Title: Hypothalamic Influence on Thyroxine Monodeiodination by Rat Anterior Pituitary Gland
Abstract: In order to determine if the monodeiodination of 131I-labeled thyroxine (T4*) to 3,5,3′-triiodothyronine (T3*) which occurs in the anterior pituitary is dependent upon hypothalamic influences, the metabolic fate of T4* in intraocular pituitary transplants has been examined chromatographically. Concentration of total radioactivity in the transplants was similar to that of the normal in situ pituitary, but the proportion of T3* was much reduced. In normal rat anterior pituitary, the relative amount of T3* was 17 % of the total radioactivity in 2 experiments; transplants, on the other hand, showed no T3* in one experiment and 9% in a second. In thyroidectomized rats the relative proportion of T3* in the anterior pituitary rose to 26 %. These findings are interpreted to indicate that monodeiodination of T4* to T3* is related to the functional activity of the anterior pituitary and that this activity depends upon intact hypothalamic-pituitary connections. (Endocrinology78: 302, 1966)
Publication Year: 1966
Publication Date: 1966-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 24
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