Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2073587350', 'doi': 'https://doi.org/10.1016/j.neulet.2013.12.046', 'title': '6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo', 'display_name': '6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo', 'publication_year': 2013, 'publication_date': '2013-12-25', 'ids': {'openalex': 'https://openalex.org/W2073587350', 'doi': 'https://doi.org/10.1016/j.neulet.2013.12.046', 'mag': '2073587350', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24373993'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.neulet.2013.12.046', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203050076', 'display_name': 'Neuroscience Letters', 'issn_l': '0304-3940', 'issn': ['0304-3940', '1872-7972'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059863379', 'display_name': 'Aisling Gavin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Aisling M Gavin', 'raw_affiliation_strings': ['Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland.'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland.', 'institution_ids': ['https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111748540', 'display_name': 'Sinéad Walsh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Sinéad Walsh', 'raw_affiliation_strings': ['Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland.'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland.', 'institution_ids': ['https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083884825', 'display_name': 'Séan Wyatt', 'orcid': 'https://orcid.org/0000-0002-0572-234X'}, 'institutions': [{'id': 'https://openalex.org/I79510175', 'display_name': 'Cardiff University', 'ror': 'https://ror.org/03kk7td41', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I79510175']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sean Wyatt', 'raw_affiliation_strings': ['School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.'], 'affiliations': [{'raw_affiliation_string': 'School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.', 'institution_ids': ['https://openalex.org/I79510175']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028459670', 'display_name': 'Gerard W. O’Keeffe', 'orcid': 'https://orcid.org/0000-0001-5149-0933'}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': "Gerard W O'Keeffe", 'raw_affiliation_strings': ['Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland. Electronic address: [email protected].'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland. Electronic address: [email protected].', 'institution_ids': ['https://openalex.org/I27577105']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062071325', 'display_name': 'Aideen M. Sullivan', 'orcid': 'https://orcid.org/0000-0001-9692-6438'}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Aideen M Sullivan', 'raw_affiliation_strings': ['Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland. Electronic address: [email protected].'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland. Electronic address: [email protected].', 'institution_ids': ['https://openalex.org/I27577105']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2940, 'currency': 'USD', 'value_usd': 2940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.393, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 6, 'citation_normalized_percentile': {'value': 0.49226, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 83}, 'biblio': {'volume': '561', 'issue': None, 'first_page': '176', 'last_page': '181'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9928, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10106', 'display_name': 'Autism Spectrum Disorder Research', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/medial-forebrain-bundle', 'display_name': 'Medial forebrain bundle', 'score': 0.83089364}, {'id': 'https://openalex.org/keywords/oxidopamine', 'display_name': 'Oxidopamine', 'score': 0.63242096}, {'id': 'https://openalex.org/keywords/hydroxydopamine', 'display_name': 'Hydroxydopamine', 'score': 0.5886527}, {'id': 'https://openalex.org/keywords/nigrostriatal-pathway', 'display_name': 'Nigrostriatal pathway', 'score': 0.5804196}], 'concepts': [{'id': 'https://openalex.org/C185856081', 'wikidata': 'https://www.wikidata.org/wiki/Q14916286', 'display_name': 'Glial cell line-derived neurotrophic factor', 'level': 4, 'score': 0.98056376}, {'id': 'https://openalex.org/C2776669363', 'wikidata': 'https://www.wikidata.org/wiki/Q4287680', 'display_name': 'Medial forebrain bundle', 'level': 4, 'score': 0.83089364}, {'id': 'https://openalex.org/C160539049', 'wikidata': 'https://www.wikidata.org/wiki/Q3064187', 'display_name': 'Neurotrophic factors', 'level': 3, 'score': 0.7566583}, {'id': 'https://openalex.org/C137183658', 'wikidata': 'https://www.wikidata.org/wiki/Q461076', 'display_name': 'Dopaminergic', 'level': 3, 'score': 0.6993868}, {'id': 'https://openalex.org/C2777288102', 'wikidata': 'https://www.wikidata.org/wiki/Q780181', 'display_name': 'Oxidopamine', 'level': 5, 'score': 0.63242096}, {'id': 'https://openalex.org/C94296188', 'wikidata': 'https://www.wikidata.org/wiki/Q5513091', 'display_name': 'GDNF family of ligands', 'level': 5, 'score': 0.62348926}, {'id': 'https://openalex.org/C2911016594', 'wikidata': 'https://www.wikidata.org/wiki/Q15946111', 'display_name': 'Hydroxydopamine', 'level': 4, 'score': 0.5886527}, {'id': 'https://openalex.org/C2776355744', 'wikidata': 'https://www.wikidata.org/wiki/Q4318555', 'display_name': 'Nigrostriatal pathway', 'level': 5, 'score': 0.5804196}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5517855}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.47177577}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.46961433}, {'id': 'https://openalex.org/C2780938664', 'wikidata': 'https://www.wikidata.org/wiki/Q753278', 'display_name': 'Substantia nigra', 'level': 4, 'score': 0.4630933}, {'id': 'https://openalex.org/C92020748', 'wikidata': 'https://www.wikidata.org/wiki/Q420457', 'display_name': 'Neurotrophin', 'level': 3, 'score': 0.4440868}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.43814325}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.43370998}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.4289621}, {'id': 'https://openalex.org/C2780062018', 'wikidata': 'https://www.wikidata.org/wiki/Q1319792', 'display_name': 'Striatum', 'level': 3, 'score': 0.42375398}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.36759567}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.14818603}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003342', 'descriptor_name': 'Corpus Striatum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051100', 'descriptor_name': 'Glial Cell Line-Derived Neurotrophic Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D055428', 'descriptor_name': 'Growth Differentiation Factor 5', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016627', 'descriptor_name': 'Oxidopamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013378', 'descriptor_name': 'Substantia Nigra', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052005', 'descriptor_name': 'Bone Morphogenetic Protein Receptors, Type I', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D052005', 'descriptor_name': 'Bone Morphogenetic Protein Receptors, Type I', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D052005', 'descriptor_name': 'Bone Morphogenetic Protein Receptors, Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052006', 'descriptor_name': 'Bone Morphogenetic Protein Receptors, Type II', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D052006', 'descriptor_name': 'Bone Morphogenetic Protein Receptors, Type II', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D052006', 'descriptor_name': 'Bone Morphogenetic Protein Receptors, Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003342', 'descriptor_name': 'Corpus Striatum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051100', 'descriptor_name': 'Glial Cell Line-Derived Neurotrophic Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051100', 'descriptor_name': 'Glial Cell Line-Derived Neurotrophic Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051097', 'descriptor_name': 'Glial Cell Line-Derived Neurotrophic Factor Receptors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051097', 'descriptor_name': 'Glial Cell Line-Derived Neurotrophic Factor Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051097', 'descriptor_name': 'Glial Cell Line-Derived Neurotrophic Factor Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D055428', 'descriptor_name': 'Growth Differentiation Factor 5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055428', 'descriptor_name': 'Growth Differentiation Factor 5', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D051096', 'descriptor_name': 'Proto-Oncogene Proteins c-ret', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051096', 'descriptor_name': 'Proto-Oncogene Proteins c-ret', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051096', 'descriptor_name': 'Proto-Oncogene Proteins c-ret', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013378', 'descriptor_name': 'Substantia Nigra', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.neulet.2013.12.046', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203050076', 'display_name': 'Neuroscience Letters', 'issn_l': '0304-3940', 'issn': ['0304-3940', '1872-7972'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24373993', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.69, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320312041', 'funder_display_name': 'Health Research Board', 'award_id': 'GO’K/AS'}, {'funder': 'https://openalex.org/F4320312041', 'funder_display_name': 'Health Research Board', 'award_id': 'HRA/2009/127'}], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1890054393', 'https://openalex.org/W1971208141', 'https://openalex.org/W1978306829', 'https://openalex.org/W1978328837', 'https://openalex.org/W1980312175', 'https://openalex.org/W1982932097', 'https://openalex.org/W1988651494', 'https://openalex.org/W1991836867', 'https://openalex.org/W1992956903', 'https://openalex.org/W1994563237', 'https://openalex.org/W1999136928', 'https://openalex.org/W2000136901', 'https://openalex.org/W2000921610', 'https://openalex.org/W2003008766', 'https://openalex.org/W2004736998', 'https://openalex.org/W2004957011', 'https://openalex.org/W2010756280', 'https://openalex.org/W2020813036', 'https://openalex.org/W2024313116', 'https://openalex.org/W2025530482', 'https://openalex.org/W2029725727', 'https://openalex.org/W2031633098', 'https://openalex.org/W2033068332', 'https://openalex.org/W2035149159', 'https://openalex.org/W2036810793', 'https://openalex.org/W2042162774', 'https://openalex.org/W2051245059', 'https://openalex.org/W2054810445', 'https://openalex.org/W2059415739', 'https://openalex.org/W2062598259', 'https://openalex.org/W2071162062', 'https://openalex.org/W2075249157', 'https://openalex.org/W2079562527', 'https://openalex.org/W2082434791', 'https://openalex.org/W2089395709', 'https://openalex.org/W2091838523', 'https://openalex.org/W2114370445', 'https://openalex.org/W2158335375'], 'related_works': ['https://openalex.org/W4229557642', 'https://openalex.org/W2409150457', 'https://openalex.org/W2079899553', 'https://openalex.org/W2074379320', 'https://openalex.org/W2073587350', 'https://openalex.org/W2073378702', 'https://openalex.org/W2036533672', 'https://openalex.org/W2000942652', 'https://openalex.org/W1978804888', 'https://openalex.org/W1497177096'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2073587350', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}], 'updated_date': '2024-12-08T02:54:45.458751', 'created_date': '2016-06-24'}