Publication Information

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304, 313, 322, 339, 572, 659, 662, 672, 724, 728, 738, 743, 759, 834, 953, 1092, 1104, 1148, 1158, 1448, 1505, 1525, 1615, 1621, 1643, 1693, 1710, 1736, 1796, 1820, 1924, 2012, 2027, 2036, 2078, 2089, 2093, 2115, 2126, 2129, 2133, 2146, 2165, 2175, 2210, 2223, 2260, 2284, 2287, 2328, 2341, 2357, 2389, 2409, 2423, 2437, 2453, 2465, 2475, 2480, 2507, 2513, 2537, 2568, 2607, 2687, 2700, 2704, 2721, 2726, 2755, 2767, 2841, 2849, 2860, 2865, 2882, 2908, 2918, 2937, 2941, 2945, 2969, 2984, 2999, 3009, 3038, 3068, 3117, 3201, 3211, 3257, 3279, 3284, 3304, 3328, 3343, 3451, 3474, 3584, 3651, 3681, 3698, 3722, 3757, 3829, 3836, 3918, 3936, 3949, 3964, 3987, 3999, 4083, 4095, 4174, 4180, 4329, 4345, 4358, 4374, 4378, 4385, 4405, 4461, 4485], 'vascular': [10, 187, 358, 640, 673, 873, 1015, 4010], 'smooth': [11, 188, 359, 591, 3093], 'muscle': [12, 189, 360, 592], 'cells': [13, 190, 361, 1024, 1701, 1711, 1737, 1767, 1799, 2251, 2325, 2382, 2529, 2613, 2724, 2728, 2836, 2867, 2966, 3004, 3097], '(VSMC)': [14, 191, 594], 'of': [15, 36, 51, 70, 76, 129, 144, 164, 192, 213, 228, 247, 253, 306, 321, 341, 368, 385, 394, 440, 463, 478, 526, 571, 723, 758, 774, 836, 1025, 1059, 1094, 1106, 1109, 1142, 1197, 1332, 1358, 1440, 1495, 1539, 1614, 1626, 1642, 1652, 1661, 1692, 1748, 1755, 1762, 1798, 1813, 1937, 2022, 2066, 2073, 2095, 2148, 2206, 2242, 2244, 2302, 2319, 2376, 2398, 2426, 2445, 2467, 2482, 2484, 2539, 2570, 2690, 2734, 2752, 2851, 2881, 2910, 2920, 3047, 3119, 3215, 3259, 3273, 3286, 3290, 3297, 3306, 3321, 3327, 3334, 3346, 3397, 3448, 3454, 3471, 3476, 3586, 3653, 3671, 3700, 3831, 3951, 3954, 3963, 3966, 3989, 4001, 4004, 4015, 4025, 4094, 4177, 4183, 4331, 4367, 4376, 4381, 4390, 4407, 4445, 4463, 4473, 4484], 'atherosclerotic': [16, 193, 829, 3191, 3564, 4026], 'lesions': [17, 194], 'but': [18, 195, 880, 3053, 3187, 3835, 3891], 'not': [19, 196, 2463, 2615, 2737, 2903, 2915, 3055, 3267, 3903, 3984], 'normal': [21, 198, 720, 959, 2493, 2612, 2832, 2972, 3010, 3184], 'vessels.': [22, 199], 'CTGF': [23, 52, 60, 71, 89, 200, 229, 237, 248, 266, 944, 1000, 1052, 1089, 1133, 1149, 1187, 1256, 1286, 2154, 2176, 2249, 2323, 2380, 2431, 2490, 2503, 2527, 2574, 2691, 2705, 2708, 2722, 2805, 2817, 2964, 3006, 3030, 3077, 3082, 3130, 3179, 3228, 3255, 3942, 4175, 4314, 4338, 4350, 4371, 4487], 'able': [25, 202], 'to': [26, 111, 203, 288, 584, 654, 658, 671, 767, 933, 947, 1154, 1524, 1573, 1620, 1640, 1759, 1778, 1810, 1816, 2011, 2203, 2491, 2506, 2521, 2764, 2766, 2863, 2957, 2997, 3071, 3392, 3590, 3695, 3721, 3756, 3769, 3791, 3827, 3927, 3948, 4019, 4166, 4249, 4326, 4453, 4457, 4469], 'promote': [27, 204, 655], 'VSMC': [28, 79, 175, 205, 256, 352, 656, 725, 741, 869, 1054, 1097, 1169, 1179, 1700, 1824, 2191, 2337, 2494, 2509, 3199, 3221, 3262, 3587, 3783], 'proliferation': [29, 206, 3222], 'and': [30, 32, 91, 133, 161, 207, 209, 268, 310, 338, 447, 456, 529, 580, 598, 651, 730, 734, 751, 763, 779, 830, 833, 875, 886, 931, 937, 966, 974, 1023, 1057, 1100, 1189, 1233, 1242, 1249, 1260, 1288, 1299, 1382, 1403, 1421, 1425, 1430, 1455, 1463, 1473, 1490, 1508, 1518, 1551, 1564, 1580, 1596, 1618, 1673, 1733, 1775, 1794, 1834, 1879, 1923, 2070, 2085, 2099, 2111, 2135, 2255, 2280, 2286, 2291, 2298, 2310, 2326, 2344, 2353, 2364, 2387, 2404, 2428, 2439, 2495, 2517, 2543, 2580, 2644, 2653, 2695, 2707, 2725, 2741, 2770, 2819, 2833, 2868, 2876, 2888, 2949, 2990, 3007, 3021, 3032, 3079, 3095, 3123, 3128, 3136, 3158, 3213, 3223, 3248, 3361, 3409, 3459, 3467, 3478, 3562, 3582, 3674, 3727, 3766, 3788, 3868, 3907, 3920, 4009, 4138, 4179, 4207, 4243, 4245, 4339, 4351, 4372, 4387, 4440, 4459, 4488], 'migration': [31, 208, 657, 1170, 1180, 3224, 3585], 'influences': [33, 210], 'composition': [35, 212], 'extracellular': [37, 165, 214, 342, 356, 395], 'matrix.': [38, 215], 'The': [39, 216, 378, 450, 911, 1112, 1407, 1468, 1481, 1556, 1577, 1624, 1646, 1745, 1766, 1888, 2004, 2017, 2240, 2395, 2731, 3193, 3318, 3331, 3469], 'mechanisms': [40, 124, 217, 301, 4084, 4447], 'for': [41, 142, 173, 218, 319, 350, 913, 1126, 1379, 1484, 1603, 1866, 1876, 1885, 1928, 1975, 2510, 2592, 2640, 2848, 3003, 3008, 3091, 3896, 4085, 4480], 'controlling': [42, 158, 219, 335], 'these': [43, 220, 3335, 3928], 'events': [44, 221], 'remain': [45, 222], 'unclear.': [46, 223, 918], 'We': [47, 65, 101, 120, 224, 242, 278, 297, 1048, 1129, 2171, 2195, 2420, 2564, 2684, 2934, 2975, 3217, 3275, 3930, 4466], 'studied': [48, 122, 225, 299, 579], 'effects': [50, 227, 1137, 2397, 2689], 'on': [53, 230, 429, 647, 1138, 1151, 1447, 1543, 1864, 1874, 2442, 2692, 2940, 3342, 3661], 'matrix': [54, 231, 354, 357, 379, 484], 'metalloproteinases': [55, 232, 380], '(MMPs)': [56, 233], 'by': [57, 87, 97, 234, 264, 274, 461, 471, 476, 737, 753, 839, 872, 883, 1118, 1157, 1183, 1351, 1532, 1612, 1786, 1969, 2104, 2231, 2498, 2546, 2552, 2573, 2588, 2620, 2650, 2960, 3044, 3057, 3134, 3227, 3269, 3483, 3624, 3655, 3690, 3761, 4241, 4319, 4334, 4370], 'introducing': [58, 235], 'a': [59, 171, 236, 348, 383, 392, 438, 464, 925, 934, 1236, 1325, 1364, 1544, 1571, 1686, 1703, 1763, 1788, 1986, 2023, 2107, 2153, 2233, 2316, 2347, 2488, 2553, 2617, 2629, 2745, 2899, 2977, 2992, 3088, 3208, 3270, 3295, 3395, 3575, 3709, 3817, 4002, 4187, 4251, 4395, 4442], 'over-expression': [61, 69, 238, 246, 2155, 2177, 2250, 2324, 2381, 2432, 2483, 2528, 2706, 2723, 2818, 2965, 3078, 3229, 3943], 'construct': [62, 239, 2156], 'into': [63, 240, 437, 1699, 2157], 'VSMC.': [64, 119, 241, 296, 2158], 'found': [66, 134, 243, 311, 583, 1050, 1087, 1131, 1777, 2197, 2269, 2429, 2496, 2581, 2869, 2950, 3177, 3196, 3219, 3560, 3931, 3997], 'that': [67, 104, 135, 244, 281, 312, 575, 956, 999, 1051, 1088, 1121, 1132, 1177, 1738, 1800, 2173, 2198, 2268, 2430, 2474, 2497, 2582, 2606, 2714, 2814, 2840, 2870, 2923, 2951, 2982, 3067, 3178, 3204, 3220, 3254, 3278, 3301, 3310, 3650, 3680, 3713, 3754, 3816, 3886, 3892, 3925, 3935, 4082, 4191], 'significantly': [72, 249, 3947], 'increased': [73, 86, 106, 250, 263, 283, 648, 2476, 2520, 2842, 3069, 3288, 3940, 4365], 'activity': [75, 83, 108, 252, 260, 285, 515, 838, 1093, 1345, 1442, 2160, 2187, 2281, 2518, 2544, 2889, 3282, 3449, 3558, 3888, 4257], 'MMP-2': [77, 82, 107, 115, 130, 147, 150, 254, 259, 284, 292, 307, 324, 327, 563, 649, 755, 824, 866, 1095, 1110, 1152, 1163, 1321, 1344, 1465, 1563, 1606, 1616, 2013, 2159, 2186, 2207, 2215, 2224, 2245, 2271, 2303, 2320, 2348, 2377, 2427, 2434, 2456, 2468, 2477, 2514, 2540, 2571, 2609, 2634, 2735, 2772, 2809, 2852, 2885, 2932, 2946, 3260, 3281, 3291, 3316, 3472, 3557, 3573, 3656, 3691, 3701, 3723, 3758, 3793, 3822, 3832, 3898, 3905, 3955, 3977, 4368], 'conditioned': [80, 257, 1098, 1347, 1359, 2166, 2312, 2329, 2342, 2390], 'medium.': [81, 258, 1744], 'was': [84, 109, 261, 286, 764, 1324, 1341, 1349, 1488, 1502, 1521, 1541, 1558, 1568, 1750, 1757, 1773, 1784, 1994, 2033, 2081, 2086, 2161, 2201, 2226, 2845, 2874, 3195, 3559, 3825], 'similarly': [85, 262], 'exogenous': [88, 265, 2501, 2547, 2820, 3033], 'treatment,': [90, 267], 'this': [92, 269, 914, 1083, 1101, 1127, 1634, 2199, 2583, 2621, 2798, 2871, 2958, 3250, 3264, 3838, 3933], 'effect': [93, 270, 3684], 'could': [94, 271, 2877, 3040], 'be': [95, 272, 435, 459, 749, 1116, 1155, 1779, 2550, 2586, 2627, 2928, 3041, 3972, 4020, 4323], 'blocked': [96, 273, 1117, 2551], 'an': [98, 112, 152, 275, 289, 329, 586, 949, 2181, 2204, 2443, 2500, 2856, 2954, 3045, 3058, 3287, 3910, 3957, 4364, 4399], 'anti-CTGF': [99, 276, 1289, 2399, 2555, 4489], 'antibody.': [100, 277, 2351, 4490], 'also': [102, 279, 735, 1090, 1610, 2450, 2565, 2604, 2685, 2927, 3113, 3971, 3995, 4316], 'showed': [103, 280], 'due': [110, 287, 2202], 'increase': [113, 290, 1102, 1114, 2184, 2200, 2205, 2243, 2318, 2454, 2538, 2569, 2850, 2883, 2919, 3265, 3272, 3950, 3965, 4182], 'mRNA': [116, 131, 293, 308, 1113, 1607, 2424, 2435, 2469, 2701, 2824, 3952], 'levels': [117, 132, 294, 309, 521, 1608, 2241, 2282, 2522, 2545, 2825, 2890], 'further': [121, 298, 1130, 2196, 2421, 2935, 3276], 'involved': [125, 156, 302, 333, 1002, 1166, 2929, 3115, 3313, 3781, 4021, 4193], 'regulation': [128, 305, 1150, 2733, 3118, 3699, 3839, 4000], 'AP-2': [137, 314, 1631, 1644, 1662, 1821, 1997, 2031, 2803, 2823, 2843, 2861, 2911, 2942, 2986, 3049, 3072, 3311, 3767, 3893, 3937, 3958, 3981, 3993, 4086, 4178, 4340, 4352], 'transcription': [138, 315, 1159, 2732, 2747, 2756, 2862, 3299, 3305, 3702, 3711, 3762, 3830, 3923], 'responsible': [141, 318, 2847], 'most': [143, 320, 722, 3962], 'CTGF-induced': [146, 323, 3315], 'transcription.': [148, 325], 'Because': [149, 326, 1162, 2214, 4313, 4392], 'important': [153, 330, 587, 950], 'directly': [155, 332, 2846], 'cell': [159, 336, 593, 1011, 1261, 2307, 2385, 3464, 3667], 'movement': [160, 337], 'turnover': [163, 340], 'matrix,': [166, 343], 'our': [167, 344, 1174, 1254, 1584, 3672], 'study': [168, 345, 1635, 2145, 3934, 4360], 'may': [169, 346, 2626, 2926, 3137, 3206, 3970, 4088], 'provide': [170, 347], 'mechanism': [172, 349, 912, 2631, 3820], 'CTGF-promoted': [174, 351, 1178], 'migration.': [176, 353], 'metalloproteinase': [355, 485], 'connective': [362], 'inhibitor': [367, 1141], 'metalloproteinase-2': [369, 1143], 'glyceraldehyde-3-phosphate': [370], 'dehydrogenase': [371], 'oligodeoxyribonucleotide(s)': [372], 'dithiothreitol': [373], 'oligonucleotide': [374], 'transforming': [375], 'factor-β': [377], '(MMPs)1': [381], 'are': [382, 452, 731, 2123, 2262, 2274, 2370, 2406, 2637, 2648, 2716, 2743, 3481, 3707, 4164, 4247, 4467], 'family': [384, 3320], 'peptidases': [386], 'that,': [387], 'upon': [388], 'activation,': [389], 'can': [390, 434, 457, 1115, 2549, 2585], 'degrade': [391, 768], 'variety': [393, 3447], 'matrices': [396], '(ECMs)': [397], 'as': [398, 400, 454, 473, 475, 963, 969, 971, 1014, 1200, 1444, 1510, 1570, 1829, 2002, 2083, 2125, 2218, 2295, 3087, 3139, 3357, 3401, 3463, 3719, 4353, 4398], 'well': [399, 474, 970, 1761], 'other': [401, 2924, 3914, 3922, 4005, 4204], 'proteins': [402, 1815, 1826, 2246, 2332, 3399], '(1Matrisian': [403, 534, 2655, 3363], 'L.M.': [404, 535, 2656, 3364], 'Ann.': [405, 536, 2657, 3365], 'N.': [406, 537, 690, 2658, 3366, 3496, 3593, 3628], 'Y.': [407, 538, 2659, 2778, 3367, 3733, 4057, 4216, 4261, 4295], 'Acad.': [408, 539, 2660, 3368], 'Sci.': [409, 540, 2661, 3369], '1994;': [410, 541, 684, 706, 2662, 3370, 3512, 3609], '732:': [411, 542, 2663, 3371], '42-50Crossref': [412, 543, 2664, 3372], 'PubMed': [413, 509, 544, 558, 612, 632, 714, 793, 861, 906, 989, 1043, 1077, 1280, 1316, 2665, 2679, 2792, 3107, 3152, 3171, 3243, 3373, 3387, 3428, 3440, 3520, 3539, 3551, 3617, 3643, 3747, 3810, 3859, 3879, 4045, 4073, 4133, 4157, 4232, 4269, 4289, 4308, 4435], 'Scopus': [414, 510, 545, 559, 613, 633, 715, 794, 862, 907, 990, 1044, 1078, 1281, 1317, 2666, 2680, 2793, 3108, 3153, 3172, 3244, 3374, 3388, 3429, 3441, 3521, 3540, 3552, 3618, 3644, 3748, 3811, 3860, 3880, 4046, 4074, 4112, 4134, 4158, 4233, 4270, 4290, 4309, 4436], '(152)': [415, 546, 2667, 3375], 'Google': [416, 512, 547, 561, 615, 635, 687, 717, 796, 822, 864, 909, 992, 1046, 1080, 1220, 1283, 1319, 2668, 2682, 2795, 3110, 3155, 3174, 3246, 3376, 3390, 3431, 3443, 3523, 3542, 3554, 3620, 3646, 3750, 3813, 3862, 3882, 4048, 4076, 4114, 4136, 4160, 4235, 4272, 4292, 4311, 4438], 'Scholar).': [417, 513, 562, 636, 718, 823, 865, 910, 993, 1047, 1081, 1221, 1284, 1320, 2683, 2796, 3111, 3156, 3444, 3555, 3621, 3863, 4077, 4161, 4236, 4312], 'More': [418], 'than': [419, 1781, 2264, 2374, 2830], 'two': [420, 3016], 'dozen': [421], 'MMPs': [422, 451, 2643, 3322, 3336, 3455], 'have': [423, 997, 1086, 2904, 3176, 3648, 3714, 3752, 3884, 4080, 4362], 'been': [424, 577, 582, 645, 1740, 2738, 2761, 3085, 3338, 3490, 3715, 3996], 'identified': [425, 3086, 3716], 'so': [426, 3717], 'far.': [427], 'Based': [428], 'their': [430, 468, 479, 2641, 3347], 'substrate': [431], 'specificities': [432], 'they': [433, 1718], 'divided': [436], 'number': [439, 1797, 3296, 3396, 4003], 'groups,': [441], 'which': [442, 771, 2009, 2448, 2625, 2759, 3349, 3480, 3663, 3945, 4016, 4169], 'include': [443, 4349], 'collagenases,': [444], 'stromelysins,': [445], 'gelatinases,': [446], 'membrane-type': [448, 482], 'MMPs.': [449, 754], 'secreted': [453, 2217], 'pro-enzymes': [455], 'only': [458, 2744, 3708], 'activated': [460], 'cleavage': [462, 3652], 'short': [465], 'peptide': [466], 'from': [467, 661, 1194, 1293, 1327, 1342, 1792, 2335, 2340, 2366, 2408, 2963, 2971, 3351, 3588], 'N-terminal': [469], 'ends': [470], 'plasmin': [472], 'one': [477, 570, 757], 'own': [480], 'members,': [481], '1': [483, 1845, 1847, 1853, 1857, 1905, 1908, 1917, 1921, 1935, 1945, 1951, 1959, 1963, 2051, 2054, 2064, 2071], '(MT-MMP-1)': [486], '(2Murphy': [487], 'G.': [488, 494, 3630, 4426], 'Stanton': [489], 'H.': [490, 899, 2776, 3731, 4063, 4222, 4275], 'Cowell': [491], 'S.': [492, 498, 618, 901, 3379, 4301, 4418], 'Butler': [493], 'Knauper': [495], 'V.': [496, 3632, 3636], 'Atkinson': [497], 'Gavrilovic': [499], 'J.': [500, 622, 703, 813, 1071, 1211, 1215, 1274, 1310, 2781, 3237, 3423, 3509, 3606, 3637, 3736, 3806, 3853, 4055, 4061, 4148, 4214, 4220, 4278, 4297, 4429], 'Acta': [501], 'Pathol.': [502, 818, 1216], 'Microbiol.': [503], 'Immunol.': [504], 'Scand.': [505], '1999;': [506, 2784, 3739], '107:': [507], '38-44Crossref': [508], '(385)': [511], 'MMP': [514, 573], 'tightly': [517], 'coordinated': [518], 'at': [519, 1239, 1384, 1452, 1534, 1599, 1714, 1881, 1931, 1971, 1978, 2039, 2140, 2699, 3686, 3973], 'several': [520, 3493, 4195], 'including': [522, 4007, 4198], 'transcriptional': [523], 'regulation,': [524, 915], 'activation': [525, 4093, 4142], 'latent': [527, 1459, 1461], 'zymogen,': [528], 'interaction': [530, 3912], 'with': [531, 1230, 1412, 1418, 1655, 1727, 1742, 1869, 2026, 2035, 2088, 2189, 2267, 2346, 2452, 2524, 2590, 2968, 3394, 3913, 3921, 4203], 'endogenous': [532, 2638, 4400], 'inhibitors': [533], 'Scholar,': [548, 616, 688, 797, 2669, 3377, 3432, 3524, 3543, 4049, 4273, 4293], '3Brown': [549, 2670], 'P.D.': [550, 2671, 3417], 'Breast': [551, 2672], 'Cancer': [552, 2673], 'Res.': [553, 608, 682, 2674, 3436], 'Treat.': [554, 2675], '1998;': [555, 903, 2676, 3437, 3856], '52:': [556, 2677], '125-136Crossref': [557, 2678], '(91)': [560, 2681], '(gelatinase': [564], 'A,': [565], 'type': [566, 776], 'IV': [567], 'collagenase)': [568], 'members': [574, 3326], 'has': [576, 581, 644, 1134, 2736, 2760, 3083, 3337, 3489, 3994], 'extensively': [578], 'play': [585, 948, 3207], 'role': [588, 951, 3209, 3577, 3837, 4397], 'increasing': [590], 'migration,': [595, 742, 1056, 3465], 'remodeling,': [597], 'tumor': [599, 3402], 'metastasis': [600], '(4Li': [601], 'Y.Y.': [602], 'McTiernan': [603], 'C.F.': [604], 'Feldman': [605], 'A.M.': [606], 'Cardiovasc.': [607], '2000;': [609, 624, 1040, 1074, 1277, 1313, 3240, 3384, 3536, 3640, 4065, 4224], '46:': [610], '214-224Crossref': [611], '(377)': [614], '5Curran': [617], 'Murray': [619, 3799], 'G.I.': [620], 'Eur.': [621], 'Cancer.': [623], '36:': [625], '1621-1630Abstract': [626], 'Full': [627, 629, 709, 711, 2787, 2789, 3515, 3517, 3612, 3614, 3742, 3744, 4068, 4070, 4130, 4227, 4229, 4266, 4284, 4286], 'Text': [628, 630, 710, 712, 2788, 2790, 3516, 3518, 3613, 3615, 3743, 3745, 4069, 4071, 4131, 4228, 4230, 4267, 4285, 4287], 'PDF': [631, 713, 2791, 3519, 3616, 3746, 4072, 4132, 4231, 4268, 4288], '(506)': [634], 'In': [637, 719, 1082, 2075, 2797, 3036, 3293, 3669, 3693, 3864, 4355], 'studying': [638], 'occlusive': [639], 'disease,': [641, 4409], 'much': [642, 2905], 'attention': [643], 'focused': [646], 'expression': [650, 867, 1257, 2572, 2610, 2694, 2698, 2774, 3258, 3771, 3794, 3978, 4333], 'its': [652, 837, 2697, 3140, 4201, 4446], 'ability': [653], 'intima': [660, 3591], 'original': [663], 'media': [664, 729, 1348, 1360, 2167, 2178, 2192, 2211, 2256, 2343, 2391, 3589], 'after': [665, 3486, 4415], 'either': [666, 1139], 'inflammatory': [667, 3778], 'or': [668, 1006, 1145, 2338], 'mechanical': [669], 'injury': [670, 874], 'wall': [674], '(6Newby': [675], 'A.C.': [676, 3804], 'Southgate': [677], 'K.M.': [678], 'Davies': [679], 'M.': [680, 696, 1067, 1209, 1270, 1306, 3233, 3502, 3599, 4121, 4125, 4146, 4424], 'Basic': [681], 'Cardiol.': [683], '89:': [685, 3385], '59-70PubMed': [686], '7Zempo': [689], 'Kenagy': [691, 3497, 3594], 'R.D.': [692, 3498, 3595], 'Au': [693, 3499, 3596], 'Y.P.': [694, 3500, 3597], 'Bendeck': [695, 3501, 3598], 'Clowes': [697, 701, 3503, 3507, 3600, 3604], 'M.M.': [698, 3504, 3601], 'Reidy': [699, 3505, 3602], 'M.A.': [700, 3506, 3603], 'A.W.': [702, 3508, 3605], 'Vasc.': [704, 856, 3166, 3510, 3607], 'Surg.': [705, 3424, 3511, 3608], '20:': [707, 3513, 3610], '209-217Abstract': [708, 3514, 3611], '(249)': [716, 3522, 3619], 'vessels,': [721], 'reside': [726], 'embedded': [732], 'immobilized': [736], 'ECM.': [739], 'During': [740, 3566], 'surrounding': [744], 'ECM': [745, 954, 1060, 3120, 4205], 'barriers': [746], 'must': [747], 'first': [748, 2162], 'degraded': [750], 'removed': [752], 'major': [760, 1136, 4091], 'ECM-degrading': [761], 'proteases': [762], 'shown': [765, 998, 2762, 3013, 3649, 3753, 3826, 3885, 4018, 4081], 'specifically': [766, 2763], 'basement': [769, 3353, 3580], 'membrane,': [770], 'consists': [772, 2021], 'mainly': [773, 3197], 'collagen': [775], 'IV,': [777], 'laminin,': [778, 3359], 'proteoglycans': [780], '(8Knox': [781], 'J.B.': [782], 'Sukhova': [783], 'G.K.': [784], 'Whittemore': [785], 'A.D.': [786], 'Libby': [787], 'P.': [788, 3850], 'Circulation.': [789, 902, 3535], '1997;': [790, 858, 986, 3104, 3149, 3168, 3425, 3876], '95:': [791], '205-212Crossref': [792], '(267)': [795], '9Li': [798], 'Z.': [799, 3382], 'Li': [800], 'L.': [801, 805, 4428], 'Zielke': [802], 'H.R.': [803, 3545], 'Cheng': [804], 'Xiao': [806], 'R.': [807, 3532, 3852, 4059, 4106, 4123, 4218], 'Crow': [808], 'M.T.': [809], 'Stetler-Stevenson': [810], 'W.G.': [811], 'Froehlich': [812], 'Lakatta': [814], 'E.G.': [815], 'Am': [816], 'J': [817], '1996;': [819, 3807, 4281], '148:': [820, 3641], '121-128PubMed': [821], 'restenotic': [831], 'lesions,': [832, 3202], 'inhibition': [835], 'synthetic': [840, 1817, 2979], 'compounds': [841], 'greatly': [842], 'reduces': [843], 'neointima': [844, 1172], 'formation': [845, 3002, 3485], '(10George': [846], 'S.J.': [847], 'Johnson': [848, 3529], 'J.L.': [849], 'Angelini': [850], 'G.D.': [851], 'Jeremy': [852], 'J.Y.': [853], 'Arterioscler.': [854, 3164], 'Thromb.': [855, 3165, 3546], 'Biol.': [857, 1073, 1276, 1312, 2782, 3167, 3239, 3639, 3737, 3855, 3875, 4153, 4279], '17:': [859], '2500-2506Crossref': [860], '(29)': [863], 'up-regulated': [871], 'low': [876], 'blood': [877, 888, 3185], 'flow': [878, 889], 'conditions': [879, 1581], 'down-regulated': [882], 'cellular': [884], 'differentiation': [885], 'high': [887], '(11Bassiouny': [890], 'H.S.': [891], 'Song': [892], 'R.H.': [893], 'Hong': [894], 'X.F.': [895], 'Singh': [896], 'A.': [897, 4035], 'Kocharyan': [898], 'Glagov': [900], '98:': [904], '157-163Crossref': [905], '(128)': [908], 'however,': [916], '38-kD': [926], 'immediate': [927], 'early': [928], 'gene': [929, 942, 2773, 4382], 'product': [930], 'belongs': [932], 'recently': [935, 3084], 'described': [936, 1201, 1265, 1301], 'structurally': [938], 'related': [939], 'CCN': [940], '(CTGF/Cyr16/Nov)': [941], 'family.': [943], 'suggested': [946], 'remodeling': [955], 'occurs': [957], 'physiological': [960], 'processes': [961, 3461, 4197], 'such': [962, 1013, 3356, 3400, 3462], 'embryogenesis,': [964, 3834], 'implantation,': [965], 'wound': [967, 3126], 'healing': [968], 'fibrosis': [973], 'scarring': [975], '(see': [976, 1029], 'review': [977, 1030], 'Ref.': [979, 1032], '12Grotendorst': [980], 'G.R.': [981, 3099, 3144], 'Cytokine': [982, 3100, 3145], 'Growth': [983, 3101, 3146], 'Factor': [984, 3102, 3147], 'Rev.': [985, 3103, 3148], '8:': [987, 3105, 3150, 3438], '171-179Crossref': [988, 3106, 3151], '(671)': [991, 3109, 3154], 'However,': [994, 2602, 2907, 3775], 'recent': [995], 'advances': [996], 'diverse': [1004], 'autocrine': [1005], 'paracrine': [1007], 'actions': [1008], 'many': [1010, 2646], 'types': [1012], 'endothelial': [1016, 4011], 'cells,': [1017, 1019, 1021, 2290, 2822, 3944], 'epithelial': [1018], 'neuronal': [1020], 'VSMC,': [1022], 'supportive': [1026], 'skeletal': [1027], 'tissues': [1028], '13Moussad': [1033], 'E.E.': [1034], 'Brigstock': [1035], 'D.R.': [1036], 'Mol.': [1037, 4151], 'Genet.': [1038], 'Metab.': [1039], '71:': [1041], '276-292Crossref': [1042], '(441)': [1045], 'previously': [1049, 1266, 1302, 3218], 'promotes': [1053], 'proliferation,': [1055, 3784], 'production': [1058, 3122], 'culture': [1063], '(14Fan': [1064, 1267, 1303, 3230], 'W.H.': [1065, 1268, 1304, 3231], 'Pech': [1066, 1269, 1296, 1305, 3232, 4472], 'Karnovsky': [1068, 1212, 1271, 1307, 3234], 'M.J.': [1069, 1213, 1272, 1308, 3235], 'Eur': [1070, 1273, 1309, 3236], 'Cell': [1072, 1185, 1275, 1311, 3238, 3435, 3638, 3854], '79:': [1075, 1278, 1314, 3241], '915-923Crossref': [1076, 1279, 1315, 3242], '(118)': [1079, 1282, 1318, 3245], 'study,': [1084, 2799, 3251], 'we': [1085, 2150, 2292, 2486, 2603, 2800, 2854, 3252, 3308, 4361], 'increases': [1091, 2372, 2433, 3025, 3256], 'medium,': [1099], 'result': [1105, 2481, 3285], 'rising': [1107], 'level': [1108, 2425, 2466, 2478, 2702, 2844, 3289, 3938, 3953, 4366], 'mRNA.': [1111, 3292], 'cycloheximide,': [1119], 'indicating': [1120, 3203], 'protein': [1122, 1287, 1506, 1988, 2279, 2304, 2321, 2410, 2457, 2578, 3121, 4117, 4139], 'synthesis': [1123, 2579, 4238], 'required': [1125], 'effect.': [1128, 2906], 'no': [1135, 2275, 2717], '(TIMP-2)': [1144], 'MMP-9.': [1146], 'Moreover,': [1147], 'seems': [1153], 'mediated': [1156, 1182, 3689], 'AP-2.': [1161], 'intimately': [1165], 'promoting': [1168, 3583], 'during': [1171, 3833], 'formation,': [1173], 'results': [1175, 2812], 'suggest': [1176], 'MMP-2.': [1184, 3967, 3990, 4184], 'Culture,': [1186], 'Plasmid,': [1188], 'Other': [1190, 3968], 'Reagents—VSMC': [1191], 'were': [1192, 1223, 1251, 1264, 1291, 1300, 1361, 1373, 1409, 1434, 1471, 1514, 1530, 1609, 1682, 1697, 1712, 1725, 1768, 1808, 1827, 1832, 1862, 1891, 1926, 1967, 1983, 2102, 2138, 2333, 2519, 2826, 3019, 3023, 3054, 3225, 4017], 'isolated': [1193, 1522], 'abdominal': [1195], 'aortas': [1196], 'Sprague-Dawley': [1198], 'rats': [1199], '(15Pukac': [1202], 'L.A.': [1203], 'Hirsch': [1204], 'G.M.': [1205], 'Lormeau': [1206], 'J.C.': [1207], 'Petitou': [1208], 'Choay': [1210], 'Am.': [1214], '1991;': [1217, 4263], '139:': [1218], '1501-1509PubMed': [1219], 'Cells': [1222, 1245, 1513, 1831], 'cultured': [1224, 2508], '20%': [1226], 'fetal': [1227], 'calf': [1228], 'serum/RPMI': [1229], 'penicillin,': [1231], 'streptomycin,': [1232], 'fungizone': [1234], 'humidified': [1237], 'atmosphere': [1238], '37': [1240, 1385, 1715], '°C': [1241, 1386, 1601, 1716, 1933], '5%': [1243, 1431], 'CO2.': [1244], 'between': [1246, 1436, 2283, 2720], 'passages': [1247], '7': [1248], '13': [1250], 'used': [1252, 1569, 1582, 1632, 1809, 2082, 2293, 2487, 2855, 2976], 'experiments.': [1255, 2368], 'plasmid': [1258, 1790], 'construction': [1259], 'transfection': [1262, 2460], 'methods': [1263], 'Recombinant': [1285], 'antibody': [1290, 1340, 2237, 2556, 2622], 'gifts': [1292], 'Dr.': [1294, 1328, 4470], 'Michael': [1295, 4471], '(Hoffmann-La': [1297], 'Roche)': [1298], 'cDNA': [1322], 'probe': [1323, 2005, 2032], 'gift': [1326, 4483], 'Jo': [1329], 'Louise': [1330], 'Seltzer': [1331], 'Washington': [1333], 'University': [1334], '(St.': [1335], 'Louis,': [1336], 'MO).': [1337], 'Anti-MMP-2': [1338], 'monoclonal': [1339, 2236, 2350], 'Sigma.': [1343], 'determined': [1350, 1984, 3277, 3309, 3339], 'zymography.': [1352, 2170], 'For': [1353, 1658, 1721], 'each': [1354, 1485, 1722, 1760], 'sample': [1355], '30': [1356, 2593], 'μl': [1357], 'loaded': [1362], 'onto': [1363, 1553, 1735], 'precast': [1365], 'SDS-PAGE': [1366], 'containing': [1367, 1391], '0.1%': [1368, 1870], 'gelatin.': [1369], 'After': [1370], 'electrophoresis,': [1371], 'gels': [1372, 1408, 1470], 'washed': [1374], '2.5%': [1376], 'Triton': [1377], 'X-100': [1378], '3': [1380], 'h': [1381, 1930], 'incubated': [1383, 1426, 1713, 1769, 1863, 1873, 2087], 'low-salt': [1388], 'collagenase': [1389], 'buffer': [1390, 1579, 1837, 1894, 1938, 2044], '50': [1392], 'mmol/liter': [1393], 'Tris,': [1394], '0.2': [1395], 'mol/liter': [1396], 'NaCl,': [1397, 1901], '5': [1398], 'mmol/': [1399], 'liter': [1400, 1936], 'anhydrous': [1401], 'CaCl2,': [1402], '0.02%': [1404], 'Brij': [1405], 'detergent.': [1406], 'subsequently': [1410], 'stained': [1411, 1801], '0.5%': [1413], 'Coomassie': [1414], 'Blue': [1415], '(G-250),': [1416], 'destained': [1417], '30%': [1419, 1428], 'methanol': [1420, 1429], '10%': [1422, 2062], 'acetic': [1423], 'acid,': [1424], 'glycerol.': [1432], 'They': [1433], 'dried': [1435], 'cellophane': [1437], 'sheets.': [1438], 'Areas': [1439], 'gelatinase': [1441, 1511], 'appeared': [1443], 'nonstaining': [1445], 'bands': [1446, 1451, 3028], 'gels.': [1449], 'Gelatinolytic': [1450], '92,': [1453], '72,': [1454], '62': [1456], 'kDa': [1457], 'represent': [1458, 2356], 'MMP-2,': [1460, 2921, 3307], 'MMP-9,': [1462], 'active': [1464], 'activity,': [1466], 'respectively.': [1467], 'zymography': [1469], 'scanned': [1472, 2113], 'analyzed': [1474], 'densitometrically': [1475], 'using': [1476, 1561, 1702, 1985, 1996, 2114, 2168, 2232], 'Molecular': [1477, 2116], 'Dynamics': [1478, 2117], 'ImageQuant': [1479], 'software.': [1480], 'image': [1482, 2417], 'density': [1483], 'gelatinolytic': [1486], 'band': [1487], 'recorded': [1489], 'reported': [1491, 1509, 3491], 'volume': [1493], 'units': [1494], 'pixel': [1496], 'intensity': [1497], '×': [1498, 1883, 1973], 'mm2.': [1499], 'Each': [1500], 'value': [1501], 'normalized': [1503, 1619], 'against': [1504, 1630, 1934, 2859], 'concentration': [1507, 1747], 'activity.': [1512, 2272, 3692], 'lysed': [1515], 'RNAzolTM,': [1517], 'total': [1519, 2306, 2384], 'RNA': [1520, 1528, 1540, 1575], 'according': [1523], "vendor's": [1526], 'instructions.': [1527], 'samples': [1529], 'quantitated': [1531, 1611], 'absorbance': [1533], '260': [1535], 'nm.': [1536], '20': [1537, 1842], 'μg': [1538, 1754, 2065, 2072], 'separated': [1542], '1%': [1545], 'agarose,': [1546], '1.1': [1547], 'm': [1548], 'formaldehyde': [1549], 'gel': [1550, 2110, 2993], 'blotted': [1552], 'nitrocellulose': [1554], 'membranes.': [1555], 'hybridization': [1557, 1578], 'carried': [1559], 'out': [1560], '32P-labeled': [1562], 'GAPDH': [1565, 1567, 1622], 'probes.': [1566], 'control': [1572, 1647, 2727, 2835, 2900, 2973, 4389], 'normalize': [1574], 'loading.': [1576], 'experiments': [1585, 2137], 'were:': [1586, 1636], '2×': [1587], "Denhardt's,": [1588], '50%': [1589], 'formamide,': [1590], '100': [1591, 1751], 'μl/ml': [1592], 'herring': [1593], 'sperm': [1594, 2068], 'DNA,': [1595, 2069], '0.25%': [1597], 'SDS': [1598], '42': [1600], 'incubation': [1602], '12': [1604], 'h.': [1605], 'densitometry': [1613, 2121], 'signals': [1617], 'levels.': [1623], 'sequences': [1625, 3916], 'phosphorothioate': [1627], 'oligonucleotides': [1628, 1818, 2001], '(ODN)': [1629], '5′-CGTCAATTTCCAAAGCAT': [1637], 'TTTCATGGATCGG-3′': [1638], '(−13': [1639], '+18': [1641], 'sequence).': [1645], 'oligonucleotide,': [1648], '5′-CAAAGTCTTGCAT': [1649], 'TATTCGGTCATAATGGCC-3′,': [1650], 'consisted': [1651], 'similar': [1653, 2651], 'nucleotides': [1654], 'scrambled': [1656, 2024], 'sequences.': [1657, 3929], 'RT-PCR': [1659], 'amplification': [1660], 'mRNA,': [1663, 2515, 2541, 2886], 'primers': [1664], '5-CCC': [1665], 'AAG': [1666], 'CCA': [1667], 'TAG': [1668], 'CTC': [1669], 'GAG': [1670], 'ACT': [1671], 'C-3′': [1672], '5-GAA': [1674], 'GTC': [1675], 'ACA': [1676], 'GAT': [1677], 'TTG': [1678], 'GGA': [1679], 'GGG': [1680], 'A-3′': [1681], 'used,': [1683], 'resulting': [1684], '531-bp': [1687], 'fragment': [1688, 2020, 2981, 3050, 3061], 'spanning': [1689], 'residues': [1690], '66–597': [1691], 'cDNA.': [1694], 'Purified': [1695], 'ODNs': [1696, 1724, 1749], 'introduced': [1698], 'cationic': [1704], 'liposome': [1705], 'reagent,': [1706], 'Lipofectin': [1707, 1728, 1756], '(Invitrogen).': [1708], 'Briefly,': [1709], 'until': [1717], 'reached': [1719], 'confluency.': [1720], 'transfection,': [1723], 'mixed': [1726, 2034], 'reagent': [1729], 'serum-free': [1731, 1743], 'medium': [1732, 2313], 'overlaid': [1734], 'had': [1739], 'rinsed': [1741], 'final': [1746], 'μm;': [1752], '2': [1753, 1929, 2253], 'added': [1758], '6-multi-well': [1764], 'plate.': [1765], 'overnight.': [1770], 'Transfection': [1771], 'efficiency': [1772], 'assayed': [1774], 'routinely': [1776], 'more': [1780, 2263], '50%.': [1782], 'This': [1783, 3445], 'done': [1785], 'co-transfecting': [1787], 'β-galactosidase': [1789], '(pRSV-βGal': [1791], 'Promega)': [1793], 'determining': [1795], 'blue': [1802], '(Promega': [1803], 'protocol).': [1804], 'Mobility': [1805], 'shift': [1806, 2995], 'assays': [1807], 'determine': [1811, 2998], 'binding': [1812, 1822, 1992, 1998, 2043, 2938, 2956, 2987, 3070, 3720, 3755], 'extract': [1814, 1991, 2038, 2308, 2386, 2962, 2970], 'representing': [1819], 'site.': [1823], 'nuclear': [1825, 1889, 2037, 2090, 2961], 'extracted': [1828, 2334], 'follows.': [1830], 'pelleted': [1833], 'resuspended': [1835, 1892], 'A': [1838, 4119], '(10': [1839, 1896], 'mm': [1840, 1843, 1848, 1854, 1858, 1897, 1900, 1903, 1906, 1909, 1912, 1918, 1943, 1946, 1949, 1952, 1960, 1964, 2046, 2049, 2052, 2055, 2058], 'KCl,': [1841, 1944, 2047], 'HEPES,': [1844, 1898], 'mmMgCl2,': [1846], 'DTT,': [1849, 1910, 1953, 2056], '0.4': [1850, 1911, 1954], 'mmphenylmethylsulfonyl': [1851, 1955], 'fluoride,': [1852, 1856, 1914, 1920, 1956, 1962], 'sodium': [1855, 1919, 1961], 'Na3VO4).': [1859, 1965], 'Samples': [1860], 'then': [1861, 2112], 'ice': [1865, 1875], '10': [1867, 1877, 1886, 2057], 'min': [1868, 1977, 2594], 'Nonidet': [1871], 'P-40,': [1872], 'min,': [1878], 'centrifuged': [1880], '3,000': [1882], 'g': [1884, 1974], 'min.': [1887], 'pellets': [1890], 'B': [1895, 2365, 4100], '400': [1899], '0.1': [1902, 1948], 'EDTA,': [1904, 1950, 2053], 'MgCl2,': [1907, 1947, 2050], 'phenylmethylsulfonyl': [1913], '15%': [1915, 1957], 'glycerol,': [1916, 1958, 2063], 'mmNa3VO4),': [1922], 'extracts': [1925, 2091], 'dialyzed': [1927], '4': [1932, 1979], 'C': [1939, 2352, 4141], '(20': [1940], 'mmHEPES,': [1941], '200': [1942], 'Extracts': [1966], 'cleared': [1968], 'centrifugation': [1970], '14,000': [1972], '15': [1976], '°C.': [1980], 'Protein': [1981], 'concentrations': [1982], 'Bio-Rad': [1987], 'assay.': [1989], 'Nuclear': [1990], 'assay': [1993, 2996], 'performed': [1995, 2139, 2991], 'site': [1999, 2959, 3073], 'double-stranded': [2000], 'probe.': [2003, 2097], 'sequence': [2006, 2015, 2025, 2988], 'included': [2007], '5′-CCCCAGCCCCGCTCTGCCAGCT-3′,': [2008], 'corresponds': [2010], 'promoter': [2014, 2947, 3724, 3759, 3919], '66–44.': [2016], 'nonspecific': [2018, 3060], 'competing': [2019], 'same': [2028], 'nucleotide': [2029], 'composition.32P-labeled': [2030], 'room': [2040], 'temperature': [2041], '(50': [2045], '2.5': [2048], 'Tris-Cl': [2059], '(pH': [2060], '7.5),': [2061], 'salmon': [2067], 'poly(dI-dC)).': [2074], 'competition': [2076], 'assay,': [2077], 'unlabeled': [2079, 3048, 3059], 'DNA': [2080, 2101, 2980], 'competitor': [2084], 'before': [2092, 2220], 'addition': [2094, 2548], 'labeled': [2096, 2978], 'Bound': [2098], 'free': [2100], 'resolved': [2103], 'electrophoresis': [2105], 'through': [2106, 4200], 'regular': [2108], 'polyacrylamide': [2109], 'PhosphorImager': [2118], 'system.': [2119], 'All': [2120], 'data': [2122, 2360, 2712], 'presented': [2124], 'mean': [2127], '±': [2128, 2361], 'standard': [2130, 2169], 'error': [2131], 'about': [2132, 2827, 2879], 'mean,': [2134], 'all': [2136], 'least': [2141, 3687], 'three': [2142, 2367, 4090], 'times.': [2143], 'To': [2144, 2472, 2838], 'functions': [2147, 3453], 'CTGF,': [2149, 2485], 'stably': [2151], 'transfected': [2152, 2289], 'measured': [2163], 'observed': [2172, 2605, 3253], 'there': [2179, 2715, 2742, 2952, 3022, 3706, 3908], 'approximate': [2182], '3-fold': [2183], 'compared': [2188, 2967], 'untransfected': [2190, 2285, 2438], '(Fig.': [2193, 2212, 2238, 2252, 2470, 2729, 3051], '1).': [2194], 'pro-enzyme': [2208, 2219, 2225], '2).': [2213, 2239], 'being': [2221], 'activated,': [2222], 'detected': [2227], 'Western': [2229, 2300], 'analysis': [2230], 'specific': [2234, 2349, 2554, 3075], 'anti-pro-MMP-2': [2235], 'both': [2248, 2294, 2379, 2816, 4014], 'A)': [2254], '(Fig.2': [2257], 'B)': [2258], 'over': [2259, 2436], 'controls': [2261, 2441], '3-fold,': [2265], 'comparable': [2266, 2523], 'There': [2273, 2369], 'apparent': [2276], 'differences': [2277], 'vector': [2288, 2393, 2440, 2834], 'controls.Figure': [2296], '2A': [2297], 'B,': [2299], 'analyses': [2301], '(A)': [2309], '(B)': [2314], 'demonstrating': [2315], 'visible': [2317], 'media.': [2330], 'Total': [2331], 'growth-arrested': [2336], 'precipitated': [2339], 'probed': [2345], 'D,': [2354], 'graphs': [2355], 'average': [2358, 2444], 'densitometric': [2359], 'S.E.': [2362, 4144], 'forA': [2363], 'significant': [2371, 2718], '(more': [2373], '3-fold)': [2375], 'versus': [2392], 'control.': [2394, 3011], 'inhibitory': [2396], 'antibody,': [2400], 'AP-1': [2401, 3887, 3900], 'antisense': [2402, 2857, 2872, 2912, 3959], 'oligo,': [2403], 'cycloheximide': [2405, 2591], 'evident': [2407], 'levels.View': [2411], 'Large': [2412], 'Image': [2413], 'Figure': [2414, 2532, 2534, 2558, 2560, 2562, 2596, 2598, 2600, 2892, 2894, 2896], 'ViewerDownload': [2415], 'Hi-res': [2416], 'Download': [2418], '(PPT)': [2419], 'examined': [2422, 2696, 2936], '3.5-fold': [2446], '(Fig.3),': [2447], 'consistent': [2451], 'level.': [2458], 'Vector': [2459], 'alone': [2461, 3901, 3982], 'does': [2462, 2614, 3902, 3983], 'change': [2464], '3).': [2471, 2535, 2563, 2601], 'confirm': [2473, 2839, 3066], 'recombinant': [2489, 2502, 4486], 'treat': [2492, 2864, 4458], 'adding': [2499], '(25': [2504], 'ng/ml)': [2505], '6': [2511], 'h,': [2512], 'antigen,': [2516, 2887], 'those': [2525], '(Figs.Figure': [2530], '1,': [2531, 2559, 2597, 2893], '2,': [2533, 2561, 2599, 2895], 'Furthermore,': [2536], 'protein,': [2542], '(Figs.': [2557, 2595, 2891], 'tested': [2566], 'whether': [2567, 2802, 4328, 4344], 'requires': [2575], 'de': [2576], 'novo': [2577], 'induction': [2584, 3988, 4087, 4176], 'inhibited': [2587], 'pretreatment': [2589], 'basal': [2608], 'show': [2616, 2713, 2813], 'marked': [2618, 3024], 'decrease': [2619], '(not': [2623], 'shown),': [2624], 'because': [2628, 3956, 3979], 'different': [2630, 3818], 'regulates': [2632], 'constitutive': [2633, 3770], 'expression.': [2635, 2810, 2933, 3317, 3899], 'TIMPs': [2636], 'antagonists': [2639], 'corresponding': [2642, 3271], 'cases': [2647], 'regulated': [2649, 4369], 'inducers': [2652], 'repressors': [2654], 'explored': [2686], 'possible': [2688, 3298], 'TIMP-2': [2693], 'protein-treated': [2709], 'cells.': [2710, 2974, 3035, 3081, 3774], 'Our': [2711, 2811], 'changes': [2719], '4).': [2730], 'completely': [2739, 2916, 3985], 'defined,': [2740], 'few': [2746, 3710], 'factors': [2748, 2925, 3300, 3411, 3712, 3763, 3924, 3969], 'reportedly': [2749], 'involved.': [2750], 'One': [2751], 'them': [2753], 'AP-2,': [2758], 'bind': [2765, 3926], 'regulatory': [2768, 3819, 4402], 'region': [2769, 2948], 'activate': [2771], '(16Qin': [2775, 3730], 'Sun': [2777, 3732], 'Benveniste': [2779, 3734], 'E.N.': [2780, 3735], 'Chem.': [2783, 3738, 4280], '274:': [2785, 3740], '29130-29137Abstract': [2786, 3741], '(257)': [2794, 3749], 'investigated': [2801], 'mediates': [2804], 'action': [2806], 'up-regulating': [2808], 'CTGF-treated': [2821, 3034, 3080], '2-fold': [2828], 'higher': [2829], '(Fig.5).': [2837], 'levels,': [2853], 'oligo': [2858, 2873, 2901, 2913, 3960], 'CTGF-transfected': [2866], 'effective': [2875], 'block': [2878, 2917, 4454], '75%': [2880], '3),': [2897], 'whereas': [2898], 'did': [2902, 2914], 'use': [2909], 'suggesting': [2922, 3815], 'CTGF-regulated': [2931], 'activities': [2939, 4383], 'element': [2943], 'enhanced': [2955], 'contains': [2983], 'consensus': [2985], '(5′-CCCCACCCCGCTGCCAGCT-3′)': [2989], 'mobility': [2994], 'DNA-protein': [3000, 3017], 'complex': [3001, 4379], 'over-expressing': [3005, 3031], 'As': [3012], 'Fig.6,': [3015], 'complexes': [3018, 3039], 'detected,': [3020], 'shifted': [3027], 'addition,': [3037], 'competed': [3042], 'away': [3043], 'excess': [3046], '6)': [3052], 'affected': [3056], '(GATA': [3062], 'fragment).': [3063], 'These': [3064], 'findings': [3065], 'novel': [3089], 'mitogen': [3090], 'endothelial,': [3092], 'muscle,': [3094], 'fibroblast': [3096, 3405], '(12Grotendorst': [3098, 3143], 'It': [3112], 'thus': [3124], 'repair': [3127], 'fibrosis.': [3129], 'strongly': [3132], 'induced': [3133], 'TGF-β': [3135, 3824, 4208, 4246, 4256, 4335, 4393], 'serve': [3138], 'downstream': [3141], 'effector': [3142], 'Oemar': [3157], 'Luscher': [3159, 3162], '(17Oemar': [3160], 'B.S.': [3161], 'T.F.': [3163], ':': [3169], '1483-1489Crossref': [3170], '(148)': [3173], 'Scholar)': [3175, 3391, 3647, 3751, 3883, 4439], 'rarely': [3181], 'detectable': [3182], 'vessels': [3186], 'overexpressed': [3189], 'lesions.': [3192, 3565], 'overexpression': [3194], 'it': [3205, 3677, 4321], 'development': [3212, 3475, 3568, 4027, 4462], 'progression': [3214], 'atherosclerosis.': [3216], 'stimulated': [3226], 'Scholar),': [3247, 3814, 4115, 4137], 'culture;': [3263], 'accompanied': [3268], 'TIMP-2.': [3274], 'elevated': [3280], 'searching': [3294], 'might': [3302], 'mediate': [3303], 'expanding': [3319], 'now': [3323], 'comprises': [3324], '25': [3325], 'zinc-dependent': [3329], 'metallopeptidases.': [3330], 'pathophysiological': [3332, 4196], 'importance': [3333, 4375], 'gradually,': [3340], 'based': [3341], 'growing': [3344], 'list': [3345], 'functions,': [3348], 'range': [3350], 'degrading': [3352, 3579], 'membrane': [3354, 3581], 'constituents': [3355], 'fibronectin,': [3358], 'collagen,': [3360], 'elastin': [3362], '18Lamparter': [3378], 'Maisch': [3380], 'B.': [3381], 'Kardiol.': [3383], '949-957Crossref': [3386], '(7)': [3389], 'interacting': [3393], 'nonmatrix': [3398], 'necrosis': [3403], 'factor-β,': [3404], 'receptor-1,': [3408], 'angiogenic': [3410], '(19Parsons': [3412], 'S.L.': [3413], 'Watson': [3414], 'S.A.': [3415], 'Brown': [3416], 'Collins': [3418], 'H.M.': [3419, 4150], 'Steele': [3420], 'R.J.': [3421], 'Br.': [3422], '84:': [3426], '160-166Crossref': [3427], '(333)': [3430], '20Sang': [3433], 'Q.X.': [3434], '171-177Crossref': [3439], '(244)': [3442], 'wide': [3446], 'reflects': [3450], 'multiple': [3452], 'regulating': [3457, 4255], 'biological': [3458], 'pathological': [3460], 'differentiation,': [3466], 'atherogenesis.': [3468], 'involvement': [3470], 'atherosclerosis': [3477], 'restenosis,': [3479], 'characterized': [3482], 'lesion': [3484, 3567], 'arterial': [3487], 'injury,': [3488, 3572], 'studies': [3494, 3623, 4079, 4163], '(7Zempo': [3495, 3592], '21Godin': [3525], 'D.': [3526], 'Ivan': [3527], 'E.': [3528, 4259], 'C.': [3530], 'Magid': [3531], 'Galis': [3533], 'Z.S.': [3534], '102:': [3537], '2861-2866Crossref': [3538], '(178)': [3541], '22Lijnen': [3544], 'Haemostasis.': [3547], '2001;': [3548, 4042], '86:': [3549], '324-333Crossref': [3550], '(408)': [3553], 'Increased': [3556], 'around': [3563], 'experimental': [3570], 'balloon': [3571], 'plays': [3574, 3840, 4394], 'key': [3576], 'Mechanistic': [3622], 'Koshikawaet': [3625], 'al.': [3626, 3729], '(23Koshikawa': [3627], 'Giannelli': [3629], 'Cirulli': [3631], 'Miyazaki': [3633], 'K.': [3634], 'Quaranta': [3635], '615-624Crossref': [3642], '(545)': [3645], 'laminin-5': [3654], 'exposes': [3657], 'cryptic': [3658], 'promigratory': [3659], 'sites': [3660], 'laminin-5,': [3662], 'turn': [3665], 'triggers': [3666], 'motility.': [3668], 'light': [3670], 'previous': [3673], 'current': [3675, 4359], 'results,': [3676], 'conceivable': [3679], 'CTGF-initiated': [3682], 'pro-migratory': [3683], 'partially': [3688], 'contrast': [3694], 'functional': [3696], 'characterization,': [3697], 'inadequately': [3704], 'delineated;': [3705], 'far': [3718], 'region.': [3725], 'Qin': [3726], 'et': [3728], 'area': [3760], 'Sp1,': [3764], 'Sp3,': [3765], 'leads': [3768], 'astroglioma': [3773], 'factors,': [3777], 'cytokines': [3779], 'commonly': [3780], 'i.e.platelet-derived': [3785], 'interleukin-1,': [3789], 'fail': [3790], 'up-regulate': [3792], '(24Fabunmi': [3795], 'R.P.': [3796], 'Baker': [3797], 'A.H.': [3798], 'E.J.': [3800], 'Booth': [3801], 'R.F.': [3802], 'Newby': [3803], 'Biochem.': [3805], '315:': [3808], '335-342Crossref': [3809], '(233)': [3812], 'governs': [3821], 'induction.': [3823], 'induce': [3828], 'atherogenesis': [3842, 4199], 'remains': [3843], 'unclear': [3844], '(25Miralles': [3845], 'F.': [3846, 4474], 'Battelino': [3847], 'T.': [3848, 4051, 4104, 4210], 'Czernichow': [3849], 'Scharfmann': [3851], '143:': [3857], '827-836Crossref': [3858], '(154)': [3861], 'another': [3865], 'report,': [3866], 'Benbow': [3867], 'Brinckerhoff': [3869, 3872], '(26Benbow': [3870], 'U.': [3871], 'C.E.': [3873], 'Matrix': [3874], '15:': [3877], '519-526Crossref': [3878], '(432)': [3881], 'needed': [3890, 4165], 'critical': [3895, 4172], 'tissue-specific': [3897], 'regulate': [3904], 'transcription,': [3906], 'essential': [3911], 'cis-acting': [3915], 'contributes': [3946], 'blocks': [3961], 'work': [3974], 'CTGF-stimulated': [3976], 'blocking': [3980], 'inhibiting': [3986], 'Transcription': [3991], 'genes,': [4006], 'biglycan': [4008, 4244, 4332], 'factor,': [4013], 'various': [4023], 'stages': [4024], '(27Celletti': [4028], 'F.L.': [4029], 'Waugh': [4030], 'J.M.': [4031, 4420], 'Amabile': [4032], 'P.G.': [4033], 'Brendolan': [4034], 'Hilfiker': [4036], 'P.R.': [4037], 'Dake': [4038], 'M.D.': [4039], 'Nat.': [4040], 'Med.': [4041], '7:': [4043], '425-429Crossref': [4044], '(620)': [4047], '28Yamakawa': [4050], 'Bai': [4052, 4211], 'H.Z.': [4053, 4212], 'Masuda': [4054, 4213], 'Sawa': [4056, 4215], 'Shirakura': [4058, 4217], 'Ogata': [4060, 4219], 'Matsuda': [4062, 4221], 'Atherosclerosis.': [4064, 4223], '152:': [4066, 4225], '287-297Abstract': [4067, 4226], '(20)': [4075, 4234], 'Previous': [4078], 'involve': [4089], 'pathways:': [4092], 'retinoic': [4096], 'acid': [4097], 'receptor': [4098], '(29Luscher': [4099], 'Mitchell': [4101], 'P.J.': [4102], 'Williams': [4103], 'Tjian': [4105], 'Genes': [4107], 'Dev.': [4108], '1989;': [4109, 4154], '10:': [4110], '1507-1517Crossref': [4111], '(211)': [4113], 'cAMP-dependent': [4116], 'kinase': [4118, 4140], '(30Imagawa': [4120], 'Chiu': [4122], 'Karin': [4124], 'Cell.': [4126, 4152, 4262], '1987;': [4127], '51:': [4128], '251-260Abstract': [4129], '(1028)': [4135], '(31Hyman': [4143], 'Comb': [4145], 'Pearlberg': [4147], 'Goodman': [4149], '9:': [4155], '321-324Crossref': [4156], '(146)': [4159], 'Further': [4162], 'help': [4167], 'elucidate': [4168], 'pathway': [4170], 'subsequent': [4181], 'Biglycan': [4185], 'small': [4188], 'leucine-rich': [4189], 'proteoglycan': [4190], 'interactions': [4202, 4380], 'molecules': [4206, 4456], '(28Yamakawa': [4209], 'Its': [4237], 'controlled': [4240, 4318], 'TGF-β,': [4242, 4320], 'thought': [4248], 'form': [4250], 'negative': [4252], 'feedback': [4253], 'loop': [4254, 4347], '(32Ruoslahti': [4258], 'Yamaguchi': [4260], '64:': [4264], '867-869Abstract': [4265], '(1162)': [4271], '33Ungefroren': [4274], 'Krull': [4276], 'N.B.': [4277], '271:': [4282], '15787-15795Abstract': [4283], '(57)': [4291], '34Wegrowski': [4294], 'Pillarisetti': [4296], 'Danielson': [4298], 'K.G.': [4299], 'Suzuki': [4300], 'Iozzo': [4302], 'R.V.': [4303], 'Genomics.': [4304], '1995;': [4305], '30:': [4306], '8-17Crossref': [4307], '(54)': [4310], 'closely': [4317], 'should': [4322, 4348], 'very': [4324], 'interesting': [4325], 'investigate': [4327], 'modulation': [4330], 'via': [4337], 'and,': [4341], 'if': [4342], 'so,': [4343], 'TGF-β-biglycan': [4346], 'well.': [4354], 'general,': [4356], 'demonstrated': [4363], 'underscored': [4373], 'understanding': [4377, 4444], 'under': [4384], 'direct': [4386], 'indirect': [4388], 'TGF-β.': [4391], 'pivotal': [4396], 'pathogenesis': [4406], 'cardiovascular': [4408, 4464], 'e.g.': [4410], 'progressive': [4411], 'neointimal': [4412], 'thickening': [4413], '(restenosis)': [4414], 'angioplasty': [4416], '(35Nikol': [4417], 'Isner': [4419], 'Pickering': [4421], 'J.G.': [4422], 'Kearney': [4423], 'Leclerc': [4425], 'Weir': [4427], 'Clin.': [4430], 'Invest.': [4431], '1992;': [4432], '90:': [4433], '1582-1592Crossref': [4434], '(350)': [4437], 'atherosclerosis,': [4441], 'better': [4443], 'will': [4448], 'surely': [4449], 'advance': [4450], 'future': [4451], 'plans': [4452], 'targeted': [4455], 'prevent': [4460], 'disease.': [4465], 'indebted': [4468], 'Hoffmann-La': [4475], 'Roche': [4476], 'Ltd.,': [4477], 'Basel,': [4478], 'Switzerland,': [4479], 'his': [4481], 'generous': [4482]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2073803749', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-09T13:46:52.416703', 'created_date': '2016-06-24'}