A Model for Oligomeric Regulation of APOBEC3G Cytosine Deaminase-dependent Restriction of HIV

Name: Work Video:
Duration: 3 min 30 s
Linda Chelico; Elizabeth J. Sacho; Dorothy A. Erie; Myron F. Goodman
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4449, 4478, 4546, 4549, 4578, 4610, 4617], '→': [9, 19, 176, 186, 408, 990, 1071, 1731, 1738], 'U': [10, 177, 1739, 3234], 'deaminations': [11, 50, 68, 178, 217, 235, 1341, 2227, 2261, 2497, 2507, 2521, 2528, 2539, 2553, 2560, 2574, 2593, 2623, 3560, 3581, 4399, 4450, 4542, 4611], 'on': [12, 179, 368, 710, 819, 1784, 1796, 1871, 2164, 2635, 3201, 3213, 3497, 3567, 3688, 3845, 4070, 4180, 4195, 4224, 4269, 4279, 4295, 4299, 4424, 4474, 4511, 4567, 4628], 'single-stranded': [13, 180, 477, 485, 4067], 'DNA': [14, 139, 164, 181, 306, 331, 413, 478, 572, 958, 1149, 1182, 1336, 1364, 1836, 1861, 2267, 2362, 2445, 3053, 3535, 3615, 4253], '(ssDNA)': [15, 182, 479], 'with': [16, 39, 41, 52, 73, 183, 206, 208, 219, 240, 404, 569, 657, 1136, 1179, 1344, 1353, 1706, 1751, 1779, 1826, 1848, 1947, 2002, 2048, 2086, 2213, 2220, 2236, 2256, 2313, 2332, 2341, 2391, 2470, 2683, 2778, 2860, 2948, 3014, 3107, 3126, 3308, 3318, 3578, 3752, 3767, 3795, 3805, 3852, 3867, 3886, 4220, 4255, 4273, 4286, 4459, 4520, 4527, 4631], 'marked': [17, 184, 3218], '3′': [18, 185, 989, 1730, 2489, 2532, 2543, 2556, 2564, 2581, 3724, 4405, 4437, 4548, 4580], '5′': [20, 187, 991, 1732, 2476, 2486, 2511, 2524, 2578, 3712, 4097, 4402, 4447, 4545, 4608], 'deamination': [21, 110, 121, 188, 277, 288, 500, 959, 983, 994, 1021, 1381, 1735, 1763, 1776, 2416, 2473, 2482, 2607, 3212, 3219, 3303, 3486, 3686, 3698, 3709, 3744, 3749, 3773, 3783, 3799, 3830, 3859, 3986, 3996, 4018, 4026, 4038, 4054, 4064, 4150, 4197, 4217, 4231, 4237, 4290, 4366, 4420, 4457, 4503, 4509, 4563, 4583], 'polarity.': [22, 122, 189, 289, 1723], 'Here': [23, 190], 'we': [24, 191, 1697, 3312], 'show': [25, 192], 'that': [26, 150, 193, 317, 357, 376, 390, 814, 981, 1379, 1728, 2618, 3210, 3376, 3629, 3708, 4049], 'A3G': [27, 98, 120, 152, 194, 265, 287, 319, 461, 551, 720, 818, 844, 945, 949, 1132, 1380, 1430, 1501, 1629, 1690, 1719, 1877, 1911, 1949, 2045, 2101, 2127, 2180, 2221, 2364, 2409, 2629, 2710, 2882, 2967, 2975, 3066, 3202, 3211, 3302, 3386, 3408, 3450, 3483, 3587, 3658, 3685, 3762, 3782, 3844, 3864, 4196, 4213, 4266, 4314, 4365, 4517, 4625], 'exists': [28, 195], 'in': [29, 196, 414, 812, 827, 947, 1029, 1064, 1076, 1079, 1329, 1398, 1429, 1432, 1439, 1506, 1632, 1642, 1704, 1734, 1806, 1989, 2020, 2169, 2181, 2374, 2649, 2713, 2725, 2741, 2767, 2810, 2878, 2885, 2897, 2913, 2974, 3041, 3049, 3080, 3095, 3229, 3274, 3326, 3397, 3407, 3411, 3507, 3675, 3756, 3787, 3913, 3988, 4022, 4028, 4065, 4207, 4241, 4341, 4380, 4429, 4477, 4572, 4586], 'oligomeric': [30, 197, 1436, 1634, 1746], 'states': [31, 198], 'whose': [32, 199], 'composition': [33, 200], 'is': [34, 201, 371, 473, 808, 1022, 1337, 1382, 2128, 2498, 2594, 3235, 3241, 3720, 3921, 3998, 4040, 4138, 4151, 4297, 4317, 4479], 'dictated': [35, 202], 'primarily': [36, 203], 'interactions': [38, 205], 'DNA,': [40, 207, 820, 1628, 2175], 'salt': [42, 209, 2013, 3278, 3367, 3705, 3754], 'playing': [43, 210], 'an': [44, 211, 943, 1023, 1033, 1349, 1433, 1797, 2214, 2254, 2308, 2673, 2840, 3127, 3398, 4107, 4184, 4375, 4521, 4536], 'important,': [45, 212], 'yet': [46, 213], 'secondary,': [47, 214], 'role.': [48, 215], 'Directional': [49, 216, 1020], 'correlate': [51, 71, 218, 238], 'the': [53, 86, 90, 112, 157, 220, 253, 257, 279, 324, 372, 398, 470, 476, 555, 717, 996, 1030, 1068, 1080, 1148, 1180, 1188, 1335, 1386, 1399, 1495, 1685, 1713, 1729, 1745, 1749, 1772, 1990, 2062, 2068, 2247, 2265, 2367, 2460, 2475, 2485, 2503, 2510, 2515, 2535, 2542, 2547, 2569, 2583, 2587, 2595, 2627, 2739, 2802, 2808, 2911, 2987, 2992, 3022, 3028, 3042, 3050, 3065, 3072, 3222, 3226, 3230, 3239, 3246, 3275, 3349, 3352, 3356, 3377, 3383, 3412, 3419, 3426, 3430, 3443, 3447, 3455, 3458, 3476, 3498, 3555, 3568, 3634, 3671, 3676, 3689, 3697, 3711, 3718, 3723, 3730, 3757, 3764, 3801, 3814, 3838, 3846, 3858, 3914, 3918, 3962, 3972, 3989, 4011, 4016, 4029, 4050, 4053, 4057, 4061, 4071, 4077, 4082, 4085, 4090, 4096, 4100, 4114, 4117, 4132, 4135, 4145, 4154, 4191, 4204, 4225, 4242, 4246, 4251, 4260, 4270, 4280, 4302, 4323, 4327, 4331, 4342, 4381, 4394, 4401, 4410, 4425, 4454, 4469, 4482, 4544, 4553, 4568, 4587, 4605, 4615], 'presence': [54, 76, 91, 221, 243, 258, 1422, 1991, 3051, 3276, 3413, 4030, 4243, 4303, 4343, 4385, 4483, 4588], 'of': [55, 77, 92, 108, 138, 222, 244, 259, 275, 305, 384, 411, 573, 719, 817, 998, 1026, 1032, 1036, 1249, 1390, 1423, 1718, 1736, 1748, 1753, 1788, 1831, 1843, 1954, 1956, 1992, 2012, 2194, 2316, 2361, 2385, 2403, 2414, 2462, 2466, 2468, 2494, 2505, 2514, 2537, 2546, 2568, 2572, 2590, 2608, 2621, 2752, 2801, 2821, 2925, 2991, 3036, 3052, 3059, 3110, 3123, 3130, 3224, 3277, 3351, 3363, 3414, 3425, 3437, 3445, 3449, 3457, 3557, 3633, 3667, 3678, 3684, 3696, 3704, 3738, 3760, 3781, 3816, 3843, 3917, 3965, 3985, 3991, 4025, 4031, 4060, 4084, 4116, 4134, 4153, 4244, 4250, 4304, 4313, 4322, 4326, 4333, 4344, 4351, 4367, 4378, 4387, 4400, 4412, 4421, 4446, 4484, 4499, 4539, 4543, 4555, 4564, 4589, 4596, 4607], 'dimers,': [56, 223, 1754], 'tetramers,': [57, 224, 1755], 'and': [58, 66, 141, 225, 233, 308, 563, 721, 822, 936, 1062, 1144, 1175, 1395, 1426, 1715, 1721, 1756, 1764, 1774, 1803, 1811, 1855, 1878, 1881, 1958, 2007, 2066, 2076, 2098, 2122, 2191, 2201, 2226, 2260, 2311, 2338, 2352, 2363, 2377, 2488, 2526, 2531, 2558, 2563, 2580, 2598, 2642, 2660, 2697, 2716, 2737, 2806, 2864, 2888, 2909, 2959, 2978, 3027, 3205, 3309, 3338, 3372, 3462, 3485, 3502, 3808, 3840, 3881, 4046, 4089, 4099, 4123, 4293, 4301, 4309, 4363, 4404, 4415, 4436, 4444, 4502, 4506, 4534, 4547, 4558, 4579, 4594, 4604, 4618], 'larger': [59, 226, 1758, 2614], 'oligomers': [60, 227, 1759], 'observed': [61, 228, 2570, 3209, 3832], 'atomic': [63, 230, 488, 1707], 'force': [64, 231, 489, 1708], 'microscopy,': [65, 232], 'random': [67, 234, 1769, 1775], 'appear': [69, 236], 'to': [70, 156, 237, 323, 397, 716, 810, 960, 1067, 1331, 1497, 1627, 1711, 1741, 2009, 2060, 2072, 2115, 2245, 2302, 2379, 2534, 2586, 2601, 2756, 2761, 2825, 2830, 2929, 2934, 2956, 2961, 2964, 2971, 2986, 3064, 3195, 3233, 3392, 3472, 3638, 3791, 3825, 3968, 3979, 4110, 4277, 4467], 'mainly': [72, 239], 'monomers.': [74, 241], 'The': [75, 242, 387, 1421, 1818, 1863, 2412, 2491, 2566, 2746, 2782, 2793, 2815, 2848, 2919, 3009, 3186, 3269, 3548, 3626, 3748, 3778, 3983, 4063, 4125, 4472], 'a': [78, 93, 105, 116, 131, 245, 260, 272, 283, 298, 363, 393, 415, 463, 835, 988, 1077, 1137, 1247, 1354, 1391, 1509, 1785, 1789, 1827, 1844, 1859, 1872, 1952, 2010, 2079, 2110, 2303, 2333, 2355, 2382, 2407, 2471, 2480, 2619, 2694, 2701, 2726, 2750, 2757, 2819, 2826, 2861, 2869, 2898, 2923, 2930, 3034, 3084, 3121, 3217, 3319, 3327, 3331, 3389, 3394, 3404, 3433, 3452, 3504, 3573, 3665, 3702, 3792, 3819, 3827, 3853, 3868, 3887, 3911, 4023, 4305, 4320, 4334, 4368, 4388, 4430, 4512, 4573], '30-nt': [79, 246, 2304, 3378, 4574], 'weakly': [80, 247], 'deaminated': [81, 248, 3763, 4340], '"dead"': [82, 249, 3341], 'zone': [83, 250, 3342, 3380, 3428, 4119, 4128, 4142], 'located': [84, 251, 3242, 3566], 'at': [85, 252, 1951, 2057, 2104, 2124, 2206, 2321, 2365, 2474, 2483, 2509, 2523, 2541, 2555, 2576, 2646, 2687, 2854, 3120, 3135, 3145, 3305, 3348, 3388, 3562, 3710, 3735, 3872, 4131, 4374, 4535], '3′-ssDNA': [87, 113, 254, 280, 3390], 'end': [88, 255, 3391], 'implies': [89, 256], 'preferred': [94, 261], 'asymmetric': [95, 262], 'direction': [96, 263], 'for': [97, 264, 475, 557, 957, 1246, 2054, 2203, 2318, 2381, 2679, 2743, 2812, 2846, 2916, 3044, 3071, 3115, 3833, 4074, 4624], 'catalysis.': [99, 266, 3401], 'Single': [100, 267, 2408, 4398, 4541], 'turnover': [101, 268, 4621], 'reaction': [102, 269, 2794, 4473, 4622], 'rates': [103, 270, 4623], 'reveal': [104, 271], 'salt-dependent': [106, 133, 273, 300], 'inhibition': [107, 274, 712], 'toward': [111, 278, 995, 1385, 3429, 3800], 'region,': [114, 281, 4076, 4147], 'offering': [115, 282], 'molecular': [117, 284, 837], 'basis': [118, 285], 'underlying': [119, 286], 'Presteady': [123, 290, 2346, 2639], 'state': [124, 291, 1701, 1747, 2347, 4497, 4514], 'analysis': [125, 292, 2413, 3149, 3627, 4498], 'demonstrates': [126, 293], 'rapid': [127, 294], 'diffusion-limited': [128, 295], 'A3G-ssDNA': [129, 296], 'binding,': [130, 297, 832, 940], 'slower': [132, 299], 'conformational': [134, 301], 'change,': [135, 302], 'possibly': [136, 303, 655, 823], 'indicative': [137, 304], 'wrapping,': [140, 307], 'long': [142, 309], '(5–15': [143, 310], 'min)': [144, 311], 'protein-DNA': [145, 312], 'complex': [146, 313, 946], 'lifetimes.': [147, 314], 'We': [148, 315, 978, 1375, 1724, 3207, 3374, 3836], 'suggest': [149, 316], 'diverse': [151, 318], 'oligomerization': [153, 320], 'modes': [154, 321, 1777], 'contribute': [155, 322, 1066], 'human': [158, 325, 495, 1689], 'immunodeficiency': [159, 326, 496], 'virus,': [160, 327], 'type': [161, 328], '1,': [162, 329, 3336, 3370, 4043, 4121], 'proviral': [163, 330, 412], 'mutational': [165, 332, 1073], 'bias.': [166, 333], 'In': [334, 1684, 3442, 3813], '2002,': [335], 'Sheehy': [336], 'et': [337], 'al.': [338], '(1Sheehy': [339], 'A.M.': [340, 633], 'Gaddis': [341], 'N.C.': [342], 'Choi': [343], 'J.D.': [344, 1452, 1521], 'Malim': [345], 'M.H.': [346], 'Nature.': [347, 431, 452, 613, 860, 1485, 1616], '2002;': [348], '418:': [349], '646-650Crossref': [350], 'PubMed': [351, 435, 456, 520, 542, 596, 617, 648, 679, 701, 748, 768, 802, 864, 895, 915, 931, 973, 1015, 1057, 1097, 1127, 1165, 1203, 1222, 1235, 1266, 1284, 1305, 1325, 1370, 1416, 1470, 1489, 1539, 1573, 1595, 1620, 1661, 1679, 1906, 1938, 1984, 2040, 2156, 2288, 2434, 2451, 3166, 3181, 3264, 3295, 3524, 3541, 3604, 3621, 3653, 3906, 3938, 3956, 4173], 'Scopus': [352, 436, 457, 521, 543, 597, 618, 649, 680, 702, 749, 769, 803, 865, 896, 916, 932, 974, 1016, 1058, 1098, 1128, 1166, 1204, 1236, 1267, 1285, 1306, 1371, 1417, 1471, 1490, 1540, 1574, 1596, 1621, 1662, 1680, 1907, 1939, 1985, 2041, 2157, 2289, 2435, 2452, 3167, 3182, 3265, 3296, 3525, 3542, 3605, 3622, 3654, 3907, 3939, 3957, 4174], '(1922)': [353], 'Google': [354, 438, 459, 523, 545, 599, 620, 651, 682, 704, 751, 771, 805, 867, 898, 918, 934, 976, 1018, 1060, 1100, 1130, 1168, 1206, 1223, 1238, 1269, 1287, 1308, 1326, 1373, 1419, 1473, 1492, 1542, 1576, 1598, 1623, 1664, 1682, 1909, 1941, 1987, 2043, 2159, 2291, 2437, 2454, 3169, 3184, 3267, 3298, 3527, 3544, 3607, 3624, 3656, 3909, 3941, 3959, 4176], 'Scholar)': [355, 652, 1061, 1493, 1988, 2455, 3545], 'determined': [356, 1743, 4585, 4627], '(A3G),': [359], 'originally': [360], 'called': [361], 'CEM15,': [362], 'proposed': [364], 'cytidine': [365, 394, 1346], 'deaminase': [366, 395, 465, 1347, 1356, 1441], 'based': [367], 'sequence': [369], 'analysis,': [370], 'nonpermissive': [373], 'host': [374], 'factor': [375, 3550, 3974], 'blocks': [377], 'virion': [378, 418], 'infectivity': [379], 'factor-defective': [380], '(Δvif)': [381], 'T': [385], 'cells.': [386], 'experimental': [388], 'determination': [389], 'CEM15': [391], 'was': [392, 1838, 1866, 1886, 1914, 2046, 2070, 2102, 2132, 2167, 2371, 2456, 2599, 2711, 2723, 2754, 2776, 2795, 2823, 2852, 2883, 2895, 2927, 2954, 2968, 2984, 3011, 3019, 3030, 3062, 3143, 3150, 3193, 3346, 3359, 3403, 3422, 3784, 3823, 3975, 4002, 4238, 4267, 4465, 4518, 4584], 'belonging': [396], 'APOBEC': [399, 1350], 'family': [400, 1351, 1442], 'followed': [401], 'soon': [402], 'after': [403, 1869, 1960], 'experiments': [405, 3047, 3271], 'demonstrating': [406], 'G': [407, 1070], 'A-induced': [409], 'hypermutation': [410], 'Δvif': [416], '(2Zhang': [419], 'H.': [420, 507, 734, 1553, 1587, 1615, 1669, 3174, 3946], 'Yang': [421, 690], 'B.': [422, 441, 505, 665], 'Pomerantz': [423], 'R.J.': [424, 693, 790], 'Zhang': [425, 579], 'C.': [426, 667, 880, 1086, 1476, 2490], 'Arunachalam': [427], 'S.C.': [428, 874], 'Gao': [429], 'L.': [430, 449, 580, 582, 695, 901, 1001, 1043, 1151, 1361, 1402, 1647, 1892, 1970, 2026, 2274, 2420, 2442, 3250, 3281, 3510, 3532, 3590, 3612, 3892, 3924, 4159], '2003;': [432, 453, 3178], '424:': [433, 454], '94-98Crossref': [434], '(921)': [437], 'Scholar,': [439, 524, 600, 621, 683, 752, 772, 868, 899, 919, 1101, 1207, 1224, 1270, 1288, 1309, 1474, 1577, 1599, 1665, 2438, 3170, 3528, 3608, 3942], '3Mangeat': [440], 'Turelli': [442], 'P.': [443, 903, 905, 1003, 1005, 1045, 1047, 1153, 1155, 1294, 1315, 1359, 1404, 1406, 1649, 1651, 1894, 1896, 1922, 1924, 1972, 1974, 2028, 2030, 2140, 2142, 2276, 2278, 2422, 2424, 2440, 3252, 3254, 3283, 3285, 3512, 3514, 3530, 3592, 3594, 3610, 3894, 3896, 3926, 3928, 4161, 4163], 'Caron': [444], 'G.': [445, 526, 756], 'Friedli': [446], 'M.': [447, 689, 736, 876, 1111], 'Perrin': [448], 'Trono': [450], 'D.': [451, 1115], '99-103Crossref': [455], '(1252)': [458], 'Scholar).': [460, 546, 705, 806, 977, 1019, 1131, 1239, 1374, 1420, 1624, 1683, 1910, 1942, 2044, 2160, 2292, 3185, 3268, 3299, 3625, 3657, 3960, 4177], 'has': [462, 1243, 1494, 1502], 'duplicated': [464], 'domain': [466, 472, 1357], 'structure,': [467], 'but': [468, 1328, 1544, 3851, 4148], 'only': [469, 4130], 'C-terminal': [471], 'responsible': [474], '2The': [480], 'abbreviations': [481], 'used': [482, 2600, 3114, 3194, 3313, 3637], 'are:': [483], 'ssDNA,': [484], 'DNA;': [486, 493], 'AFM,': [487], 'microscopy;': [490], 'dsDNA,': [491, 4461], 'double-stranded': [492], 'HIV,': [494], 'virus;': [497], 'nt,': [498], 'nucleotide(s).': [499], 'activity': [501, 2163, 3358, 3436, 3448, 4312], '(4Navarro': [502], 'F.': [503, 578, 627, 685], 'Bollman': [504], 'Chen': [506, 1483], 'Konig': [508, 1104], 'R.': [509, 738, 776, 1084, 1105, 1446, 1478, 1515, 1561, 1920, 2138], 'Yu': [510, 672], 'Q.': [511, 1103], 'Chiles': [512, 1108], 'K.': [513, 608, 639, 661, 742, 855, 1109, 1567, 1585, 1611, 1671, 3948], 'Landau': [514, 1118], 'N.R.': [515, 1119], 'Virology.': [516], '2005;': [517, 534, 614, 861], '333:': [518], '374-386Crossref': [519], '(269)': [522], '5Hache': [525], 'Liddament': [527], 'M.T.': [528], 'Harris': [529, 761, 791, 1588, 1612], 'R.S.': [530, 762, 792, 1589, 1613], 'J.': [531, 585, 671, 674, 696, 743, 763, 797, 1213, 1280, 1316, 1450, 1456, 1459, 1519, 1525, 1528, 1568, 1674, 1927, 2145, 3159, 3951], 'Biol.': [532, 586, 911, 1011, 1053, 1123, 1161, 1214, 1317, 1412, 1460, 1529, 1657, 1902, 1928, 1980, 2036, 2146, 2284, 2430, 3260, 3291, 3520, 3600, 3902, 3934, 4169], 'Chem.': [533, 587, 1215, 1318, 1461, 1530, 1929, 2147, 3161], '280:': [535], '10920-10924Abstract': [536], 'Full': [537, 539, 591, 593, 1219, 1322, 1465, 1467, 1534, 1536, 1933, 1935, 2151, 2153], 'Text': [538, 540, 592, 594, 1220, 1323, 1466, 1468, 1535, 1537, 1934, 1936, 2152, 2154], 'PDF': [541, 595, 1221, 1324, 1469, 1538, 1937, 2155], '(157)': [544, 1286], 'Apart': [547], 'from': [548, 1692, 1815, 2113, 2520, 2552, 2693, 2734, 2906, 3021, 3245, 3469, 3475, 3717, 3729, 3977, 4081, 4330, 4358], 'A3G-catalyzed': [549, 982], 'deamination,': [550], 'may': [552, 713, 722, 842, 1630, 3381], 'also': [553, 1342, 1548, 2240, 3803, 4020], 'have': [554, 979, 1376, 1698, 4194], 'capacity': [556], 'blocking': [558], 'reverse': [559], 'transcription,': [560], '(+)-DNA': [561], 'synthesis,': [562], 'provirus': [564], 'formation': [565], 'either': [566, 2947, 3083, 4219], 'interacting': [568, 656], 'RNA': [570, 831, 939, 1081], 'or': [571, 653, 1040, 2177, 2196, 2222, 2331, 2410, 2479, 2630, 2662, 2787, 2949, 3087, 3366, 4221, 4349, 4384], '(6Li': [575], 'X.Y.': [576], 'Guo': [577], 'Kleiman': [581, 694], 'Cen': [583, 686], 'S.': [584, 687, 732, 740, 890, 1090, 1107, 1113, 1300, 1551, 1555, 3643], '2007;': [588, 645, 676, 698, 745, 799, 928, 970, 1367, 1486, 1592, 2448, 3538, 3618], '282:': [589], '32065-32074Abstract': [590], '(128)': [598], '7Chiu': [601], 'Y.L.': [602, 849, 870], 'Soros': [603, 850, 877], 'V.B.': [604, 851, 878, 921, 963], 'Kreisberg': [605, 852], 'J.F.': [606, 853, 1228, 1259, 1276], 'Stopak': [607, 854], 'Yonemoto': [609, 856, 922, 964], 'W.': [610, 631, 857, 923, 965], 'Greene': [611, 858, 883, 924, 966], 'W.C.': [612, 859, 884, 925, 967], '435:': [615, 862], '108-114Crossref': [616, 863], '(393)': [619, 866], '8Iwatani': [622], 'Y.': [623, 691, 1563, 1583, 1609, 1667, 3172, 3944], 'Chan': [624], 'D.S.': [625], 'Wang': [626, 662, 3173], 'Maynard': [628], 'K.S.': [629], 'Sugiura': [630], 'Gronenborn': [632], 'Rouzina': [634], 'I.': [635], 'Williams': [636], 'M.C.': [637], 'Musier-Forsyth': [638], 'Levin': [640, 1564, 1672, 3949], 'J.G.': [641, 1565, 1673, 3950], 'Nucleic': [642, 1091, 1229, 1260], 'Acids': [643, 1092, 1230, 1261], 'Res.': [644, 1093, 1231, 1262], '35:': [646], '7096-7108Crossref': [647], '(254)': [650], 'proteins': [659, 1252], '(9Luo': [660], 'T.': [663, 882], 'Liu': [664], 'Tian': [666], 'Xiao': [668], 'Z.': [669], 'Kappes': [670], 'X.F.': [673], 'Virol.': [675, 697, 744, 764, 798, 1569, 1675, 3952], '81:': [677, 699, 746, 800], '7238-7248Crossref': [678], '(189)': [681], '10Guo': [684], 'Niu': [688], 'Gorelick': [692, 789], '11322-11331Crossref': [700], '(104)': [703], 'However,': [706, 3961, 4010], 'these': [707], 'noncatalytic': [708], 'effects': [709], 'HIV': [711, 938, 954], 'be': [714, 724, 951, 1742, 3382, 3489, 3636, 3969, 4111], 'attributable': [715], 'overexpression': [718], 'not': [723, 3661, 3883], 'occurring': [725, 1028, 1178, 2508, 2522, 2540, 2554, 3561], 'during': [726], 'normal': [727], '(11Miyagi': [729], 'E.': [730, 1559, 1603], 'Opi': [731], 'Takeuchi': [733, 1552, 1668, 3945], 'Khan': [735, 1556], 'Goila-Gaur': [737, 1560], 'Kao': [739, 1554], 'Strebel': [741, 1566, 1670, 3947], '13346-13353Crossref': [747], '(126)': [750], '12Schumacher': [753], 'A.J.': [754], 'Hache': [755], 'Macduff': [757], 'D.A.': [758, 3158, 3176], 'Brown': [759, 785], 'W.L.': [760, 786], '2008;': [765, 1617], '82:': [766], '2652-2660Crossref': [767], '(135)': [770], '13Mbisa': [773], 'J.L.': [774], 'Barr': [775], 'Thomas': [777], 'J.A.': [778], 'Vandegraaff': [779], 'N.': [780, 1581], 'Dorweiler': [781], 'I.J.': [782], 'Svarovskaia': [783], 'E.S.': [784], 'Mansky': [787], 'L.M.': [788], 'Engelman': [793], 'A.': [794, 891, 1301, 1448, 1517, 1607, 1996], 'Pathak': [795], 'V.K.': [796], '7099-7110Crossref': [801], '(234)': [804], 'It': [807], 'important': [809, 4108], 'bear': [811], 'mind': [813], 'any': [815], 'actions': [816], 'catalytic': [821, 1392, 1425, 1499, 1722], 'noncatalytic,': [824], 'are': [825, 1547, 1804, 2624, 3674, 3694, 4407, 4451, 4550, 4612], 'balanced': [826], 'vivo': [828], 'against': [829, 937], 'cellular': [830], 'which': [833, 841, 941, 948, 3693], 'forms': [834, 942, 1546], 'high': [836, 1780, 3888], 'mass': [838], 'A3G-RNA': [839], 'complex,': [840], 'prevent': [843], 'incorporation': [845], 'into': [846, 1187], 'virions': [847], '(7Chiu': [848], '14Chiu': [869], 'Witkowska': [871], 'H.E.': [872], 'Hall': [873], 'Santiago': [875], 'Esnault': [879], 'Heidmann': [881], 'Proc.': [885, 1295], 'Natl.': [886, 1296], 'Acad.': [887, 1297], 'Sci.': [888, 1298], 'U.': [889, 1299], '2006;': [892, 912, 1012, 1054, 1094, 1162, 1413, 1462, 1531, 1570, 1658, 1676, 1903, 1981, 2037, 2285, 2431, 3261, 3292, 3521, 3601, 3903, 3935, 3953, 4170], '103:': [893], '15588-15593Crossref': [894], '(211)': [897], '15Chelico': [900], 'Pham': [902, 1002, 1044, 1152, 1403, 1648, 1893, 1921, 1971, 2027, 2139, 2275, 2421, 3251, 3282, 3511, 3591, 3893, 3925, 4160], 'Calabrese': [904, 1004, 1046, 1154, 1405, 1650, 1895, 1923, 1973, 2029, 2141, 2277, 2423, 3253, 3284, 3513, 3593, 3895, 3927, 4162], 'Goodman': [906, 1006, 1048, 1156, 1362, 1407, 1481, 1652, 1897, 1925, 1975, 2031, 2143, 2279, 2425, 2443, 3255, 3286, 3515, 3533, 3595, 3613, 3646, 3897, 3929, 4164], 'M.F.': [907, 1007, 1049, 1157, 1363, 1408, 1482, 1653, 1898, 1926, 1976, 2032, 2144, 2280, 2426, 2444, 3256, 3287, 3516, 3534, 3596, 3614, 3647, 3898, 3930, 4165], 'Nat.': [908, 1008, 1050, 1120, 1158, 1409, 1654, 1899, 1977, 2033, 2281, 2427, 3257, 3288, 3517, 3597, 3899, 3931, 4166], 'Struct.': [909, 1009, 1051, 1121, 1159, 1410, 1655, 1900, 1978, 2034, 2282, 2428, 3258, 3289, 3518, 3598, 3900, 3932, 4167], 'Mol.': [910, 1010, 1052, 1122, 1160, 1411, 1656, 1901, 1979, 2035, 2283, 2429, 3259, 3290, 3519, 3599, 3901, 3933, 4168], '13:': [913, 1013, 1055, 1163, 1414, 1659, 1904, 1982, 2038, 2286, 2432, 3262, 3293, 3522, 3602, 3904, 3936, 4171], '392-399Crossref': [914, 1014, 1056, 1164, 1415, 1660, 1905, 1983, 2039, 2287, 2433, 3263, 3294, 3523, 3603, 3905, 3937, 4172], '(241)': [917, 1017, 1059, 1167, 1418, 1663, 1908, 1986, 2042, 2290, 2436, 3266, 3297, 3526, 3606, 3908, 3940, 4175], '16Soros': [920], 'PLoS': [926, 968], 'Pathog.': [927, 969], '3:': [929, 971], 'e15Crossref': [930, 972], '(113)': [933, 975], 'Scholar),': [935, 1169, 1327, 1543, 3910], 'intravirion': [944], 'must': [950], 'activated': [952], 'RNase': [955, 1995], 'H': [956], 'ensue': [961], '(16Soros': [962], 'shown': [980, 4452, 4476, 4613], 'occurs': [984, 4129, 4510], 'processively': [985, 2634], 'while': [986], 'exhibiting': [987], 'polarity': [992, 3487, 3687, 3750], 'favoring': [993, 1760], '5′-region': [997], 'ssDNA': [999, 1846, 2165, 2209, 2721, 2774, 2791, 2849, 2893, 3060, 3215, 3247, 3315, 3333, 3353, 3459, 3500, 3570, 3848, 3877, 4182, 4192, 4296, 4336, 4372, 4475, 4525, 4629], '(15Chelico': [1000, 1042, 1150, 1401, 1646, 1891, 1969, 2025, 2273, 2419, 3249, 3280, 3509, 3589, 3891, 3923, 4158], 'intrinsic': [1024], 'property': [1025], 'A3G,': [1027, 1332], 'absence': [1031, 3444, 3759, 3990, 4350, 4382, 4595], 'obvious': [1034], 'source': [1035], 'energy': [1037], '(e.g.': [1038, 1253], 'ATP': [1039], 'GTP)': [1041], 'can': [1063, 3488], 'principle': [1065], 'A': [1072, 1834, 2359, 2612, 3337, 3340, 3371, 3682, 4122, 4308, 4505], 'bias,': [1074, 3220, 4198], 'increasing': [1075], '3′-direction': [1078], 'genome': [1082], '(17Suspene': [1083], 'Rusniok': [1085], 'Vartanian': [1087], 'J.P.': [1088], 'Wain-Hobson': [1089], '34:': [1095], '4677-4684Crossref': [1096], '(94)': [1099], '18Yu': [1102], 'Pillai': [1106], 'Kearney': [1110], 'Palmer': [1112], 'Richman': [1114], 'Coffin': [1116], 'J.M.': [1117], '2004;': [1124, 1232, 1263, 1930, 2148], '11:': [1125], '435-442Crossref': [1126], '(510)': [1129], 'processivity': [1133, 1720, 3484, 3549, 3659, 3672, 3966, 3973, 4274, 4294, 4442, 4501, 4602], 'appears': [1134, 1740], 'consistent': [1135], 'three-dimensional': [1138], 'facilitated': [1139], 'diffusion': [1140, 1186], 'process': [1141], 'involving': [1142], 'sliding': [1143, 3915], 'jumping': [1145, 1171, 3963], 'motions': [1146], 'along': [1147, 1334, 3330], 'where': [1170, 2199, 3221, 3355, 3670], 'involves': [1172], 'microscopic': [1173], 'dissociation': [1174], 'reassociation': [1176], 'events': [1177], 'same': [1181, 2584, 2628, 3499, 3569, 4261, 4426, 4569], 'molecule,': [1183], 'rather': [1184], 'than': [1185, 2615, 3631, 3876], 'surrounding': [1189], 'bulk': [1190], 'solution': [1191, 1507, 2360], '(19Berg': [1192], 'O.G.': [1193, 1212], 'Winter': [1194], 'R.B.': [1195], 'von': [1196], 'Hippel': [1197, 1209], 'P.H.': [1198, 1210], 'Biochemistry.': [1199], '1981;': [1200], '20:': [1201], '6929-6948Crossref': [1202], '(971)': [1205], '20von': [1208], 'Berg': [1211], '1989;': [1216], '264:': [1217], '675-678Abstract': [1218], '21Halford': [1225], 'S.E.': [1226, 1257, 1278, 4357], 'Marko': [1227, 1258, 1275], '32:': [1233, 1264], '3040-3052Crossref': [1234, 1265], '(713)': [1237, 1268], 'Three-dimensional': [1240], 'movement': [1242], 'been': [1244, 1503], 'documented': [1245], 'variety': [1248], 'site-specific': [1250], 'DNA-targeting': [1251], 'restriction': [1254], 'endonucleases)': [1255], '(21Halford': [1256], '22Stanford': [1271], 'N.P.': [1272], 'Szczelkun': [1273], 'M.D.': [1274], 'Halford': [1277], 'EMBO': [1279], '2000;': [1281], '19:': [1282], '6546-6557Crossref': [1283], '23Jack': [1289], 'W.E.': [1290, 1313], 'Terry': [1291], 'B.J.': [1292, 1311], 'Modrich': [1293, 1314], '1982;': [1302], '79:': [1303], '4010-4014Crossref': [1304], '(144)': [1307], '24Terry': [1310], 'Jack': [1312], '1985;': [1319], '260:': [1320], '13130-13137Abstract': [1321], 'contrast': [1330], 'catalysis': [1333], 'random.': [1338], 'Random': [1339], 'occur': [1343, 1778], 'activation-induced': [1345], '(AID),': [1348], 'member': [1352], 'single': [1355, 2472, 3574, 4620], '(25Pham': [1358], 'Chelico': [1360, 2441, 3531, 3611], 'Repair': [1365, 2446, 3536, 3616], '(Amst.).': [1366, 2447, 3537, 3617], '6:': [1368, 2449, 3539, 3619], '689-692Crossref': [1369, 2450, 3540, 3620], '(24)': [1372, 2453, 3543, 3623], 'previously': [1377, 1890, 1918, 1968, 2023, 2135, 2272, 2418, 3153, 3208], 'suggested': [1378], 'strongly': [1383], 'favored': [1384, 3721, 3798], '5′-direction,': [1387], 'perhaps': [1388, 1757], 'because': [1389, 3797], 'orientation': [1393, 3399], 'specificity': [1394], 'structural': [1396, 1716], 'asymmetries': [1397], 'enzyme': [1400, 3575], 'multiple': [1424, 1639], 'binding': [1427, 4248], 'domains': [1428], 'contained': [1431, 2241, 2785], 'elongated': [1434], 'rod-shaped': [1435], 'structure': [1437], 'found': [1438], 'this': [1440], '(26Wedekind': [1443, 1512], 'J.E.': [1444, 1513], 'Gillilan': [1445, 1514], 'Janda': [1447, 1516], 'Krucinska': [1449, 1518], 'Salter': [1451, 1520], 'Bennett': [1453, 1522], 'R.P.': [1454, 1523], 'Raina': [1455, 1524], 'Smith': [1457, 1526], 'H.C.': [1458, 1527], '281:': [1463, 1532], '38122-38126Abstract': [1464, 1533], '(83)': [1472, 1541], '27Prochnow': [1475], 'Bransteitter': [1477], 'Klein': [1479], 'M.G.': [1480], 'X.S.': [1484], '445:': [1487], '447-451Crossref': [1488], '(175)': [1491], 'potential': [1496], 'impose': [1498], 'directionality.': [1500], 'structurally': [1504], 'characterized': [1505], 'as': [1508, 1636, 1888, 1916, 1966, 2022, 2134, 2231, 2270, 2399, 2749, 2818, 2922, 3070, 3152, 3238, 3418, 3664, 3701, 3789, 4319, 4409, 4552], 'tail-to-tail': [1510], 'dimer': [1511], 'monomeric': [1545], 'active': [1549], '(28Opi': [1550], 'M.A.': [1557], 'Miyagi': [1558], 'Iwatani': [1562], '80:': [1571, 1677, 3954], '4673-4682Crossref': [1572], '(69)': [1575], '29Chen': [1578], 'K.M.': [1579, 1601], 'Martemyanova': [1580], 'Lu': [1582, 1608], 'Shindo': [1584, 1610], 'Matsuo': [1586, 1614], 'FEBS': [1590], 'Lett.': [1591], '581:': [1593], '4761-4766Crossref': [1594], '(44)': [1597], '30Chen': [1600], 'Harjes': [1602], 'Gross': [1604], 'P.J.': [1605], 'Fahmy': [1606], '452:': [1618], '116-119Crossref': [1619], '(188)': [1622], 'When': [1625], 'bound': [1626, 3865], 'exist': [1631], 'different': [1633, 3328, 3586], 'states,': [1635], 'implied': [1637], 'A3G-DNA': [1640], 'bands': [1641], 'gel': [1643, 2517, 2549], 'shift': [1644], 'analyses': [1645, 1703], '31Iwatani': [1666, 3943], '5992-6002Crossref': [1678, 3955], '(161)': [1681, 3958], 'present': [1686, 3347, 4466], 'work,': [1687], 'using': [1688, 1858, 2109, 2354, 2672, 2700, 2839, 2868, 3024, 3033, 3082], 'produced': [1691], 'baculovirus-infected': [1693], 'Sf9': [1694, 1943], 'insect': [1695], 'cells,': [1696], 'applied': [1699], 'presteady': [1700, 4513], 'kinetic': [1702], 'combination': [1705], 'microscopy': [1709], '(AFM)': [1710], 'investigate': [1712], 'dynamic': [1714], 'determinants': [1717], 'provide': [1725], 'evidence': [1726], 'showing': [1727], 'bias': [1733, 3304, 3780, 3831, 3987, 4027, 4218], 'enzyme,': [1750], 'populations': [1752], 'directionally': [1761], 'biased': [1762], 'most': [1765], 'likely': [1766], 'monomers': [1767], 'deamination.': [1770], 'Both': [1771], 'directional': [1773, 3779], 'processivity,': [1781], 'readily': [1782], 'observable': [1783], 'time': [1786, 2386, 2753, 2822, 2926, 4515], 'scale': [1787], 'few': [1790], 'seconds.': [1791], 'Substrates—DNA': [1792], 'oligonucleotides': [1793], 'were': [1794, 1813, 1822, 1945, 1964, 1999, 2120, 2218, 2228, 2251, 2262, 2295, 2327, 2349, 2396, 2645, 2670, 2837, 2866, 2995, 3078, 3113, 3118, 3272, 4200, 4259, 4626], 'synthesized': [1795], 'Applied': [1798, 2674, 2841], 'Biosystems': [1799], '3400': [1800], 'DNA/RNA': [1801], 'synthesizer': [1802], 'listed': [1805], 'supplemental': [1807], 'Table': [1808], 'S1.': [1809], 'Fluorescein-dT': [1810], 'pyrrolo-dC': [1812], 'purchased': [1814], 'Glen': [1816], 'Research.': [1817], 'partially': [1819, 4460], 'dsDNA': [1820, 2238, 3866, 3885, 4013, 4051, 4101, 4146, 4186, 4306], 'substrates': [1821, 2166, 2210, 2239, 2294, 2469, 4630], 'constructed': [1823, 1839, 1887], 'annealing': [1825, 2301], '1.4-fold': [1828], 'molar': [1829], 'excess': [1830, 3017], 'complementary': [1832, 2305, 4390], 'ssDNA.': [1833], 'circular': [1835, 1864, 4226, 4252, 4271], 'substrate': [1837, 1847, 2722, 2775, 2894, 3061, 3501, 3571, 3635, 4088, 4272, 4282, 4337, 4373, 4526], '5′-end': [1841, 3802, 3829], 'phosphorylation': [1842], '118-nt': [1845, 3847, 4369], 'T4': [1849], 'polynucleotide': [1850], 'kinase': [1851], '(New': [1852], 'England': [1853], 'Biolabs)': [1854], 'subsequent': [1856], 'ligation': [1857], 'linker': [1860], 'oligonucleotide.': [1862], 'product': [1865], 'then': [1867, 2000, 2339, 2397, 2499, 2969, 2996, 3031, 3463], 'purified': [1868, 2133], 'resolution': [1870, 2299], '10%': [1873, 2099], 'denaturing': [1874], 'polyacrylamide': [1875], 'gel.': [1876], 'AID': [1879, 2131, 2223, 2631], 'Expression': [1880], 'Purification—A': [1882], 'baculovirus-expressed': [1883], 'GST-A3G': [1884], 'protein': [1885, 2993, 3073], 'described': [1889, 1917, 1967, 2024, 2136, 2232, 2271, 2400, 2417, 3154], 'recombinant': [1912, 1948], 'virus': [1913, 1950], 'obtained': [1915], '(32Bransteitter': [1919, 2137], '279:': [1931, 2149], '51612-51621Abstract': [1932, 2150], '(127)': [1940, 2158], 'cells': [1944], 'infected': [1946], 'multiplicity': [1953], '1': [1957, 2095, 2188, 2616, 2657, 3131, 3133], 'harvested': [1959], '72': [1961], 'h.': [1962], 'Cells': [1963], 'lysed': [1965], '50': [1993, 2073, 2087, 2092, 2172, 2652, 2732, 2904, 3471], 'μg/ml': [1994], 'Cleared': [1997], 'lysates': [1998], 'incubated': [2001, 2202, 2219, 2712, 2724, 2884, 2896, 4519], 'glutathione-Sepharose': [2003], 'resin': [2004], '(GE': [2005, 2052, 2083], 'Healthcare)': [2006, 2053, 2084], 'subjected': [2008], 'series': [2011], 'washes': [2014], '(0.25–1': [2015], 'm': [2016], 'NaCl)': [2017], 'before': [2018, 2297, 2389, 2729, 2901, 3038, 3068, 3467], 'elution': [2019], 'buffer': [2021, 2182, 2650, 2941], 'treated': [2047, 2398], '0.02': [2049], 'units/μl': [2050], 'thrombin': [2051], '16': [2055], 'h': [2056], '21': [2058], '°C': [2059, 2648, 2958], 'release': [2061], 'glutathione': [2063], 'S-transferase': [2064], 'tag,': [2065], 'subsequently': [2067], 'sample': [2069, 2994, 3010, 3067], 'diluted': [2071, 2970], 'mm': [2074, 2088, 2093, 2096, 2106, 2117, 2184, 2189, 2243, 2653, 2658, 2664, 2943, 2952, 2980, 3416, 3479, 3740, 4008, 4033, 4346, 4463, 4486, 4591], 'NaCl': [2075, 2107, 2244, 3809, 4464], 'loaded': [2077], 'onto': [2078, 2998], 'DEAE': [2080], 'FF': [2081], 'column': [2082], 'equilibrated': [2085], 'Tris-HCl,': [2089], 'pH': [2090, 2186, 2655, 2945], '8.9,': [2091], 'NaCl,': [2094, 3818], 'dithiothreitol,': [2097, 2190, 2659], 'glycerol.': [2100], 'eluted': [2103], '∼200': [2105], 'linear': [2111, 3214, 4257, 4281], 'gradient': [2112], '75': [2114], '1000': [2116], 'NaCl.': [2118], 'Fractions': [2119], 'collected': [2121, 3119], 'stored': [2123], '-70': [2125], '°C.': [2126, 2208, 2323], '∼95%': [2129], 'pure.': [2130], 'Deamination': [2161, 2405, 3203, 4178], 'Assays—A3G': [2162], 'measured': [2168, 2340, 2877, 3490], 'reactions': [2170, 2235, 2348, 4458], 'containing': [2171, 2307, 2651, 2850, 3343], 'nm': [2173, 2179, 2689, 2718, 2771, 2780, 2856, 2890, 2973, 3056], '32P-labeled': [2174], '5': [2176, 2314, 2663, 2951, 3415, 4032, 4345, 4590], '500': [2178], '(50': [2183, 2804, 2942, 4338], 'HEPES,': [2185, 2654, 2944], '7.3,': [2187, 2656], 'varied': [2192], 'amounts': [2193], 'MgCl2': [2195, 2953, 3446, 3668, 3736, 3992, 4034, 4223, 4300, 4347, 4352, 4592, 4597], 'other': [2197], 'salts': [2198], 'indicated)': [2200], '2.5–60': [2204], 'min': [2205, 2320], '37': [2207, 2322, 2647], '(0.3–0.5': [2211], 'μm)': [2212], 'internal': [2215, 4140], 'fluorescein': [2216, 3505], 'label': [2217, 3506], '(20–300': [2224], 'nm),': [2225], 'carried': [2229], 'out': [2230, 3424, 3695], 'above.': [2233, 2401], 'All': [2234, 3075], 'partial': [2237], '30': [2242, 3344, 4462, 4485], 'stabilize': [2246, 4468], 'duplex': [2248, 4470], 'region.': [2249, 4307, 4471], 'Reactions': [2250], 'terminated': [2252], 'extraction': [2255], 'phenol/chloroform/isoamyl': [2257, 2392], 'alcohol': [2258, 2393], '(25:24:1),': [2259], 'detected': [2263, 4408, 4551], 'uracil': [2266], 'glycosylase': [2268], 'assay,': [2269], 'Circular': [2293, 4181], 'linearized': [2296], 'PAGE': [2298], 'oligonucleotide': [2306, 3855, 4391], 'MseI': [2309, 2317], 'site': [2310], 'incubating': [2312], 'units': [2315], '60': [2319], 'Gel': [2324], 'band': [2325, 2464, 2518, 2550], 'intensities': [2326, 2519, 2551], 'visualized': [2328], 'phosphorimaging': [2330], 'FX': [2334], 'fluorescence': [2335, 2835, 2875, 2914, 2920], 'scanner': [2336], '(Bio-Rad)': [2337], 'ImageQuant': [2342], 'software': [2343], '(Amersham': [2344], 'Biosciences).': [2345], 'mechanically': [2350], 'sampled': [2351], 'quenched': [2353], 'KinTek': [2356], 'quench-flow': [2357], 'instrument.': [2358], 'twice': [2366], 'final': [2368], 'intended': [2369], 'concentration': [2370, 3368, 3822], 'rapidly': [2372, 2730, 2902], 'mixed': [2373], 'equal': [2375, 2799], 'volumes': [2376, 2800], 'allowed': [2378, 2960], 'react': [2380], 'given': [2383], 'amount': [2384], '(0.1–180': [2387], 's)': [2388], 'quenching': [2390], '(25:24:1).': [2394], 'Samples': [2395], 'Analysis': [2402], 'Processive': [2404, 4582], 'AID—': [2411], '25Pham': [2439, 3529, 3609], 'used.': [2457], 'This': [2458], 'entails': [2459], 'quantification': [2461], 'integrated': [2463, 2516, 2548], 'intensity': [2465], 'fractions': [2467], 'Cor3′': [2477], 'double': [2481, 2496, 2527, 2559, 2573, 2592, 2622, 2758, 2827, 2931, 3559, 3580, 4419, 4562], 'both': [2484, 2577, 2636, 4422, 4565], 'predicted': [2492, 2588], 'fraction': [2493, 2504, 2536, 2571, 2589, 3556], 'independent': [2495, 2591, 4360], 'calculated': [2500], 'multiplying': [2502], 'all': [2506, 2538], '(sum': [2513, 2545], '(5′': [2529, 2561, 3741, 3770, 3993, 4035, 4434, 4577], 'C))': [2533], 'C)).': [2565], 'ratio': [2567, 2613, 3774, 3997, 4039, 4232, 4377, 4538], '(occurring': [2575], 'Con': [2582], 'molecule)': [2585], '"processivity': [2596], 'factor"': [2597], 'determine': [2602, 2706, 2765, 2874], '(i.e.': [2604], 'correlated': [2605, 3558], 'double)': [2606], 'two': [2609, 3494, 3563, 3585, 3690, 4017, 4058, 4395, 4528], 'target': [2610, 2637, 3232, 3364, 3420, 3714, 3726, 4072, 4079, 4092, 4156], 'motifs.': [2611, 2638], 'indicates': [2617], 'majority': [2620], 'caused': [2625], 'molecule': [2632, 3334, 3576, 4205, 4227, 4427, 4570], 'acting': [2633], 'State': [2640], 'Anisotropy': [2641], 'Fluorescence': [2643], 'Assays—Reactions': [2644], '0': [2661, 4007], 'MgCl2.': [2665], 'Stopped': [2666, 2833], 'flow': [2667, 2834], 'anisotropy': [2668, 2680, 2742, 2747, 2811, 2816], 'measurements': [2669, 2836], 'performed': [2671, 2838, 3273], 'Photophysics': [2675, 2842], 'Π*180': [2676, 2843], 'spectrofluorometer': [2677, 2844], 'equipped': [2678, 2845], 'exciting': [2682], 'vertically': [2684], 'polarized': [2685], 'light': [2686], '494': [2688], '(2.5-nm': [2690], 'slit': [2691, 2858], 'width)': [2692, 2859], 'xenon': [2695], 'lamp': [2696], 'monitoring': [2698, 2738, 2807, 2910], 'emissions': [2699, 2865], '515-nm': [2702], 'cut-off': [2703, 2871], 'filter.': [2704, 2872], 'To': [2705, 2764, 2873, 3300], 'on-rates,': [2707], '0.8–2': [2708], 'μm': [2709, 2789, 2881, 3134], 'one': [2714, 2768, 2886], 'syringe,': [2715, 2728, 2769, 2887, 2900], '200': [2717, 2889, 3055], 'fluorescein-labeled': [2719, 2772, 4371, 4524], '69-nt': [2720, 2773, 2892, 3332, 4335], 'second': [2727, 2783, 2899], 'mixing': [2731, 2798, 2903], 'μl': [2733, 2905], 'each': [2735, 2907, 3317, 4066, 4075], 'syringe': [2736, 2784, 2908], 'change': [2740, 2748, 2809, 2817, 2912, 2921, 3662], '0.2': [2744], 's.': [2745, 2814, 2918], 'function': [2751, 2820, 2924, 3666, 3703, 4321], 'fit': [2755, 2824, 2928], 'exponential': [2759, 2828, 2932], 'equation': [2760, 2933], 'obtain': [2762, 2831, 2935, 3826], 'on-rates.': [2763], 'off-rates,': [2766], '100': [2770, 2972], 'preincubated': [2777], '400': [2779], 'A3G.': [2781], '10': [2786], '20': [2788], 'unlabeled': [2790], 'substrate.': [2792, 4062], 'initiated': [2796], 'syringes': [2803], 'μl)': [2805], '500–1000': [2813], 'decay': [2829], 'off-rates.': [2832], 'fluorescence.': [2847], 'pyrrolo-C': [2851], 'excited': [2853], '335': [2855], '(2-nm': [2857], 'xenon-mercury': [2862], 'lamp,': [2863], 'monitored': [2867], '435-nm': [2870], 'changes,': [2876], 'volts,': [2879], '2': [2880], 'pyrrolo-C-labeled': [2891], 'emission': [2915], '0.6': [2917], 'rates.': [2936, 4504], 'Atomic': [2937], 'Force': [2938], 'Microscopy—A3G': [2939], 'imaging': [2940, 2976], '7.3)': [2946], 'without': [2950, 3310, 4222], 'heated': [2955], '65': [2957], 'cool': [2962], 'slowly': [2963], 'dissolve': [2965], 'salts.': [2966, 3835], 'buffer,': [2977], '0.1': [2979], 'dithiothreitol': [2981], '(final': [2982, 3057], 'concentration)': [2983, 3058], 'added': [2985, 3063], 'sample.': [2988], 'Ten': [2989], 'microliters': [2990], 'deposited': [2997], 'freshly': [2999], 'cleaved': [3000], 'mica': [3001], '(Spruce': [3002], 'Pine': [3003], 'Mica': [3004], 'Company,': [3005], 'Spruce': [3006], 'Pine,': [3007], 'NC).': [3008], 'rinsed': [3012], 'immediately': [3013], 'nanopure': [3015], 'water,': [3016], 'water': [3018], 'wicked': [3020], 'surface': [3023, 3029], 'filter': [3025], 'paper,': [3026], 'dried': [3032], 'stream': [3035], 'nitrogen': [3037], 'being': [3039], 'placed': [3040], 'AFM': [3043, 3076], 'imaging.': [3045, 3116], 'For': [3046, 4456], 'done': [3048, 3151], 'substrate,': [3054, 3354], 'depositing': [3069], 'alone.': [3074], 'images': [3077], 'captured': [3079], 'air': [3081], 'Nanoscope': [3085], 'III': [3086], 'IIIa': [3088], '(Digital': [3089], 'Instruments,': [3090], 'Santa': [3091], 'Barbara,': [3092], 'CA)': [3093], 'microscope': [3094], 'tapping': [3096, 3100], 'mode.': [3097], 'Pointprobe': [3098], 'Plus': [3099], 'mode': [3101], 'silicon': [3102], 'probes': [3103], '(Agilent,': [3104], 'Tempe,': [3105], 'AZ)': [3106], 'resonance': [3108], 'frequencies': [3109], '∼170': [3111], 'kHz': [3112], 'Images': [3117], 'speed': [3122], '2–3': [3124], 'Hz': [3125], 'image': [3128, 4493], 'size': [3129, 4073, 4157], '×': [3132, 3137], '512': [3136, 3138], 'pixel': [3139], 'resolution.': [3140], 'Each': [3141], 'experiment': [3142], 'repeated': [3144], 'least': [3146], 'twice.': [3147], 'Volume': [3148], '(33Ratcliff': [3155], 'G.C.': [3156], 'Erie': [3157, 3175], 'Am.': [3160], 'Soc.': [3162], '2001;': [3163], '123:': [3164], '5632-5635Crossref': [3165], '(108)': [3168], '34Yang': [3171], 'Methods.': [3177], '29:': [3179], '175-187Crossref': [3180], '(91)': [3183], 'program': [3187], 'Kaleidagraph': [3188], '(Synergy': [3189], 'Software,': [3190], 'Reading,': [3191], 'PA)': [3192], 'generate': [3196], 'statistical': [3197], 'plots.': [3198], 'Electrostatic': [3199], 'Influence': [3200], 'Polarity': [3204, 4179], 'Processivity—': [3206], 'exhibits': [3216], 'rate': [3223], 'deaminating': [3225], 'third': [3227], '5′-CCC': [3231], 'enhanced': [3236], 'significantly': [3237, 3663], 'motif': [3240, 3325, 3396, 3421, 4329], 'further': [3243], 'away': [3244], '3′-end': [3248, 3350, 3477, 4083, 4133, 4332], 'earlier': [3270], '(MgCl2)': [3279], 'study': [3301], 'higher': [3306, 3821], 'resolution,': [3307], 'salt,': [3311], '11': [3314, 3438], 'substrates,': [3316], '5′-A(G/T)A': [3320], 'CCC': [3321, 3395, 3495, 3564, 4328, 4529, 4632], 'AAA': [3322], 'hot': [3323], 'spot': [3324], 'location': [3329], '(Fig.': [3335, 3369, 3440, 3481, 3546, 3680, 3849, 3861, 3981, 4102, 4120, 4210], 'B).': [3339, 3373, 4124], 'nt': [3345, 3474, 3716, 3728, 4087, 4230, 4532], 'specific': [3357, 3409, 3435, 3793, 4311], '<1': [3360], 'pmol/μg/min': [3361, 3439], 'irrespective': [3362], 'position': [3365], 'speculate': [3375], 'dead': [3379, 3427, 3699, 4118, 4127, 4141], 'optimal': [3384], 'space': [3385], 'needs': [3387], 'encounter': [3393], 'allowing': [3400], 'There': [3402, 4104], 'monotonic': [3405], 'increase': [3406], 'activity,': [3410, 4291], 'MgCl2,': [3417, 3761, 4245], 'moved': [3423], '5′-end,': [3431], 'achieving': [3432], 'maximum': [3434], '1A).': [3441], 'reached': [3451], 'peak': [3453], 'near': [3454, 3758], 'center': [3456], '(∼15': [3460], 'pmol/μg/min)': [3461], 'remained': [3464], 'roughly': [3465, 3733], 'constant': [3466], 'decreasing': [3468], 'about': [3470], '69': [3473], '(0': [3478], 'MgCl2)': [3480], '1B).': [3482], 'simultaneously': [3491], 'placing': [3493], 'motifs': [3496, 3565, 4530], 'having': [3503], 'between': [3508, 3857, 4015, 4052, 4095, 4393], '1C).': [3547, 3681, 3747, 3777], '(see': [3551, 4004], '"Experimental': [3552], 'Procedures")': [3553], 'measures': [3554], 'compared': [3577, 4254], 'uncorrelated': [3579], 'catalyzed': [3582], 'independently': [3583], 'molecules': [3588], 'requires': [3628], 'less': [3630, 3753], '∼15%': [3632], 'maintain': [3639], 'single-hit': [3640], 'kinetics': [3641], '(35Creighton': [3642], 'Bloom': [3644], 'L.B.': [3645], 'Methods': [3648], 'Enzymol.': [3649], '1995;': [3650], '262:': [3651], '232-256Crossref': [3652], '(226)': [3655], 'did': [3660], 'concentration,': [3669, 3706], 'factors': [3673, 4275], 'range': [3677], '5–9': [3679], 'measurement': [3683], 'targets,': [3692], 'zone,': [3700], 'shows': [3707, 4214], '(100': [3715], '3′-end)': [3719, 3731], 'over': [3722], '(36': [3727], '2-fold': [3734], 'concentrations': [3737], '>5': [3739], 'C/3′': [3742, 3771, 3994, 4036, 4448, 4609], 'ratio;': [3745], 'Fig.': [3746, 3776, 3811, 3879, 4000, 4005, 4042, 4208, 4234, 4284, 4287], 'decreased': [3751], 'until,': [3755], 'targets': [3766, 3860, 4019], 'no': [3768, 4139, 4216], 'preference': [3769], '∼1;': [3775, 4041], 'clearly': [3785], 'electrostatic': [3786], 'origin': [3788], 'opposed': [3790], 'interaction': [3794], 'Mg2+,': [3796], 'occurred': [3804], 'CaCl2,': [3806], 'MnCl2,': [3807], '(supplemental': [3810, 3878], 'S1).': [3812], 'case': [3815], 'monovalent': [3817], '20-fold': [3820], 'required': [3824], 'similar': [3828, 4276], 'divalent': [3834], 'reexamined': [3837], 'polar': [3839], 'properties': [3842], '1C)': [3850], '20-nt': [3854, 4389], 'annealed': [3856, 4012, 4392], '1D).': [3862, 3982, 4103], 'Since': [3863], 'low': [3869], 'GC': [3870, 3889], 'content': [3871, 3890], '∼5-fold': [3873], 'lower': [3874], 'affinity': [3875], 'S2)': [3880], 'does': [3882], 'bind': [3884], 'loss': [3912, 4024], 'component': [3916, 3964], 'motion': [3920], 'expected': [3922, 4003], 'appeared': [3967], 'retained,': [3970], 'since': [3971], 'reduced': [3976], '8': [3978], '4': [3980], 'lack': [3984], '1;': [3999], '1D)': [4001], '1C,': [4006], 'MgCl2).': [4009], 'region': [4014, 4068, 4094], 'resulted': [4021], 'compare': [4044], 'D),': [4047], 'indicating': [4048], 'sites': [4055], 'decoupled': [4056], 'sides': [4059], 'depended': [4069], '36-nt': [4078], 'length': [4080, 4093], '118': [4086], '33-nt': [4091], 'is,': [4105], 'however,': [4106], 'distinction': [4109], 'made': [4112], 'regarding': [4113], 'occurrence': [4115], '∼30-nt': [4126], 'ssDNA;': [4136], 'there': [4137], 'created': [4143], 'instead': [4149], 'dependent': [4152, 4298], 'nucleotide': [4155], 'Requires': [4183], 'Intervening': [4185], 'Region—To': [4187], 'examine': [4188], 'what': [4189], 'effect': [4190], 'ends': [4193, 4199], 'eliminated': [4201], 'circularizing': [4203], 'depicted': [4206], '1C': [4209], '2A,': [4211], 'sketch).': [4212], 'essentially': [4215], '(81': [4228], 'nt/100': [4229], '∼1.1–1.3;': [4233], '2A).': [4235], 'Although': [4236], 'slightly': [4239], 'inhibited': [4240], 'apparent': [4247], 'constants': [4249], 'its': [4256], 'counterpart': [4258], '(Kd': [4262], '∼': [4263], '160': [4264], 'nm).': [4265], 'those': [4278], '(compare': [4283], '2A': [4285], '1C).FIGURE': [4288], '1A3G': [4289], 'polarity,': [4292, 4500], 'B,': [4310, 4507], '(5': [4315], 'nm)': [4316, 4339], 'plotted': [4318], 'distance': [4324], '(d)': [4325], '(A)': [4348, 4593], '(B).': [4353, 4598], 'Error': [4354], 'bars,': [4355], '±1': [4356], 'three': [4359], 'experiments.': [4361], 'D,': [4364, 4619], 'internally': [4370, 4523], 'enzyme/DNA': [4376, 4537], '1:20': [4379], '(C)': [4383], '(D)': [4386], 'targets.': [4397], 'appearance': [4411, 4554], 'labeled': [4413, 4432, 4556, 4575], '100-': [4414], '81-nt': [4416], 'fragments,': [4417, 4560], 'respectively;': [4418, 4561], 'Cs': [4423, 4566], 'results': [4428, 4571], '63-nt': [4431], 'fragment': [4433, 4576], 'C).': [4438, 4581], 'Substrate': [4439, 4599], 'usages': [4440, 4600], '(%),': [4441, 4601], 'factors,': [4443, 4603], 'ratios': [4445, 4606], 'below': [4453, 4614], 'gels.': [4455, 4616], 'unaffected': [4480], 'NaCl.View': [4487], 'Large': [4488], 'Image': [4489], 'Figure': [4490], 'ViewerDownload': [4491], 'Hi-res': [4492], 'Download': [4494], '(PPT)FIGURE': [4495], '3Presteady': [4496], 'scale.': [4516], '85-nt': [4522], '28': [4531], 'apart': [4533], '1:1.': [4540], '67-': [4557], '48-nt': [4559]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2072816807', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-24T06:58:25.399966', 'created_date': '2016-06-24'}
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