Title: Soft drugs: Principles and methods for the design of safe drugs
Abstract: Medicinal Research ReviewsVolume 4, Issue 4 p. 449-469 Article Soft drugs: Principles and methods for the design of safe drugs Nicholas Bodor, Nicholas Bodor Department of Medicinal Chemistry, J. Hillis Miller Health Center, Box J-4, University of Florida, Gainesville, Florida 32610Search for more papers by this author Nicholas Bodor, Nicholas Bodor Department of Medicinal Chemistry, J. Hillis Miller Health Center, Box J-4, University of Florida, Gainesville, Florida 32610Search for more papers by this author First published: October/December 1984 https://doi.org/10.1002/med.2610040402Citations: 83AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 N. Bodor and M. E. Brewster, Pharmac. Ther., 19, 337 (1983) and references cited. 2 A. Albert, Selective Toxicity, ( 6th ed.), Wiley, New York, 1974. 3 A. A. Sinkula and S. H. Yalkowsky, J. Pharm. Sci., 64, 181 (1975). 4 N. Bodar, in Optimization of Drug Delivery, (Alfred Benzon Symp. 17) Munksgaard, 1982, p. 156. 5 N. Bodar, Drugs of the Future, 6, 165 (1981). 6 J. R. Gillette, Progr. Drug Res., 6, 11 (1963). 7 G. J. Mannering, in Concepts in Drug Metabolism, P. Jenner and B. Testa, eds., 1981. P. B, Chap. 2, p. 141. 8 H. Bartsch, G. P. Margison, C. Malaveille, A. M. Camus, G. Brun, J. M. Margison, G. F. Kolar, and M. Weissler, Arch. Toxicol. 39, 51 (1977). 9 J. R. Gillette, J. R. Mitchell, and B. B. Brodie, Am. Rev. Pharmacol., 14, 271 (1974). 10 S. D. Nelson, J. R. Mitchell, E. Dybing, and H. A. Sasame, Biochem. Biophys. Res. Comm., 70, 1157 (1976). 11 T. C. Orton, C. Lowery, and W. E. Lindrup, Proc. Brit. Pharm. Soc., 60, 319 (1977). 12 E. J. Ariens, in Drug Design, (Vol. 1), E. J. Ariens Ed., Academic, New York, 1971, p. 1. 13 E. J. Ariens, in Drug Design, (Vol. 2) E. J. Ariens Ed., Academic, New York, 1971, p. 1. 14 E. J. Ariens, in Pharmacochemistry Library, (Vol. 2) 1977, p. 1; and reference cited. 15 E. J. Ariens and A. M. Simonis, in Drug Design and Adverse Reactions, Alfred Benzon Symp. 10, Munksgaard, 1977, p. 317. 16 E. J. Ariens, Strategy in Drug Research, Presentation at the IUPAC-IUPHAR Symposium, Noordwijkerhout, Netherlands, August, 1981. 17 N. Bodor, in Strategy in Drug Research, J. A. Keverling Buisman, Ed., Elsevier, Amsterdam-Oxford-New York, 1982, p. 137. 18 N. Bodor, "Soft drugs: Strategies for design of low toxicity drugs," Proceedings of the Centre de Recherches Clin Midy Symposium on Drug Metabolism and Drug Design: Quo Vadis?, Montpellier, November 26–27, 1981. 19 N. Bodor, "Designing safer drugs based on the soft drug approach," Trends in Pharmacol. Sci. 3(2), 53 (1982). 20 N. Bodar and A. M. Simonis, Strategy in Drug Research, J. A. Keverling Buisman, Ed., Elsevier, Amsterdam-Oxford-New York, 1982, p. 165. 21 A. Albert, Chem. Austral. 49, 412 (1982). 22 N. Bodor, Design of Biopharmaceutical Properties Through Prodrugs and Analogs, E. B. Roche (Ed.), Acad. Pharm. Sci., Washington, DC, 1977, p. 98. 23 N. Bodor, Novel approaches to the design of membrane transport properties of drugs, in Design of Bio-Pharmaceutical Properties Through Pro-Drugs and Analogs, E. B. Roche (Ed.), Symposium Proceedings of Acad. Pharm. Sci., Chap. 7, 1977, p. 98. 24 N. Bodor, U. S. Patent 4,061,722, December 6, 1977. 25 N. Bodor and L. Freiberg, U. S. Patent 4,262,765, April 28, 1981. 26 N. Bodor, J. Kaminski and S. H. Selk, J. Med. Chem., 23, 469 (1980). 27 N. Bodor, R. Woods, C. Raper, P. Kearney, and J. J. Kaminski, J. Med. Chem., 23, 474 (1980). 28 F. S. Kilmer McMillan, H. M. Reller, and R. H. Snyder, J. Invest. Dermatol., 43, 363 (1964). 29 N. Bodor, Y. Oshiro, K. Nitani, and T. Loftsson, to be published. 30 K. M. Kutty, J. E. Jacob, C. J. Hutton, P. J. Davis, and S. C. Peterson, Clin. Biochem., 8, 379 (1975). 31 K. M. Kutty, R. Redheendran, and D. Murphy, Experimentia, 33, 420 (1977). 32 N. Bodor, Y. Oshiro, T. Loftsson, and W. Caldwell, in print. 33 N. Bodor, J. J. Kaminski, S. D. Worley, R. J. Colton, T. H. Lee, and J. W. Rabalais, J. Pharm. Sci. 63, 1387 (1974). 34 J. J. Kaminski, N. Bodor and T. Higuchi, J. Pharm. Sci., 65, 553 (1976). 35 J. J. Kaminski, N. Bodor and T. Higuchi, J. Pharm. Sci., 65, 1733 (1976). 36 J. J. Kaminski, M. M. Huycke, S. H. Selk, N. Bodor, and T. Higuchi, J. Pharm. Sci., 65, 1736 (1976). 37 M. Kosugi, J. J. Kaminski, S. H. Selk, I. H. Pitman, N. Bodor, and T. Higuchi, J. Pharm. Sci., 65, 1743 (1976). 38 H. H. Kohl, W. B. Wheatley, S. D. Worley, and N. Bodor, J. Pharm. Sci., 69, 1292 (1980). 39 N. Bodor and J. J. Kaminski, J. Med. Chem., 23, 566 (1980). 40 N. Bodor, J. J. Kaminski, S. D. Worley, and S. H. Gerson, Z. Naturforsch, 35b, 758 (1980). 41 N. Bodor and H. H. Farag, J. Med. Chem., 26, 313 (1983). 42 N. Bodor, K. B. Sloan, R. J. Little, S. H. Selk, and L. Caldwell, Int. J. Pharmaceutics, 10, 307 (1982). 43 W. M. Schubert and Y. Motoyama, J. Am. Chem. Soc., 87, 5507 (1965). 44 K. B. Sloan, N. Bodor and R. J. Little, Tetrahedron, 37, 3467 (1981). 45 K. B. Sloan, N. Bodor and J. Zupan, Tetrahedron, 37, 3463 (1981). 46 N. Bodor and K. B. Sloan, J. Pharm. Sci., 71, 514 (1982). 47 N. Bodor and K. B. Sloan, U. S. Patents 4,069,322, January 17, 1978 and U. S. Patents 4,239,757, December 16, 1980. 48 N. Bodor and H. H. Farag, J. Med. Chem., 26, 538 (1983). 49 N. Bodor and J. Simpkins, Science, 221, 65 (1983). 50 N. Bodor and H. H. Farag, J. Pharm. Sci., 73, 385 (1984). 51 N. Bodor and G. Visor, to be published. 52 R. J. Francis, P. B. East, S. J. McLaren and J. Larman, Biomed. Mass Spectrometry, 3, 281 (1976). 53 M. B. Abou-Donia and D. B. Menzel, Biochem. Pharmacol., 17, 2143 (1968). 54 W. Mutzel, Arz. Forsch., 27, 2230 (1977). 55 H. Laurent, E. Gerhards and R. Wiechert, Ang. Chem., 14, 65 (1975). 56 N. Bodor, Belg, BE 889,563 (CL. CO7J), November 3, 1981. 57 N. Bodor and R. J. Little, unpublished results. 58 N. Bodor, K. Nakagawa, S. Tamada, and R. J. Little, unpublished results. 59 N. Bodor, Y. Oshiro, T. Loftsson and W. Caldwell, in print. 60 P. W. Erhardt, C. M. Woo, W. G. Anderson and R. J. Gorczynski, J. Med. Chem., 25, 1408 (1982). Citing Literature Volume4, Issue4October/December 1984Pages 449-469 ReferencesRelatedInformation
Publication Year: 1984
Publication Date: 1984-10-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 96
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