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1621, 1658, 1665, 1667, 1672, 1731, 1759, 1789, 1796, 1800, 1825, 1876, 1909, 1932, 1969, 1973, 2105, 2266, 2330, 2406, 2598], 'Department': [52, 99], 'of': [53, 69, 81, 84, 100, 116, 128, 131, 193, 209, 213, 228, 235, 242, 267, 287, 311, 331, 350, 355, 369, 382, 393, 395, 409, 435, 441, 478, 493, 502, 516, 523, 547, 567, 584, 593, 605, 621, 630, 637, 656, 674, 678, 684, 711, 758, 784, 789, 812, 835, 876, 907, 916, 954, 968, 1000, 1006, 1015, 1036, 1066, 1093, 1133, 1149, 1258, 1264, 1275, 1294, 1301, 1336, 1366, 1373, 1392, 1410, 1423, 1428, 1436, 1444, 1448, 1459, 1480, 1503, 1524, 1588, 1613, 1664, 1671, 1749, 1777, 1788, 1799, 1829, 1857, 1895, 1928, 1946, 1968, 1972, 1987, 2012, 2070, 2086, 2100, 2107, 2133, 2137, 2175, 2181, 2201, 2282, 2310, 2332, 2381, 2409, 2450, 2463, 2548, 2580, 2597, 2636, 2697, 2809, 2831, 2861], 'Medicine': [54, 85, 101, 132], '(Cardiology)': [55, 102], 'Marc': [58, 105], 'Ruti': [60, 107], 'Bell': [61, 108], 'Vascular': [62, 109, 2341, 2588, 2643, 2653, 2660, 2703, 2744, 2775, 2786, 2862, 2871], 'Biology': [63, 110], 'Program,': [64, 111], 'New': [65, 71, 112, 118, 1983, 1994, 2545], 'York': [66, 113, 1984], 'University': [67, 80, 114, 127, 1985], 'School': [68, 83, 115, 130, 1986], 'Medicine,': [70, 117, 1988, 2549], 'York,': [72, 119, 1995], 'NY': [73, 89, 120, 136, 1996], '(E.A.F.);': [74, 121], 'Aab': [76, 123], 'Cardiovascular': [77, 124], 'Research': [78, 125], 'Institute,': [79, 126], 'Rochester': [82, 129], 'Dentistry,': [87, 134], 'Rochester,': [88, 135], '(J.M.M.)': [90, 137], 'MianoJoseph': [94], 'Miano': [96, 2305, 2396], 'Originally': [138, 2895], 'published15': [139], 'Apr': [140], '2014https://doi.org/10.1161/CIRCULATIONAHA.114.009075Circulation.': [141], '2014;129:1545–1547Vascular': [142], 'smooth': [143, 428, 652, 1018, 1039, 1135, 1938, 2014, 2071, 2101, 2134, 2170, 2204, 2315, 2361, 2385, 2416], 'muscle': [144, 429, 653, 1040, 1136, 1939, 2015, 2102, 2135, 2171, 2205, 2259, 2316, 2362, 2386, 2417], 'cells': [145, 184, 443, 483, 550, 607, 1016, 1060, 1083, 1353, 1616, 1765, 1834, 1878, 1940, 2016, 2022, 2073, 2103, 2136, 2172, 2206, 2264, 2291], '(VSMCs)': [146], 'play': [147], 'important': [148, 257, 672, 763, 807, 921, 1101, 1778], 'physiological': [149], 'pathophysiological': [151], 'roles.': [152], 'Two': [153], 'articles': [154, 281], 'current': [157], 'issue': [158, 381, 1422], 'focus': [159], 'on': [160, 534, 1062, 1398, 1451, 2477], 'latter': [162, 306], 'atherosclerosis1': [164], 'pulmonary': [167, 215, 963, 1009, 1037, 1142, 1338, 1368, 1504, 1516, 1581, 1651, 1674, 2075, 2344, 2451, 2487, 2522], 'arterial': [168, 1038, 1190], 'hypertension': [169], '(PAH).2': [170], 'Notably,': [171], 'Allahverdian': [172, 384, 471, 622, 917, 1552, 2001], 'et': [173, 198, 385, 472, 623, 724, 918, 945, 1553], 'al1': [174, 386, 473, 919], 'report': [175, 200, 677], 'that,': [176, 201, 566], 'human': [178, 332, 357, 361, 404, 588, 759, 797, 824, 931, 1242, 1337, 1367, 1460, 2024, 2413], 'coronary': [179, 337, 397, 411, 760, 2414], 'artery': [180, 216, 398, 964, 1143, 1675, 2415], 'atherosclerotic': [181], 'plaques,': [182, 932], 'many': [183], 'typically': [185, 1207], 'classified': [186], 'as': [187, 375, 432, 453, 598, 650, 904, 965, 990, 992, 1108, 1110, 1213, 1414, 1728, 1893], 'macrophages': [188, 229, 585, 683, 957], 'are': [189, 349, 510, 591, 671, 1058, 1090, 1173, 1206, 1768, 1773, 1851, 1863, 1964, 2364], 'likely': [190, 217, 1888], 'be': [192, 663, 698, 766, 794, 806, 855, 864, 882, 893, 1377, 1475, 1717, 1808, 1814, 1842], 'VSMC': [194, 288, 312, 715, 790, 819, 901, 1112, 1526, 1574, 1790, 1827], 'origin,': [195], 'Ricard': [197, 944, 2029], 'al2': [199, 946], 'PAH,': [203, 942, 1302, 1677, 1875], 'VSMCs': [204, 260, 362, 394, 522, 611, 638, 828, 848, 951, 1197, 1461, 1860], 'contributing': [205], 'obstructive': [207, 1004], 'remodeling': [208, 1005, 2342, 2484], 'distal': [211, 962, 1008, 1141, 1189, 1239, 1673], 'branches': [212], 'arose': [218], 'from': [219, 245, 294, 413, 950, 976, 1032, 1045, 1251, 1267, 1341, 1351, 1355, 1770], 'pericytes.Article': [220], 'see': [221, 272, 1199, 1463, 1483], 'p': [222, 225], '1551': [223], '1586Although': [226], 'studies': [227, 307, 354, 644, 704, 1904], 'atherosclerosis': [231, 335, 370], 'far': [232], 'outnumber': [233], 'those': [234, 1967], 'VSMCs,': [236, 436], 'there': [237, 1172, 1233, 1418, 1645, 1715, 1772, 1812], 'is': [238, 284, 341, 929, 1002, 1028, 1052, 1146, 1154, 1231, 1234, 1419, 1678, 1745, 1783, 1887, 1941, 2067, 2177], 'nonetheless': [239], 'a': [240, 400, 433, 582, 602, 617, 675, 712, 717, 814, 858, 865, 873, 905, 966, 985, 1155, 1169, 1298, 1311, 1407, 1548, 1625, 1634, 1775, 1784, 1870, 2068, 2178, 2208, 2308, 2311, 2774], 'trove': [241], 'data,': [243], 'including': [244, 840], 'humans,': [246], 'going': [247], 'back': [248], 'more': [249, 299, 707, 1285, 1312, 1650, 1695], 'than': [250, 1656], '50': [251], 'years': [252], 'that': [253, 324, 475, 490, 543, 581, 590, 612, 788, 857, 1122, 1128, 1232, 1467, 1608, 1763, 1889, 2256], 'clearly': [254], 'support': [255, 293, 308, 633, 1605], 'an': [256, 372, 691, 728, 745, 878, 1558, 1629], 'role': [258, 1435, 2099], 'for': [259, 389, 554, 575, 817, 849, 871, 1050, 1158, 1328, 1499, 1568, 1573, 1596, 1654, 1688, 2314, 2367, 2384, 2405, 2454], 'both': [262, 445, 1896], 'acute': [263], 'chronic': [265, 2486], 'pathologies': [266], 'vessel': [269, 1288, 1399], 'wall': [270], '(eg,': [271, 1198, 1462, 1482, 1820], 'References': [273, 1200], '3–5).': [274], 'Of': [275], 'particular': [276], 'relevance': [277], '2': [280, 1283, 1849], 'under': [282], 'discussion': [283], 'concept': [286], 'phenotypic': [289, 313, 364, 391, 614, 635, 830, 850, 902], 'plasticity,': [290, 314], 'which': [291, 687, 1011, 1051], 'has': [292, 1471, 1733], 'classic': [295, 1525], 'ultrastructural': [296], 'studies5': [297], 'recent': [300, 676], 'lineage': [301, 702, 730], 'tracing': [302, 703, 731], 'experiments.6': [303], 'Although': [304, 1697], 'phenomenon': [310, 928], 'they': [315, 527, 1077, 1089, 1280, 1303], 'have': [316, 726, 1879], 'been': [317, 1472, 1734], 'limited': [318], 'experimental': [320, 1478], 'animal': [321], 'model': [322, 1300, 1409, 1627], 'systems': [323], 'may': [325, 861, 1716, 1813, 1922], 'not': [326, 592, 862, 1866, 1914, 1965], 'faithfully': [327], 'recapitulate': [328], 'all': [329], 'aspects': [330], 'pathology.': [333], 'Indeed,': [334], 'or': [338, 460, 462, 469, 899, 909, 1752, 1971], 'cerebral': [339], 'arteries': [340, 1240], 'rarely': [342], 'examined': [343], 'mice,': [345], 'whereas': [346], 'these': [347, 1152, 1374, 1415, 1533, 1848], 'sites': [348], 'great': [351], 'interest': [352], 'disease.': [358, 913], 'Thus,': [359], 'whether': [360, 810, 894], 'undergo': [363, 829], 'conversions': [365, 903], 'context': [368], 'remains': [371], 'unanswered': [373], 'question.Now,': [374], 'alluded': [376], 'above,': [378], 'this': [380, 494, 721, 939, 1159, 1329, 1441, 1449, 1689, 1907, 1962], 'Circulation,': [383, 2845], 'provide': [387, 626], 'evidence': [388, 631, 1049], 'conversion': [392, 615, 636, 710, 1148], 'macrophage-like': [401, 524, 618, 718, 859, 1871, 2021, 2209], 'state': [402, 1455, 1540, 2210], 'during': [403], 'atherogenesis.1': [405], 'Through': [406, 2633], 'special': [407], 'fixation': [408], 'vessels': [412], 'explanted': [414], 'hearts,': [415], 'authors': [417, 564, 600, 972, 1087, 1119, 1228, 1431, 1490, 1556, 1622], 'were': [418, 528, 551, 573, 1402, 1565, 1593, 1610, 1646], 'able': [419], 'preserve': [421, 2261], 'intracellular': [422], 'lipid': [423, 446, 503], 'deposition': [424], 'and,': [425, 1873], 'using': [427, 775], 'α-actin': [430], '(ACTA2)': [431], 'marker': [434, 539, 578, 1569, 1590, 1631], 'show': [437, 542, 706], 'up': [438, 1924], '50%': [440], 'intimal': [442, 482, 506, 548, 606, 2013], 'being': [444, 1506], 'engorged': [447], 'ACTA2+.': [449], 'By': [450, 2533], 'categorizing': [451], 'lesions': [452, 757], 'early': [454, 557], '(American': [455, 464], 'Heart': [456, 465, 1975, 2600, 2891], 'Association': [457, 466], 'type': [458, 467, 774, 2387], 'I': [459], 'II)': [461], 'advanced': [463, 559, 911], 'III': [468], 'IV),': [470], 'showed': [474], 'level': [477, 875], 'ABCA1': [479, 785], 'ACTA2+': [481, 505], 'was': [484, 1245, 1330, 1545], 'reduced': [485, 833], 'late': [487], 'lesions,': [488], 'suggesting': [489, 580], 'lower': [491], 'levels': [492, 811, 834, 1587], 'reverse': [495], 'cholesterol': [496, 529, 2018, 2212], 'transporter': [497], 'might': [498], 'explain': [499], 'accumulation': [501, 2019], 'cells.': [507, 1756], 'findings': [509, 620, 1534], 'consistent': [511], 'with': [512, 645, 738, 978, 1081, 1183, 1216, 1253, 1261, 1269, 1309, 1323, 1343, 1406, 1487, 1501, 1845, 2521], 'our': [513], 'previous': [514], 'demonstration': [515], 'acquisition': [518], 'mouse': [520, 886, 1299, 1408, 1626, 2202], 'aortic': [521, 2203], 'features': [525, 1427], 'after': [526, 2084, 2211], 'loaded': [530], 'vitro.7They': [532], 'went': [533], 'use': [536], 'macrophage': [538], 'CD68': [540], '≈18%': [544], '40%': [546], 'CD68-positive': [549], 'also': [552, 854, 1043, 1774, 1839], 'positive': [553, 574, 1507, 1567, 1595, 1653, 2366], 'ACTA2': [555, 679, 1655, 1836], 'atheromas,': [560], 'respectively.': [561], 'Finally,': [562, 781], 'discovered': [565], 'CD68+': [569], 'cells,': [570, 1041, 2363], 'only': [571, 1915], '≈35%': [572], 'leukocyte': [577], 'CD45,': [579], 'population': [583, 1138, 1828], 'exist': [586], 'atheromas': [589, 798], 'myeloid': [595], 'lineage.': [596], 'Rather,': [597], 'conclude,': [601], 'significant': [603], 'proportion': [604], 'represent': [608], 'once': [609, 713], 'contractile': [610, 714, 1454], 'underwent': [613], 'state.The': [619], 'al,1': [624, 1554], 'then,': [625, 889, 1230], 'yet': [627], 'another': [628], 'piece': [629], 'into': [639, 716, 935, 1747, 1832], 'other': [640, 646, 800, 1457, 1815, 1901], 'cell': [641, 654, 773, 776, 860, 956, 1137, 1858], 'types.': [642], 'Additional': [643, 1903], 'definitive': [647], 'markers,': [648], 'such': [649, 1212], 'isoforms': [655], 'myosin': [657], 'heavy': [658], 'chain': [659], 'calponin,': [661], 'will': [662, 697, 765, 892, 1913], 'valuable': [664], 'further': [666, 768, 1048, 1604], 'strengthen': [667], 'their': [668, 982, 1072, 1493, 1522, 1846, 1882], 'findings.': [669], 'These': [670], 'because': [673, 1443], 'staining': [680], 'activated': [682, 1476], 'bone': [685, 1750, 2267, 2439], 'marrow,8': [686], 'could': [688, 1376], 'conceivably': [689], 'seed': [690], 'evolving': [692, 755], 'atheroma.': [693], 'In': [694, 720, 1547, 1561, 1810], 'addition,': [695, 1811], 'it': [696, 804, 869], 'critical': [699, 2179], 'perform': [701], 'definitively': [708], 'cell.': [719], 'regard,': [722], 'Gomez': [723, 2273], 'al9': [725], 'developed': [727], 'elegant': [729], 'tool': [732], 'combining': [734], 'situ': [736], 'hybridization': [737], 'proximity': [740], 'ligation': [741, 2085], 'assay': [742], 'track': [744], 'indelible': [746], 'epigenetic': [747], 'mark': [748], '(H3K4me2)': [749], 'over': [750], 'MYH11': [752], 'locus': [753], 'neointimal': [756], 'arteries.': [761], 'Another': [762, 1742], 'endeavor': [764], 'characterize': [769], 'VSMC-macrophage': [771], 'chimeric': [772], 'sorting': [777], 'RNA-seq': [779], 'technology.': [780], 'mechanism': [783, 1798], 'downregulation': [786], '(and': [787], 'differentiation': [791, 1539, 1746], 'markers)': [792], 'should': [793, 853], 'explored': [795], 'arteriopathies.': [801], 'For': [802], 'example,': [803, 872], 'would': [805], 'know': [809], 'myocardin,': [813], 'molecular': [815, 1797, 1910, 2312], 'switch': [816, 2313], 'differentiated': [820], 'state,10': [821], 'changes': [822], 'vascular': [825, 1094, 1937, 2360, 2483], 'diseases': [826], 'where': [827], 'conversions.': [831], 'Perhaps': [832], 'myocardin': [836], '(or': [837], 'its': [838, 1468, 1793, 2781], 'targets,': [839], 'microRNAs': [841], 'long': [843], 'noncoding': [844], 'RNAs)': [845], 'sensitize': [846], 'conversion.': [851], 'It': [852, 1886], 'considered': [856, 880], 'necessarily': [863, 1966], 'plaque': [866], 'villain,': [867], 'if': [868, 1865], 'exerts,': [870], 'high': [874], 'efferocytosis,': [877], 'activity': [879], 'disease': [883, 1295], 'limiting': [884], 'models.11': [887], 'Ultimately,': [888], 'question': [891], 'intervene': [896], 'thwart': [898], 'encourage': [900], 'means': [906], 'preventing': [908], 'reversing': [910], 'atheromatous': [912], 'The': [914, 971, 1118, 1326, 1348, 1390, 1430, 1686, 1822, 2098], 'work': [915], 'contributes': [920, 1129], 'information,': [922], 'especially': [923, 1722], 'just': [924], 'how': [925], 'prevalent': [926], 'take': [934], 'consideration': [936], 'answering': [938], 'question.Turning': [940], 'theme': [948], 'shifts': [949], 'assuming': [952], 'characteristics': [953, 1458], 'foam': [955], 'pericytes': [959, 994, 1150, 1195, 1276, 1286, 1369, 1425, 1505, 1564, 1578, 1609, 1652, 1748, 1880, 2383], 'source': [967, 1612, 1794, 2069], 'VSMC-like': [969, 1615, 1764, 1877], 'cells.2': [970], 'studied': [973], 'lung': [974, 1249, 1270, 1543], 'tissues': [975, 1544], 'patients': [977, 1252, 1268, 1342, 1359], 'PAH': [979, 1001, 1145, 1290, 1345, 1358, 1481, 1494, 1577, 1740, 1767, 1805], 'extended': [981, 1403], 'investigations': [983], 'murine': [986], 'retinal': [987, 1411], 'angiogenesis': [988], 'model,': [989], 'well': [991, 1109, 1785], 'culture.': [996], 'One': [997], 'striking': [998, 1313], 'feature': [999], 'arteries,': [1010, 1582, 1620], 'includes': [1012], 'appearance': [1014], 'expressing': [1017, 1628, 1835], 'muscle-restricted': [1019], 'markers': [1020, 1274, 1527], 'normally': [1022], 'nonmuscular': [1023], 'small': [1024, 1067], 'diameter': [1025], 'vessels.': [1026, 1325], 'This': [1027], 'thought': [1029], 'result': [1031], 'proliferation': [1033, 1365, 1708], 'migration': [1035, 1363, 1710], 'but': [1042, 1070, 1308, 1592, 1792, 1920], 'potentially': [1044], 'cellular': [1046, 1125], 'transdifferentiation,12': [1047], 'provided': [1053], 'present': [1056, 1186], 'article.Pericytes': [1057], 'mainly': [1061], 'external': [1064], 'surface': [1065], 'blood': [1068, 1115], 'vessels,': [1069], 'given': [1071], 'elongated': [1073], 'multibranched': [1075], 'morphology,': [1076], 'contact': [1078], 'communicate': [1080], 'endothelial': [1082], '(ECs).': [1084], 'As': [1085, 1161], 'note,': [1088], 'well-established': [1091], 'regulators': [1092], 'development,': [1095], 'stabilization,': [1096], 'maturation,': [1097], 'remodeling,': [1099], 'through': [1100], 'roles': [1102], 'EC': [1104], 'growth': [1105, 1382, 1394, 1438, 1519, 1699, 1724, 1781, 2063, 2399, 2444], 'proliferation,': [1107], 'contraction': [1113], 'flow': [1116, 1643], 'control.2': [1117], 'now': [1120], 'propose': [1121], 'aforementioned': [1124], 'transdifferentiation': [1126, 1170], 'component': [1127, 2309], 'expansion': [1132], 'cells.There': [1153], 'strong': [1156], 'basis': [1157, 1327], 'proposal.': [1160], 'reviewed': [1162], 'article,': [1165], 'even': [1166, 1310, 1844], 'without': [1167], 'invoking': [1168], 'process,': [1171], 'close': [1174], 'biochemical,': [1175], 'morphologic,': [1176], 'functional': [1178], 'relationships': [1179], '(notably,': [1180], 'contraction,': [1181], 'particularly': [1182], 'hypoxia': [1185, 1638], 'vasculature': [1191], 'PAH)': [1193], 'between': [1194], '13': [1201], '14).': [1203], 'Pericytes,': [1204, 2358], 'however,': [1205], 'abundant': [1208], 'microvasculature,': [1211], 'capillaries,': [1215], 'some': [1217], 'arterioles.': [1219], 'A': [1220, 2823], 'key': [1221], 'finding': [1222, 1244, 1663], 'making': [1223], 'plausible': [1224], 'scenario': [1226], 'envision,': [1229], 'excessive': [1235], 'pericyte': [1236, 1320, 1400, 1538, 1669, 1707, 1737, 2057], 'coverage': [1237, 1321, 1401, 1670, 2058], 'PAH.This': [1243], 'accomplished': [1246], 'studying': [1248], 'specimens': [1250], 'idiopathic': [1254, 1344, 1357], 'heritable': [1256], 'forms': [1257], 'disease,': [1260], 'control': [1262, 1324, 1511, 1562], 'samples': [1263, 1496], 'nondiseased': [1265], 'regions': [1266], 'cancer.': [1271], 'Using': [1272, 1297], 'common': [1273], '(NG2': [1277], '3G5),': [1279], 'found': [1281, 1304, 1491], 'approximately': [1282, 1647], 'times': [1284, 1649], 'per': [1287], 'patient': [1291], 'samples,': [1292], 'independent': [1293], 'form.': [1296], 'qualitatively': [1305], 'similar': [1306, 1549, 1890], 'results': [1307, 1416], 'increase': [1314], '(up': [1315], '6': [1317], 'times)': [1318], 'compared': [1322], 'investigated': [1331], 'first': [1332, 1661], 'establishing': [1334], 'cultures': [1335], 'ECs': [1339, 1705, 1830], 'isolated': [1340], 'controls.': [1347], 'conditioned': [1349, 1388], 'medium': [1350], 'sourced': [1354], 'significantly': [1360], 'stimulated': [1361], 'vitro.': [1371], 'Much': [1372], 'effects': [1375, 1391, 1447], 'attributable': [1378], 'fibroblast': [1381, 1393, 1698, 2062], 'factor-2': [1383, 1395, 1700, 2064], 'interleukin-6': [1385, 1397, 1702, 2066], 'medium.': [1389], 'vivo': [1405, 1714], 'angiogenesis.As': [1412], 'interesting': [1413], 'are,': [1417, 1692], 'still': [1420], 'acquiring': [1426], 'VSMCs.': [1429], 'turned': [1432, 1623], 'transforming': [1437, 1518, 2443], 'factor-β': [1439, 1520, 1782, 2445], 'process': [1442], 'well-known': [1446], 'factor': [1450, 1725], 'promoting': [1452], 'Reference': [1464, 1484], '15)': [1465], 'signaling': [1469, 1802, 2446], 'pathway': [1470, 1803], 'shown': [1473], 'models': [1479, 2449], '16).': [1485], 'Consistent': [1486], 'this,': [1488], 'tissue': [1495, 1753], 'increased': [1497, 1521, 1668, 1801], 'immunostaining': [1498, 1559], 'p-SMAD2,': [1500], '≈45%': [1502], '(versus': [1508], '≈6%': [1509], 'tissues).': [1512], 'Furthermore,': [1513], 'cultured': [1515], 'pericytes,': [1517, 1771], 'expression': [1523], 'Acta2': [1528], 'Cnn1.': [1530], 'To': [1531, 1603], 'extend': [1532], 'vivo,': [1536], 'examined.': [1546], 'strategy': [1550], 'used': [1557], 'approach.': [1560], 'tissues,': [1563], 'strongly': [1566, 1594, 1679], '3G5': [1570], 'negative': [1572], 'markers.': [1575], 'Many': [1576], 'around': [1579], 'remodeled': [1580, 1619], 'contrast,': [1584], 'exhibited': [1585], 'low': [1586], 'NG2': [1591], 'TAGLN': [1597], '(also': [1598], 'called': [1599], 'SM22α)': [1600], 'ACTA2.': [1602], 'suggestion': [1607], 'NG2-driven': [1630], 'protein.': [1632], 'After': [1633], '21-day': [1635], 'exposure': [1636], '(to': [1639, 1950, 1953, 1957], 'simulate': [1640], 'PAH),': [1641], 'cytometry': [1644], '3': [1648], 'normoxic': [1659], 'samples.The': [1660], 'major': [1662, 1761], 'studies,': [1666], 'supported': [1680, 1942], 'relatively': [1682], 'straightforward': [1683], 'histologic': [1684], 'studies.': [1685], 'mechanisms': [1687, 1911], 'humans': [1691], 'necessity,': [1694], 'indirect.': [1696], 'secreted': [1703], 'promoted': [1706], 'vitro,': [1712], 'additional': [1718], 'factors': [1719, 1817], 'play,': [1721], 'platelet-derived': [1723], 'signaling,': [1726], 'which,': [1727], 'noted': [1729], 'authors,': [1732], 'implicated': [1735], 'recruitment': [1738], 'pathogenesis.': [1741], 'possibility': [1743], 'raised': [1744], 'marrow-derived': [1751], 'resident': [1754], 'progenitor': [1755], 'Turning': [1757], 'second': [1760], 'finding,': [1762], 'derived': [1769], 'number': [1776], 'questions.': [1779], 'Transforming': [1780, 2398], 'known': [1786], 'promoter': [1787], 'phenotype,': [1791], 'remain': [1806], 'established.': [1809], 'VSMC-promoting': [1816], 'consider': [1819, 1854], 'NOTCH).': [1821], 'contribution': [1823, 2481], 'expanded': [1826], 'transitioning': [1831], 'mesenchymal': [1833], 'PAH17,18': [1838], 'needs': [1840], 'determined.Nevertheless,': [1843], 'limitations,': [1847], 'reports': [1850], 'fascinating': [1852], 'terms': [1856], 'plasticity.': [1859], 'atheroma': [1862], 'traveling,': [1864], 'already': [1867], 'there,': [1868], 'state,': [1872], 'rear': [1883], 'view': [1884], 'mirror.': [1885], 'phenomena': [1891], 'occur': [1892], 'part': [1894], 'normal': [1897], 'development': [1898], 'pathologies.': [1902], 'establish': [1906], 'involved': [1912], 'illuminate': [1916], 'fundamental': [1917], 'biological': [1918], 'processes': [1919], 'ultimately': [1921], 'open': [1923], 'new': [1925], 'therapeutic': [1926], 'approaches.Sources': [1927], 'FundingThe': [1929], 'research': [1930], "authors'": [1933], 'laboratories': [1934], 'related': [1935], 'National': [1944], 'Institutes': [1945], 'Health': [1947], 'grants': [1948], 'HL084312': [1949], 'E.A.F.),': [1951, 1954], 'HL098055': [1952], 'HL117907': [1956], 'J.M.M.).DisclosuresNone.FootnotesThe': [1958], 'opinions': [1959], 'expressed': [1960], 'article': [1963], 'editors': [1970], 'American': [1974, 2599, 2807, 2890], 'Association.Correspondence': [1976], 'PhD,': [1982], 'Smilow': [1989], '7,': [1990], '522': [1991], 'First': [1992], 'Ave,': [1993], '10016.': [1997], 'E-mail': [1998], '[email': [1999], 'protected]References1.': [2000], 'S,': [2002, 2119, 2163, 2228, 2252, 2564, 2714], 'Chehroudi': [2003], 'AC,': [2004, 2153], 'McManus': [2005], 'BM,': [2006], 'Abraham': [2007], 'T,': [2008, 2226, 2501, 2671], 'Francis': [2009], 'GA.': [2010], 'Contribution': [2011], 'atherosclerosis.Circulation.': [2025], '2014;': [2026, 2077, 2524], '129:1551–1559.LinkGoogle': [2027], 'Scholar2.': [2028], 'N,': [2030, 2613], 'Tu': [2031], 'L,': [2032, 2425, 2499, 2503, 2735, 2852], 'Le': [2033], 'Hiress': [2034], 'M,': [2035, 2053, 2195, 2431, 2681, 2722], 'Huertas': [2036], 'A,': [2037, 2047, 2224, 2230, 2238, 2244, 2427, 2507, 2673, 2677, 2718, 2731], 'Phan': [2038], 'C,': [2039, 2043, 2572, 2724], 'Thuillet': [2040], 'R,': [2041, 2123, 2558, 2568, 2675, 2687, 2737], 'Sattler': [2042], 'Fadel': [2044], 'E,': [2045, 2121, 2197, 2232, 2246, 2469, 2607, 2617], 'Seferian': [2046], 'Montani': [2048], 'D,': [2049, 2274, 2505], 'Dorfmuller': [2050], 'P,': [2051, 2355], 'Humbert': [2052], 'Guignabert': [2054], 'C.': [2055], 'Increased': [2056], 'mediated': [2059], 'endothelial-derived': [2061], 'muscle-like': [2072], 'hypertension.Circulation.': [2076, 2523], '129:1586–1597.LinkGoogle': [2078], 'Scholar3.': [2079], 'Buck': [2080], 'RC.': [2081], 'Intimal': [2082, 2832], 'thickening': [2083], 'arteries.Circ': [2087], 'Res.': [2088, 2372], '1961;': [2089], '9:418–426.LinkGoogle': [2090], 'Scholar4.': [2091], 'Haust': [2092], 'More': [2094], 'RH,': [2095], 'Movat': [2096], 'HZ.': [2097], 'fibrogenesis': [2106], 'arteriosclerosis.Am': [2108], 'J': [2109, 2489, 2771, 2800], 'Pathol.': [2110, 2144], '1960;': [2111], '37:377–389.MedlineGoogle': [2112], 'Scholar5.': [2113], 'Imai': [2114], 'H,': [2115, 2151, 2609], 'Lee': [2116], 'KT,': [2117], 'Pastori': [2118], 'Panlilio': [2120], 'Florentin': [2122], 'Thomas': [2124], 'WA.': [2125], 'Atherosclerosis': [2126], 'rabbits:': [2128], 'architectural': [2129], 'subcellular': [2131], 'alterations': [2132], 'aortas': [2138], 'response': [2140], 'hyperlipemia.Exp': [2142], 'Mol': [2143, 2318, 2346, 2493], '1966;': [2145], '5:273–310.CrossrefMedlineGoogle': [2146], 'Scholar6.': [2147], 'Nemenoff': [2148], 'RA,': [2149], 'Horita': [2150], 'Ostriker': [2152], 'Furgeson': [2154], 'SB,': [2155], 'Simpson': [2156], 'PA,': [2157], 'VanPutten': [2158], 'V,': [2159, 2377], 'Crossno': [2160], 'J,': [2161, 2300, 2535, 2611, 2669, 2683, 2720], 'Offermanns': [2162], 'Weiser-Evans': [2164], 'MC.': [2165], 'SDF-1α': [2166], 'induction': [2167], 'mature': [2169], 'inactivation': [2174], 'PTEN': [2176], 'mediator': [2180], 'exacerbated': [2182], 'injury-induced': [2183], 'neointima': [2184], 'formation.Arterioscler': [2185], 'Thromb': [2186], 'Vasc': [2187], 'Biol.': [2188, 2390], '2011;': [2189, 2334, 2421], '31:1300–1308.LinkGoogle': [2190], 'Scholar7.': [2191], 'Rong': [2192], 'JX,': [2193], 'Shapiro': [2194], 'Trogan': [2196], 'EA.': [2199], 'Transdifferentiation': [2200], 'loading.Proc': [2213], 'Natl': [2214], 'Acad': [2215], 'Sci': [2216], 'U': [2217], 'S': [2218, 2577], '2003;': [2220], '100:13531–13536.CrossrefMedlineGoogle': [2221], 'Scholar8.': [2222], 'Ludin': [2223], 'Itkin': [2225], 'Gur-Cohen': [2227], 'Mildner': [2229], 'Shezen': [2231], 'Golan': [2233], 'K,': [2234, 2619, 2726, 2733], 'Kollet': [2235], 'O,': [2236], 'Kalinkovich': [2237], 'Porat': [2239], 'Z,': [2240, 2566, 2570], "D'Uva": [2241], 'G,': [2242, 2615, 2795], 'Schajnovitz': [2243], 'Voronov': [2245], 'Brenner': [2247], 'DA,': [2248], 'Apte': [2249], 'RN,': [2250], 'Jung': [2251], 'Lapidot': [2253], 'T.': [2254], 'Monocytes-macrophages': [2255], 'express': [2257], 'α-smooth': [2258], 'actin': [2260], 'primitive': [2262], 'hematopoietic': [2263], 'marrow.Nat': [2268], 'Immunol.': [2269], '2012;': [2270], '13:1072–1082.CrossrefMedlineGoogle': [2271], 'Scholar9.': [2272], 'Shankman': [2275], 'LS,': [2276], 'Nguyen': [2277], 'AT,': [2278], 'Owens': [2279], 'GK.': [2280], 'Detection': [2281], 'histone': [2283], 'modifications': [2284], 'at': [2285], 'specific': [2286], 'gene': [2287], 'loci': [2288], 'single': [2290], 'histological': [2293], 'sections.Nat': [2294], 'Methods.': [2295], '2013;': [2296, 2349], '10:171–177.CrossrefMedlineGoogle': [2297], 'Scholar10.': [2298], 'Chen': [2299, 2796], 'Kitchen': [2301], 'CM,': [2302], 'Streb': [2303], 'JW,': [2304], 'JM.': [2306, 2397], 'Myocardin:': [2307], 'differentiation.J': [2317], 'Cell': [2319, 2389, 2492, 2585, 2811], 'Cardiol.': [2320], '2002;': [2321], '34:1345–1356.CrossrefMedlineGoogle': [2322], 'Scholar11.': [2323], 'Moore': [2324], 'KJ,': [2325], 'Tabas': [2326], 'I.': [2327], 'Macrophages': [2328], 'pathogenesis': [2331], 'atherosclerosis.Cell.': [2333], '145:341–355.CrossrefMedlineGoogle': [2335], 'Scholar12.': [2336], 'Shimoda': [2337], 'LA,': [2338], 'Laurie': [2339], 'SS.': [2340], 'hypertension.J': [2345], 'Med': [2347], '(Berl).': [2348], '91:297–309.CrossrefMedlineGoogle': [2350], 'Scholar13.': [2351], 'Joyce': [2352], 'NC,': [2353], 'DeCamilli': [2354], 'Boyles': [2356], 'J.': [2357], 'like': [2359], 'immunocytochemically': [2365], 'cyclic': [2368], 'GMP-dependent': [2369], 'protein': [2370, 2441], 'kinase.Microvasc': [2371], '1984;': [2373], '28:206–219.CrossrefMedlineGoogle': [2374], 'Scholar14.': [2375], 'Nehls': [2376], 'Drenckhahn': [2378], 'D.': [2379], 'Heterogeneity': [2380], 'microvascular': [2382], 'alpha-actin.J': [2388], '1991;': [2391], '113:147–154.CrossrefMedlineGoogle': [2392], 'Scholar15.': [2393], 'Long': [2394, 2424], 'X,': [2395, 2429], 'factor-β1': [2400], '(TGF-β1)': [2401], 'utilizes': [2402], 'distinct': [2403], 'pathways': [2404], 'transcriptional': [2407], 'activation': [2408], 'microRNA': [2410], '143/145': [2411], 'cells.J': [2418], 'Biol': [2419], 'Chem.': [2420], '286:30119–30129.CrossrefMedlineGoogle': [2422], 'Scholar16.': [2423], 'Crosby': [2426], 'Yang': [2428, 2684], 'Southwood': [2430], 'Upton': [2432], 'PD,': [2433], 'Kim': [2434], 'DK,': [2435], 'Morrell': [2436], 'NW.': [2437], 'Altered': [2438], 'morphogenetic': [2440], 'rat': [2448], 'hypertension:': [2452], 'potential': [2453, 2480], 'activin': [2455], 'receptor-like': [2456], 'kinase-5': [2457], 'inhibition': [2458], 'prevention': [2460], 'progression': [2462], 'disease.Circulation.': [2464], '2009;': [2465], '119:566–576.LinkGoogle': [2466], 'Scholar17.': [2467], 'Arciniegas': [2468], 'Frid': [2470], 'MG,': [2471], 'Douglas': [2472], 'IS,': [2473], 'Stenmark': [2474], 'KR.': [2475], 'Perspectives': [2476], 'endothelial-to-mesenchymal': [2478], 'transition:': [2479], 'hypertension.Am': [2488], 'Physiol': [2490], 'Lung': [2491], 'Physiol.': [2494], '2007;': [2495], '293:L1–L8.CrossrefMedlineGoogle': [2496], 'Scholar18.': [2497], 'Qiao': [2498], 'Nishimura': [2500], 'Shi': [2502], 'Sessions': [2504], 'Thrasher': [2506], 'Trudell': [2508], 'JR,': [2509], 'Berry': [2510], 'GJ,': [2511], 'Pearl': [2512], 'RG,': [2513], 'Kao': [2514], 'PN.': [2515], 'Endothelial': [2516], 'fate': [2517], 'mapping': [2518], 'mice': [2520], '129:692–703.LinkGoogle': [2525], 'Scholar': [2526], 'Previous': [2527], 'Back': [2528], 'top': [2530], 'Next': [2531], 'FiguresReferencesRelatedDetailsCited': [2532], 'Jarcho': [2534], 'Vergallo': [2536], 'R': [2537], 'Crea': [2539], 'F': [2540], '(2020)': [2541], 'Atherosclerotic': [2542], 'Plaque': [2543], 'Healing,': [2544], 'England': [2546], 'Journal': [2547, 2596, 2808], '10.1056/NEJMra2000317,': [2550], '383:9,': [2551], '(846-857),': [2552], 'Online': [2553, 2603, 2647, 2664, 2764, 2790, 2818, 2848, 2875], 'publication': [2554, 2604, 2648, 2665, 2765, 2791, 2819, 2849, 2876], 'date:': [2555, 2605, 2649, 2666, 2766, 2792, 2820, 2850, 2877], '27-Aug-2020.': [2556], 'Wang': [2557, 2576], 'Wu': [2559], 'W,': [2560, 2562, 2679], 'Li': [2561, 2565, 2573], 'Huang': [2563], 'Liu': [2567], 'Shan': [2569], 'Zhang': [2571], 'W': [2574], '(2018)': [2578], 'Activation': [2579], 'NLRP3': [2581], 'Inflammasome': [2582], 'Promotes': [2583], 'Foam': [2584], 'Formation': [2586, 2632], 'Atherogenesis': [2593], 'Via': [2594], 'HMGB1,': [2595], 'Association,': [2601, 2892], '7:19,': [2602], '2-Oct-2018.Endorf': [2606], 'Qing': [2608], 'Aono': [2610], 'Terami': [2612], 'Doyon': [2614], 'Hyzny': [2616], 'Jones': [2618], 'Findeisen': [2620], 'H': [2621], 'Bruemmer': [2623], 'D': [2624, 2742], '(2016)': [2625, 2652], 'Telomerase': [2626], 'Reverse': [2627], 'Transcriptase': [2628], 'Deficiency': [2629], 'Prevents': [2630], 'Neointima': [2631], 'Chromatin': [2634], 'Silencing': [2635], 'E2F1': [2637], 'Target': [2638], 'Genes,': [2639], 'Arteriosclerosis,': [2640, 2657, 2783, 2868], 'Thrombosis,': [2641, 2658, 2784, 2869], 'Biology,': [2644, 2661, 2787, 2814, 2872], '37:2,': [2645], '(301-311),': [2646], '1-Feb-2017.Majesky': [2650], 'M': [2651, 2692, 2768], 'Cells,': [2656], '36:10,': [2662], '(e82-e86),': [2663], '1-Oct-2016.': [2667], 'Kleinhenz': [2668], 'Murphy': [2670], 'Pokutta-Paskaleva': [2672], 'Gleason': [2674], 'Lyle': [2676], 'Taylor': [2678], 'Blount': [2680], 'Cheng': [2682, 2713], 'Q,': [2685], 'Sutliff': [2686], 'Hart': [2688], 'C': [2689], 'Meloni': [2691], '(2015)': [2693, 2743, 2772, 2801, 2824, 2858], 'Muscle-Targeted': [2695], 'Overexpression': [2696], 'Peroxisome': [2698], 'Proliferator': [2699], 'Activated': [2700], 'Receptor-γ': [2701], 'Disrupts': [2702], 'Wall': [2704], 'Structure': [2705], 'Function,': [2707], 'PLOS': [2708], 'ONE,': [2709], '10.1371/journal.pone.0139756,': [2710], '10:10,': [2711], '(e0139756)': [2712], 'Ramachandran': [2715], 'B,': [2716], 'Behrmann': [2717], 'Shao': [2719], 'Mead': [2721], 'Smith': [2723], 'Krchma': [2725], 'Bello': [2727], 'Arredondo': [2728], 'Y,': [2729], 'Kovacs': [2730], 'Kapoor': [2732], 'Brill': [2734], 'Perera': [2736], 'Williams': [2738], 'B': [2739], 'Towler': [2741], 'LRP6': [2747], 'Limits': [2748], 'Arteriosclerotic': [2749], 'Calcification': [2750], 'Diabetic': [2752], 'LDLR−/−': [2753], 'Mice': [2754], 'Restraining': [2756], 'Noncanonical': [2757], 'Wnt': [2758], 'Signals,': [2759], 'Circulation': [2760], 'Research,': [2761], '117:2,': [2762], '(142-156),': [2763], '3-Jul-2015.Huff': [2767], 'Pickering': [2770], 'Can': [2773], 'Muscle–Derived': [2777], 'Foam-Cell': [2778], 'Really': [2779], 'Change': [2780], 'Spots?,': [2782], '35:3,': [2788], '(492-495),': [2789], '1-Mar-2015.': [2793], 'Zhou': [2794], 'T': [2797], 'Raj': [2799], 'MicroRNAs': [2802], 'Pulmonary': [2804], 'Hypertension,': [2806], 'Respiratory': [2810], 'Molecular': [2813], '10.1165/rcmb.2014-0166TR,': [2815], '52:2,': [2816], '(139-151),': [2817], '1-Feb-2015.': [2821], 'Kumar': [2822, 2827], 'Letter': [2825], 'Regarding': [2828], 'Article,': [2829], '"Contribution': [2830], 'Cholesterol': [2837], 'Accumulation': [2838], 'Macrophage-Like': [2840], 'Human': [2843], 'Atherosclerosis",': [2844], '131:3,': [2846], '(e24-e24),': [2847], '20-Jan-2015.Maegdefessel': [2851], 'Rayner': [2853], 'K': [2854], 'Leeper': [2856], 'N': [2857], 'MicroRNA': [2859], 'Regulation': [2860], 'Function': [2865], 'Phenotype,': [2867], '35:1,': [2873], '(2-6),': [2874], '1-Jan-2015.': [2878], 'April': [2879], '15,': [2880, 2897], '2014Vol': [2881], 'Issue': [2883], '15': [2884], 'Advertisement': [2885, 2901], 'Article': [2886], 'InformationMetrics': [2887], '©': [2888], '2014': [2889, 2898], 'Inc.https://doi.org/10.1161/CIRCULATIONAHA.114.009075PMID:': [2893], '24733539': [2894], 'publishedApril': [2896], 'KeywordshypertensionmacrophagesEditorialsatherosclerosispericytesPDF': [2899], 'download': [2900], 'SubjectsSmooth': [2902], 'Proliferation': [2904], 'Differentiation': [2906]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2072641477', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 6}], 'updated_date': '2024-09-14T12:27:02.251593', 'created_date': '2016-06-24'}