Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2073162583', 'doi': 'https://doi.org/10.1016/j.biotechadv.2014.10.011', 'title': 'Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer', 'display_name': 'Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer', 'publication_year': 2014, 'publication_date': '2014-10-31', 'ids': {'openalex': 'https://openalex.org/W2073162583', 'doi': 'https://doi.org/10.1016/j.biotechadv.2014.10.011', 'mag': '2073162583', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25447422'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.biotechadv.2014.10.011', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S160877137', 'display_name': 'Biotechnology Advances', 'issn_l': '0734-9750', 'issn': ['0734-9750', '1873-1899'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101637110', 'display_name': 'Shengpeng Wang', 'orcid': 'https://orcid.org/0000-0002-8997-456X'}, 'institutions': [{'id': 'https://openalex.org/I204512498', 'display_name': 'University of Macau', 'ror': 'https://ror.org/01r4q9n85', 'country_code': 'MO', 'type': 'education', 'lineage': ['https://openalex.org/I204512498']}], 'countries': ['MO'], 'is_corresponding': False, 'raw_author_name': 'Shengpeng Wang', 'raw_affiliation_strings': ['State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China', 'institution_ids': ['https://openalex.org/I204512498']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027816847', 'display_name': 'Jian-Ge Qiu', 'orcid': 'https://orcid.org/0000-0003-3885-0775'}, 'institutions': [{'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiange Qiu', 'raw_affiliation_strings': ['Department of Cell Biology and Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology and Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I159948400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048003025', 'display_name': 'Zhi Shi', 'orcid': 'https://orcid.org/0000-0002-8328-0305'}, 'institutions': [{'id': 'https://openalex.org/I204512498', 'display_name': 'University of Macau', 'ror': 'https://ror.org/01r4q9n85', 'country_code': 'MO', 'type': 'education', 'lineage': ['https://openalex.org/I204512498']}, {'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}], 'countries': ['CN', 'MO'], 'is_corresponding': True, 'raw_author_name': 'Zhi Shi', 'raw_affiliation_strings': ['Department of Cell Biology and Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China', 'State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China', 'institution_ids': ['https://openalex.org/I204512498']}, {'raw_affiliation_string': 'Department of Cell Biology and Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I159948400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100347063', 'display_name': 'Ying Wang', 'orcid': 'https://orcid.org/0000-0002-1407-2668'}, 'institutions': [{'id': 'https://openalex.org/I204512498', 'display_name': 'University of Macau', 'ror': 'https://ror.org/01r4q9n85', 'country_code': 'MO', 'type': 'education', 'lineage': ['https://openalex.org/I204512498']}], 'countries': ['MO'], 'is_corresponding': False, 'raw_author_name': 'Yitao Wang', 'raw_affiliation_strings': ['State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China', 'institution_ids': ['https://openalex.org/I204512498']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103103310', 'display_name': 'Meiwan Chen', 'orcid': 'https://orcid.org/0000-0002-8642-5979'}, 'institutions': [{'id': 'https://openalex.org/I204512498', 'display_name': 'University of Macau', 'ror': 'https://ror.org/01r4q9n85', 'country_code': 'MO', 'type': 'education', 'lineage': ['https://openalex.org/I204512498']}], 'countries': ['MO'], 'is_corresponding': True, 'raw_author_name': 'Meiwan Chen', 'raw_affiliation_strings': ['State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China', 'institution_ids': ['https://openalex.org/I204512498']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5048003025', 'https://openalex.org/A5103103310'], 'corresponding_institution_ids': ['https://openalex.org/I204512498', 'https://openalex.org/I159948400', 'https://openalex.org/I204512498'], 'apc_list': {'value': 5300, 'currency': 'USD', 'value_usd': 5300, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.484, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.995349, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '33', 'issue': '1', 'first_page': '224', 'last_page': '241'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10063', 'display_name': 'Nanoparticle-Based Drug Delivery Systems', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10063', 'display_name': 'Nanoparticle-Based Drug Delivery Systems', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10207', 'display_name': 'DNA Nanotechnology and Bioanalytical Applications', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/taxane', 'display_name': 'Taxane', 'score': 0.929165}, {'id': 'https://openalex.org/keywords/efflux', 'display_name': 'Efflux', 'score': 0.5652912}, {'id': 'https://openalex.org/keywords/drug-delivery', 'display_name': 'Drug Delivery', 'score': 0.524038}, {'id': 'https://openalex.org/keywords/cancer-therapy', 'display_name': 'Cancer Therapy', 'score': 0.506779}, {'id': 'https://openalex.org/keywords/nucleic-acid-delivery', 'display_name': 'Nucleic Acid Delivery', 'score': 0.505821}], 'concepts': [{'id': 'https://openalex.org/C2777511904', 'wikidata': 'https://www.wikidata.org/wiki/Q425227', 'display_name': 'Taxane', 'level': 4, 'score': 0.929165}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.71926695}, {'id': 'https://openalex.org/C133936738', 'wikidata': 'https://www.wikidata.org/wiki/Q643839', 'display_name': 'Multiple drug resistance', 'level': 3, 'score': 0.6819934}, {'id': 'https://openalex.org/C200082930', 'wikidata': 'https://www.wikidata.org/wiki/Q22327148', 'display_name': 'Efflux', 'level': 2, 'score': 0.5652912}, {'id': 'https://openalex.org/C89611455', 'wikidata': 'https://www.wikidata.org/wiki/Q6804646', 'display_name': 'Mechanism (biology)', 'level': 2, 'score': 0.5144451}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.5080068}, {'id': 'https://openalex.org/C2779820397', 'wikidata': 'https://www.wikidata.org/wiki/Q1392806', 'display_name': 'Drug delivery', 'level': 2, 'score': 0.47602326}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4393348}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.42408237}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41941875}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32327682}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.32131547}, {'id': 'https://openalex.org/C171250308', 'wikidata': 'https://www.wikidata.org/wiki/Q11468', 'display_name': 'Nanotechnology', 'level': 1, 'score': 0.20360112}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.09927791}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.079068124}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.06347126}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C111472728', 'wikidata': 'https://www.wikidata.org/wiki/Q9471', 'display_name': 'Epistemology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016503', 'descriptor_name': 'Drug Delivery Systems', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D043823', 'descriptor_name': 'Taxoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016503', 'descriptor_name': 'Drug Delivery Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053758', 'descriptor_name': 'Nanoparticles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D053758', 'descriptor_name': 'Nanoparticles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043823', 'descriptor_name': 'Taxoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014404', 'descriptor_name': 'Tubulin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014404', 'descriptor_name': 'Tubulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.biotechadv.2014.10.011', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S160877137', 'display_name': 'Biotechnology Advances', 'issn_l': '0734-9750', 'issn': ['0734-9750', '1873-1899'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25447422', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.85, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '31271444'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81201726'}, {'funder': 'https://openalex.org/F4320322841', 'funder_display_name': 'Universidade de Macau', 'award_id': 'MRG004/CMW/2014/ICMS'}, {'funder': 'https://openalex.org/F4320322841', 'funder_display_name': 'Universidade de Macau', 'award_id': 'MYRG2014-00033-ICMS-QRCM'}, {'funder': 'https://openalex.org/F4320322841', 'funder_display_name': 'Universidade de Macau', 'award_id': 'MYRG2014-00051-ICMS-QRCM'}, {'funder': 'https://openalex.org/F4320323893', 'funder_display_name': 'Fundo para o Desenvolvimento das Ciências e da Tecnologia', 'award_id': '062/2013/A2'}], 'datasets': [], 'versions': [], 'referenced_works_count': 266, 'referenced_works': ['https://openalex.org/W133997253', 'https://openalex.org/W1543782774', 'https://openalex.org/W1581728177', 'https://openalex.org/W1624280239', 'https://openalex.org/W1752310561', 'https://openalex.org/W1956617916', 'https://openalex.org/W1961735798', 'https://openalex.org/W1963614111', 'https://openalex.org/W1963675633', 'https://openalex.org/W1963837352', 'https://openalex.org/W1964223890', 'https://openalex.org/W1964414451', 'https://openalex.org/W1964617786', 'https://openalex.org/W1965426853', 'https://openalex.org/W1965688487', 'https://openalex.org/W1965729165', 'https://openalex.org/W1965910946', 'https://openalex.org/W1966414861', 'https://openalex.org/W1967945605', 'https://openalex.org/W1968436748', 'https://openalex.org/W1970110601', 'https://openalex.org/W1971019100', 'https://openalex.org/W1971390550', 'https://openalex.org/W1973345865', 'https://openalex.org/W1973522717', 'https://openalex.org/W1973701873', 'https://openalex.org/W1974994114', 'https://openalex.org/W1975002354', 'https://openalex.org/W1976033985', 'https://openalex.org/W1977258127', 'https://openalex.org/W1977968648', 'https://openalex.org/W1978166647', 'https://openalex.org/W1978728170', 'https://openalex.org/W1978932462', 'https://openalex.org/W1979900568', 'https://openalex.org/W1980810506', 'https://openalex.org/W1981825595', 'https://openalex.org/W1982056054', 'https://openalex.org/W1982420329', 'https://openalex.org/W1983081876', 'https://openalex.org/W1983573620', 'https://openalex.org/W1984001915', 'https://openalex.org/W1984677400', 'https://openalex.org/W1985460342', 'https://openalex.org/W1985698590', 'https://openalex.org/W1986749685', 'https://openalex.org/W1987104113', 'https://openalex.org/W1987751336', 'https://openalex.org/W1988313934', 'https://openalex.org/W1988816960', 'https://openalex.org/W1988867169', 'https://openalex.org/W1989618497', 'https://openalex.org/W1990575167', 'https://openalex.org/W1990711717', 'https://openalex.org/W1991140433', 'https://openalex.org/W1991554669', 'https://openalex.org/W1993210270', 'https://openalex.org/W1994205310', 'https://openalex.org/W1994835212', 'https://openalex.org/W1996830477', 'https://openalex.org/W1997788846', 'https://openalex.org/W2000186097', 'https://openalex.org/W2001684619', 'https://openalex.org/W2001736308', 'https://openalex.org/W2001762874', 'https://openalex.org/W2002077468', 'https://openalex.org/W2002244693', 'https://openalex.org/W2002486553', 'https://openalex.org/W2002571673', 'https://openalex.org/W2003335129', 'https://openalex.org/W2004934153', 'https://openalex.org/W2005234005', 'https://openalex.org/W2005308681', 'https://openalex.org/W2006583554', 'https://openalex.org/W2007287727', 'https://openalex.org/W2008530649', 'https://openalex.org/W2008954677', 'https://openalex.org/W2010001534', 'https://openalex.org/W2012149136', 'https://openalex.org/W2013041233', 'https://openalex.org/W2013270956', 'https://openalex.org/W2013485244', 'https://openalex.org/W2015346163', 'https://openalex.org/W2015561372', 'https://openalex.org/W2017052864', 'https://openalex.org/W2017322644', 'https://openalex.org/W2018422154', 'https://openalex.org/W2018752396', 'https://openalex.org/W2018835423', 'https://openalex.org/W2019207861', 'https://openalex.org/W2019633596', 'https://openalex.org/W2022569128', 'https://openalex.org/W2023517900', 'https://openalex.org/W2025785292', 'https://openalex.org/W2026250154', 'https://openalex.org/W2026712777', 'https://openalex.org/W2026881684', 'https://openalex.org/W2027360722', 'https://openalex.org/W2028282570', 'https://openalex.org/W2028646432', 'https://openalex.org/W2029122883', 'https://openalex.org/W2030680926', 'https://openalex.org/W2030763904', 'https://openalex.org/W2032621729', 'https://openalex.org/W2033117421', 'https://openalex.org/W2033263935', 'https://openalex.org/W2033578921', 'https://openalex.org/W2033931090', 'https://openalex.org/W2034038847', 'https://openalex.org/W2034081600', 'https://openalex.org/W2035393653', 'https://openalex.org/W2035523654', 'https://openalex.org/W2035805036', 'https://openalex.org/W2037490361', 'https://openalex.org/W2038695289', 'https://openalex.org/W2040803875', 'https://openalex.org/W2041665769', 'https://openalex.org/W2042316019', 'https://openalex.org/W2042619042', 'https://openalex.org/W2043478531', 'https://openalex.org/W2045510646', 'https://openalex.org/W2045605237', 'https://openalex.org/W2046542140', 'https://openalex.org/W2046639188', 'https://openalex.org/W2047182837', 'https://openalex.org/W2047778962', 'https://openalex.org/W2048217586', 'https://openalex.org/W2048420511', 'https://openalex.org/W2048454522', 'https://openalex.org/W2048912984', 'https://openalex.org/W2049684674', 'https://openalex.org/W2049823629', 'https://openalex.org/W2050285145', 'https://openalex.org/W2050555289', 'https://openalex.org/W2050564805', 'https://openalex.org/W2050767064', 'https://openalex.org/W2051215695', 'https://openalex.org/W2051776823', 'https://openalex.org/W2051950678', 'https://openalex.org/W2052078667', 'https://openalex.org/W2052705131', 'https://openalex.org/W2053649039', 'https://openalex.org/W2056772956', 'https://openalex.org/W2057848113', 'https://openalex.org/W2058497845', 'https://openalex.org/W2059935962', 'https://openalex.org/W2060265857', 'https://openalex.org/W2062265555', 'https://openalex.org/W2062398476', 'https://openalex.org/W2062771754', 'https://openalex.org/W2062843221', 'https://openalex.org/W2063183292', 'https://openalex.org/W2063486043', 'https://openalex.org/W2063554383', 'https://openalex.org/W2064111887', 'https://openalex.org/W2064580048', 'https://openalex.org/W2064674946', 'https://openalex.org/W2065302847', 'https://openalex.org/W2066009484', 'https://openalex.org/W2066076859', 'https://openalex.org/W2066791556', 'https://openalex.org/W2068433296', 'https://openalex.org/W2069360982', 'https://openalex.org/W2069400786', 'https://openalex.org/W2069412624', 'https://openalex.org/W2069494381', 'https://openalex.org/W2069651638', 'https://openalex.org/W2072517578', 'https://openalex.org/W2073199799', 'https://openalex.org/W2074688366', 'https://openalex.org/W2075206227', 'https://openalex.org/W2075727303', 'https://openalex.org/W2078265076', 'https://openalex.org/W2079142824', 'https://openalex.org/W2079268495', 'https://openalex.org/W2080849576', 'https://openalex.org/W2082690743', 'https://openalex.org/W2083716957', 'https://openalex.org/W2083870878', 'https://openalex.org/W2084552074', 'https://openalex.org/W2086616583', 'https://openalex.org/W2087224485', 'https://openalex.org/W2087266891', 'https://openalex.org/W2087483515', 'https://openalex.org/W2087733030', 'https://openalex.org/W2090580827', 'https://openalex.org/W2091269867', 'https://openalex.org/W2092524156', 'https://openalex.org/W2093066634', 'https://openalex.org/W2093855538', 'https://openalex.org/W2094915747', 'https://openalex.org/W2094974725', 'https://openalex.org/W2095114785', 'https://openalex.org/W2096928036', 'https://openalex.org/W2097090651', 'https://openalex.org/W2098142549', 'https://openalex.org/W2098672749', 'https://openalex.org/W2099818449', 'https://openalex.org/W2100531566', 'https://openalex.org/W2101792017', 'https://openalex.org/W2102660250', 'https://openalex.org/W2102912734', 'https://openalex.org/W2103091270', 'https://openalex.org/W2103349496', 'https://openalex.org/W2105072076', 'https://openalex.org/W2107436374', 'https://openalex.org/W2108550209', 'https://openalex.org/W2108929767', 'https://openalex.org/W2109506936', 'https://openalex.org/W2112237903', 'https://openalex.org/W2112543601', 'https://openalex.org/W2112765020', 'https://openalex.org/W2114768355', 'https://openalex.org/W2115843648', 'https://openalex.org/W2115852285', 'https://openalex.org/W2116092152', 'https://openalex.org/W2117130243', 'https://openalex.org/W2117204942', 'https://openalex.org/W2118069529', 'https://openalex.org/W2120369408', 'https://openalex.org/W2122754213', 'https://openalex.org/W2123647020', 'https://openalex.org/W2125089526', 'https://openalex.org/W2132244669', 'https://openalex.org/W2132722996', 'https://openalex.org/W2134994441', 'https://openalex.org/W2137215170', 'https://openalex.org/W2137634849', 'https://openalex.org/W2140429278', 'https://openalex.org/W2140731073', 'https://openalex.org/W2143546230', 'https://openalex.org/W2143992183', 'https://openalex.org/W2145269041', 'https://openalex.org/W2145555831', 'https://openalex.org/W2146148552', 'https://openalex.org/W2148665822', 'https://openalex.org/W2148899154', 'https://openalex.org/W2149797564', 'https://openalex.org/W2149959721', 'https://openalex.org/W2150960568', 'https://openalex.org/W2151388261', 'https://openalex.org/W2154094988', 'https://openalex.org/W2154335454', 'https://openalex.org/W2160441913', 'https://openalex.org/W2161531885', 'https://openalex.org/W2162097287', 'https://openalex.org/W2163758521', 'https://openalex.org/W2165836181', 'https://openalex.org/W2166153381', 'https://openalex.org/W2166201304', 'https://openalex.org/W2166699788', 'https://openalex.org/W2168587151', 'https://openalex.org/W2170145859', 'https://openalex.org/W2171490806', 'https://openalex.org/W2318420170', 'https://openalex.org/W2323579145', 'https://openalex.org/W2332790596', 'https://openalex.org/W2341209396', 'https://openalex.org/W2901502263', 'https://openalex.org/W3026011768', 'https://openalex.org/W4212909492', 'https://openalex.org/W4235607015', 'https://openalex.org/W4239563344', 'https://openalex.org/W4355260', 'https://openalex.org/W77720024', 'https://openalex.org/W85696438'], 'related_works': ['https://openalex.org/W4378527957', 'https://openalex.org/W4294953116', 'https://openalex.org/W4294636674', 'https://openalex.org/W3217358971', 'https://openalex.org/W3216929939', 'https://openalex.org/W3039789841', 'https://openalex.org/W2392656729', 'https://openalex.org/W2358788612', 'https://openalex.org/W2047703453', 'https://openalex.org/W2044044282'], 'abstract_inverted_index': {'Taxanes': [0], 'are': [1], 'one': [2], 'type': [3], 'of': [4, 29, 40, 44, 58, 61, 68, 75, 94, 108, 116], 'the': [5, 92, 102, 106], 'most': [6], 'extensively': [7], 'used': [8], 'chemotherapeutic': [9], 'agents': [10], 'to': [11, 121], 'treat': [12], 'cancers.': [13], 'However,': [14, 73], 'their': [15], 'clinical': [16, 88], 'use': [17], 'is': [18], 'severely': [19], 'limited': [20], 'by': [21], 'intrinsic': [22], 'and': [23, 50, 111], 'acquired': [24], 'resistance.': [25, 72, 124], 'A': [26], 'diverse': [27], 'variety': [28], 'mechanisms': [30, 60, 107], 'has': [31, 64], 'been': [32], 'implicated': [33], 'about': [34], 'taxane': [35, 62, 76, 109, 123], 'resistance,': [36, 110], 'such': [37], 'as': [38], 'alterations': [39], 'drug': [41, 53], 'targets,': [42], 'overexpression': [43], 'efflux': [45], 'transporters,': [46], 'defective': [47], 'apoptotic': [48], 'machineries,': [49], 'barriers': [51], 'in': [52], 'transport.': [54], 'The': [55], 'deepening': [56], 'understanding': [57, 104], 'molecular': [59], 'resistance': [63, 77], 'spawned': [65], 'a': [66, 113], 'number': [67], 'targets': [69], 'for': [70], 'reversing': [71], 'circumvention': [74], 'would': [78], 'not': [79], 'only': [80], 'possess': [81], 'therapeutic': [82], 'potential,': [83], 'but': [84], 'also': [85], 'face': [86], 'with': [87], 'challenge,': [89], 'which': [90], 'accelerates': [91], 'development': [93], 'optimal': [95], 'nanoscale': [96, 118], 'delivery': [97, 119], 'systems.': [98], 'This': [99], 'review': [100], 'highlights': [101], 'current': [103], 'on': [105], 'provides': [112], 'comprehensive': [114], 'analysis': [115], 'various': [117], 'systems': [120], 'reverse': [122]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2073162583', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 5}], 'updated_date': '2024-09-17T15:57:56.039545', 'created_date': '2016-06-24'}