Publication Information

{'id': 'https://openalex.org/W2072627505', 'doi': 'https://doi.org/10.1126/science.146257', 'title': 'Membrane Enzymes: Artifacts in Arrhenius Plots Due to Temperature Dependence of Substrate-Binding Affinity', 'display_name': 'Membrane Enzymes: Artifacts in Arrhenius Plots Due to Temperature Dependence of Substrate-Binding Affinity', 'publication_year': 1978, 'publication_date': '1978-02-24', 'ids': {'openalex': 'https://openalex.org/W2072627505', 'doi': 'https://doi.org/10.1126/science.146257', 'mag': '2072627505', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/146257'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.146257', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058761281', 'display_name': 'John R. Silvius', 'orcid': 'https://orcid.org/0000-0003-4050-509X'}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'John R. Silvius', 'raw_affiliation_strings': ['Department of Biochemistry, University of Alberta , Edmonton, Alberta Canada T6G 2H7.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Alberta , Edmonton, Alberta Canada T6G 2H7.', 'institution_ids': ['https://openalex.org/I154425047']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013403023', 'display_name': 'Brian D. Read', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Brian D. Read', 'raw_affiliation_strings': ['Department of Biochemistry, University of Alberta , Edmonton, Alberta Canada T6G 2H7.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Alberta , Edmonton, Alberta Canada T6G 2H7.', 'institution_ids': ['https://openalex.org/I154425047']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109997414', 'display_name': 'Ronald N. McElhaney', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Ronald N. McElhaney', 'raw_affiliation_strings': ['Department of Biochemistry, University of Alberta , Edmonton, Alberta Canada T6G 2H7.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Alberta , Edmonton, Alberta Canada T6G 2H7.', 'institution_ids': ['https://openalex.org/I154425047']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 20.498, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 132, 'citation_normalized_percentile': {'value': 0.952497, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '199', 'issue': '4331', 'first_page': '902', 'last_page': '904'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12094', 'display_name': 'Hemoglobin structure and function', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/arrhenius-plot', 'display_name': 'Arrhenius plot', 'score': 0.93485105}, {'id': 'https://openalex.org/keywords/michaelis–menten-kinetics', 'display_name': 'Michaelis–Menten kinetics', 'score': 0.4726062}], 'concepts': [{'id': 'https://openalex.org/C8739425', 'wikidata': 'https://www.wikidata.org/wiki/Q695171', 'display_name': 'Arrhenius plot', 'level': 3, 'score': 0.93485105}, {'id': 'https://openalex.org/C86183883', 'wikidata': 'https://www.wikidata.org/wiki/Q507505', 'display_name': 'Arrhenius equation', 'level': 3, 'score': 0.9236589}, {'id': 'https://openalex.org/C2777289219', 'wikidata': 'https://www.wikidata.org/wiki/Q7632154', 'display_name': 'Substrate (aquarium)', 'level': 2, 'score': 0.7080105}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.571296}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5664322}, {'id': 'https://openalex.org/C134121241', 'wikidata': 'https://www.wikidata.org/wiki/Q899301', 'display_name': 'Yield (engineering)', 'level': 2, 'score': 0.56365824}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.53594697}, {'id': 'https://openalex.org/C64915919', 'wikidata': 'https://www.wikidata.org/wiki/Q613955', 'display_name': 'Michaelis–Menten kinetics', 'level': 4, 'score': 0.4726062}, {'id': 'https://openalex.org/C543218039', 'wikidata': 'https://www.wikidata.org/wiki/Q660', 'display_name': 'Magnesium', 'level': 2, 'score': 0.42478967}, {'id': 'https://openalex.org/C97355855', 'wikidata': 'https://www.wikidata.org/wiki/Q11473', 'display_name': 'Thermodynamics', 'level': 1, 'score': 0.40189272}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.38044488}, {'id': 'https://openalex.org/C95121573', 'wikidata': 'https://www.wikidata.org/wiki/Q190474', 'display_name': 'Activation energy', 'level': 2, 'score': 0.37202072}, {'id': 'https://openalex.org/C28212737', 'wikidata': 'https://www.wikidata.org/wiki/Q5381543', 'display_name': 'Enzyme assay', 'level': 3, 'score': 0.3562017}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.24822444}, {'id': 'https://openalex.org/C147789679', 'wikidata': 'https://www.wikidata.org/wiki/Q11372', 'display_name': 'Physical chemistry', 'level': 1, 'score': 0.1856519}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.13967332}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.07874009}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.07421753}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000251', 'descriptor_name': 'Adenosine Triphosphatases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008566', 'descriptor_name': 'Membranes', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D000128', 'descriptor_name': 'Acholeplasma laidlawii', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000128', 'descriptor_name': 'Acholeplasma laidlawii', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D000251', 'descriptor_name': 'Adenosine Triphosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005227', 'descriptor_name': 'Fatty Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005227', 'descriptor_name': 'Fatty Acids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008566', 'descriptor_name': 'Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013696', 'descriptor_name': 'Temperature', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013816', 'descriptor_name': 'Thermodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.146257', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/146257', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 11, 'referenced_works': ['https://openalex.org/W1492376818', 'https://openalex.org/W1565382010', 'https://openalex.org/W1965727628', 'https://openalex.org/W1970335294', 'https://openalex.org/W1979067298', 'https://openalex.org/W1980932566', 'https://openalex.org/W1988753083', 'https://openalex.org/W1994723914', 'https://openalex.org/W2014281089', 'https://openalex.org/W2015052088', 'https://openalex.org/W2022393615'], 'related_works': ['https://openalex.org/W4283379096', 'https://openalex.org/W4213042696', 'https://openalex.org/W2996821302', 'https://openalex.org/W2367555855', 'https://openalex.org/W2144771795', 'https://openalex.org/W2060451851', 'https://openalex.org/W2052545310', 'https://openalex.org/W1999977692', 'https://openalex.org/W1995240288', 'https://openalex.org/W1992482402'], 'abstract_inverted_index': {'For': [0], 'the': [1, 10, 16], 'membrane': [2], 'sodium-stimulated': [3], 'magnesium-adenosinetriphosphatase': [4], 'of': [5, 24, 39], 'Acholeplasma': [6], 'laidlawii': [7], 'B': [8], 'both': [9], 'Vmax': [11], 'and': [12], 'Km': [13, 34], 'values': [14], 'in': [15], 'Michaelis': [17], 'equation': [18], 'very': [19], 'strongly': [20], 'with': [21, 31], 'temperature.': [22], 'Simulations': [23], 'Arrhenius': [25, 40], 'plots': [26], 'show': [27], 'that': [28], 'an': [29], 'enzyme': [30], 'a': [32, 37, 52], 'temperature-dependent': [33], 'can': [35], 'yield': [36], 'variety': [38], 'plot': [41], 'artifacts,': [42], 'most': [43], 'notably': [44], 'erroneous': [45], '"breaks,"': [46], 'if': [47], 'activity': [48], 'is': [49], 'assayed': [50], 'at': [51], 'fixed': [53], 'substrate': [54], 'concentration.': [55]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2072627505', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-11T04:56:34.437773', 'created_date': '2016-06-24'}