Title: The relationship between morphine analgesia and the levels of biogenic amines in the mouse brain
Abstract: The effects of morphine on noradrenaline and 5-hydroxytyptamine levels in the mouse brain were determined fluorometrically. The doses of morphine used corresponded to its ED50 values in two analgesic tests. The ED50 of morphine in the phenylquinone-writhing test (0.85 mg/kg) produced a decrease only in 5-hydroxytryptamine levels of the brain whereas the ED50 for morphine in the hot plate test (8.5 mg/kg) reduced both noradrenaline and 5-hydroxytryptamine levels of the brain.
Publication Year: 1970
Publication Date: 1970-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 42
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