BICALUTAMIDE MONOTHERAPY COMPARED WITH CASTRATION IN PATIENTS WITH NONMETASTATIC LOCALLY ADVANCED PROSTATE CANCER: 6.3 YEARS OF FOLLOWUP

Name: Work Video:
Duration: 3 min 30 s
Peter Iversen; C. Tyrrell; Amir V. Kaisary; John Anderson; Hendrik Van Poppel; Teuvo L.J. Tammela; M. C. Chamberlain; Kevin Carroll; I. Melezínek
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'were': [146, 169, 180, 214, 263, 297, 326, 344], 'treated': [147, 491], 'either': [149], '150': [150, 184, 353, 672, 1048, 1175, 1297], 'mg.': [151, 185, 193, 354], 'bicalutamide': [152, 186, 269, 316, 355], 'or': [154, 188, 191, 253, 1388, 1398], 'castration.': [155], 'Materials': [156], 'Methods:': [158], 'Data': [159], 'open': [162, 645], 'label,': [163], 'multicenter': [164, 713], 'identical': [167], 'design': [168], 'pooled': [170], 'according': [171], 'protocol.': [173], 'Patients': [174, 984, 1395], 'stage': [176, 412], 'T3/4': [177], 'cancer': [179, 213, 368, 592], 'randomized': [181, 215, 714], 'receive': [183], 'daily': [187], 'castration': [189, 307, 361, 620, 676, 701], '(orchiectomy': [190], '3.6': [192], 'goserelin': [194, 589], 'acetate': [195], 'every': [196], '28': [197], 'days)': [198], '2:1': [201], 'ratio.': [202], 'Results:': [203], 'A': [204, 666, 1134], 'total': [205], '480': [207], 'treatment.': [217], 'After': [218, 1013], 'median': [220, 718], 'followup': [221], 'years': [224], 'mortality': [225], 'was': [226, 229, 329], '56%.': [227], 'There': [228, 262], 'no': [230, 340], 'statistically': [231, 264], 'significant': [232, 265], 'difference': [233], 'between': [234], 'the': [235, 268, 273, 298, 306, 315, 511, 551, 572, 678, 1056, 1406], 'groups': [237], 'overall': [239], '(hazard': [241], 'ratio': [242], '1.05,': [243], 'upper': [244], '1-sided': [245], '95%': [246], 'confidence': [247], 'limit': [248], '1.31,': [249], 'p': [250, 259], '=': [251, 260, 283, 289], '0.70)': [252], 'time': [254], 'progression': [256], '(1.20,': [257], '1.45,': [258], '0.11).': [261], 'benefits': [266], 'group': [271], 'quality': [275, 425, 731], 'life': [277, 427, 733, 754], 'parameters': [278], 'sexual': [280, 444], 'interest': [281, 1444, 1459, 1490, 1505, 1519, 1533, 1547], '(p': [282, 288], '0.029)': [284], 'physical': [286], 'capacity': [287], '0.046).': [290], 'The': [291, 318, 1046], 'highest': [292], 'incidences': [293, 319], 'adverse': [295, 324], 'events': [296, 325], 'pharmacological': [299], 'side': [300], 'effects': [301], 'hot': [303], 'flashes': [304], 'group,': [308], 'breast': [310], 'pain': [311], 'gynecomastia': [313], 'group.': [317], 'other': [321, 1446, 1461, 1492, 1507, 1521, 1535, 1549], 'types': [322], 'low.': [327], 'Bicalutamide': [328, 568, 584, 638, 1047, 1327, 1382], 'well': [330], 'tolerated,': [331], 'few': [333], 'drug': [334], 'related': [335], 'withdrawals': [336], 'study,': [338], 'new': [341, 552], 'issues': [343, 755], 'identified': [345], 'during': [346, 470, 548], 'this': [347, 1453, 1468, 1476, 1484, 1499, 1514, 1528, 1542, 1556], 'longer': [348], 'followup.': [349], 'Conclusions:': [350], 'Monotherapy': [351, 926, 1328], 'is': [356, 374], 'attractive': [358], 'alternative': [359], 'whom': [370], 'immediate': [371], 'hormone': [372], 'therapy': [373, 473], 'indicated.': [375], 'References': [376], '1': [377], ':': [378, 393, 406, 422, 440, 467, 485, 504, 521, 545, 567, 583, 610, 637, 665, 694, 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