682, 3007], 'resulting': [2116], 'mobility': [2117], 'might': [2123, 3260], 'designed': [2125], 'promote': [2127], 'radical': [2131], 'intermediates.': [2132], 'accords': [2134], 'view': [2137], 'catalyst': [2147, 2609], 'notable': [2154], 'class': [2157, 4089], 'minute': [2164], 'before': [2167], 'turnover-related': [2169], 'inactivation': [2170], 'kills': [2171], '(36Hada': [2174], 'Takahashi': [2178, 2270], 'Yamamoto': [2180, 2272], '1083:': [2186, 2278], '89-93Crossref': [2187, 2279], '(66)': [2190, 2282, 4290], 'cleanly': [2197, 2892], 'catalyze': [2198, 2911, 2991], '8-LOX,': [2212], '15-LOX-2)': [2216], 'keep': [2218], 'running': [2219], 'near': [2220], 'linear': [2222], 'rate': [2223, 2930], 'hour': [2226], '28Fürstenberger': [2240], '36Hada': [2266], 'Lipoxygenase-catalyzed': [2285], 'unsaturated': [2288], 'triglycerides': [2293], 'germination': [2298], 'process': [2299], 'oil-seed': [2301], '(37Feussner': [2303], 'Wasternack': [2307], 'FEBS': [2309, 3723], 'Lett.': [2310, 3724], '406:': [2312], '1-5Crossref': [2313], '(41)': [2316], 'After': [2319], 'conversion': [2320], 'specifically': [2321], '13-hydroperoxy': [2324], 'esters,': [2325], 'available': [2330, 2526, 3298], 'β-oxidation': [2332], 'utilization': [2334], 'fuel': [2337], 'source': [2338], 'developing': [2341], 'embryo.': [2342], 'equivalent': [2344, 3981], 'biology,': [2352], 'yet': [2353, 3500, 3553, 3633], 'peroxidation': [2355, 2612], 'stores': [2358, 2379], 'serves': [2359], 'model': [2363, 2713, 2862], 'rationalize,': [2365], 'content': [2371], 'certain': [2373], 'oocytes,': [2375], 'which': [2376, 2530], 'carry': [2378], 'embryo': [2381], '38Hawkins': [2385], 'D.J.': [2386], '262:': [2393], '7629-7634Abstract': [2394], 'polypeptide': [2406], 'mass': [2411], '∼75–80': [2413], 'kDa': [2414, 2419], '∼94–104': [2418], 'plants.': [2421], 'N-terminal': [2426, 3895], 'β-barrel': [2427, 2807, 3452, 3513, 3565, 3899], '3,': [2430], 'top': [2431, 2717], 'panel,': [2432], 'white,': [2433], 'discussed': [2435], 'later': [2436], '"Acquisition': [2438], 'Substrate")': [2440], 'larger': [2443], 'atom': [2449], 'non-heme': [2451], 'iron': [2452, 2482, 2759, 3119], '3).': [2454, 2479], 'metal': [2456, 2644], 'liganded': [2458], 'conserved': [2460, 2469, 3118, 3451], 'histidines': [2461], 'carboxyl': [2465, 3277], 'group': [2466], 'isoleucine': [2470], 'terminus': [2474, 3467], 'non-heme,': [2484], 'appear': [2486], 'virtually': [2487], 'colorless': [2488], 'eye.': [2491], 'ferrous': [2498, 2836], '(inactive)': [2499, 2837], 'isolated.': [2502], 'Oxidation': [2503], 'ferric': [2507], 'required': [2510], '(SchemeFS2).Figure': [2513], 'FS2View': [2514], 'Large': [2515], 'Image': [2516], 'Figure': [2517], 'ViewerDownload': [2518], 'Hi-res': [2519], 'image': [2520, 3041, 3183], 'Download': [2521], '(PPT)': [2522], 'four': [2525], 'crystal': [2527, 2737], 'structures,': [2528], 'three': [2531, 2831, 3855], 'arachidonate': [2535], '15-lipoxygenases,': [2536], 'L-1,': [2538], '(39Boyington': [2543], 'J.C.': [2544], 'Gaffney': [2545], 'B.J.': [2546], 'Amzel': [2547, 2615, 2811], 'L.M.': [2548, 2616, 2812], 'Science.': [2549, 4181], '1993;': [2550, 3725], '260:': [2551], '1482-1486Crossref': [2552], '(460)': [2555], '40Minor': [2558], 'Steczko': [2560], 'Stec': [2562], 'Otwinowski': [2564], 'Z.': [2565, 3718], 'Bolin': [2566], 'Walter': [2568], 'Axelrod': [2570], 'Biochemistry.': [2572, 3202], '35:': [2574, 3204], '10687-10701Crossref': [2575], '(396)': [2578], '41Gillmor': [2581], 'Villaseñor': [2583, 2685, 3474, 3533], 'Fletterick': [2585, 2687, 3476, 3535], 'Sigal': [2587, 2689, 3478, 3537], 'Browner': [2589, 2691, 3480, 3539], 'M.F.': [2590, 2692, 3481, 3540], 'Nat.': [2591, 2693, 3482, 3541], 'Struct.': [2592, 2622, 2694, 2818, 3483, 3542], '4:': [2595, 2697, 3486, 3545], '1003-1009Crossref': [2596, 2698, 3487, 3546], '(399)': [2599, 2701, 3490, 3549], 'fourth,': [2604], 'L-3,': [2606], 'nonspecific': [2611], '(42Skrzypczak-Jankun': [2613, 2809], 'Kroa': [2617, 2813], 'B.A.': [2618, 2814], 'M.O.J.': [2620, 2816], 'Proteins': [2621, 2817], 'Funct.': [2623, 2819], '29:': [2626, 2822], '15-31Crossref': [2627, 2823], '(150)': [2630, 2826], 'consensus': [2636, 4006], 'gains': [2640], 'access': [2641, 2706, 3502, 3577], 'center': [2645], 'information': [2649], 'binding.': [2652], 'bound': [2659], 'inhibitor': [2660, 3798, 3818], 'lying': [2661], 'opposite': [2662, 3166], 'His-3': [2663], 'Fig.': [2669, 2725, 2763], '(see': [2671], 'legend),': [2672], 'position': [2675], 'helps': [2676], 'identify': [2677], 'likely': [2679, 2845], 'binding': [2681, 3567, 3863, 3867, 4008], '(41Gillmor': [2683, 3472, 3531], 'apparent': [2705], 'channel': [2707], 'opens': [2714], 'onto': [2715], 'viewed': [2723], '3.': [2726], 'route': [2728, 2782], 'obstructed': [2730], 'overlying': [2732], 'helices': [2733], 'structures': [2738, 2832], 'L-3': [2744, 2794], 'enzymes.': [2745], 'large': [2752], 'cavity': [2753], 'right': [2756], 'portrayed': [2761], 'opening': [2767, 2783, 2803], 'right-hand': [2774], 'side.': [2775], 'second': [2779], 'restricted': [2781], 'lower': [2786], 'protein.': [2790, 3598], 'addition,': [2792], 'shows': [2796], 'potentially': [2797], 'accessible': [2798], 'space': [2799], 'extending': [2800], 'left': [2801], 'out': [2804, 2887], 'toward': [2805], 'Significantly,': [2829], 'all': [2830, 3571], 'enzyme.': [2841], 'quite': [2844, 3218], 'movements': [2847], 'occur': [2848], 'transition': [2850], 'into': [2851, 3592], 'Fe3+': [2854], 'unifying': [2861], 'isozyme': [2868], '"pure"': [2871], 'which,': [2873], 'concentrations,': [2877], '15': [2880, 2993], 'S-HPETE': [2881], 'acid.': [2884], 'carries': [2886], 'first': [2889], 'very': [2891], 'compared': [2893], 'Soybean': [2905], 'is,': [2907], 'nonetheless,': [2908], 'able': [2909, 2989], '5': [2913, 2944, 2995], 'S': [2914, 2917, 2999, 3030], 'oxygenations.': [2918], 'initial': [2920], 'product,': [2921], 'further': [2924, 3582], 'oxygenated': [2925], 'much': [2928], 'slower': [2929], '(overcome': [2931], 'use': [2933], 'higher': [2935], 'concentration)': [2937], 'S,15': [2945, 2949], 'S-di-HPETE': [2946, 2950], '(43Van': [2951], 'Os': [2952], 'C.P.A.': [2953], 'Rijke-Schilder': [2954], 'G.P.M.': [2955], 'Van': [2956], 'Halbeek': [2957], 'Verhagen': [2959], 'Vliegenthart': [2961, 3357], 'J.F.G.': [2962, 3358], '1981;': [2966], '663:': [2967], '177-193Crossref': [2968], '(162)': [2971], 'conclusion': [2976], 'presumably': [2983], 'site,': [2987], 'stereospecific': [2992], 'S,': [2994, 2996], 'reactions.': [3001], 'Substrate': [3002], 'alignment': [3003], 'keys': [3012], '(Fig.4).': [3019], 'stereochemistry.': [3031], 'Nonetheless,': [3032, 4000], 'we': [3033], 'recognize': [3034], 'mirror': [3040, 3182], 'R': [3042], 'configuration': [3043], 'widespread,': [3047], 'being': [3048], 'aquatic': [3051], 'invertebrates': [3052], '(3De': [3053], '(2Gerwick': [3076], 'recently': [3090, 3945], '(11Boeglin': [3093], 'R-Lipoxygenases': [3114], 'motifs': [3124, 3161], 'S-lipoxygenases': [3130], '(44Brash': [3131], 'Chang': [3135], 'M.S.': [3136], 'Shieh': [3137, 4175], 'B.-H.': [3138, 4176], '271:': [3143], '20949-20957Abstract': [3144], '(74)': [3152], 'sequences': [3159, 3857], 'stereospecificity,': [3167], 'relatively': [3170], 'must': [3176], 'capable': [3178], 'giving': [3180], 'product.': [3184], 'Arachidonic': [3185], 'linoleic': [3187, 3312, 4045, 4124], 'p': [3191], 'Ka': [3192], 'between': [3193, 4037], 'pH': [3194, 3226], '7': [3195], '(45Glickman': [3198], 'M.H.': [3199], 'Klinman': [3200], 'J.P.': [3201], '12882-12892Crossref': [3205], '(136)': [3208], 'therefore': [3212], 'partly': [3215], 'unionized': [3216], 'insoluble': [3219], 'water': [3221], '7.4.': [3228], 'Under': [3229], 'conditions,': [3231], '"released"': [3236], 'action': [3239], 'lipase': [3242, 3512], 'little': [3245], 'tendency': [3246], 'leave': [3248], 'unless': [3251], 'association': [3253, 3387, 3670], 'carrier.': [3256], 'expected': [3262], 'lie': [3264], 'long': [3267], 'hydrophobic': [3271, 3507, 3526], 'bilayer': [3272], 'polar': [3276], '(charged': [3278], 'uncharged)': [3280], 'aqueous': [3283], 'environment': [3284], 'head': [3289], 'groups': [3290], 'phospholipids.': [3292], 'metabolism.': [3301], 'careful': [3304], 'study': [3305, 3892], 'membrane-associated': [3310], 'linolenic': [3314, 4126], 'L-2': [3324, 3341], 'would': [3326], 'metabolize': [3328, 3414], 'membranes.': [3335], 'experiments,': [3339], '(but': [3343], 'L-1)': [3345], 'metabolized': [3346], 'esters': [3349], '(46Maccarrone': [3350], 'van': [3352], 'Aarle': [3353], 'P.G.': [3354], 'Veldink': [3355], '1190:': [3363], '164-169Crossref': [3364], '(65)': [3367], 'stimulated': [3385], 'biomembranes': [3389], '(47Brinckmann': [3390], 'Schnurr': [3392], 'Heydeck': [3394], 'Rosenbach': [3396], 'Kolde': [3398], 'Blood.': [3402], '64-74Crossref': [3405], 'without': [3417], 'requiring': [3418], 'detergent': [3419], 'solubilization': [3421], 'A': [3437], 'clue': [3439], 'mechanisms': [3441, 4058], 'came': [3446], 'recognition': [3448], 'shares': [3456], 'significant': [3457], 'located': [3463], 'lipases': [3471, 3497], 'Like': [3493], 'cytosolic': [3499, 3629], 'need': [3501], 'protein-protein': [3521, 3611, 4156], 'interactions': [3523, 3527, 3612], 'particles': [3530], 'direct': [3557], 'substrate.': [3568], 'Notably,': [3569], 'understanding': [3574], 'clouded': [3583], 'uncertainties': [3585], 'regarding': [3586], 'point': [3588], 'entry': [3591], 'lipoxygenase,': [3602], '5-LOX,': [3605], 'complex': [3610], 'translocation,': [3617], 'activation,': [3618], 'intact': [3624, 3683, 3815], 'cells.': [3625, 3684], 'resting': [3631], 'neutrophils': [3632], 'macrophages': [3636], '(48Woods': [3637], 'J.W.': [3638], 'Coffey': [3639], 'Brock': [3641], 'T.G.': [3642], 'Singer': [3643], 'I.I.': [3644], 'Peters-Golden': [3645], 'Clin.': [3648], 'Invest.': [3649], '2035-2046Crossref': [3652], '(160)': [3655], 'stimulation': [3659], 'results': [3660], 'translocation': [3662, 4016], 'FLAP,': [3672], '18-kDa': [3674], 'integral': [3675], 'FLAP': [3685, 3802, 3831, 3972], 'acts': [3686], 'transfer': [3691], '"presents"': [3694], '(49Mancini': [3705], 'Abramovitz': [3707], 'Cox': [3709], 'M.E.': [3710], 'Wong': [3711], 'Charleson': [3713], 'Perrier': [3715], 'Wang': [3717], 'Prasit': [3719], 'Vickers': [3721], 'P.J.': [3722, 3769], '318:': [3726], '277-281Crossref': [3727], '(185)': [3730], 'C4': [3738], 'synthase': [3739], '(50Lam': [3740], 'B.K.': [3741], 'Penrose': [3742], 'J.F.': [3743], 'Freeman': [3744], 'G.J.': [3745], 'Austen': [3746], 'K.F.': [3747], '7663-7667Crossref': [3757], '(253)': [3760], 'microsomal': [3765], 'glutathione': [3766], 'transferases': [3767], '(51Jakobsson': [3768], 'Mancini': [3770], 'Riendeau': [3772], 'Ford-Hutchinson': [3774], 'A.W.': [3775], '22934-22939Abstract': [3781], '(140)': [3789], 'but': [3792], 'enzymatic': [3794], 'itself.': [3796], 'MK886': [3799], 'binds': [3800], 'blocks': [3804], 'production': [3806], 'exogenous': [3809], 'endogenous': [3811], 'cells;': [3816], 'inactive': [3820], 'broken': [3822], 'purified': [3826], '5-LOX.': [3827], 'involvement': [3829], 'does': [3832], 'explain': [3834], 'localization': [3837, 3942], 'types': [3843], 'mechanism': [3846], 'translocation.': [3849], 'Recent': [3850], 'implicates': [3852], 'events:': [3860], 'actin': [3862], 'SH3': [3866, 4007], 'domain,': [3868, 4009], 'bipartite': [3871], 'localizing': [3873], '(52Lepley': [3875], 'R.A.': [3876], 'Fitzpatrick': [3877], 'F.A.': [3878], 'Arch.': [3879], '356:': [3883], '71-76Crossref': [3884], '(36)': [3887], 'independent': [3891], 'concluded': [3893], 'sufficient': [3904], 'targeting': [3907], '(53Chen': [3908], 'X.S.': [3909], 'Zhang': [3910], 'Y.Y.': [3911], '31237-31244Abstract': [3919], '(55)': [3927], 'Three': [3930], 'additional': [3931], '5-LOX-interacting': [3932], 'regulation': [3939], 'and/or': [3940], 'were': [3943], 'using': [3946], 'two-hybrid': [3949], 'screen': [3950], '(54Provost': [3951], 'Samuelsson': [3953], 'Rådmark': [3955], 'O.': [3956, 4174], '1881-1885Crossref': [3966], '(107)': [3969], 'appears': [3973], 'unique.': [3976], 'No': [3977], 'handling,': [3985], 'requirement': [3988], 'one,': [3990], 'oxygenase.': [3999], 'activation.': [4019], 'discovery': [4021, 4101, 4193], 'manganese': [4024], 'unique': [4028], 'oxygenate': [4031], 'carbon': [4036], 'bonds': [4042], '(C-11': [4043], 'acid)': [4046], 'provides': [4047], 'many': [4048], 'new': [4049, 4088], 'questions': [4050], '(55Su': [4059], 'Oliw': [4061, 4308], 'E.H.': [4062], '13072-13079Abstract': [4068], '(159)': [4076], 'remains': [4080], 'seen': [4083], 'if': [4084], 'superfamily.': [4098], 'Similarly': [4099], 'oxygenase': [4105], 'provide': [4113], 'interesting': [4114], 'contrasts': [4115], 'substrates,': [4123], '(56Sanz': [4128], 'Moreno': [4130], 'J.I.': [4131], 'Castresana': [4132], '10:': [4137], '1523-1537Crossref': [4138], '(122)': [4141], 'lipoxygenase-peroxidase': [4145], 'fusion': [4146], 'prostaglandin-containing': [4150], 'coral': [4151], 'raised': [4152], 'novel': [4153], 'interaction': [4157], 'peroxide-metabolizing': [4163], '(57Koljak': [4171], 'Boutaud': [4173], 'Samel': [4177], '277:': [4183], '1994-1996Crossref': [4184], '(100)': [4187], 'Finally,': [4190], 'recent': [4192], 'R-lipoxygenase': [4195], 'systems': [4198], 'spur': [4200], 'interest': [4202], 'utility': [4209], 'unraveling': [4211], 'basis': [4213], 'stereospecificity': [4216], '59Sun': [4259], 'McDonnell': [4261], 'X.-S.': [4264], 'Lakkis': [4265], 'M.M.': [4266], 'Li': [4267], 'Isaacs': [4269], 'S.N.': [4270], '33540-33547Abstract': [4282], 'Thanks': [4293], 'Drs.': [4295], 'Bih-Hwa': [4296], 'Shieh,': [4297], 'Claus': [4298], 'Schneider,': [4299], 'Betty': [4300], 'Gaffney,': [4301], 'David': [4302], 'Hildebrand,': [4303], 'Colin': [4304], 'Funk,': [4305], 'Ernst': [4307], 'comments': [4310], 'Scott': [4312], 'Rowlinson': [4313], 'graphics.': [4318]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2074203890', 'counts_by_year': [{'year': 2024, 'cited_by_count': 31}, {'year': 2023, 'cited_by_count': 29}, {'year': 2022, 'cited_by_count': 50}, {'year': 2021, 'cited_by_count': 41}, {'year': 2020, 'cited_by_count': 44}, {'year': 2019, 'cited_by_count': 51}, {'year': 2018, 'cited_by_count': 52}, {'year': 2017, 'cited_by_count': 43}, {'year': 2016, 'cited_by_count': 49}, {'year': 2015, 'cited_by_count': 59}, {'year': 2014, 'cited_by_count': 67}, {'year': 2013, 'cited_by_count': 61}, {'year': 2012, 'cited_by_count': 64}], 'updated_date': '2024-12-28T02:03:26.523214', 'created_date': '2016-06-24'}