Publication Information

{'id': 'https://openalex.org/W2072542349', 'doi': 'https://doi.org/10.1074/jbc.m702422200', 'title': 'Pannexin1 Channels Contain a Glycosylation Site That Targets the Hexamer to the Plasma Membrane', 'display_name': 'Pannexin1 Channels Contain a Glycosylation Site That Targets the Hexamer to the Plasma Membrane', 'publication_year': 2007, 'publication_date': '2007-08-23', 'ids': {'openalex': 'https://openalex.org/W2072542349', 'doi': 'https://doi.org/10.1074/jbc.m702422200', 'mag': '2072542349', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17715132'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m702422200', 'pdf_url': 'http://www.jbc.org/article/S0021925820686987/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820686987/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046102875', 'display_name': 'Daniela Boassa', 'orcid': 'https://orcid.org/0000-0003-4631-4139'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Daniela Boassa', 'raw_affiliation_strings': ['National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, La Jolla, California 92093-0608'], 'affiliations': [{'raw_affiliation_string': 'National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, La Jolla, California 92093-0608', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017869114', 'display_name': 'Cinzia Ambrosi', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cinzia Ambrosi', 'raw_affiliation_strings': ['National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, La Jolla, California 92093-0608'], 'affiliations': [{'raw_affiliation_string': 'National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, La Jolla, California 92093-0608', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013957351', 'display_name': 'Feng Qiu', 'orcid': 'https://orcid.org/0000-0002-0450-229X'}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Feng Qiu', 'raw_affiliation_strings': ['Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136', 'institution_ids': ['https://openalex.org/I145608581']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003820941', 'display_name': 'Gerhard Dahl', 'orcid': 'https://orcid.org/0000-0002-1782-8133'}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gerhard Dahl', 'raw_affiliation_strings': ['Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136', 'institution_ids': ['https://openalex.org/I145608581']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058619463', 'display_name': 'Guido Gaietta', 'orcid': 'https://orcid.org/0000-0003-2455-1264'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Guido Gaietta', 'raw_affiliation_strings': ['National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, La Jolla, California 92093-0608'], 'affiliations': [{'raw_affiliation_string': 'National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, La Jolla, California 92093-0608', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033530478', 'display_name': 'Gina E. Sosinsky', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Gina Sosinsky', 'raw_affiliation_strings': ['Department of Neurosciences, University of California, San Diego, La Jolla, California 92093-0608', 'National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, La Jolla, California 92093-0608'], 'affiliations': [{'raw_affiliation_string': 'National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, La Jolla, California 92093-0608', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Neurosciences, University of California, San Diego, La Jolla, California 92093-0608', 'institution_ids': ['https://openalex.org/I36258959']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5046102875', 'https://openalex.org/A5033530478'], 'corresponding_institution_ids': ['https://openalex.org/I36258959'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 5.154, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 264, 'citation_normalized_percentile': {'value': 0.999982, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '282', 'issue': '43', 'first_page': '31733', 'last_page': '31743'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11480', 'display_name': 'Connexins and lens biology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11480', 'display_name': 'Connexins and lens biology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13551', 'display_name': 'Biochemical effects in animals', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 0.9844, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pannexin', 'display_name': 'Pannexin', 'score': 0.845845}, {'id': 'https://openalex.org/keywords/membrane-topology', 'display_name': 'Membrane topology', 'score': 0.5321317}], 'concepts': [{'id': 'https://openalex.org/C127992366', 'wikidata': 'https://www.wikidata.org/wiki/Q410332', 'display_name': 'Pannexin', 'level': 5, 'score': 0.845845}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5836011}, {'id': 'https://openalex.org/C534586', 'wikidata': 'https://www.wikidata.org/wiki/Q6815143', 'display_name': 'Membrane topology', 'level': 4, 'score': 0.5321317}, {'id': 'https://openalex.org/C158157758', 'wikidata': 'https://www.wikidata.org/wiki/Q232438', 'display_name': 'Gap junction', 'level': 3, 'score': 0.50020814}, {'id': 'https://openalex.org/C144647389', 'wikidata': 'https://www.wikidata.org/wiki/Q423042', 'display_name': 'Membrane protein', 'level': 3, 'score': 0.47545832}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.47013196}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40396565}, {'id': 'https://openalex.org/C2780228694', 'wikidata': 'https://www.wikidata.org/wiki/Q423489', 'display_name': 'Connexin', 'level': 4, 'score': 0.32423812}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2358236}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.21609491}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.1959582}], 'mesh': [{'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017630', 'descriptor_name': 'Connexins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D017630', 'descriptor_name': 'Connexins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007473', 'descriptor_name': 'Ion Channels', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': True}, {'descriptor_ui': 'D001216', 'descriptor_name': 'Asparagine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001216', 'descriptor_name': 'Asparagine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019921', 'descriptor_name': 'Biotinylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D017630', 'descriptor_name': 'Connexins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017630', 'descriptor_name': 'Connexins', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D017630', 'descriptor_name': 'Connexins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003432', 'descriptor_name': 'Cross-Linking Reagents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003432', 'descriptor_name': 'Cross-Linking Reagents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004594', 'descriptor_name': 'Electrophysiology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006031', 'descriptor_name': 'Glycosylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007473', 'descriptor_name': 'Ion Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017433', 'descriptor_name': 'Protein Structure, Secondary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013388', 'descriptor_name': 'Succinimides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013388', 'descriptor_name': 'Succinimides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m702422200', 'pdf_url': 'http://www.jbc.org/article/S0021925820686987/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17715132', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m702422200', 'pdf_url': 'http://www.jbc.org/article/S0021925820686987/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1509216925', 'https://openalex.org/W1529417725', 'https://openalex.org/W1555716918', 'https://openalex.org/W1964535559', 'https://openalex.org/W1971842172', 'https://openalex.org/W1995307208', 'https://openalex.org/W2000063742', 'https://openalex.org/W2004491285', 'https://openalex.org/W2012168396', 'https://openalex.org/W2016224591', 'https://openalex.org/W2019209052', 'https://openalex.org/W2022023926', 'https://openalex.org/W2030980065', 'https://openalex.org/W2033256959', 'https://openalex.org/W2035420382', 'https://openalex.org/W2042259903', 'https://openalex.org/W2052138319', 'https://openalex.org/W2058358053', 'https://openalex.org/W2059030264', 'https://openalex.org/W2069422493', 'https://openalex.org/W2077857158', 'https://openalex.org/W2079901569', 'https://openalex.org/W2081906155', 'https://openalex.org/W2101108802', 'https://openalex.org/W2102155514', 'https://openalex.org/W2102694854', 'https://openalex.org/W2141480740'], 'related_works': ['https://openalex.org/W2776627242', 'https://openalex.org/W2736010006', 'https://openalex.org/W2497752759', 'https://openalex.org/W2407960705', 'https://openalex.org/W2164771884', 'https://openalex.org/W2163056759', 'https://openalex.org/W2085082795', 'https://openalex.org/W2059157949', 'https://openalex.org/W2050127546', 'https://openalex.org/W1969183124'], 'abstract_inverted_index': {'Pannexins': [0, 170, 598, 680], 'are': [1, 29, 138, 171, 199, 308, 632, 681, 923, 1235, 2538, 3246], 'newly': [2, 172, 2176, 4255], 'discovered': [3, 173], 'channel': [4, 44, 73, 174, 214, 243, 389, 1171, 1190, 1227, 2362], 'proteins': [5, 162, 175, 332, 484, 502, 570, 631, 1172, 1868, 2179, 3438, 3455, 3523, 3613, 3742, 4003, 4012, 4123, 4193, 4207, 4258, 4329, 4338], 'expressed': [6, 176, 682, 1047, 3109, 3339], 'in': [7, 13, 167, 177, 183, 337, 344, 488, 494, 499, 522, 539, 683, 689, 771, 783, 795, 865, 887, 925, 1048, 1056, 1065, 1102, 1121, 1157, 1173, 1229, 1279, 1437, 1485, 1540, 1595, 1599, 1642, 1765, 1803, 1812, 1931, 1963, 1978, 2054, 2057, 2130, 2155, 2169, 2222, 2245, 2400, 2592, 2599, 2620, 2705, 2769, 2842, 2846, 2872, 2968, 2977, 3048, 3069, 3140, 3199, 3248, 3256, 3340, 3353, 3477, 3547, 3600, 3621, 3642, 3693, 3768, 3840, 3871, 3880, 3887, 3926, 3989, 3999, 4082, 4086, 4181, 4234, 4252, 4285, 4314, 4317], 'many': [8, 178, 684], 'different': [9, 168, 179, 338, 346, 376, 685, 1057, 1174, 2864, 2957, 3014, 3369, 3971, 4076], 'tissues': [10, 180], 'and': [11, 24, 45, 65, 87, 181, 194, 215, 235, 257, 357, 517, 524, 527, 544, 554, 626, 642, 646, 672, 687, 700, 782, 792, 799, 931, 1038, 1051, 1068, 1110, 1191, 1309, 1317, 1386, 1408, 1417, 1426, 1434, 1516, 1523, 1555, 1607, 1644, 1657, 1680, 1720, 1728, 1775, 1789, 1808, 1815, 1857, 1901, 1921, 1939, 1949, 1956, 1972, 2067, 2080, 2136, 2236, 2248, 2270, 2310, 2330, 2407, 2419, 2548, 2580, 2630, 2666, 2734, 2749, 2808, 2826, 2835, 2845, 3030, 3078, 3092, 3157, 3171, 3185, 3240, 3244, 3285, 3291, 3309, 3343, 3349, 3375, 3391, 3397, 3436, 3452, 3465, 3472, 3480, 3489, 3511, 3518, 3535, 3551, 3555, 3699, 3711, 3721, 3731, 3733, 3740, 3770, 3821, 3833, 3949, 3996, 4023, 4096, 4154, 4212, 4292, 4346], 'abundantly': [12, 182, 688], 'the': [14, 47, 67, 78, 141, 157, 164, 184, 217, 237, 248, 311, 327, 334, 365, 393, 513, 540, 545, 549, 555, 690, 777, 861, 868, 876, 879, 888, 926, 934, 1036, 1052, 1103, 1150, 1153, 1165, 1182, 1204, 1207, 1210, 1221, 1225, 1271, 1337, 1356, 1363, 1367, 1381, 1398, 1413, 1419, 1579, 1612, 1618, 1630, 1702, 1850, 1979, 2002, 2042, 2050, 2063, 2068, 2071, 2170, 2183, 2186, 2190, 2197, 2420, 2428, 2543, 2570, 2588, 2593, 2600, 2603, 2612, 2617, 2621, 2628, 2631, 2642, 2656, 2660, 2675, 2708, 2714, 2722, 2732, 2740, 2752, 2762, 2820, 2833, 2853, 2863, 2949, 2978, 2981, 3000, 3008, 3040, 3056, 3070, 3097, 3101, 3111, 3132, 3149, 3158, 3203, 3249, 3257, 3267, 3315, 3319, 3356, 3362, 3378, 3388, 3408, 3418, 3424, 3444, 3459, 3478, 3499, 3513, 3538, 3557, 3568, 3571, 3575, 3595, 3601, 3616, 3622, 3626, 3643, 3649, 3656, 3665, 3670, 3694, 3697, 3704, 3755, 3789, 3804, 3811, 3837, 3848, 3858, 3863, 3866, 3876, 3881, 3888, 3891, 3898, 3906, 3911, 3921, 3930, 3940, 3946, 3977, 3990, 4000, 4015, 4087, 4102, 4112, 4127, 4132, 4139, 4149, 4168, 4175, 4191, 4204, 4210, 4216, 4225, 4235, 4238, 4248, 4254, 4260, 4266, 4269, 4273, 4302], 'vertebrate': [15, 185, 612, 691], 'central': [16, 186, 692], 'nervous': [17, 187, 693], 'system.': [18, 188, 694], 'Based': [19, 189, 695, 2534], 'on': [20, 72, 190, 242, 696, 1518, 1553, 1570, 1609, 1682, 1782, 1926, 2253, 2319, 2535, 2680, 3110, 3570, 3910, 4215], 'membrane': [21, 95, 161, 191, 265, 331, 697, 805, 890, 1039, 1117, 1795, 2414, 2987, 4129, 4218, 4240], 'topology,': [22, 192, 698], 'folding': [23, 193, 699], 'secondary': [25, 195, 701, 1967], 'structure': [26, 196, 702], 'prediction,': [27, 197, 703], 'pannexins': [28, 198, 547, 625, 704], 'proposed': [30, 200, 707], 'to': [31, 113, 163, 201, 283, 333, 374, 486, 564, 603, 634, 708, 878, 894, 917, 1209, 1231, 1361, 1379, 1411, 1560, 1624, 1646, 1700, 1791, 2265, 2540, 2542, 2611, 2721, 2799, 2804, 2870, 2886, 3064, 3131, 3154, 3280, 3296, 3334, 3361, 3400, 3567, 3580, 3588, 3609, 3810, 3847, 3868, 3897, 3915, 3929, 3945, 4057, 4196, 4259, 4375], 'form': [32, 114, 202, 284, 709, 2725, 4331], 'gap': [33, 133, 203, 303, 382, 387, 520, 710, 812, 4141, 4332], 'junction-like': [34, 204, 711, 4333], 'structures.': [35, 205], 'We': [36, 75, 144, 206, 245, 314, 3229, 3785, 3933], 'show': [37, 76, 207, 246, 1180], 'here': [38, 208, 1179], 'that': [39, 81, 88, 108, 124, 146, 209, 251, 258, 278, 294, 316, 362, 618, 776, 856, 915, 1185, 1200, 1220, 1234, 2041, 2655, 2686, 2862, 2994, 3096, 3325, 3442, 3470, 3564, 3754, 3857], 'Pannexin1': [40, 82, 100, 125, 136, 149, 210, 252, 270, 295, 306, 319, 658, 2456, 2746, 3194, 3909, 4324], 'forms': [41, 211, 1187, 2496, 2550, 2605, 3172], 'a': [42, 152, 212, 322, 386, 1188, 1193, 1216, 1519, 1561, 1596, 1600, 1647, 1776, 1783, 1792, 2085, 2458, 2464, 2497, 2520, 2554, 2561, 2681, 2743, 2847, 3017, 3273, 3303, 3329, 3746, 3763, 3794, 3959, 3986, 4106, 4147, 4161], 'hexameric': [43, 213, 397, 2549, 2724], 'reaches': [46, 216], 'cell': [48, 165, 218, 335, 1211, 2773, 2850, 3112, 3144, 3460, 3500, 3572, 3666, 3713, 4261, 4319], 'surface': [49, 104, 166, 219, 274, 336, 1199, 3113, 3461, 3653, 3667, 3714], 'but,': [50, 220], 'unlike': [51, 221], 'connexins,': [52, 222], 'is': [53, 83, 91, 223, 253, 261, 390, 620, 855, 1045, 1201, 1224, 2515, 2883, 2996, 3169, 3255, 3270, 3313, 3598, 3605, 3636, 3681, 3689], 'N-glycosylated.': [54, 224], 'Using': [55, 225], 'site-directed': [56, 226, 3278, 3916], 'mutagenesis': [57, 227, 1333, 3279], 'we': [58, 228, 1034, 2500, 2737, 2801, 2960, 3276, 3502, 3584, 3676, 3918, 4013, 4335], 'analyzed': [59, 229, 1707, 2468, 3202, 3512], 'three': [60, 230, 656, 2013, 3173], 'putative': [61, 231, 3210], 'N-linked': [62, 232, 3043, 3953], 'glycosylation': [63, 98, 233, 268, 1194, 1217, 2916, 3211, 3274, 3330, 3925, 4251], 'sites': [64, 234, 3212, 3234, 3269], 'examined': [66, 236, 3344], 'effects': [68, 238], 'of': [69, 99, 148, 159, 239, 269, 318, 329, 349, 359, 367, 378, 395, 399, 483, 519, 534, 569, 630, 655, 779, 810, 863, 870, 928, 936, 1041, 1106, 1155, 1168, 1206, 1215, 1351, 1397, 1421, 1453, 1475, 1564, 1650, 1672, 1689, 1692, 1845, 1855, 1874, 1882, 1908, 1997, 2033, 2172, 2185, 2234, 2463, 2505, 2523, 2557, 2563, 2595, 2602, 2623, 2652, 2662, 2690, 2755, 2764, 2829, 2874, 2880, 2953, 2980, 3003, 3020, 3193, 3207, 3261, 3266, 3318, 3371, 3433, 3443, 3625, 3640, 3655, 3669, 3696, 3718, 3806, 3825, 3865, 3883, 3890, 3908, 3923, 3939, 3979, 4063, 4078, 4089, 4101, 4114, 4152, 4170, 4250, 4268, 4304, 4312, 4323], 'each': [70, 240, 477, 1242], 'mutation': [71, 241, 1358, 3859], 'expression.': [74, 244], 'for': [77, 93, 155, 247, 263, 325, 1181, 1203, 1451, 1529, 1572, 1589, 1611, 1684, 1817, 1892, 1914, 1935, 1941, 2036, 2113, 2164, 2196, 2230, 2250, 2325, 2357, 2409, 2477, 2819, 2919, 2999, 3209, 3970, 4075, 4109, 4199, 4282], 'first': [79, 249, 1183], 'time': [80, 250, 1184, 2188, 2452, 3980, 4079], 'glycosylated': [84, 254, 3015, 3044, 3414, 3592, 3682], 'at': [85, 101, 255, 271, 1196, 1431, 1525, 1532, 1585, 1592, 1661, 1895, 1898, 1917, 2027, 2116, 2152, 2182, 2450, 2649, 2751, 3235, 3314, 3458, 3498, 3683, 3703, 4339], 'Asn-254': [86, 256, 3254, 3705], 'this': [89, 259, 566, 1032, 2673, 3061, 3311, 3604, 3687, 3841, 4197, 4318], 'residue': [90, 260, 3312, 3684, 3706], 'important': [92, 262, 1202, 3271, 3691, 4310], 'plasma': [94, 142, 264, 312, 804, 889, 1116, 3931, 4128, 4217, 4239], 'targeting.': [96, 266], 'The': [97, 267, 650, 882, 1176, 1213, 1371, 1535, 1566, 1581, 1603, 1632, 1664, 1704, 1843, 1943, 1966, 2175, 2323, 2385, 2395, 2412, 2878, 3076, 3118, 3300, 3332, 3430, 3521, 3831, 3843, 4120, 4298], 'its': [102, 272, 1197], 'extracellular': [103, 273, 640, 880, 1198, 3259, 3287], 'makes': [105, 275], 'it': [106, 276, 2473, 2719, 2892, 3129, 3322, 3326, 3366, 3385, 3416, 3468, 3565, 3586], 'unlikely': [107, 277, 3324], 'two': [109, 279, 345, 396, 639, 1238, 2527, 4059], 'oligomers': [110, 280], 'could': [111, 150, 281, 320, 2955, 3012, 3860], 'dock': [112, 282], 'an': [115, 285, 621, 1247, 1838, 1985, 2516, 2663, 2668, 2786, 2790, 2962, 3529, 3630, 3690, 3773, 3872, 3997, 4309], 'intercellular': [116, 286, 360, 379, 788], 'channel.': [117, 287, 3796, 3874], 'Ultrastructural': [118, 288], 'analysis': [119, 289, 1996, 3348, 3984], 'by': [120, 290, 392, 742, 885, 1237, 1328, 1402, 1668, 1708, 1735, 2144, 2392, 2590, 2758, 3124, 3195, 3345, 3516, 3526, 3615, 3878, 3902], 'electron': [121, 291], 'microscopy': [122, 292, 2217], 'confirmed': [123, 293, 1401, 3664, 4111, 4247], 'junctional': [126, 296], 'areas': [127, 297], 'do': [128, 298, 858], 'not': [129, 299, 859, 2046, 2585, 2626, 2637, 2646, 2667, 2868, 2997, 3037, 3122, 3162, 3164, 3405, 3759, 3829, 4118, 4186, 4243], 'appear': [130, 300], 'as': [131, 301, 352, 510, 560, 1246, 1733, 2275, 2366, 2472, 2701, 2742, 2767, 2805, 2891, 2917, 2983, 3272, 3365, 3384, 3415, 3619], 'canonical': [132, 302, 811], 'junctions.': [134, 304, 383], 'Rather,': [135, 305], 'channels': [137, 307, 361, 2921], 'distributed': [139, 309, 4125], 'throughout': [140, 310, 4126], 'membrane.': [143, 313, 3932], 'propose': [145, 315], 'N-glycosylation': [147, 317, 3233, 3702], 'be': [151, 321, 895, 2467, 3328], 'significant': [153, 323, 3987], 'mechanism': [154, 324, 1151], 'regulating': [156, 326, 1152], 'trafficking': [158, 328, 1205, 3695], 'these': [160, 330, 1169, 2326, 2729, 4337], 'tissues.': [169, 339, 1175], 'Intercellular': [340], 'communication': [341], 'takes': [342], 'place': [343], 'ways:': [347], 'release': [348, 927], 'molecules': [350], 'such': [351], 'neurotransmitters,': [353], 'hormones,': [354], 'or': [355, 1652, 1714, 1829, 1866, 1879, 1904, 2109, 2123, 2140, 2203, 2219, 2315, 2404, 2777, 2789, 2915, 3022, 3506, 4085, 4379], 'ATP;': [356], 'formation': [358, 2661], 'connect': [363, 875], 'directly': [364, 867], 'cytoplasm': [366, 869, 877, 4211], 'adjacent': [368, 478, 871], 'cells.': [369], 'Multicellular': [370], 'organisms': [371], 'have': [372, 599, 635, 705, 801, 891], 'evolved': [373, 530], 'use': [375, 1639], 'types': [377], 'channels,': [380], 'called': [381], 'In': [384, 1031, 2075, 3166], 'vertebrates,': [385], 'junction': [388, 4142], 'formed': [391, 884, 1236, 3793], 'apposition': [394], 'assemblies': [398], 'connexins': [400, 487, 2478, 2897], '(Cx),': [401], '2The': [402], 'abbreviations': [403, 439], 'used': [404, 440, 1270, 1360, 1617, 2961, 3277, 3934, 4014], 'are:': [405, 441], 'Cx,': [406, 442], 'connexins;': [407, 443], 'Panx,': [408, 444], 'pannexins;': [409, 445], 'Inx,': [410, 446], 'innexins;': [411, 447], 'DSP,': [412, 448, 2513], 'dithio-bis(succinimidylpropionate);': [413, 449], 'PNGase': [414, 450, 3033, 3085, 3125, 3155, 3401], 'F,': [415, 451, 3034], 'N-glycosidase': [416, 452, 1883], 'F;': [417, 453], 'Endo': [418, 454, 3028, 3052, 3082, 3581], 'H,': [419, 455], 'endoglycosidase': [420, 456, 1875], 'H;': [421, 457], 'CIAP,': [422, 458], 'calf': [423, 459, 1909], 'intestinal': [424, 460, 1910], 'alkaline': [425, 461, 1911, 2963], 'phosphatase;': [426, 462], 'MDCK,': [427, 463], 'Madin-Darby': [428, 464], 'canine': [429, 465], 'kidney;': [430, 466], 'ER,': [431, 467], 'endoplasmic': [432, 468], 'reticulum;': [433, 469], 'EGFP,': [434, 470], 'enhanced': [435, 471], 'green': [436, 472, 4020, 4176], 'fluorescent': [437, 473, 4021, 4025, 4177], 'protein.2The': [438], 'protein.': [474, 3135], 'one': [475, 2059, 3160, 3286], 'from': [476, 1763, 1860, 2390, 2775, 2823], 'cell.': [479], 'A': [480, 1687, 2377, 2811, 3464, 3550], 'new': [481, 567], 'class': [482, 568], 'analogous': [485], 'their': [489], 'folding,': [490], 'but': [491, 607, 873, 3422], 'completely': [492, 3869], 'unrelated': [493], 'sequence': [495, 543, 601, 1404, 3206], 'has': [496, 615, 2893], 'been': [497, 616, 706, 892, 2475, 2894], 'identified': [498, 538], 'invertebrates.': [500], 'These': [501, 4245], 'were': [503, 536, 1325, 1359, 1429, 1456, 1467, 1481, 1706, 1731, 1761, 1800, 1835, 1869, 1924, 1954, 1975, 2011, 2025, 2111, 2161, 2180, 2209, 2243, 2273, 2317, 2355, 2397, 2529, 2634, 2645, 2783, 2797, 2838, 2867, 3081, 3138, 3294, 3337, 3456, 3475, 3524, 3743, 3836, 3964, 4070, 4124, 4194, 4277], 'named': [504], 'innexins': [505, 535], '(invertebrate': [506], 'connexin': [507, 526], 'analogs,': [508], 'abbreviated': [509, 559], 'Inx).': [511], 'Despite': [512], 'conserved': [514], 'structure,': [515], 'properties,': [516], 'functions': [518], 'junctions': [521, 813], 'vertebrates': [523], 'invertebrates,': [525], 'innexin': [528, 605], 'structures': [529, 712, 1233, 4334], 'independently.': [531], 'Mammalian': [532], 'analogs': [533], 'recently': [537], 'human': [541, 651], 'genome': [542], 'term': [546], '(from': [548], 'Greek': [550], 'word': [551], 'pan,': [552], '“throughout”': [553], 'Latin': [556], 'nexus,': [557], '“connection,”': [558], 'Panx)': [561], 'was': [562, 1100, 1119, 1334, 1374, 1400, 1538, 1568, 1583, 1605, 1635, 1666, 1698, 1847, 1999, 2052, 2060, 2142, 2194, 2364, 2388, 2415, 2425, 2567, 2678, 2816, 2856, 2975, 3025, 3121, 3152, 3161, 3359, 3381, 3398, 3411, 3439, 3496, 3561, 3578, 3766, 3850, 4144, 4157, 4179, 4219, 4231], 'coined': [563], 'name': [565], '(1Panchin': [571, 713], 'Y.': [572, 714, 836, 1014, 1016, 1135], 'Kim': [573, 715, 748, 816, 837, 901, 941, 957, 971, 991, 1011, 1074, 1132, 1252, 1283, 1741, 2093, 2280, 2334, 2435, 2481, 2900, 2924, 3220, 4029, 4350], 'I.': [574, 716, 2923], 'Matz': [575, 717], 'M.': [576, 718], 'Lukyanov': [577, 581, 719, 723], 'K.': [578, 720], 'Usman': [579, 721], 'N.': [580, 722], 'S.': [582, 724, 761, 815, 825, 902, 940, 990, 1081, 1282, 1292, 1750, 3221], 'Curr.': [583, 725], 'Biol.': [584, 726, 974, 1259, 2906, 2931], '2000;': [585, 727, 1261, 2484], '10:': [586, 728, 1024], 'R473-R474Abstract': [587, 729], 'Full': [588, 590, 730, 732, 979, 981, 2936, 2938], 'Text': [589, 591, 731, 733, 980, 982, 2937, 2939], 'PDF': [592, 734, 983, 2940], 'PubMed': [593, 735, 766, 830, 847, 910, 950, 964, 984, 1004, 1026, 1092, 1143, 1264, 1297, 1755, 2104, 2300, 2344, 2445, 2487, 2910, 2941, 4049, 4370], 'Scopus': [594, 736, 767, 831, 848, 911, 951, 965, 985, 1005, 1027, 1093, 1144, 1265, 1298, 1756, 2105, 2301, 2345, 2446, 2488, 2911, 2942, 4050, 4371], '(399)': [595, 737], 'Google': [596, 738, 769, 833, 850, 913, 953, 967, 987, 1007, 1029, 1095, 1146, 1267, 1300, 1758, 2107, 2303, 2347, 2448, 2490, 2913, 2944, 4052, 4373], 'Scholar).': [597, 739, 851, 1030, 1096, 1147, 1268, 1759, 2304, 2384, 2491, 2945, 3228, 4053], 'some': [600, 3610], 'similarity': [602], 'invertebrate': [604], 'proteins,': [606, 2049, 2693, 3762, 4275], 'share': [608], 'no': [609, 808, 2973, 4213], 'homology': [610], 'with': [611, 785, 807, 1128, 1336, 1366, 1376, 1557, 1723, 1820, 1837, 1871, 1905, 1958, 2015, 2030, 2062, 2070, 2078, 2119, 2146, 2189, 2201, 2212, 2255, 2399, 2417, 2427, 2512, 2896, 2985, 3441, 3484, 3537, 3629, 3648, 3745, 3772, 3799, 3862, 3966, 4019, 4072, 4093, 4105, 4131, 4174, 4224, 4279, 4289, 4306], 'connexins.': [613], 'It': [614], 'speculated': [617], 'there': [619, 3635, 4230], 'evolutionary': [622], 'relationship': [623], 'between': [624, 3039], 'innexins.': [627], 'Both': [628, 3449], 'groups': [629], 'predicted': [633, 3232, 3250, 3268], 'four': [636, 3231], 'transmembrane': [637], 'regions,': [638], 'loops': [641], 'intracellular': [643, 2048, 3284, 3612, 3761, 4236], 'amino': [644, 661, 668, 676, 3204], '(NH2)': [645], 'carboxyl': [647], '(COOH)': [648], 'termini.': [649], 'pannexin': [652], 'family': [653], 'consists': [654], 'members:': [657], '(Panx1,': [659], '426': [660], 'acids,': [662, 669, 677], '47.6': [663], 'kDa),': [664, 671, 2573, 2576, 2579, 3814, 3817, 3820], 'Pannexin2': [665], '(Panx2,': [666], '664': [667], '73.3': [670], 'Pannexin3': [673], '(Panx3,': [674], '392': [675], '44.7': [678], 'kDa).': [679, 2552, 2615, 2727], 'systems': [686], 'Earlier': [740], 'studies': [741, 794], 'Bruzzone': [743], 'et': [744, 1737], 'al.': [745, 1738], '(2Bruzzone': [746], 'R.': [747, 1087, 3219], 'S.G.': [749], 'Barbe': [750], 'M.T.': [751], 'Herb': [752], 'A.': [753, 762, 826, 958, 972, 1012, 1018, 1077, 1293, 1751], 'Monyer': [754], 'H.': [755, 1740], 'Proc.': [756, 820, 1287, 1745], 'Natl.': [757, 821, 1288, 1746], 'Acad.': [758, 822, 1289, 1747], 'Sci.': [759, 823, 1290, 1748], 'U.': [760, 824, 1291, 1749], '2003;': [763], '100:': [764], '13644-13649Crossref': [765], '(614)': [768], 'Scholar)': [770, 914, 2449, 4374], 'paired': [772], 'Xenopus': [773], 'oocytes': [774, 2391, 2396, 2421], 'found': [775, 3230, 3599], 'expression': [778, 1053, 3668], 'Panx1,': [780], 'alone': [781], 'combination': [784], 'Panx2,': [786], 'induces': [787, 3707], 'channels.': [789], 'However,': [790, 3467, 3634], 'functional': [791, 1166], 'localization': [793, 1064, 1154, 3432], 'erythrocytes,': [796], 'cultured': [797], 'neurons,': [798], 'glia': [800], 'shown': [802, 893, 2476, 2704, 2768, 2895, 3047, 3352, 3546, 3620], 'only': [803, 2852, 3055, 3412], 'staining': [806, 1118, 4116, 4137], 'evidence': [809], '(3Locovei': [814], 'L.': [817, 900, 1284], 'Dahl': [818, 903, 943, 997, 1084, 1285], 'G.': [819, 904, 944, 998, 1073, 1085, 1131, 1286, 2279, 2370, 4028, 4349], '2006;': [827, 947, 961, 1023, 1140, 1294], '103:': [828, 1295], '7655-7659Crossref': [829, 1296], '(421)': [832, 1299], 'Scholar,': [834, 954, 968, 988, 1008], '4Huang': [835], 'J.B.': [838], 'Abrams': [839], 'C.K.': [840], 'Scherer': [841], 'S.S.': [842], 'Glia.': [843], '2007;': [844, 976, 1001, 1089], '55:': [845], '46-56Crossref': [846], '(148)': [849], 'One': [852], 'current': [853], 'hypothesis': [854], 'Panxs': [857], 'duplicate': [860], 'function': [862], 'Cxs': [864], 'connecting': [866], 'cells,': [872, 1112, 1125], 'rather': [874], 'space.': [881], 'hemichannels': [883], 'Panx1': [886, 1042, 1044, 1061, 1186, 1322, 1627, 1864, 2403, 2495, 2723, 2756, 2795, 2865, 2954, 3495, 3928, 3993, 4011, 4110, 4257, 4305, 4315, 4328], 'mechanosensitive': [896], 'ATP': [897], 'conduits': [898], '(5Bao': [899], 'FEBS': [905, 945, 999, 1138], 'Lett.': [906, 946, 1000, 1139], '2004;': [907, 2933], '572:': [908], '65-68Crossref': [909], '(618)': [912], 'respond': [916], 'several': [918, 1049, 2165], 'signal': [919], 'transduction': [920], 'pathways.': [921], 'They': [922], 'involved': [924], 'small': [929], 'molecules,': [930], 'may': [932], 'promote': [933], 'propagation': [935], 'calcium': [937], 'waves': [938], '(6Locovei': [939], 'J.': [942, 960, 973, 1019, 1257, 1744, 2285, 2439, 2904, 2925, 2930, 4034, 4355], '580:': [948, 1141], '239-244Crossref': [949], '(415)': [952], '7Pelegrin': [955], 'P.': [956, 970], 'EMBO': [959], '25:': [962], '5071-5082Crossref': [963], '(1126)': [966], '8Pelegrin': [969], 'Chem.': [975, 2932], '282:': [977], '2386-2394Abstract': [978], '(253)': [986], '9Locovei': [989], 'E.': [992, 1075, 2927], 'Qiu': [993], 'F.': [994], 'Spray': [995], 'D.C.': [996, 2434], '581:': [1002], '483-488Crossref': [1003], '(353)': [1006], '10Litvin': [1009], 'O.': [1010, 2287, 4036, 4357], 'Connell-Alberts': [1013], 'Panchin': [1015, 1134], 'Baranova': [1017], 'Cell': [1020, 1424, 2007, 2339, 2753, 3652, 3912], 'Mol.': [1021], 'Med.': [1022, 1258], '613-634Crossref': [1025], '(53)': [1028], 'study,': [1033], 'investigated': [1035], 'stoichiometry': [1037], 'targeting': [1040, 3927, 4253], 'oligomers.': [1043], 'widely': [1046], 'tissues,': [1050], 'pattern': [1054, 2815, 2952, 2979, 3011], 'varies': [1055], 'locations.': [1058], 'For': [1059], 'example,': [1060], 'revealed': [1062, 2761, 3985], 'postsynaptic': [1063], 'rodent': [1066], 'hippocampal': [1067], 'cortical': [1069], 'principal': [1070], 'neurons': [1071], '(11Zoidl': [1072], 'Ray': [1076], 'Meier': [1078], 'C.': [1079], 'Bunse': [1080], 'Habbes': [1082], 'H.W.': [1083], 'Dermietzel': [1086], 'Neuroscience.': [1088], '146:': [1090], '9-16Crossref': [1091], '(122)': [1094], 'Furthermore,': [1097, 3407, 4221], 'Panx1-specific': [1098], 'labeling': [1099, 3639, 4017, 4156, 4214, 4233], 'evident': [1101, 2857], 'perinuclear': [1104], 'region': [1105], 'retinal': [1107, 1123], 'ganglion': [1108, 1124], 'cells': [1109, 1428, 1460, 1466, 1480, 1764, 1862, 2010, 2082, 2198, 2208, 2242, 2507, 2782, 3342, 3510, 3956, 4066, 4104], 'horizontal': [1111], 'whereas': [1113, 2841, 3253], 'relatively': [1114, 3637], 'little': [1115, 3638], 'observed': [1120, 2531, 2568, 2635, 2647, 2739, 2798, 2818, 2976], 'neonatal': [1122], 'gradually': [1126], 'increasing': [1127], 'age': [1129], '(12Dvoriantchikova': [1130], 'D.': [1133, 2374], 'Shestopalov': [1136], 'V.I.': [1137], '2178-2182Crossref': [1142], '(84)': [1145], 'To': [1148, 2039, 2492, 2670, 2946, 3005, 3263, 3491, 3674, 3752, 4005, 4263], 'uncover': [1149], 'pannexins,': [1156], 'particular': [1158], 'subcellular': [1159], 'compartments,': [1160], 'might': [1161], 'provide': [1162], 'insights': [1163], 'into': [1164, 1388, 1458], 'role': [1167, 4311], 'novel': [1170], 'data': [1177, 4246], 'presented': [1178], 'multimeric': [1189, 2498, 3795], 'contains': [1192], 'site': [1195, 1218], 'protein': [1208, 2465, 2757, 2822, 3024, 3104, 3364, 3372, 3447, 3514, 3540, 3569, 3867, 3924, 4163, 4226], 'surface.': [1212, 3573, 4262], 'presence': [1214, 2171, 2594, 2763, 2879, 3882, 4088, 4169], 'argues': [1219], 'single': [1222, 2744, 3844], 'hexamer': [1223, 1243, 2581, 2644, 2733, 3822, 3832], 'primary': [1226, 1273, 1821, 1944], 'state': [1228, 2462], 'contrast': [1230], 'connexin-based': [1232], 'docked': [1239], 'hexamers': [1240], 'where': [1241, 2832, 3148], 'can': [1244, 2466], 'act': [1245], 'independent': [1248], 'unit': [1249, 3944], '(13Verselis': [1250], 'V.K.': [1251], 'E.B.': [1253], 'Bukauskas': [1254], 'F.F.': [1255], 'Braz.': [1256], 'Res.': [1260, 2340], '33:': [1262], '379-389Crossref': [1263], '(41)': [1266], 'Antibodies—We': [1269], 'following': [1272, 4222], 'antibodies:': [1274], 'chicken': [1275, 1823, 2064, 3747], 'anti-Panx1': [1276, 1824, 2065, 2787], '(4515,': [1277], 'characterized': [1278], 'Ref.': [1280, 3217], '3Locovei': [1281], 'Scholar);': [1301, 2348], 'mouse': [1302, 1306, 1826, 1830, 2072, 2848], 'monoclonal': [1303, 1831], 'anti-Myc': [1304, 1724, 1832, 1947, 2791], '(Sigma);': [1305, 1308], 'anti-α-tubulin': [1307, 1827, 2073], 'rabbit': [1310, 1950], 'polyclonal': [1311, 1951, 3748, 4107], 'anti-calnexin': [1312, 1952], '(Stressgen,': [1313], 'Victoria,': [1314], 'Canada).': [1315], 'Plasmids': [1316, 1448], 'Mutagenesis—The': [1318], 'cDNAs': [1319], 'encoding': [1320], 'rat': [1321, 2843], 'wild-type,': [1323, 3434], 'myc-tagged': [1324], 'kindly': [1326], 'provided': [1327], 'Dr.': [1329], 'Roberto': [1330], 'Bruzzone.': [1331], 'Site-directed': [1332, 3196], 'done': [1335, 2000], 'QuikChange': [1338], 'kit': [1339, 1840], '(Stratagene,': [1340], 'La': [1341], 'Jolla,': [1342], 'CA)': [1343], 'using': [1344, 1406, 1461, 1849, 2001, 2469, 2694, 2785, 3027, 4343], 'Pfu': [1345], 'Turbo': [1346], 'DNA': [1347, 1384, 1403], 'polymerase.': [1348], 'Complementary': [1349], 'pairs': [1350], 'synthetic': [1352], 'oligonucleotide': [1353], 'primers': [1354, 1410], 'containing': [1355, 1442, 1768, 2020, 4272], 'desired': [1357], 'amplify': [1362], 'full-length': [1364], 'plasmid': [1365], 'rPanx1': [1368, 1415, 2089, 3168, 3208, 3680, 3792, 3827, 3962], 'cDNA': [1369], 'insert.': [1370], 'PCR': [1372], 'product': [1373], 'treated': [1375, 2501, 3965], 'DpnI': [1377], 'endonuclease': [1378], 'digest': [1380], 'methylated': [1382], 'wild-type': [1383, 1865, 3451], 'template,': [1385], 'transformed': [1387], 'MAX': [1389], 'Efficiency': [1390], 'DH5α': [1391], 'Competent': [1392], 'Cells': [1393, 2024, 2160], '(Invitrogen).': [1394, 1447, 1464], 'Successful': [1395], 'incorporation': [1396], 'mutations': [1399], 'analyses,': [1405], 'forward': [1407], 'reverse': [1409, 2627], 'check': [1412], 'entire': [1414], 'sequence,': [1416], 'confirm': [1418, 2040, 2672, 3753], 'absence': [1420, 2622], 'random': [1422], 'mutations.': [1423], 'Culture': [1425, 1477], 'Transfections—HEK-293T': [1427], 'maintained': [1430], '37': [1432, 1896, 1918, 2117, 2153], '°C,': [1433], '10%': [1435, 1443], 'CO2': [1436], "Dulbecco's": [1438], 'modified': [1439], "Eagle's": [1440], 'medium': [1441, 4084], 'fetal': [1444], 'bovine': [1445], 'serum': [1446], '(0.5': [1449], 'μg': [1450], 'transfection': [1452], '35-mm': [1454], 'dish)': [1455], 'transfected': [1457], 'HEK-293T': [1459, 1479, 1861, 2506, 2781, 3341], 'Lipofectamine': [1462], '2000': [1463], 'Transfected': [1465], 'processed': [1468, 2356, 3042, 3103, 3189, 3992], '1-2': [1469], 'days': [1470], 'post-transfection.': [1471], 'Triton': [1472, 1558, 2502], 'X-100': [1473, 1559], 'Solubilization': [1474], 'Tissue': [1476], 'Cells—Adherent': [1478], 'washed': [1482, 2012], '3': [1483, 1893, 1915], 'times': [1484, 1577, 2014, 3973], 'ice-cold': [1486], 'incubation': [1487, 1541, 3972], 'buffer': [1488, 1542, 1767, 1960, 2225, 2247], '(137': [1489], 'mm': [1490, 1493, 1496, 1499, 1502, 1505, 1508, 1511, 1772, 2257, 2260, 2263], 'NaCl,': [1491], '5.4': [1492], 'KCl,': [1494], '0.34': [1495], 'Na2HPO4,': [1497], '0.35': [1498], 'KH2PO4,': [1500], '0.8': [1501], 'MgSO4,': [1503], '2.7': [1504], 'CaCl2,': [1506], '20': [1507, 1670, 1811, 1936, 2150, 2239, 2259], 'HEPES,': [1509], '200': [1510], 'phenylmethylsulfonyl': [1512, 1773], 'fluoride,': [1513, 1774], 'pH': [1514, 1676, 1696, 1899, 2228], '7.4,': [1515], 'filtered': [1517], '0.22-μm': [1520], 'filter),': [1521], 'scraped,': [1522], 'centrifuged': [1524, 1584], '11,500': [1526], '×': [1527, 1587], 'g': [1528, 1588], '10': [1530, 1690, 1906], 'min': [1531, 1660, 2151, 2240, 2252], '4': [1533, 1593, 2028], '°C.': [1534, 1919], 'cellular': [1536], 'pellet': [1537], 'resuspended': [1539], '(1': [1543], 'ml/confluent': [1544], '60-mm': [1545], 'dish),': [1546], 'sonicated': [1547], '(3': [1548], 'pulses,': [1549], '30': [1550, 1573, 1659, 1685, 2037, 2251], 's': [1551], 'each,': [1552], 'ice),': [1554], 'supplemented': [1556], 'final': [1562, 1648], 'concentration': [1563, 1649, 2522, 2556], '1%.': [1565], 'sample': [1567, 2677], 'incubated': [1569, 1658, 1681, 1816, 1870, 2026, 2163, 2408, 4074, 4281], 'ice': [1571, 1610, 1683, 2254], 'min,': [1574, 1937], 'vortexing': [1575], '3-4': [1576], 'during': [1578], 'incubation.': [1580], 'extract': [1582], '301,000': [1586], '1': [1590, 1673, 1693, 1771, 1818, 2114, 3554], 'h': [1591, 1819, 1894, 1916, 2115, 4167, 4284], '°C': [1594, 1897, 2029, 2118, 2154], 'SW55': [1597], 'rotor': [1598], 'Beckman': [1601], 'ultracentrifuge.': [1602], 'supernatant': [1604], 'recovered': [1606, 3525], 'stored': [1608], 'cross-linking': [1613, 3798, 3855], 'procedure.': [1614], 'Chemical': [1615, 3797], 'Cross-linking—We': [1616], 'homobifunctional,': [1619], 'amine-reactive': [1620], 'reagent': [1621, 2044, 3757], 'DSP': [1622, 1633, 2524, 2558, 2653, 2658, 3802], '(dithio-bis(succinimidylpropionate))': [1623], 'covalently': [1625], 'link': [1626], 'monomers': [1628, 3849], 'within': [1629, 4209], 'oligomer.': [1631], 'solution': [1634, 1688, 2019], 'prepared': [1636], 'just': [1637, 2712], 'before': [1638], '(12.5': [1640], 'mg/ml': [1641, 2032], 'Me2SO),': [1643], 'added': [1645, 1699], '50': [1651, 2262], '300': [1653, 2650, 3800], 'μg/ml,': [1654], 'vortex': [1655, 1678], 'mixed,': [1656, 1679], 'room': [1662], 'temperature.': [1663], 'reaction': [1665], 'stopped': [1667], 'adding': [1669], 'μl/ml': [1671, 1691], 'm': [1674, 1694], 'glycine,': [1675, 1695, 1713], '9.2,': [1677], 'min.': [1686, 2038], '7.2,': [1697], 'restore': [1701], 'pH.': [1703], 'samples': [1705, 2354], '4-20%': [1709, 1784], 'SDS-PAGE,': [1710], '4-12%': [1711], 'Tris': [1712, 1716, 1785, 2683], '3-8%': [1715, 2682], 'acetate': [1717, 2684], 'gradient': [1718], 'gels': [1719], 'Western': [1721, 2759, 3346, 3519, 3982], 'blot': [1722, 1730, 2760, 3347, 3627, 3983], 'antibody.': [1725, 2074, 2792], 'Gel': [1726], 'Electrophoresis': [1727], 'Immunoblotting—Western': [1729], 'performed': [1732, 2274, 2365, 3026], 'described': [1734, 2277, 2367], 'Towbin': [1736], '(14Towbin': [1739], 'T.': [1742], 'Gordon': [1743], '1979;': [1752], '76:': [1753], '4350-4354Crossref': [1754], '(44843)': [1757], 'Proteins': [1760], 'extracted': [1762], 'SDS': [1766], '4%': [1769, 1932, 2213, 2351], 'β-mercaptoethanol,': [1770], 'protease': [1777], 'inhibitor': [1778], 'mixture': [1779], '(Sigma),': [1780], 'separated': [1781], 'glycine': [1786, 2264], 'gel': [1787, 2685, 3765], '(Invitrogen),': [1788], 'transferred': [1790], 'polyvinylidene': [1793], 'difluoride': [1794], '(Millipore,': [1796], 'Bedford,': [1797], 'MA).': [1798], 'Membranes': [1799], 'blocked': [1801, 2249], 'overnight': [1802], '5%': [1804, 2596, 3884], 'nonfat': [1805], 'dry': [1806], 'milk': [1807], '0.5%': [1809], 'Tween': [1810], 'phosphate-buffered': [1813, 1964], 'saline,': [1814], 'antibody:': [1822], '(1:1000),': [1825], '(1:7000),': [1828], '(1:5000).': [1833], 'Blots': [1834], 'developed': [1836], 'ECL': [1839], '(Amersham': [1841], 'Biosciences).': [1842], 'intensity': [1844], 'signals': [1846], 'quantified': [1848], 'ImageJ': [1851], 'software': [1852], '(rsb.info.nih.gov/ij).': [1853], 'Analysis': [1854], 'Glycosylation': [1856, 3192], 'Phosphorylation—Cell': [1858], 'lysates': [1859, 2774, 2988, 3515], 'expressing': [1863, 2084, 2312, 2508, 2780, 3143, 3508, 3958, 4068], 'mutant': [1867, 3358, 3380, 3410, 3437, 3454, 3672, 3723, 3791], '1,500': [1872, 1880], 'units': [1873, 1881, 1907], 'H': [1876, 3029, 3053, 3083, 3582], '(Endo': [1877], 'H)': [1878], 'F': [1884, 3086, 3126, 3402], '(PNGase': [1885], 'F)': [1886], '(New': [1887], 'England': [1888], 'Biolabs,': [1889], 'Beverly,': [1890], 'MA)': [1891], '5.5': [1900], '7.5,': [1902], 'respectively;': [1903], 'phosphatase': [1912], '(CIAP)': [1913], 'Immunocytochemistry': [1920], 'Confocal': [1922], 'Microscopy—Cells': [1923], 'grown': [1925, 2318], 'poly-d-lysine-coated': [1927, 2320], 'glass': [1928, 2321], 'coverslips,': [1929], 'fixed': [1930, 2211], 'paraformaldehyde/phosphate-buffered': [1933], 'saline': [1934], 'washed,': [1938], 'labeled': [1940, 2112, 2200, 3614, 4092, 4173, 4288], 'immunofluorescence.': [1942, 2358, 3350], 'antibodies': [1945, 1968], '(mouse': [1946], '1:200,': [1948], '1:200)': [1953], 'mixed': [1955], 'diluted': [1957, 1961, 1976], 'blocking': [1959], '5-fold': [1962], 'saline.': [1965], '(fluorescein': [1969], 'isothiocyanate-conjugated': [1970], 'anti-mouse': [1971], 'Cy5-conjugated': [1973], 'anti-rabbit)': [1974], '1:100': [1977], 'same': [1980, 4103], 'buffer.': [1981], 'Image': [1982, 1995, 3778], 'processing': [1983], 'employed': [1984], 'Olympus': [1986], 'FluoView1000': [1987], 'laser-scanning': [1988], 'confocal': [1989], 'microscope': [1990], '(Olympus,': [1991], 'Center': [1992], 'Valley,': [1993], 'PA).': [1994], 'z-scan': [1998], 'Imaris': [2003], 'Software': [2004], '(Bitplane': [2005], 'AG).': [2006], 'Surface': [2008], 'Biotinylation—HEK-293T': [2009], "Hanks'": [2016, 2131, 2156], 'balanced': [2017, 2132, 2157], 'salt': [2018, 2133, 2158], '0.05%': [2021], 'sodium': [2022, 2223], 'azide.': [2023], '0.25': [2031], 'Sulfo-NHS-SS-Biotin': [2034], '(Pierce)': [2035], 'biotinylation': [2043, 3617, 3654, 3717, 3756], 'did': [2045, 2625, 3758, 4185], 'label': [2047, 3760, 4058, 4377], 'experiment': [2051], 'conducted': [2053], '2': [2055], 'blots': [2056], 'parallel,': [2058], 'hybridized': [2061, 3628, 3771], 'antibody': [2066, 2788, 3631, 3749, 3774, 4108], 'other': [2069], 'Vivo': [2076], 'Labeling': [2077], 'ReAsH-EDT2': [2079, 2122, 2202, 4026, 4155], 'FlAsH-EDT2—MDCK': [2081], 'stably': [2083, 2311, 3142, 3957, 4067], 'tetracysteine': [2086, 3960], 'domain': [2087], '(FLNCCPGCCME)-tagged': [2088], '(rPanx1-4C)': [2090, 3963], '(15Martin': [2091], 'B.R.': [2092], 'B.N.': [2094], 'Adams': [2095, 2282, 4031, 4352], 'S.R.': [2096, 2283, 4032, 4353], 'Tsien': [2097, 2292, 4041, 4362], 'R.Y.': [2098, 2293, 4042, 4363], 'Nat.': [2099], 'Biotechnol.': [2100], '2005;': [2101], '23:': [2102], '1308-1314Crossref': [2103], '(348)': [2106], 'Scholar),': [2108, 2914], 'rCx43-GFP-4C': [2110], '0.5': [2120], 'μm': [2121, 2125, 2128], '0.9': [2124], 'FlAsH-EDT2,': [2126, 4022, 4073, 4153], '12.5': [2127], 'EDT': [2129, 2147], 'solution.': [2134], 'Free': [2135], 'nonspecifically': [2137], 'bound': [2138, 3602, 3644], 'ReAsH': [2139], 'FlAsH': [2141], 'removed': [2143, 2389, 2416], 'washing': [2145], '(600': [2148], 'μm,': [2149], 'solution).': [2159], 'then': [2162, 4091, 4293], 'hours': [2166], '(chase': [2167, 4080], 'time)': [2168, 4081], 'complete': [2173], 'medium.': [2174], 'synthesized': [2177, 4256], 'recombinant': [2178, 2875], 'stained': [2181, 4071, 4278], 'end': [2184, 3317], 'chase': [2187], 'second': [2191, 3258, 3764], 'label,': [2192], 'which': [2193, 2514, 2800, 3035, 3265, 3936, 4159, 4184], 'FlAsH-EDT2': [2195, 4178], 'initially': [2199, 4172], 'vice': [2204], 'versa.': [2205], 'After': [2206, 4165], 'washing,': [2207], 'either': [2210], 'paraformaldehyde': [2214, 2352], '(for': [2215], 'light': [2216], 'imaging)': [2218], '2%': [2220], 'glutar-aldehyde': [2221], 'cacodylate': [2224, 2246], '(0.1': [2226], 'm,': [2227], '7.4)': [2229], 'EM': [2231, 2271, 4321, 4342], 'processing.': [2232], 'Photoconversion': [2233, 2269], 'Diaminobenzidine': [2235], 'Electron': [2237], 'Microscopy—After': [2238], 'fixation,': [2241, 2353], 'rinsed': [2244], '5': [2256], 'KCN,': [2258], 'aminotrizole,': [2261], 'reduce': [2266], 'nonspecific': [2267], 'background.': [2268], 'preparation': [2272], 'previously': [2276], '(16Gaietta': [2278, 4027, 4348], 'T.J.': [2281, 4030, 4351], 'Bouwer': [2284, 4033, 4354], 'Tour': [2286, 4035, 4356], 'Laird': [2288, 4037, 4358], 'D.W.': [2289, 4038, 4359], 'Sosinsky': [2290, 4039, 4360], 'G.E.': [2291, 4040, 4361], 'Ellisman': [2294, 4043, 4364], 'M.H.': [2295, 2333, 4044, 4365], 'Science.': [2296, 4045, 4366], '2002;': [2297, 3225, 4046, 4367], '296:': [2298, 4047, 4368], '503-507Crossref': [2299, 4048, 4369], '(794)': [2302, 4051, 4372], 'Scrape': [2305], 'Dye': [2306], 'Loading/Transfer': [2307], 'Assay—MDCK': [2308], 'parental': [2309, 2776], 'rPanx1-wt,': [2313, 3719], 'rPanx1-4C,': [2314], 'rCx43-4C': [2316], 'coverslips.': [2322], 'procedure': [2324], 'assays': [2327], 'follows': [2328], 'el-Fouly': [2329], 'colleagues': [2331], '(17el-Fouly': [2332], 'J.E.': [2335], 'Chang': [2336], 'C.C.': [2337], 'Exp.': [2338], '1987;': [2341], '168:': [2342], '422-430Crossref': [2343], '(643)': [2346], 'however,': [2349], 'after': [2350, 2454, 3051, 3854], 'Electrophysiology—The': [2359], 'oocyte': [2360], 'cell-cell': [2361], 'assay': [2363], 'earlier': [2368], '(18Dahl': [2369], 'Stevenson': [2371], 'B.G.W.': [2372], 'Paul': [2373], 'Cell-Cell': [2375], 'Interactions,': [2376], 'Pratical': [2378], 'Approach.': [2379], 'IRL': [2380], 'Press,': [2381], 'Oxford1992:': [2382], '143-165Google': [2383], 'follicle': [2386], 'layer': [2387], 'collagenase': [2393], 'treatment.': [2394], 'injected': [2398], 'vitro': [2401], 'transcribed': [2402], 'Cx46': [2405], 'cRNA': [2406], '2-3': [2410], 'days.': [2411], 'vitelline': [2413], 'forceps': [2418], 'paired.': [2422], 'Junctional': [2423], 'conductance': [2424], 'determined': [2426, 2918], 'dual': [2429], 'voltage': [2430], 'clamp': [2431], 'technique': [2432], '(19Spray': [2433], 'A.L.': [2436], 'Bennett': [2437], 'M.V.': [2438], 'Gen.': [2440], 'Physiol.': [2441], '1981;': [2442], '77:': [2443], '77-93Crossref': [2444], '(260)': [2447], 'various': [2451], 'points': [2453], 'pairing.': [2455], 'Forms': [2457], 'Multimeric': [2459], 'Channel—The': [2460], 'oligomeric': [2461, 2664, 3873], 'chemical': [2470], 'cross-linkers,': [2471], 'had': [2474, 3302], '(20VanSlyke': [2479], 'J.K.': [2480], 'L.S.': [2482, 2899], 'Methods.': [2483], '20:': [2485], '156-164Crossref': [2486], '(56)': [2489], 'test': [2493, 2947, 3006, 4326], 'whether': [2494, 2948, 3007, 3494, 3788, 4327], 'channel,': [2499], 'X-100-solubilized': [2503], 'extracts': [2504], 'rPanx1-Myc': [2509, 2544, 2778, 3023, 3507], '(49': [2510, 2572, 2614, 3813], 'kDa)': [2511, 2547, 2583, 3824], 'amino-reactive': [2517], 'reagent.': [2518], 'At': [2519, 2553], 'high': [2521, 3065, 3182, 3708, 3942, 4340], '(300': [2525], 'μg/ml)': [2526, 2560, 3969], 'bands': [2528, 2796, 2837, 2882, 2982, 3002, 3080, 3094, 3394, 3835], 'clearly': [2530, 2839], '(Fig.': [2532, 2606, 2858, 2989, 3072, 3114, 3298, 3395, 3428, 3462, 3486, 3659, 3974, 4098, 4296], '1B).': [2533], 'size,': [2536], 'they': [2537], 'likely': [2539, 3607], 'correspond': [2541], 'dimeric': [2545], '(98': [2546, 2575, 3816], '(∼290': [2551, 2582, 2726, 3823], 'lower': [2555, 2809, 2836, 2854, 3079, 3119, 3159, 3304, 3623], '(50': [2559], 'ladder': [2562], 'partially': [2564, 3413], 'cross-linked': [2565, 2676, 3807, 3892], 'products': [2566, 2610, 2633, 3808, 3896], 'including': [2569], 'monomer': [2571, 2613, 2741, 3812, 3834], 'dimer': [2574, 2735, 3815], 'trimer': [2577, 3818], '(147': [2578, 3819], '(data': [2584, 2636, 3163, 3404, 3828, 4117, 4242], 'shown).': [2586, 2638, 3165, 3406, 3830, 4119, 4244], 'Breaking': [2587, 3875], 'cross-links': [2589, 2629, 3877], 'boiling': [2591, 2619, 3879], 'β-mercaptoethanol': [2597, 2624, 3885], 'resulted': [2598, 3886], 'disappearance': [2601, 3889], 'intermediate': [2604, 2632, 3057, 3093, 3389, 3419, 3596], '1B),': [2607], 'reducing': [2608, 3894], 'all': [2609, 3368, 3895, 3952], 'On': [2616], 'contrary,': [2618], 'Bands': [2639], 'higher': [2640, 2709, 3098, 3150], 'than': [2641, 3307], 'corresponding': [2643, 3809, 3846], 'even': [2648], 'μg/ml': [2651, 3801], 'indicating': [2654, 2718], 'cross-linker': [2657], 'allowed': [2659, 4055], 'complex': [2665], 'aggregate.': [2669], 'further': [2671, 3492, 3663, 3786, 4264], 'result,': [2674], 'run': [2679, 3767], 'allows': [2687], 'better': [2688], 'resolving': [2689], 'very': [2691], 'large': [2692], 'HiMark': [2695], 'Pre-stained': [2696], 'HMV': [2697], 'Protein': [2698], 'Standard': [2699], '(Invitrogen)': [2700], 'reference.': [2702], 'As': [2703, 3046, 3351, 3545, 4146], 'Fig.': [2706, 2770, 2969, 3049, 3354, 3548], '1C,': [2707], 'band': [2710, 2717, 2855, 2951, 3010, 3058, 3062, 3099, 3120, 3151, 3420, 3427, 3559, 3577, 3597, 3845], 'mapped': [2711], 'above': [2713], '268-kDa': [2715], 'marker': [2716], 'corresponds': [2720, 3063, 3566, 3587], 'Under': [2728], 'conditions,': [2730], 'besides': [2731], 'bands,': [2736, 2766], 'also': [2738, 2817], 'band.': [2745], 'Is': [2747], 'N-Glycosylated': [2748], 'Expressed': [2750], 'Surface—Analysis': [2754], 'multiple': [2765, 2813, 2881, 2950, 3001, 3009], '2A.': [2771], 'Here,': [2772], 'transiently': [2779, 3338], 'probed': [2784, 3744], 'Three': [2793], 'specific': [2794], 'will': [2802], 'refer': [2803], 'upper,': [2806], 'intermediate,': [2807], 'bands.': [2810], 'similar': [2812, 3360, 4162], 'banding': [2814], 'native': [2821], 'whole': [2824], 'heart': [2825], 'brain': [2827], 'lysate': [2828, 3541], 'adult': [2830], 'mouse,': [2831], 'upper': [2834, 3077, 3091, 3392, 3425, 3558, 3576], 'distinguished,': [2840], 'astrocytes,': [2844], 'endothelial': [2849], 'line': [2851, 3145], '2B).': [2859], 'This': [2860, 4054], 'indicated': [2861], 'species': [2866, 3370, 3839], 'due': [2869, 2885, 3608], 'differences': [2871], 'trafficking/processing': [2873], 'tagged': [2876], 'constructs.': [2877], 'often': [2884], 'post-translational': [2887], 'modifications': [2888], 'like': [2889], 'phosphorylation,': [2890], '(21Musil': [2898], 'E.C.': [2901], 'Goodenough': [2902], 'D.A.': [2903], 'Membr.': [2905], '1990;': [2907], '116:': [2908], '163-175Crossref': [2909], '(298)': [2912], 'potassium': [2920], '(22Watanabe': [2922], 'Recio-Pinto': [2926], 'Thornhill': [2928], 'W.B.': [2929], '279:': [2934], '8879-8885Abstract': [2935], '(92)': [2943], 'represent': [2956, 3013], 'phosphorylated': [2958], 'species,': [2959, 3016, 3893], 'phosphatase-based': [2964], 'dephosphorylation': [2965], 'protocol': [2966, 4018], '(CIAP': [2967], '2C,': [2970, 2990, 3050, 3073, 3115], 'lane': [2971, 2991, 3074, 3116], '2):': [2972], 'change': [2974], 'compared': [2984, 3440, 3536, 3647], 'untreated': [2986], '1)': [2992], 'suggesting': [2993, 3060, 3095, 3128, 3856, 4190], 'phosphorylation': [2995], 'responsible': [2998], 'Panx1.': [3004, 3751], 'glycosidase': [3018], 'treatment': [3019, 3054, 3087, 3156, 3403, 4203, 4223], 'rPanx1-WT': [3021, 3505], 'another': [3031, 3141], 'enzyme,': [3032], 'does': [3036], 'distinguish': [3038], 'differentially': [3041], 'sugars.': [3045], 'shifted': [3059, 3089], 'mannose-type': [3066, 3183], 'glycoproteins': [3067, 3590, 3994], 'residing': [3068, 3446], 'ER': [3071, 3445, 3479, 3709], '3).': [3075], 'insensitive.': [3084], 'down': [3088], 'both': [3090, 3387, 4188], 'represented': [3100], 'fully': [3102, 3188, 3382, 3991], '(mature-type': [3105], 'glycoprotein,': [3106], 'trans-Golgi': [3107], 'glycosylated)': [3108], '4).': [3117], 'affected': [3123], 'treatment,': [3127, 3583], 'corresponded': [3130], 'non-glycosylated': [3133, 3177, 4001], 'core': [3134, 3178, 4002], 'Similar': [3136], 'results': [3137], 'obtained': [3139], '(MDCK': [3146], 'rPanx1-4C)': [3147], 'sensitive': [3153], 'summary,': [3167], 'N-glycosylated': [3170], 'species:': [3174], 'GLY0': [3175], '(the': [3176, 3181, 3187], 'protein),': [3179], 'GLY1': [3180], 'glycoprotein),': [3184], 'GLY2': [3186], 'glycoprotein).': [3190], 'Preventing': [3191], 'Mutagenesis': [3197], 'Results': [3198], 'Intracellular': [3200], 'Localization—We': [3201], 'acid': [3205], '(CBS': [3213], 'prediction': [3214, 3305], 'server,': [3215], 'NetNGlyc,': [3216], '23Gupta': [3218], 'Pac.': [3222], 'Symp.': [3223], 'Biocomput.': [3224], '7:': [3226], '310-322Google': [3227], 'asparagine': [3236, 3288], '204,': [3237], '254,': [3238], '337,': [3239], '423.': [3241], 'Asn-204,': [3242], 'Asn-337,': [3243, 3290], 'Asn-423': [3245, 3301], 'located': [3247], 'cytoplasmic': [3251, 4182, 4270], 'domains,': [3252], 'loop': [3260], 'rPanx1.': [3262], 'determine': [3264], 'site,': [3275], 'inhibit': [3281], 'N-glycosylation.': [3282], 'Two': [3283], '(Asn-204,': [3289], 'Asn-254,': [3292], 'respectively)': [3293], 'mutated': [3295], 'glutamine': [3297], '3A).': [3299], 'score': [3306], 'Asn-337': [3308], 'because': [3310], 'distal': [3316], 'C': [3320, 3488], 'terminus': [3321], 'seemed': [3323], 'would': [3327, 4330], 'site.': [3331], 'Asn': [3333], 'Gln': [3335], 'mutants': [3336, 3474, 3658], '3B,': [3355], 'N204Q': [3357, 3453, 3671], 'WT': [3363], 'showed': [3367, 3417, 3481, 3677], '(GLY0,': [3373], 'GLY1,': [3374], 'GLY2);': [3376], 'conversely,': [3377], 'N254Q': [3379, 3471, 3790, 3826], 'glycosylation-deficient': [3383], 'lacked': [3386, 3423], '(GLY1)': [3390], '(GLY2)': [3393, 3426, 3560], '3C)': [3396], 'resistant': [3399], 'N337Q': [3409, 3473], '(GLY1),': [3421], '3C).': [3429], 'immunocytochemical': [3431], 'Myc-tagged': [3435, 3450], 'calnexin.': [3448], 'localized': [3457, 3497], '4,': [3463, 3487, 3729], 'B).': [3466], 'appeared': [3469], 'retained': [3476], 'clear': [3482], 'co-localization': [3483, 4303], 'calnexin': [3485], 'D).': [3490], 'investigate': [3493, 4265], 'surface,': [3501], 'biotinylated': [3503, 3522], 'intact': [3504], 'HEK293T': [3509], 'SDS-PAGE': [3517], 'blot.': [3520], 'passage': [3527], 'through': [3528], 'avidin': [3530], 'resin': [3531], 'column': [3532], '(bound': [3533], 'fraction)': [3534], 'total': [3539], '(unbound': [3542], 'fraction,': [3543, 3603], 'nonbiotinylated).': [3544], '5,': [3549, 3739], 'B,': [3552], 'lanes': [3553, 3661, 3727, 3736], '2,': [3556, 3728], 'biotinylated,': [3562], 'demonstrating': [3563], 'Because': [3574], 'insensitive': [3579], 'concluded': [3585], 'mature-type': [3589], '(trans-Golgi': [3591], 'proteins).': [3593], 'Although': [3594], 'most': [3606], 'residual': [3611], 'reagent,': [3618], 'part': [3624], 'against': [3632, 3750, 3775], 'α-tubulin.': [3633], 'α-tubulin': [3641], 'fraction': [3645], 'when': [3646], 'unbound': [3650], 'one.': [3651], 'N': [3657, 3722], '5B,': [3660], '3-8)': [3662], 'only.': [3673], 'summarize,': [3675], 'that:': [3678], '(i)': [3679], 'Asn-254;': [3685], '(ii)': [3686], 'process': [3688], 'step': [3692], 'protein;': [3698], '(iii)': [3700], 'preventing': [3701], 'retention': [3710], 'inhibits': [3712, 3937], 'expression.FIGURE': [3715], '5Cell-surface': [3716], 'rPanx1-Myc,': [3720], 'proteins.': [3724], 'Biotinylated': [3725], '(bound,': [3726], '6,': [3730], '8)': [3732], 'non-biotinylated': [3734], '(unbound,': [3735], '1,': [3737], '3,': [3738], '7)': [3741], 'parallel': [3769], 'α-tubulin.View': [3776], 'Large': [3777], 'Figure': [3779], 'ViewerDownload': [3780], 'Hi-res': [3781], 'image': [3782], 'Download': [3783], '(PPT)': [3784], 'tested': [3787, 3919], 'caused': [3803], 'appearance': [3805], 'predominant': [3838], 'gel.': [3842], 'always': [3851], 'highly': [3852], 'distinguishable': [3853], 'interfere': [3861], 'ability': [3864], 'assemble': [3870], 'single-band': [3899], 'monomers.': [3900], 'Deglycosylation': [3901], 'Pharmacological': [3903], 'Treatment': [3904], 'Prevents': [3905], 'Expression': [3907], 'Surface—In': [3913], 'addition': [3914], 'mutagenesis,': [3917], 'pharmacologically': [3920], 'effect': [3922], 'tunicamycin,': [3935, 4090], 'transfer': [3938], 'initial': [3941], 'mannose': [3943], 'nascent': [3947, 4008, 4205], 'peptide': [3948], 'thus': [3950], 'prevents': [3951], 'glycosylation.': [3954], 'MDCK': [3955, 4065], 'domain-tagged': [3961], 'tunicamycin': [3967, 4202], '(2': [3968], '6).': [3975], 'Over': [3976], 'periods': [3978, 4077], 'tested,': [3981], 'decline': [3988], '(GLY2),': [3995], 'increase': [3998], '(GLY0).': [4004], 'spatially': [4006], 'segregate': [4007], 'versus': [4009], 'older': [4010, 4133, 4192, 4274], 'pulse-chase': [4016], 'red': [4024], 'us': [4056], 'temporally': [4060], 'distinct': [4061], 'pools': [4062], 'rPanx1-4C.': [4064], 'rPanx1-4C': [4069, 4122, 4171, 4276, 4378], 'regular': [4083, 4286], 'ReAsH-EDT2,': [4094, 4280], 'fixed,': [4095], 'imaged': [4097, 4295, 4336], '7).': [4099], 'Immunolabeling': [4100], 'specificity': [4113], 'FlAsH/ReAsH': [4115], 'newer': [4121], 'mixing': [4130], 'ones.': [4134], 'No': [4135], 'punctate': [4136], 'resembling': [4138], 'typical': [4140], 'plaque': [4143], 'observed.': [4145, 4220], 'control,': [4148], 'temporal': [4150], 'order': [4151], 'reversed,': [4158], 'produced': [4160], 'distribution.': [4164], '15-18': [4166], 'increased': [4180], 'vesicles,': [4183], 'contain': [4187], 'colors': [4189], 'targeted': [4195], 'compartment': [4198, 4241], 'degradation.': [4200], 'Following': [4201], 'Panx1-4C': [4206], 'accumulated': [4208], 'synthesis': [4227], 'inhibitor,': [4228], 'cycloheximide,': [4229], 'neither': [4232], 'nor': [4237], 'importance': [4249], 'nature': [4267], 'vesicles': [4271], '15': [4283], 'medium,': [4287], 'Lysotracker': [4290], 'Blue,': [4291], 'live': [4294], '8).': [4297], 'merged': [4299], 'view': [4300], 'demonstrated': [4301], 'lysosomes': [4307, 4313], 'highlighting': [4308], 'degradation': [4316], 'type.': [4320], 'Imaging': [4322], 'Proteins—To': [4325], 'resolution': [4341], '4C': [4344], 'technology': [4345], 'photoconversion': [4347], 'specifically': [4376]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2072542349', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 21}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 21}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 31}, {'year': 2013, 'cited_by_count': 17}, {'year': 2012, 'cited_by_count': 20}], 'updated_date': '2024-12-13T21:20:37.118666', 'created_date': '2016-06-24'}