Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2072394892', 'doi': 'https://doi.org/10.1021/ja909996p', 'title': 'Comparative Analysis of Small Molecules and Histone Substrate Analogues as LSD1 Lysine Demethylase Inhibitors', 'display_name': 'Comparative Analysis of Small Molecules and Histone Substrate Analogues as LSD1 Lysine Demethylase Inhibitors', 'publication_year': 2010, 'publication_date': '2010-02-11', 'ids': {'openalex': 'https://openalex.org/W2072394892', 'doi': 'https://doi.org/10.1021/ja909996p', 'mag': '2072394892', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20148560', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2843942'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ja909996p', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111155417', 'display_name': 'Journal of the American Chemical Society', 'issn_l': '0002-7863', 'issn': ['0002-7863', '1520-5126', '1943-2984'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2843942?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043691947', 'display_name': 'Jeffrey C. Culhane', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802697821', 'display_name': 'Johns Hopkins Bayview Medical Center', 'ror': 'https://ror.org/04pwc8466', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I2802697821']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}, {'id': 'https://openalex.org/I4210126319', 'display_name': 'Duke-NUS Medical School', 'ror': 'https://ror.org/02j1m6098', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596', 'https://openalex.org/I170897317', 'https://openalex.org/I4210126319']}], 'countries': ['SG', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey C. Culhane', 'raw_affiliation_strings': ['Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, and Cardiovascular and Metabolic Diseases Program, Duke-NUS Graduate Medical School, Singapore 169857'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, and Cardiovascular and Metabolic Diseases Program, Duke-NUS Graduate Medical School, Singapore 169857', 'institution_ids': ['https://openalex.org/I2802697821', 'https://openalex.org/I145311948', 'https://openalex.org/I4210126319']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100670772', 'display_name': 'Dongqing Wang', 'orcid': 'https://orcid.org/0000-0001-8856-4289'}, 'institutions': [{'id': 'https://openalex.org/I2802697821', 'display_name': 'Johns Hopkins Bayview Medical Center', 'ror': 'https://ror.org/04pwc8466', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I2802697821']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}, {'id': 'https://openalex.org/I4210126319', 'display_name': 'Duke-NUS Medical School', 'ror': 'https://ror.org/02j1m6098', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596', 'https://openalex.org/I170897317', 'https://openalex.org/I4210126319']}], 'countries': ['SG', 'US'], 'is_corresponding': False, 'raw_author_name': 'Dongqing Wang', 'raw_affiliation_strings': ['Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, and Cardiovascular and Metabolic Diseases Program, Duke-NUS Graduate Medical School, Singapore 169857'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, and Cardiovascular and Metabolic Diseases Program, Duke-NUS Graduate Medical School, Singapore 169857', 'institution_ids': ['https://openalex.org/I2802697821', 'https://openalex.org/I145311948', 'https://openalex.org/I4210126319']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015934115', 'display_name': 'Paul M. Yen', 'orcid': 'https://orcid.org/0000-0002-3790-8114'}, 'institutions': [{'id': 'https://openalex.org/I2802697821', 'display_name': 'Johns Hopkins Bayview Medical Center', 'ror': 'https://ror.org/04pwc8466', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I2802697821']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}, {'id': 'https://openalex.org/I4210126319', 'display_name': 'Duke-NUS Medical School', 'ror': 'https://ror.org/02j1m6098', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596', 'https://openalex.org/I170897317', 'https://openalex.org/I4210126319']}], 'countries': ['SG', 'US'], 'is_corresponding': False, 'raw_author_name': 'Paul M. Yen', 'raw_affiliation_strings': ['Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, and Cardiovascular and Metabolic Diseases Program, Duke-NUS Graduate Medical School, Singapore 169857'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, and Cardiovascular and Metabolic Diseases Program, Duke-NUS Graduate Medical School, Singapore 169857', 'institution_ids': ['https://openalex.org/I2802697821', 'https://openalex.org/I145311948', 'https://openalex.org/I4210126319']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5018061374', 'display_name': 'Philip A. Cole', 'orcid': 'https://orcid.org/0000-0001-6873-7824'}, 'institutions': [{'id': 'https://openalex.org/I2802697821', 'display_name': 'Johns Hopkins Bayview Medical Center', 'ror': 'https://ror.org/04pwc8466', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I2802697821']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}, {'id': 'https://openalex.org/I4210126319', 'display_name': 'Duke-NUS Medical School', 'ror': 'https://ror.org/02j1m6098', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596', 'https://openalex.org/I170897317', 'https://openalex.org/I4210126319']}], 'countries': ['SG', 'US'], 'is_corresponding': False, 'raw_author_name': 'Philip A. Cole', 'raw_affiliation_strings': ['Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, and Cardiovascular and Metabolic Diseases Program, Duke-NUS Graduate Medical School, Singapore 169857'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, and Cardiovascular and Metabolic Diseases Program, Duke-NUS Graduate Medical School, Singapore 169857', 'institution_ids': ['https://openalex.org/I2802697821', 'https://openalex.org/I145311948', 'https://openalex.org/I4210126319']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.02, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 146, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '132', 'issue': '9', 'first_page': '3164', 'last_page': '3176'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11736', 'display_name': 'Role of Histone Deacetylases in Cellular Regulation', 'score': 0.9713, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11337', 'display_name': 'Neuroimmune Interaction in Psychiatric Disorders', 'score': 0.965, 'subfield': {'id': 'https://openalex.org/subfields/2803', 'display_name': 'Biological Psychiatry'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tranylcypromine', 'display_name': 'Tranylcypromine', 'score': 0.6814132}, {'id': 'https://openalex.org/keywords/demethylase', 'display_name': 'Demethylase', 'score': 0.5938018}, {'id': 'https://openalex.org/keywords/demethylation', 'display_name': 'Demethylation', 'score': 0.48521045}, {'id': 'https://openalex.org/keywords/histone-deacetylases', 'display_name': 'Histone Deacetylases', 'score': 0.482508}, {'id': 'https://openalex.org/keywords/phenelzine', 'display_name': 'Phenelzine', 'score': 0.42148718}], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.93003273}, {'id': 'https://openalex.org/C2777118369', 'wikidata': 'https://www.wikidata.org/wiki/Q420885', 'display_name': 'Tranylcypromine', 'level': 4, 'score': 0.6814132}, {'id': 'https://openalex.org/C2781364455', 'wikidata': 'https://www.wikidata.org/wiki/Q2531584', 'display_name': 'Demethylase', 'level': 4, 'score': 0.5938018}, {'id': 'https://openalex.org/C202199734', 'wikidata': 'https://www.wikidata.org/wiki/Q900386', 'display_name': 'Demethylation', 'level': 5, 'score': 0.48521045}, {'id': 'https://openalex.org/C161624437', 'wikidata': 'https://www.wikidata.org/wiki/Q1988322', 'display_name': 'Small molecule', 'level': 2, 'score': 0.46865076}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.4511931}, {'id': 'https://openalex.org/C2776024655', 'wikidata': 'https://www.wikidata.org/wiki/Q410867', 'display_name': 'Monoamine oxidase', 'level': 3, 'score': 0.44672713}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.44547912}, {'id': 'https://openalex.org/C2781073023', 'wikidata': 'https://www.wikidata.org/wiki/Q1747559', 'display_name': 'Phenelzine', 'level': 4, 'score': 0.42148718}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.41508964}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.39340597}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.37434882}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.063133895}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D056466', 'descriptor_name': 'Histone Demethylases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D006834', 'descriptor_name': 'Hydrazines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010293', 'descriptor_name': 'Pargyline', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011437', 'descriptor_name': 'Propylamines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019032', 'descriptor_name': 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ja909996p', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111155417', 'display_name': 'Journal of the American Chemical Society', 'issn_l': '0002-7863', 'issn': ['0002-7863', '1520-5126', '1943-2984'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2843942', 'pdf_url': 'https://europepmc.org/articles/pmc2843942?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843942', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20148560', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2843942', 'pdf_url': 'https://europepmc.org/articles/pmc2843942?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.68}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1513129282', 'https://openalex.org/W1546296744', 'https://openalex.org/W1550877969', 'https://openalex.org/W1977851507', 'https://openalex.org/W1983015568', 'https://openalex.org/W1985180051', 'https://openalex.org/W1998004148', 'https://openalex.org/W2004499293', 'https://openalex.org/W2011263116', 'https://openalex.org/W2013557200', 'https://openalex.org/W2013810007', 'https://openalex.org/W2019620912', 'https://openalex.org/W2030363874', 'https://openalex.org/W2036158314', 'https://openalex.org/W2038504509', 'https://openalex.org/W2045580211', 'https://openalex.org/W2054643318', 'https://openalex.org/W2057437339', 'https://openalex.org/W2061811800', 'https://openalex.org/W2061985450', 'https://openalex.org/W2063929711', 'https://openalex.org/W2064887977', 'https://openalex.org/W2068739830', 'https://openalex.org/W2071513524', 'https://openalex.org/W2076427374', 'https://openalex.org/W2077642616', 'https://openalex.org/W2082086284', 'https://openalex.org/W2096083625', 'https://openalex.org/W2099803844', 'https://openalex.org/W2120586432', 'https://openalex.org/W2139977642', 'https://openalex.org/W2141410747', 'https://openalex.org/W2142261306', 'https://openalex.org/W2153997114', 'https://openalex.org/W2158732261', 'https://openalex.org/W2167153608', 'https://openalex.org/W2171598595', 'https://openalex.org/W2417720463', 'https://openalex.org/W2471717479', 'https://openalex.org/W2948493777', 'https://openalex.org/W2950187336', 'https://openalex.org/W2953209066', 'https://openalex.org/W4212766227', 'https://openalex.org/W4242164740'], 'related_works': ['https://openalex.org/W4242433836', 'https://openalex.org/W2798170467', 'https://openalex.org/W2414338841', 'https://openalex.org/W2413572817', 'https://openalex.org/W2268665763', 'https://openalex.org/W2165521077', 'https://openalex.org/W2127974139', 'https://openalex.org/W2093651732', 'https://openalex.org/W2073876672', 'https://openalex.org/W116902245'], 'abstract_inverted_index': {'LSD1': [0, 16, 69, 96, 115, 135, 144, 162, 191], 'is': [1, 93, 102, 141, 197], 'a': [2, 94, 142, 189, 218], 'flavin-dependent': [3], 'histone': [4, 14, 210], 'demethylase': [5], 'that': [6, 33, 46, 139, 195, 206], 'oxidatively': [7], 'removes': [8], 'methyl': [9], 'groups': [10], 'from': [11], 'Lys-4': [12], 'of': [13, 61, 122], 'H3.': [15], 'belongs': [17], 'to': [18, 28, 31, 37, 127, 157, 187], 'the': [19, 86, 129, 159], 'amine': [20], 'oxidase': [21, 48], 'enzyme': [22], 'superfamily': [23], 'which': [24], 'utilize': [25], 'molecular': [26], 'oxygen': [27], 'transform': [29], 'amines': [30], 'imines': [32], 'are': [34, 67], 'hydrolytically': [35], 'cleaved': [36], 'formaldehyde.': [38], 'In': [39, 84], 'prior': [40], 'studies,': [41], 'it': [42, 196, 216], 'has': [43], 'been': [44], 'shown': [45, 156], 'monoamine': [47], 'inhibitory': [49], 'scaffolds': [50, 126], 'such': [51], 'as': [52, 58, 134, 217], 'propargylamines': [53], 'and': [54, 132, 193, 221], 'cyclopropylamines': [55], 'can': [56, 208], 'serve': [57], 'mechanism-based': [59, 143], 'inactivators': [60], 'LSD1.': [62, 83], 'Propargylamine-histone': [63], 'H3': [64], 'peptide': [65, 112, 125], 'analogues': [66], 'potent': [68, 161, 200], 'inhibitors,': [70], 'whereas': [71, 146], 'small': [72, 87, 109], 'molecule': [73, 88, 110], 'antidepressant': [74, 181], 'MAO': [75, 89, 180], 'acetylenic': [76], 'inhibitors': [77], 'like': [78], 'pargyline': [79], 'do': [80], 'not': [81, 149], 'inhibit': [82], 'contrast,': [85], 'cyclopropylamine': [90], 'inhibitor': [91, 97, 164], 'tranylcypromine': [92], 'time-dependent': [95, 151], 'but': [98], 'exo-cyclopropylamine-peptide': [99], 'substrate': [100], 'analogue': [101], 'not.': [103], 'To': [104], 'provide': [105], 'further': [106, 119], 'insight': [107], 'into': [108], 'versus': [111], 'relationships': [113], 'in': [114, 124, 172, 213], 'inhibition,': [116], 'herein': [117], 'we': [118], 'our': [120], 'analysis': [121], 'warheads': [123], 'include': [128], 'chlorovinyl,': [130], 'endo-cyclopropylamine,': [131], 'hydrazine-functionalities': [133], 'inactivators.': [136], 'We': [137, 178, 204], 'find': [138], 'chlorovinyl-H3': [140], 'inactivator': [145], 'endo-cyclopropylamine-H3': [147], 'does': [148], 'show': [150, 205], 'inactivation.': [152], 'The': [153], 'hydrazine-H3': [154], 'was': [155], 'be': [158, 188], 'most': [160], 'suicide': [163], 'yet': [165], 'reported,': [166], 'more': [167, 170, 199], 'than': [168, 175, 201], '20-fold': [169], 'efficient': [171], 'inhibiting': [173], 'demethylation': [174, 212], 'propargylamine-H3': [176], 'derivatives.': [177], 're-explored': [179], 'agent': [182], 'phenelzine': [183, 207], '(phenethylhydrazine),': [184], 'previously': [185, 202], 'reported': [186], 'weak': [190], 'inhibitor,': [192], 'found': [194], 'far': [198], 'appreciated.': [203], 'block': [209], 'H3K4Me': [211], 'cells,': [214], 'validating': [215], 'pharmacologic': [219], 'tool': [220], 'potential': [222], 'lead': [223], 'structure': [224], 'for': [225], 'anticancer': [226], 'therapy.': [227]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2072394892', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 15}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2024-08-14T00:38:47.777709', 'created_date': '2016-06-24'}